Review
Immunology
Charlie Bridgewood, Darren Newton, Nicola Bragazzi, Miriam Wittmann, Dennis McGonagle
Summary: The IL-23/IL-17 cytokine axis is associated with spondyloarthropathy (SpA) pattern diseases that target the skin, eye, gut and joints, sharing some common characteristics with Th2 type or allergic diseases but also exhibiting distinct features. These findings suggest a dynamic Th2 and Th17 cytokine counter regulation in vivo in humans.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Article
Dermatology
Tiago Torres, Luis Puig, Ron Vender, Charles Lynde, Stefano Piaserico, Jose M. Carrascosa, Paolo Gisondi, Esteban Dauden, Curdin Conrad, Pedro Mendes-Bastos, Paulo Ferreira, Luiz Leite, Justin D. Lu, J. Valerio, M. Bruni, F. Messina, A. Nidegger, M. Llamas-Velasco, E. del Alcazar, A. Mufti, Kyra White, G. Caldarola, Laetitia Teixeira, Paolo Romanelli, K. Desai, Spyridon Gkalpakiotis, Marco Romanelli, Jensen Yeung, Miguel Nogueira, Andrea Chiricozzi
Summary: In this study, drug survival analysis of the most recent biologic agents approved for the treatment of psoriasis was conducted. Factors such as female sex, higher BMI, and prior exposure to biologic agents were found to significantly increase the risk of drug discontinuation. The study also showed that the drug survival of guselkumab and risankizumab was higher than that of ustekinumab, while secukinumab had a lower drug survival rate.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Review
Immunology
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis, with genetic predisposition playing a key role in its development. The IL-23/IL-17 axis is highlighted as important in the immunopathogenesis of PsA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Sara Kamp Felbo, Mikkel Ostergaard, Inge Juul Sorensen, Lene Terslev
Summary: This study investigated the prevalence of ultrasound enthesitis lesions in patients with peripheral spondyloarthritis in the heel region. The results showed that less than 50% of clinically tender entheses were related to inflammatory enthesitis, and other inflammatory pathologies were identified in some cases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Hao Li, George C. Tsokos
Summary: Inflammatory rheumatic disorders involve the immune system attacking connective tissues and internal organs. Advances in understanding the cellular and molecular mechanisms have led to targeting the IL-23/IL-17 axis therapeutically, resulting in clinical benefits. The complicated interrelationship between IL-23 and IL-17 may be uncoupled in certain disease settings.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Bram Verstockt, Azucena Salas, Bruce E. Sands, Clara Abraham, Haim Leibovitzh, Markus Neurath, Niels Vande Casteele
Summary: IL-12 and IL-23 play a crucial role in intestinal homeostasis and inflammation, and are implicated in the pathogenesis of inflammatory bowel disease. Monoclonal antibodies targeting IL-12 and/or IL-23 have been developed for the treatment of Crohn's disease and ulcerative colitis. This Review summarizes the biological characteristics of IL-12 and IL-23, discusses their role in intestinal homeostasis and inflammation, and highlights the development of drugs targeting IL-12 and/or IL-23.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Immunology
Angela Ceribelli, Francesca Motta, Matteo Vecellio, Natasa Isailovic, Francesco Ciccia, Carlo Selmi
Summary: Spondyloarthritis (SpA) is a group of inflammatory musculoskeletal diseases with common genetic backgrounds, and IL-17 and IL-23 have been identified as key cytokines in its pathogenesis. Treatment options for axial SpA differ significantly from peripheral arthritis, with new therapies targeting these cytokines showing promising results for both axial psoriatic arthritis and ankylosing spondylitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yanpeng Li, Zhilei Li, Kutty Selva Nandakumar, Rikard Holmdahl
Summary: A recent study found that a single nucleotide variant (NCF1(R90H)) on the NCF1 gene was associated with low production of reactive oxygen species (ROS) and causative for several autoimmune diseases. The study induced psoriasis in the skin and psoriatic arthritis using mannan and evaluated the effects. It was found that the NCF1(90H) variant promoted psoriasis and psoriatic arthritis by hyperactivating macrophages, expanding keratinocytes, and increasing numbers of γδT17 cells.
Article
Dermatology
L. Mastorino, S. Susca, C. Cariti, N. Sliquini, A. Verrone, E. Stroppiana, M. Ortoncelli, P. Dapavo, S. Ribero, P. Quaglino
Summary: Many European national guidelines recommend initial treatment with anti-TNF-alpha adalimumab for psoriasis and psoriatic arthritis due to economic reasons. This study evaluated the efficacy and safety of IL-17 and IL-23 inhibitors for patients who had previously received adalimumab treatment compared to adalimumab-naive patients. The findings suggested that there were no significant differences in efficacy between IL-17 and IL-23 inhibitors for both adalimumab-experienced and adalimumab-naive patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, Research & Experimental
Christian F. Krebs, Jan-Eric Turner, Jan-Hendrik Riedel, Ulf Panzer
Summary: Immune-mediated kidney diseases are a major cause of end-stage renal disease. The immunopathogenesis of these diseases is not fully understood, leading to a lack of specific therapies. However, research has shown that cytokines related to T cell response play a crucial role in renal autoimmunity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Andre Lopes Saraiva, Raphael Sanches Peres, Flavio Protasio Veras, Jhimmy Talbot, Kalil Alves de Lima, Joao Paulo Mesquita Luiz, Thiago Mattar Cunha, Paulo Louzada-Junior, Fernando Queiroz Cunha, Jose Carlos Alves-Filho
Summary: The experimental arthritis model established using citrullinated human plasma fibrinogen revealed the importance of IL-23/IL-17 immune axis-mediated inflammatory responses in the pathogenesis of rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Diksha Jawale, Shweta Khandibharad, Shailza Singh
Summary: IL-6, IL-17, IL-23, and IL-1 beta are important cytokines in controlling inflammation and immune response during L. major infection. The CD4+ Th17 subset plays a crucial role in lesion formation by stimulating infected macrophages and producing pro-inflammatory cytokines. The study suggests that targeting SATB1 may modulate the secretion of pro-inflammatory cytokines and abnormal immune functioning, potentially leading to the elimination of the intracellular parasite. The use of systems immunological methods helps in understanding crucial components and developing therapeutic interventions for L. major infection.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)