Article
Genetics & Heredity
Ze Zhang, Min Kyung Lee, Laurent Perreard, Karl T. Kelsey, Brock C. Christensen, Lucas A. Salas
Summary: This study compared the data quality of BS-treated and oxBS-treated samples and observed a consistent loss of high-quality data in oxBS-treated samples. The authors offer a bioinformatic tool to evaluate potential quality issues in the process and provide some technical advice to reduce false signals in the data. Therefore, they emphasize the importance of preserving DNA integrity when using tandem BS- and oxBS-treated DNA to measure 5-methylcytosine and 5hmC.
Article
Clinical Neurology
Sigrid Pedersen, Magnhild Kverneland, Karl Otto Nakken, Knut Rudi, Per Ole Iversen, Kristina Gervin, Kaja Kristine Selmer
Summary: This study investigated the impact of the modified ketogenic diet on DNA methylation in adults with epilepsy. The results showed a genome-wide decrease in DNA methylation after dietary treatment, and some differentially methylated sites were associated with genes related to epilepsy, lipid metabolism, and transcriptional regulation. Genes related to inositol phosphate metabolism may play a role in attenuating seizures.
Article
Oncology
Luanfeng Li, Wensi Liu, Haichao Tang, Xiangyi Wang, Xinli Liu, Zhaojin Yu, Yanan Gao, Xiaobin Wang, Minjie Wei
Summary: A study established a genetic feature model related to hypoxia in bladder urothelial carcinoma, showing that the high-risk group had better outcomes, each gene affected patient survival, immune-related pathways were enriched, and immune checkpoints were more highly expressed in the high-risk group.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Environmental Sciences
Paulina Jedynak, Lucile Broseus, Jorg Tost, Florence Busato, Stephan Gabet, Cathrine Thomsen, Amrit K. Sakhi, Isabelle Pin, Remy Slama, Johanna Lepeule, Claire Philippat
Summary: A previous study found positive associations between maternal urinary concentrations of triclosan and placental DNA methylation in male fetuses. This study aimed to validate and expand on these findings by examining triclosan exposure and placental DNA methylation in a cohort of male and female fetuses. The results confirmed associations between triclosan and certain genes in both sexes, with the majority of associations being positive and mapping to imprinted genes. The study also identified mediation effects of placental tissue heterogeneity on the associations. In conclusion, triclosan exposure is associated with placental DNA methylation, particularly in imprinted genes.
ENVIRONMENTAL POLLUTION
(2023)
Article
Oncology
Jiahui Zhao, Chunting Wu, Yongxing Wang, Mingchuan Li, Yongguang Jiang, Yong Luo
Summary: The study revealed the important role of pyroptosis in bladder cancer patients. By establishing a risk model based on pyroptosis-related genes, it can help evaluate the clinical prognosis of patients and provide new insights for future research to improve overall survival and responses to cancer therapy targeting pyroptosis.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Animesh Acharjee, Prasoon Agarwal, Katrina Nash, Subia Bano, Taufiq Rahmans, Georgios Gkoutos
Summary: Colon adenocarcinoma is a common gastrointestinal tumor with high mortality, and research has identified immune-related genes playing a vital role in its development. The LGALS4 gene is significantly downregulated in COAD and BLCA, serving as a potential prognostic and diagnostic marker for these cancers. This analysis reveals novel drug targets and molecular markers that may help explain the pathogenesis of COAD and BLCA.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Safayat Mahmud Khan, Tonmoy Das, Sajib Chakraborty, Abdul Matin Anamur Rashid Choudhury, Howlader Fazlul Karim, Munshi Akid Mostofa, Hasib Uddin Ahmed, Md Akmal Hossain, Florence Le Calvez-Kelm, Md Ismail Hosen, Hossain Uddin Shekhar
Summary: This study investigated the role of p53 pathway genes in bladder cancer through transcriptomics analysis. Two subtypes of bladder cancer were identified, one associated with immune-related pathways and poor prognosis, and the other associated with steroid synthesis and drug metabolism pathways and better prognosis. A signature gene set consisting of six genes was created and a risk model was developed. This study has the potential to significantly impact the development of biomarkers for bladder cancer.
Article
Genetics & Heredity
Akshay Pramod Ware, Kapaettu Satyamoorthy, Bobby Paul
Summary: Chromosome 19 microRNA cluster (C19MC) is the largest miRNA cluster in humans, consisting of 46 miRNAs embedded tandemly. In this study, we examined the regulation, expression patterns, and impact of C19MC on bladder cancer (BCa) using multiomics data analysis. We found that 43 C19MC members were highly expressed in BCa, but their co-localization with copy number variation (CNV) gain was not statistically significant. The CpG probes at the well-established CpG island upstream of the transcription start site were hypomethylated, and the promoter region of C19MC was regulated by a group of transcription factors and chromatin modifiers. Furthermore, C19MC targeted multiple tumor suppressor genes that were downregulated and correlated with patient survival. These findings suggest the potential of using C19MC and its regulators as diagnostic, prognostic, and therapeutic indicators for BCa.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Han-Chen Ho, Dan-Yun Chiou, Hann-Chorng Kuo
Summary: Urine oxidative stress biomarkers and inflammatory cytokines play important roles in diagnosing and differentiating clinical subtypes of interstitial cystitis/bladder pain syndrome (IC/BPS).
Article
Medicine, General & Internal
Daniela Dzubinska, Milan Zvarik, Boris Kollarik, Libusa Sikurova
Summary: Bladder cancer is the most common type of carcinoma in the urological system, and there is no reliable non-invasive method to distinguish patients with bladder cancer from those with non-malignant hematuria. The study found that using 3D HPLC in combination with computer processing of multiple datasets can help differentiate between patients with bladder cancer and non-malignant hematuria.
Article
Biology
Jae-Hak Ahn, Chan-Koo Kang, Eun-Mee Kim, Ah-Ram Kim, Aram Kim
Summary: Bladder cancer is the fourth most common cancer in men, with most cases being non-muscle-invasive. The high recurrence rate in non-muscle-invasive bladder cancer is a critical issue. Limited urine tests hinder the effective detection of superficial and small bladder tumors. Cystoscopy, although the gold standard for diagnosis, is associated with complications. Therefore, the development of urinary biomarkers is necessary for the detection of bladder cancer.
Review
Oncology
Nicholas Lee, Ashan Canagasingham, Mohit Bajaj, Ramesh Shanmugasundaram, Anthony Hutton, Joseph Bucci, Peter Graham, James Thompson, Jie Ni
Summary: Bladder cancer is one of the top ten most common cancers and top ten causes of cancer death globally. Survival rates have decreased, and the current gold standard for diagnosis is invasive. Exosomes show potential as biomarkers for bladder cancer diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Urology & Nephrology
Jinkun Li, Bisheng Cheng, Hongbing Xie, Chuanchuan Zhan, Shipeng Li, Peiming Bai
Summary: In this study, liquid chromatography-mass spectrometry was used to analyze the urine of bladder cancer patients and cancer-free controls, and identified significant differences in 27 metabolites between the two groups. The results suggest that non-invasive clinical diagnoses of bladder cancer may be possible through the use of these candidate biomarkers identified in the study.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Oncology
Makito Miyake, Nobutaka Nishimura, Sayuri Ohnishi, Yuki Oda, Takuya Owari, Kenta Ohnishi, Yosuke Morizawa, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Kazumasa Torimoto, Tomomi Fujii, Nobumichi Tanaka, Kiyohide Fujimoto
Summary: This study investigated the potential diagnostic and prognostic values of urine Nectin-2 and Nectin-4 in bladder cancer (BCa). The results showed that urine Nectin-4 levels were significantly higher than Nectin-2 levels. Both Nectin-2 and Nectin-4 had higher sensitivity than cytology for diagnosing BCa.