Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2018, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2018/5236324
Keywords
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Funding
- National Key Research and Development Program of China [2016YFD-0300203-3]
- General Program of National Science Foundation of China [31372105]
- Henan Postdoctoral Scientific Research Project
- Science-Technology Foundation for High-level Talent of Henan Institute of Science and Technology [2015028]
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Cotton leaf spot (Alternaria macrospora) is a widespread disease that occurs in the main cotton-producing area of China. In managing this disease, a novel chitosan-based biopesticide, an amphiphilic N-alkyl-O-carboxymethyl chitosan derivative, was prepared. The product was selected from variations of chitosan with different molecular structures, which were obtained via a two-step reaction. First, carboxymethyl chitosans with varying molecular sizes were obtained by etherification with chloroacetic acid; then the carboxymethyl chitosan was alkylated with C4-C12 fatty aldehyde through a Schiff-base reaction. This procedure resulted in derivatives of amphiphilic N-alkyl-O-carboxymethyl chitosan, which showed strong antifungal activities against A. macrospora, and the efficacy was determined by its molecular structure.
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