Article
Chemistry, Applied
Zhiguo Zhou, Han Zhou, Kang Zhang, Yaning Wang, Yucong Gao, Fang Liu, Hong Yang, Shiping Yang
Summary: Cy-ZnDPA is a targeted probe that can accurately diagnose DILI and locate the lesion area, with potential applications in other apoptotic-related physiological and pathological processes.
Article
Chemistry, Analytical
Chu Tang, Hongjuan Tong, Bin Liu, Xinan Wang, Yushen Jin, Erli Tian, Fu Wang
Summary: In this study, a novel estrogen receptor alpha (ER α)-targeted near-infrared fluorescence probe was developed for rapid and sensitive detection of hydrazine levels. The probe exhibited good ER α affinity, excellent selectivity, and high biocompatibility. It can visualize hydrazine concentration rapidly and provide high contrast in vivo imaging.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Hira Fatima, Muhammad Rizwan Azhar, Mehdi Khiadani, Yijun Zhong, Wei Wang, Chao Su, Zongping Shao
Summary: The development of a near-infrared-responsive photocatalyst Fe3O4@PB@ZnO has successfully addressed the challenge of low-wavelength photon absorption in ZnO-based photocatalysis for wastewater treatment. The enhanced photocatalytic rate of Fe3O4@PB@ZnO is attributed to the presence of PB with low bandgap, which results in sufficient production of reactive oxygen species.
MATERIALS TODAY ENERGY
(2022)
Article
Chemistry, Multidisciplinary
Bochao Chen, Shumei Mao, Yanyan Sun, Liyuan Sun, Ning Ding, Chengde Li, Jin Zhou
Summary: A mitochondria-targeted fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity, which was applied to detect intracellular viscosity and image pancreatic tissue in a diabetic mouse model. Probe NIR-V provides an effective way to diagnose viscosity related diseases.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Siyu Jiang, Jiaxin Hong, Shengyi Gong, Qianhua Li, Guoqiang Feng
Summary: With the widespread use of drugs, drug-induced acute kidney injury (AKI) has become a serious health concern worldwide. However, early diagnosis of drug-induced AKI is challenging due to the lack of effective biomarkers and noninvasive imaging tools. This study introduces a highly sensitive near-infrared fluorescence probe called DSMN, which reveals the relationship between SO2 and drug-induced AKI for the first time. The probe selectively and rapidly responds to SO3 (2-)/HSO3 (-) and successfully detects changes in the SO2 concentration in living cells and mice, making it a powerful tool for studying and diagnosing drug-induced AKI.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Songjiao Li, Ke Yang, Ying Liu, Peipei Wang, Dan Cheng, Longwei He
Summary: Recent study suggests a close relationship between excess hypochlorous acid (HClO) and diabetes due to its induction of endoplasmic reticulum stress. However, developing a near-infrared (NIR) fluorescent probe for detecting ER HClO still remains challenging. In this study, a highly selective, sensitive, and hypotoxic NIR probe (NIR-ER-HClO) was designed and synthesized for accurately monitoring HClO variations in living cells. Moreover, NIR-ER-HClO successfully imaged HClO in a diabetic mice model, showing stronger NIR fluorescence signal compared to the control group and in the blood of people with diabetes. Therefore, NIR-ER-HClO provides an effective method for diagnosing ER HClO in related diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Miao Zhao, Edward Leggett, Struan Bourke, Souzana Poursanidou, Sadie Carter-Searjeant, Steve Po, Marciano Palma do Carmo, Lea Ann Dailey, Philip Manning, Sean G. Ryan, Laura Urbano, Mark A. Green, Aliaksandra Rakovich
Summary: Conjugated polymer nanoparticles (CPNs) based on PTB7 were prepared and evaluated for their potential in theranostic applications involving bioimaging and photosensitization. The CPNs showed efficient NIR-I transparency for bioimaging and demonstrated photosensitizing capabilities in both aqueous solutions and cell cultures. The photosensitizing ability of CPNs was found to be influenced by the stabilizing shell material, with Pluronic F-127 leading to enhanced ROS production and poly[styrene-co-maleic anhydride] completely quenching the process.
Article
Spectroscopy
Mengwen Yi, Xiangjun Liu, Jing Liu, Shengnan Li, Dandan Li, Xiangru Zhang, Nan Zhang, Yongbiao Wei, Dihua Shangguan
Summary: A new near-infrared fluorescent probe A1 with good mitochondria targeting ability was developed for colorimetric and fluorescence detection of HSO3-. It has potential applications in biological systems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Lan-Fang Pang, Yu-Cheng Sun, Xiao-Feng Guo, Hong Wang
Summary: In this study, carbon dots with near-infrared fluorescence were prepared using a hydrothermal method and successfully used for quantitative determination of H2S and imaging of endogenous H2S efflux from cell membrane. The NIR-CDs showed specific location on cell membrane and offered a new strategy for the design of targeted fluorescent probes in different functional regions of the cell membrane in the future.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Environmental
Lizhou Yue, Huawei Huang, Wenhui Song, Weiying Lin
Summary: In this study, a near-infrared fluorescent probe targeted to the endoplasmic reticulum (ER) was developed for highly selective and sensitive detection of sulfur dioxide (SO2). The probe successfully allowed imaging of SO2 in living systems and revealed the role of SO2 in ER-associated diseases.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Xiaoyu Kang, Meng Li, Lei Liu, Shaopeng Liu, Hao Hu, Rui Zhang, Siming Ning, Zuhong Tian, Yanglin Pan, Xuegang Guo, Kaichun Wu
Summary: In this study, the SNF-Cy5.5 probe was synthesized and characterized for its high efficiency and purity. In vitro and in vivo tests confirmed the high affinity, specificity, and tumor-targeting efficacy of SNF-Cy5.5, making it a promising optical probe for imaging of esophageal adenocarcinoma. The in vivo experiment demonstrated excellent tumor-to-background contrast at 2 hours post-injection.
BMC GASTROENTEROLOGY
(2021)
Article
Chemistry, Analytical
Songjiao Li, Peipei Wang, Ying Liu, Ke Yang, Rongbin Zhong, Dan Cheng, Longwei He
Summary: Idiopathic pulmonary fibrosis (IPF) is a fatal chronic inflammatory disease with challenges in diagnosis and early treatment. Hypochlorous acid (HClO) has been proposed as a potential diagnostic tool for inflammation, including pulmonary fibrosis. A new probe called NIR-PTZ-HClO was developed for detecting HClO levels in cells and mice models. This advanced probe demonstrated high sensitivity, selectivity, and quick detection of HClO. It has the potential to improve the diagnosis of lung fibrosis and enhance treatment efficacy.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Zhuang Hu, Ruihan Li, Xinyue Cui, Changjun Hu, Zilin Chen
Summary: Osteosarcoma (OS) is a common and deadly carcinoma of the skeletal system. Detecting the tumor early and implementing effective interventional therapies can improve limb salvage and overall survival rates. Carbonic anhydrase IX (CA IX) is an important functional protein in tumor acidification and is considered a potential biomarker. This study developed a pH-sensitive near-infrared imaging probe called ABSi-783 by combining the CA IX inhibitor ABSi with IR783. The probe has high selectivity for osteosarcoma imaging, can detect pH changes in vitro, and has demonstrated potential for targeted diagnosis and surgical treatment monitoring of osteosarcoma.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Rui Luo, Chunqing Ou, Xinchao Li, Yanfang Wang, Wei Du, Gaolin Liang, Changyang Gong
Summary: In this study, a molecular probe was synthesized using a CBT-Cys click condensation reaction to initiate the disassembly of self-assembled nanoparticles in response to tumor acidity, achieving tumor-targeted imaging.
Article
Chemistry, Multidisciplinary
Khanh Ha, Xiaoxin Zheng, Chase W. Kessinger, Adam Mauskapf, Wenzhu Li, Yoichiro Kawamura, Makoto Orii, Scott A. Hilderbrand, Farouc A. Jaffer, Jason R. McCarthy
Summary: The study developed a near-infrared fluorescence probe based on tirofiban, which can rapidly and accurately visualize activated platelets in vivo, offering a potential new application for clinical diagnosis.
Review
Chemistry, Multidisciplinary
Peng Guo, Jing Huang, Yaping Zhao, Charles R. Martin, Richard N. Zare, Marsha A. Moses
Article
Multidisciplinary Sciences
Peng Guo, Daxing Liu, Kriti Subramanyam, Biran Wang, Jiang Yang, Jing Huang, Debra T. Auguste, Marsha A. Moses
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Jing Huang, Peng Guo, Marsha A. Moses
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Multidisciplinary Sciences
Peng Guo, Jiang Yang, Daxing Liu, Lan Huang, Gillian Fell, Jing Huang, Marsha A. Moses, Debra T. Auguste
Article
Biochemical Research Methods
Peng Guo, Jing Huang, Alexander Moses-Gardner, Edward R. Smith, Marsha A. Moses
Article
Multidisciplinary Sciences
Peng Guo, Alexander Moses-Gardner, Jing Huang, Edward R. Smith, Marsha A. Moses
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Peng Guo, Jiang Yang, Jing Huang, Debra T. Auguste, Marsha A. Moses
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Oncology
Run Lin, Hui Zhang, Yujie Yuan, Qiong He, Jianwen Zhou, Shuhua Li, Yu Sun, Daniel Y. Li, Hai-Bo Qiu, Wei Wang, Zhehong Zhuang, Bin Chen, Yonghui Huang, Chuwei Liu, Yingzhao Wang, Shirong Cai, Zunfu Ke, Weiling He
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Urology & Nephrology
Bin Chen, Haitao Dai, Jianyong Yang, Keyu Tang, Guiyuan Zhang, Xianhong Xiang, Run Lin, Yonghui Huang
Summary: This study demonstrates the hemodynamic performance of patients with central venous stenosis treated with stent placement using computational fluid dynamics simulation. The results show that stent placement can effectively improve hemodynamic parameters and relieve symptoms such as swelling in patients.
SEMINARS IN DIALYSIS
(2022)
Article
Multidisciplinary Sciences
Peng Guo, Jing Huang, Bing Zhu, Andrew C. Huang, Lingxiao Jiang, Jianmin Fang, Marsha A. Moses
Summary: In this study, a rationally designed antibody drug conjugate (ADC) was developed for the treatment of late-stage and refractory triple-negative breast cancer (TNBC). The overexpression of intercellular adhesion molecule-1 (ICAM1) in TNBC was found to efficiently facilitate receptor-mediated antibody internalization. Four ICAM1 ADCs with different chemical linkers and warheads were constructed and their efficacy was evaluated in vitro and in vivo using multiple human TNBC cell lines and TNBC animal models. An ICAM1 antibody conjugated with monomethyl auristatin E (MMAE) via a protease-cleavable valine-citrulline linker was identified as the optimal ADC formulation due to its outstanding efficacy and safety, and could serve as an effective ADC candidate for TNBC therapy.
Article
Oncology
Bin Chen, Haitao Dai, Jianyong Yang, Guiyuan Zhang, Chunyong Wen, Xianhong Xiang, Run Lin, Yonghui Huang
Summary: This study evaluated the efficacy and safety of combining transarterial chemoembolization (TACE) with hepatic arterial infusion chemotherapy (HAIC) and a tyrosine kinase inhibitor (TKI) for the treatment of unresectable large hepatocellular carcinoma (HCC). The results showed that this triple therapy regimen was well-tolerated and showed promise in treating large, unresectable HCC.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Materials Science, Biomaterials
Yan Zhang, Keyu Tang, Bin Chen, Su Zhou, Nan Li, Chuwei Liu, Jianyong Yang, Run Lin, Tao Zhang, Weiling He
BIOMATERIALS SCIENCE
(2019)
Article
Biophysics
Run Lin, Yuancheng Li, Tobey MacDonald, Hui Wu, James Provenzale, Xingui Peng, Jing Huang, Liya Wang, Andrew Y. Wang, Jianyong Yang, Hui Mao
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)