Article
Chemistry, Multidisciplinary
G. Lesly Jimenez, Binita Shrestha, Tyron Porter, Bartlomiej Starzyk, Magdalena Lesniak, Marta Kuwik, Marcin Kochanowicz, Magdalena Szumera, R. Lisiecki, D. Dorosz
Summary: Up-conversion nanoparticles have attracted attention for their ability to convert low energy light into high-energy light, but their low efficiency poses limitations. By doping fluoroindate glasses with Yb3+ and Er3+, efficient energy transfer and improved biocompatibility can be achieved, making them suitable for biomedical applications.
Article
Energy & Fuels
Le Liu, Dali Liu, Rui Sun, Donglei Zhou, Yanjie Wu, Xinmeng Zhuang, Shuainan Liu, Wenbo Bi, Nan Wang, Lu Zi, Boxue Zhang, Zhichong Shi, Hongwei Song
Summary: The research developed a defect passivation method using an N-type semiconductor AgBiS2 as a modified layer and a solvent annealing treatment with DMSO mixed PEG, which successfully improved the charge transport characteristic and grain size of PSCs, leading to an increase in PCE and stability.
Article
Chemistry, Physical
Abdolhalim Torrik, Shamim Zaerin, Mahdi Zarif
Summary: Multidrug resistance is a major obstacle to the success of anticancer treatments. This study used molecular dynamics simulations to investigate the co-loading of anticancer drugs Doxorubicin and Imatinib using carbon nanotubes coated with Chitosan and Polyethylene Glycol polymers. The results showed that the number of polymer chains affects the drug loading, and Chitosan polymer has a more significant impact on the loading process.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Chemical
Yang Chen, Zhihui Qu, Hui Hu, Yuanhong Gao
Summary: This research proposed a series of nonaqueous phase change solvents for CO2 capture, including amino-phenolic dual-functionalized ILs and PEGs, which showed good capture and regenerability performance, and could reduce the regeneration heat load.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Matthew Blakeley, Prashant K. Sharma, Hans J. Kaper, Nagihan Bostanci, Thomas Crouzier
Summary: Disruption of lubrication between oral surfaces due to salivary gland hypofunction can negatively impact quality of life. Research suggests that functionalizing polyethylene glycol with wheat germ agglutinin and immobilizing it on oral epithelial cells and tissue can mimic the salivary film, providing long-lasting relief from mucosal dryness.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yaqi Cao, Junshi Zhang, Lan Wang, Mingjun Cen, Wenchao Peng, Yang Li, Fengbao Zhang, Juan Tan, Xiaobin Fan
Summary: Gene therapy is a revolutionary biomedical technique that requires safe and efficient intracellular gene delivery vectors for successful treatment. A recent study introduces dual-functionalized nanosheets as nonviral vectors, with superior gene transfection performance and lower cytotoxicity, especially at low dosages.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Hoon Hyun, Min Ho Park, Gayoung Jo, Bo Young Lee, Jae Won Choi, Heung Jae Chun, Hyeon Soo Kim, Dae Hyeok Yang
Summary: The study developed a novel drug carrier for breast cancer therapy, with MGC/CDPF-ic-PTX showing promising anti-cancer effects, enhanced cellular uptake, sustained release, and potential therapeutic efficacy against breast cancer.
Article
Chemistry, Multidisciplinary
Qingrong Han, Fei Liu, Chengjiu Wang, Zhentao Tang, Cheng Peng, Yuzhu Tan
Summary: In recent years, there has been great attention worldwide to the quality and safety issues of Chinese medicinal herbs, especially heavy metal contamination. This study designed and synthesized a magnetic nanomaterial, Fe3O4@MIL-101(Cr)@PEG, to efficiently remove heavy metals from Ligusticum chuanxiong Hort decoction. The results showed that the nanomaterial had good removal efficiency for As5+, Cd2+, and Pb2+, with certain removal efficiency for Ni2+ and Zn2+, without significantly affecting the effective components of the decoction. This material is recommended for heavy metal removal from aqueous solutions of medicinal herbs.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Physical
Khushbu Chauhan, Jin Woo, Woong Jung, Dong-Eun Kim
Summary: This article reviews the recent advancements of PEGylated GO in gene/drug delivery and nucleic acid amplification techniques, highlighting its significant value in the field of biomedicine.
Article
Biochemistry & Molecular Biology
Pranjita Zantye, Indrani Talukdar, Sutapa Roy Ramanan, Meenal Kowshik
Summary: The study presents a biocompatible self-fluorescent nano delivery vehicle based on HAp and CPP-octa-arginine for investigating the mechanisms of intracellular fate of a gene delivery agent. The results show that the nanoparticles mainly enter cells through clathrin-mediated and macropinocytosis pathways, and they escape endosomal degradation by buffering the pH and triggering osmotic rupture.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Yunxiao Zhao, Miaomiao Sun, Yulu Zhang, Yuzeng Zhao, Honghua Ge
Summary: This study achieved the efficient degradation of high molecular weight polyethylene glycol (PEG) using ammonium jarosite as a catalyst in a heterogeneous electro-Fenton process. The mechanism involved the production of highly oxidative hydroxyl radicals, which effectively oxidized PEG molecules and resulted in the breakdown of polymer chains and the formation of aldehyde and carboxylic acid intermediates, ultimately converting to CO2 and H2O.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Mustafa A. Jihad, Farah T. M. Noori, Majid S. Jabir, Salim Albukhaty, Faizah A. AlMalki, Amal A. Alyamani
Summary: The study focused on synthesizing graphene oxide nanoparticles, capping them with polyethylene glycol, and loading them with Nigella sativa seed extract to create a potential smart drug delivery system. The GO-PEG NPs were characterized structurally using various methods and were found to effectively destroy bacteria by permeating their membranes and damaging their nucleic acids.
Article
Pharmacology & Pharmacy
Roxana Cristina Popescu, Bogdan Stefan Vasile, Diana Iulia Savu, George Dan Mogosanu, Ludovic Everard Bejenaru, Ecaterina Andronescu, Alexandru Mihai Grumezescu, Laurentiu Mogoanta
Summary: Iron oxide nanoparticles (IONPs) have been widely used in biomedical applications due to their biocompatibility and magnetic properties. This study synthesized IONPs using a modified Massart method and evaluated their characteristics. The results showed that the functionalized IONPs had good biocompatibility and the ability to be cleared by the body.
Article
Biochemistry & Molecular Biology
Yusuke Hamashita, Takahiro Shibata, Akiko Takeuchi, Takashi Okuno, Naoki Kise, Toshihiko Sakurai
Summary: The artificial nucleic acid i-PPc demonstrated the ability to detect single nucleotide mutations and suppress gene expression, showing potential for antisense therapy targeting single nucleotide polymorphisms (SNP).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Wenhao Qian, Tao Song, Mao Ye, Xiaoyu Huang, Yongjun Li, Bingjie Hao
Summary: This article reports a dopamine detection sensor based on gold nanoparticles and functionalized nanographene oxide. By stepwise functionalization, the in-situ growth of gold nanoparticles on nanographene oxide is achieved, forming a stable sensor. Dopamine levels can be accurately detected using electrochemical detection methods.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Elham Akbari, Rana Imani, Parvin Shokrollahi, Saeed Heidari Keshel
Summary: A novel ring-implanted PVA contact lens successfully loaded with HA for sustained release, demonstrating stability, high light transmittance, and non-cytotoxicity in cellular study.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Polymer Science
Mahsa Khalili, Hamid Keshvari, Rana Imani, Alireza Naderi Sohi, Elaheh Esmaeili, Maryam Tajabadi
Summary: Nanotechnology, particularly the synthesis of G3-SPIONs and magnetic PCL nanofibers, shows promise in bone tissue regeneration. The combination of osteogenic media and PEMF exposure on ADMSCs cultured on the magnetic scaffold enhances osteogenic differentiation. The study highlights the potential of utilizing magnetic scaffolds in tissue engineering applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Materials Science, Multidisciplinary
Mohammad Mehdi Esmaeili, Mahboobeh Mahmoodi, Ali Mokhtarzade, Rana Imani
Summary: Coating Ti-6Al-4V with Ta2C/MWCNT can increase the hardness and corrosion resistance of the alloy, reduce the release of harmful ions, and improve tribological properties.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2022)
Article
Biotechnology & Applied Microbiology
Rana Imani, Satya Prakash, Hojatollah Vali, John F. Presley, Shahab Faghihi
Summary: The study introduces a multifunctional carrier that achieves FA-functionalization, CQ-equipping, and localized release of gene nanocomplexes. The covalently coconjugated FA with PEG and R8 enhances cellular uptake, and the CQ-equipped nanocarrier shows an efficient release mechanism for CQ.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Roozbeh Riazi Moghadam, Hamid Keshvari, Rana Imani, Masoumeh Haghbin Nazarpak
Summary: This study developed a three-layered fiber/hydrogel scaffold that replicated the structural features of healthy articular cartilage tissue. The scaffold exhibited favorable mechanical properties and cytocompatibility. It has the potential to be used for articular cartilage tissue regeneration.
BIOMEDICAL MATERIALS
(2022)
Article
Engineering, Biomedical
Elham Akbari, Rana Imani, Parvin Shokrollahi, Saeed Heidari Keshel
Summary: In this study, a nanofiber-containing ring implant poly (vinyl alcohol) (PVA) hydrogel was designed as a carrier for hyaluronic acid (HA) delivery. The results showed that the incorporation of nanofibers in the designed contact lens (CL) significantly reduced burst release and supported sustained release of HA.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Review
Pharmacology & Pharmacy
Elham Akbari, Rana Imani, Parvin Shokrollahi, Reyhaneh Jarchizadeh, Saeed Heidari Keshel
Summary: The anterior segment of the eye is prone to various injuries and diseases, which can lead to lasting corneal defects, opacification, and vision loss. Traditional topical drugs like eye drops are commonly used, but they may be inefficient due to quick evaporation and blinking. Advanced ocular drug delivery technologies, particularly hydrogel-based formulations, have been considered as alternative methods to improve drug retention time and bioavailability. This review summarizes recent research progress in drug delivery systems for the anterior segment of the eye, focusing on hydrogel-based formulations and discussing drug loading strategies for commonly used drugs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shirin Nour, Rana Imani, Mehrnaz Mehrabani, Atefeh Solouk, Maryam Iranpour, Sasan Jalili-Firoozinezhad, Ali Mohammad Sharifi
Summary: By developing a hybrid double-layer nanofibrous scaffold loaded with niosomal Deferoxamine (NDFO), this study demonstrated enhanced angiogenesis and wound healing. The controlled and sustained release of DFO from the scaffold promoted vascular sprouting and accelerated wound healing both in vitro and in vivo. This biomimetic hybrid scaffold holds great promise for the treatment of full-thickness wounds and soft tissue regeneration.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Ali Mokhtarzade, Rana Imani, Parvin Shokrollahi
Summary: Injectable hydrogels are promising osteochondral (OC) tissue engineering scaffolds due to the complexity of the lesion sites. Here, a gradient GelMA/agarose structure is proposed as an injectable four-layered scaffold for OC repair. The scaffold shows uniform swelling, degradation, and mechanical properties, making it an excellent potential injectable structure for OC tissue engineering.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Mohamad Sadegh Aghajanzadeh, Rana Imani, Masoumeh Haghbin Nazarpak
Summary: A novel in situ forming hydrogel based on aldehyde-modified xanthan gum (AXG) and gelatin (Gel) has been developed, exhibiting suitable morphological and physical characteristics for biomedical and tissue engineering applications. Cell culture experiment shows that the hydrogel can provide a suitable substrate for cell viability and adhesion. However, more studies are needed.
JOURNAL OF MATERIALS SCIENCE
(2023)
Review
Materials Science, Biomaterials
Fatemeh Edrisi, Nafiseh Baheiraei, Mehdi Razavi, Kaveh Roshanbinfar, Rana Imani, Negin Jalilinejad
Summary: Cardiovascular diseases are the leading cause of death globally. Tissue engineering techniques using graphene-based nanomaterials (GBNs) show promise in restoring heart function after myocardial infarction by enhancing angiogenesis, proliferation, and differentiation of implanted stem cells, as well as improving the electrical and mechanical properties of scaffolds for cardiac tissue engineering (CTE). GBNs offer high mechanical strength, angiogenesis, antibacterial and antioxidant properties, and cost-effectiveness, making them an attractive material for CTE.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Soheila Rezaei, Rana Imani
Summary: This study introduces a promising wound dressing based on a combination of egg white and Carbomer-940. The hydrofilm dressing provides high absorbency and bioactivity, making it suitable for managing exudate-secreting wounds, such as diabetic wounds.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Azin Ghasemi, Elham Akbari, Rana Imani
Summary: Islet transplantation is a promising strategy for treating type 1 diabetes by replacing damaged beta-cells with new islets in a minimally invasive procedure. However, it faces significant drawbacks such as long-term immunosuppression and a lack of compatible donors. Biomaterial-assisted islet transplantation, particularly using hydrogels, is an emerging technology that aims to overcome these challenges and improve beta-cell viability, decrease inflammatory responses, and enhance insulin secretion.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Raziyeh Najafloo, Nafiseh Baheiraei, Rana Imani
Summary: A novel N-Col/beta-TCP scaffold embedded with thymol as an antibacterial reagent showed sustained release and significantly higher cell viability compared to a scaffold without thymol. Among the synthesized samples, Col/beta-TCP1 demonstrated the greatest antimicrobial activity, especially against Gram-positive bacteria. The results suggest the potential of the niosomal-thymol loaded Col/beta-TCP1 scaffold as an antibacterial bone substitute for possible osteomyelitis treatment.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2021)