Article
Nanoscience & Nanotechnology
Jialang Zhuang, Siqi Chen, Ye Hu, Fan Yang, Qin Huo, Ni Xie
Summary: The study developed tumor-targeted and redox-responsive mesoporous silica nanoparticles (MSNs) for the co-delivery of Doxorubicin and siTIE2 to improve the treatment of metastatic breast cancer. The controlled release of drugs within cells was achieved through redox-sensitive disulfide bonds, resulting in enhanced therapeutic effects in vitro and in vivo, including lower IC50 values and improved anti-tumor and anti-metastatic effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biophysics
Yueli Zhang, Zhilan Ye, Ruixuan He, Yuyang Li, Bei Xiong, Mengqi Yi, Yuqi Chen, Jia Liu, Bo Lu
Summary: This study developed a drug carrier consisting of hollow mesoporous silica nanoparticle (HMSNs) encapsulated with folic acid-modified bovine serum albumin (BSA-FA) for tumor targeting and controlled drug release. The carrier achieved specific intracellular drug delivery through folic acid and released the drug in response to intracellular conditions. The targeted and controlled drug release properties of the carrier make it a promising approach for cancer treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Miguel Gisbert-Garzaran, Maria Vallet-Regi
Summary: Mesoporous silica nanoparticles are widely used in cancer treatment, with a focus on redox-responsive systems. This trend in design includes biological rationale, gatekeeper types, and nucleic acid scaffold nanoparticles.
Article
Biophysics
Shatadal Ghosh, Sayanta Dutta, Abhijit Sarkar, Mousumi Kundu, Parames C. Sil
Summary: Curcumin, a natural antioxidant, was delivered through Mesoporous silica nanoparticles to enhance its anticancer efficacy by targeting cancer cells with hyaluronic acid. The synthesized nanohybrid showed cell death in MDA-MB-231 cells and decreased tumor volume in tumor-bearing mice by inducing ROS, cell cycle arrest, and modulation of apoptotic pathways. Overall, the study found that the nanohybrid had increased anticancer efficacy compared to free curcumin.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Oncology
Etienne J. Slapak, Lily Kong, Mouad el Mandili, Rienk Nieuwland, Alexander Kros, Maarten F. Bijlsma, C. Arnold Spek
Summary: Systemic chemotherapy for pancreatic cancer is limited by toxicity-dependent dose restrictions, leading to premature termination of treatment. Targeted drug delivery using a protease-dependent system can reduce collateral toxicity and enhance efficacy by delivering chemotherapy drugs specifically to cancer cells without affecting healthy tissue. This study successfully demonstrated the feasibility of protease-mediated drug release in pancreatic cancer, highlighting the potential of this approach to improve treatment outcomes and reduce side effects.
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Madhappan Santhamoorthy, Vanaraj Ramkumar, Kokila Thirupathi, Lalitha Gnanasekaran, Vanitha Karuppannan, Thi Tuong Vy Phan, Seong-Cheol Kim
Summary: In this study, L-lysine modified mesoporous silica nanoparticles (MS@Lys NPs) were synthesized for the delivery of the anticancer drug curcumin (Cur) to cancer cells. The functionalization of L-lysine groups onto the mesopore channel surfaces of MS@GPTS NPs was achieved through a ring-opening reaction. The structural properties of MS@Lys NPs were examined using various instrumental techniques. The drug loading and pH-responsive drug delivery behavior of MS@Lys NPs were investigated using curcumin as a model drug, and their cytocompatibility and cell uptake behavior were evaluated using MDA-MB-231 cells. The results suggest that MS@Lys NPs have potential for pH-responsive drug delivery in cancer therapy.
Review
Pharmacology & Pharmacy
Thashini Moodley, Moganavelli Singh
Summary: Cancer remains a devastating non-communicable disease with increasing incidence and mortality rates. The development of novel therapeutic strategies using multimodal nanotechnology is critical in enhancing therapeutic outcomes and overcoming resistance. Mesoporous silica nanoparticles have shown promising potential in cancer therapy with their stimuli-responsive controlled release functions and increased bioavailability.
Article
Biochemistry & Molecular Biology
Rosemeyre Cordeiro, Ana Carvalho, Luisa Duraes, Henrique Faneca
Summary: Mesoporous silica nanoparticles show promise as drug delivery systems with high drug loading capacity and biocompatibility. By conjugating with targeting moieties, these particles can overcome limitations of free drugs and improve therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tais de Cassia Ribeiro, Rafael Miguel Sabio, Marcela Tavares Luiz, Lucas Canto de Souza, Bruno Fonseca-Santos, Luis Carlos Cides da Silva, Marcia Carvalho de Abreu Fantini, Cleopatra da Silva Planeta, Marlus Chorilli
Summary: This study investigated the use of curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) and a thermo-responsive hydrogel for the treatment of Alzheimer's disease (AD). The results showed that the MSN-CCM and hydrogel had excellent properties and high permeation values. In vivo studies confirmed the potential of the hydrogel-MSN-CCM formulation in reverting cognitive deficits in an AD model.
Article
Pharmacology & Pharmacy
Zahra Mohebian, Mirzaagha Babazadeh, Nosratollah Zarghami, Hanieh Mousazadeh
Summary: In this study, Curcumin was successfully incorporated into mesoporous silica nanoparticles and then embedded into a polymer via a blending electrospinning process to create a nanofiber-mediated drug release system. The resulting composite nanofibers showed sustained drug release properties and demonstrated high cytotoxicity and low migration in treating breast cancer cells, suggesting a promising potential for post-surgical breast cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Biomaterials
Jie Chang, Liufang Mo, Jinfeng Song, Xiaochen Wang, Hanhan Liu, Chenchen Meng, Yijun Wu
Summary: Researchers developed a targeted drug delivery system based on pH responsive mesoporous silica nanoparticles, which can specifically aggregate at the tumor site and release drugs to target breast cancer cells, showing great potential for tumor therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Applied
Reema Narayan, Shivaprasad Gadag, Sri Pragnya Cheruku, Ashok M. Raichur, Candace Minhthu Day, Sanjay Garg, Suman Manandhar, Karkala Sreedhara Ranganath Pai, Akhil Suresh, Chetan Hasmukh Mehta, Yogendra Nayak, Nitesh Kumar, Usha Yogendra Nayak
Summary: The study developed glycosylated pH-sensitive mesoporous silica nanoparticles for targeting colorectal cancer, which showed high drug loading capacity and controlled drug release, demonstrating promising antitumor efficacy in vitro with reduced toxicity.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Noyel Ghosh, Mousumi Kundu, Sumit Ghosh, Abhishek Kumar Das, Samhita De, Joydeep Das, Parames C. Sil
Summary: Cancer is a global disease and the use of phytochemicals with inherent anticancer efficacy is important. Nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. In this study, folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles were used for targeted delivery of chrysin to breast cancer cells. Chrysin loaded nanoparticles showed increased cytotoxicity and induced apoptosis in the cancer cells. Furthermore, in tumor-bearing mice, the nanoparticles enhanced the anti-neoplastic effects of chrysin. This study highlights the potential of chrysin and the importance of nanotechnology in biomedical research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Lejiao Jia, Zhenyu Li, Dandan Zheng, Zhiying Li, Zhongxi Zhao
Summary: A novel folic acid mediated chitosan oligosaccharide-grafted disulfide-containing polyethylenimine copolymer-based silica nanohybrids were fabricated for co-delivering paclitaxel and P-shRNA. These nanoparticles efficiently protect P-shRNA against degradation and exhibit excellent antitumor effects on multidrug-resistant breast cancer cells.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Biomedical
Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang
Summary: In this study, a metal-organic framework (MOF)-red blood cell (RBC) membrane-camouflaged multi-drug-delivery nanoplatform was designed and fabricated for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer. The nanoplatform, created through a solvothermal synthesis process, demonstrated the ability to deplete glutathione, increase reactive oxidative species oxidative stress, and exhibit remarkable anticancer properties. This research provides a new strategy for overcoming multidrug resistance.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Shuwen Ma, Jiaqi Li, Lixia Pei, Nianping Feng, Yongtai Zhang
Summary: Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and can be used as a substitute for blood in drug analysis. However, current ISF extraction techniques are bulky, time-consuming, and complicated. Microneedles have been widely used for transdermal drug delivery and can be successfully employed for ISF extraction, facilitating subsequent analysis. The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring, and wearable devices with monitoring and delivery functions allow real-time dose modification. This review discusses the progress, future opportunities, and challenges of drug analysis based on microneedle-assisted ISF extraction.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
Wansi Li, Yongtai Zhang, Panwen Huang, Ying Liu, Yongjia Zhang, Zhi Wang, Nianping Feng
Summary: The use of the liquisolid compression technique in preparing mini-tablets containing supercritical fluid extracts of frankincense and myrrh (SFE-FM) can improve the oral bioavailability of their active compounds. Various drug-loaded liquisolid formulations were prepared and evaluated, showing superior release of active compounds compared to traditional mini-tablets.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Xiaolin Hou, Meng Long, Nianping Feng, Yongtai Zhang
Summary: In this study, cinnamon oil was encapsulated in nanocapsules and incorporated into microneedles to create a new transdermal drug delivery system. The system showed improved transdermal flux and alleviated symptoms of primary dysmenorrhea in rats.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Multidisciplinary
Xiang Wang, Xuefeng Hou, Yihan Wu, Jingwen Guo, Haichuan Tai, Yongtai Zhang, Nianping Feng
Summary: In this study, a new preparation of CHR-loaded liposomal gel (CHR-LipGel) with good physicochemical stability and efficient antiphotoaging properties was described. The CHR-loaded liposomes were hybridized with D-a-tocopherol polyethylene glycol succinate and Poloxamer 188, and dispersed in sodium hyaluronate-formed hydrogel to obtain CHR-Lip-Gel. The CHR-Lip-Gel significantly increased skin permeability and skin retention of chrysin, and showed superior cellular uptake and anti-photoaging effects compared to free CHR. The newly developed CHR-Lip-Gel is a superior anti-photoaging system. Rating: 8/10.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Instruments & Instrumentation
Hang Ruan, Lina Shen, Xiaolin Hou, Jiaqi Li, Teng Guo, Chunyun Zhu, Nianping Feng, Yongtai Zhang
Summary: A new type of glycerosome (S-glycerosome), stabilized by beta-sitosterol, was developed and optimized for transdermal drug delivery. The inclusion of peppermint oil (PO) improved the permeation properties of S-glycerosomes, allowing them to penetrate deeper into the skin. Furthermore, the transdermal administration of LA-loaded PO-S-glycerosomes improved the treatment efficacy of inflammation without causing skin irritation.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Xiaolin Hou, Jiaqi Li, Yongyu Hong, Hang Ruan, Meng Long, Nianping Feng, Yongtai Zhang
Summary: Transdermal drug delivery (TDD) is a key approach for treating diseases and improving patient compliance. Microneedling is a relatively simple and efficient means of drug delivery, and is often used to improve the efficiency of TDD.
Article
Pharmacology & Pharmacy
Hongyu Zhang, Jingwen Guo, Zhi Wang, Na Wang, Nianping Feng, Yongtai Zhang
Summary: This study aimed to compare the performance differences of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) in transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol((R)) 888 ATO, ethyl oleate, Cremophor((R)) EL, and Transcutol(R) P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for trans-ferulic acid (p < 0.05). In vitro cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (p < 0.05). Compared to SLNs, NLCs greatly enhanced trans-ferulic acid permeation through the Millicell (TM) membrane (p < 0.05). This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells.
ACTA PHARMACEUTICA
(2023)
Article
Biophysics
Huining Ding, Qing Xia, Jiaqi Shen, Chunyun Zhu, Yongtai Zhang, Nianping Feng
Summary: The clinical translational success of nanomedicine and immunotherapy has demonstrated the immense potential of nanotechnology and immunization. Combining immunotherapy with nanomedicine effectively overcomes the limitations of single therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Biomaterials
Jing Zang, Jinniu Zhang, Yijun Mei, Yaoxuan Xiong, Tianyuan Ci, Nianping Feng
Summary: Immunogenic dead cells, engineered through the sequential treatment of live tumor cells with UV irradiation and cryo-shocking, can serve as a lung-targeting vehicle and tumor vaccine for chemoimmunotherapy. The drug-loaded dead cells can be trapped in the pulmonary capillaries and enhance drug accumulation in local tissues, while also eliciting antitumor immune responses. In a lung tumor-bearing mice model, this system achieved synergistic antitumor efficacy and prolonged survival.
BIOMATERIALS SCIENCE
(2023)
