Article
Chemistry, Multidisciplinary
Takayuki Imoto, Masahiro Goto
Summary: The study analyzed the self-assembled structure of Pal-GH and confirmed its effectiveness as a permeation enhancer, finding that it does not disrupt the skin structure when permeating the stratum corneum.
Review
Pharmacology & Pharmacy
Victor Hmingthansanga, Nidhi Singh, Superna Banerjee, Sivakumar Manickam, Ravichandiran Velayutham, Subramanian Natesan
Summary: Delivery of drugs via transdermal routes offers advantages, but overcoming the skin's barrier properties remains challenging. Chemical permeation enhancers (CPEs) can improve transdermal drug delivery, but may have side effects. With advancements in analytical techniques, synthetic chemistry, and combinatorial studies, CPEs-aided transdermal drug delivery is expected to reach its full potential.
Article
Pharmacology & Pharmacy
Hans Schoenfelder, Yali Liu, Dominique Jasmin Lunter
Summary: Trans-epidermal water loss (TEWL) is a widely used method to evaluate the skin barrier and the effects of topical products. This study optimized the experimental procedures for detecting in-vitro TEWL and analyzed the impact of emulsifiers on the skin barrier. The results provide a validated protocol for measuring in-vitro TEWL and improve understanding of the effects of emulsifiers on the skin barrier.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Ralph W. Eckert, Sabrina Wiemann, Cornelia M. Keck
Summary: The study used smartFilm technology to improve the dermal penetration efficacy of curcumin, showing better results compared to nanosuspensions and bulk suspensions. Increasing the number of curcumin particles in the suspensions was found to increase the passive dermal penetration. These findings suggest a new dermal penetration mechanism for active compounds from nano-particulate drug delivery systems, which could lead to the development of topical drug products with improved penetration efficacy in the future.
Article
Dermatology
Y. Amar, E. Schneider, M. Koberle, T. Seeholzer, S. Musiol, I. M. Hoelge, S. Gschwendtner, D. Krappmann, K. Steiger, T. Biedermann, C. B. Schmidt-Weber, F. Alessandrini
Summary: This study analyzed the skin microbiome of two commonly used murine models for atopic dermatitis (AD) and found similarities in dysbiosis with human AD. These findings are important for translational research on AD with a focus on the microbiome.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chukwuebuka Emmanuel Umeyor, Varsha Shelke, Apurva Pol, Prafull Kolekar, Sarika Jadhav, Nikita Tiwari, Ankita Anure, Abhit Nayak, Ghanshamdas Bairagi, Aniket Agale, Vaishnavi Raut, Sumedh Bahadure, Aniruddha Chaudhari, Vandana B. Patravale
Summary: Microneedles (MNs) technology, which combines the advantages of hypodermic needles and transdermal delivery, has emerged as a novel biomimetic technology for efficient transport of drugs across the stratum corneum.
FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Immunology
Aurelien Trompette, Niki D. Ubags
Summary: Our skin has a unique barrier function that protects the body from external pathogens and environmental insults. Skin immunity develops over time and is influenced by factors such as lifestyle, genetics, and environmental exposures. Alterations in early life skin immune and structural development may have long-term consequences for skin health.
MUCOSAL IMMUNOLOGY
(2023)
Review
Dermatology
Garrett J. Patrick, Nathan K. Archer, Lloyd S. Miller
Summary: Atopic dermatitis is a common chronic inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to its pathogenesis, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex multidirectional network that can exacerbate atopic skin disease but can also be ameliorated by targeted therapies.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Chemistry, Medicinal
Jaru Taechalertpaisarn, Satoshi Ono, Okimasa Okada, Timothy C. Johnstone, R. Scott Lokey
Summary: Replacing hydrogen-bond donors in side chains can significantly improve the aqueous solubility and permeability of cyclic peptides.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Kanika Sharma, Payal Kesharwani, Shiv Kumar Prajapati, Ankit Jain, Dolly Jain, Nishi Mody, Swapnil Sharma
Summary: Cancer is a major cause of death worldwide. This review focuses on the use of pomegranate as an alternative source of medication for cancer treatment. The polyphenols found in pomegranate have shown promising anticancer activity. The review discusses the chemical structure, properties, and role of pomegranate in the treatment of breast, lung, thyroid, colon, and prostate cancer. It also explores targeted drug delivery approaches and ongoing clinical trials related to pomegranate compounds.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Sarjana Raikwar, Ankit Jain, Shivani Saraf, Pooja Das Bidla, Pritish Kumar Panda, Ankita Tiwari, Amit Verma, Sanjay K. Jain
Summary: Breast carcinoma is a leading cause of cancer-related death in women due to poor response to traditional therapies. Combining chemotherapy and immunotherapy has been introduced to overcome challenges such as cytotoxicity and drug resistance. Nanotechnology-based drug delivery systems show promise in targeted and controlled drug release for more effective treatment.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Automation & Control Systems
Ankit Jain, Abhishek Srivastava
Summary: This research proposes a novel vision-based fire detection framework that preserves privacy by using a near infrared camera. The framework proves to have superior performance and model size compared to existing techniques. The effectiveness of the system in resource-constrained environments is validated through a real-world implementation.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2022)
Article
Chemistry, Analytical
Ankita Tiwari, Devasish Bose, Pooja Mishra, Ankit Jain, Sanjay K. Jain
Summary: A micellar-HPLC method was developed for the determination of oxaliplatin and curcumin, aiming to provide a rapid, cost-effective, environmentally friendly, time-efficient, easy-to-handle, and safe analytical approach. The optimized conditions and compliance with ICH guidelines ensured accuracy and precision in the analysis. The results demonstrated the method's robustness and capability for quantitative analysis of the drugs in mice serum/blood, potentially contributing to the development of pharmaceutical preparations for colorectal cancer treatment.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Plant Sciences
Shiv Kumar Prajapati, Akanksha Malaiya, Gaurav Mishra, Dolly Jain, Payal Kesharwani, Nishi Mody, Amirhossein Ahmadi, Rishi Paliwal, Ankit Jain
Summary: The review emphasizes the potential of herbal medicines in enhancing immunity and treating COVID-19, highlighting their importance in combating SARS-COV-2 infection and potential future applications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Orthopedics
Ankit Jain, Anil Agarwal, Ravi Jethwa, Jatin Raj Sareen, Yogesh Patel
Summary: Migration of epiphyseal screws into growing physis is a known complication in tension band plating. This study investigated the technical details contributing to this complication in 10 patients. The length of the screw, proximity to the physis, trajectory angle, and correction rate were analyzed. Migrated plates had a closer starting point to the physis and a more divergent screw trajectory compared to uncomplicated plates. Osteopenic bone and pathological physis were identified as predisposing factors.
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2023)
Article
Instruments & Instrumentation
Shivani Saraf, Sanjay K. Jain
Summary: This project aims to increase the delivery of drugs to solid tumors by using endosomal escape. Topotecan and capsaicin were encapsulated in liposomes to improve therapeutic efficacy. The developed pH-sensitive liposomes showed improved intracellular drug delivery and demonstrated potential for targeted drug delivery to solid tumors.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ashwini Kumar Mishra, S. L. Neha, Laxmi Rani, Ankit Jain, Hitesh Kumar Dewangan, Pravat Kumar Sahoo
Summary: The proposed research focuses on utilizing a nanoplatform based on eudragit RL for the delivery of drugs and natural bioenhancers. This approach aims to enhance efficacy, bioavailability, synergistic effects, and minimize toxic effects. The study successfully encapsulated Silymarin and Piperine in nanoparticles and demonstrated their effectiveness in enhancing antioxidant characteristics and hepatoprotective effects.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Letter
Dermatology
Sumit Goel, Ankit Jain, Swati Gupta, Kamarthi Nagaraju, Sangeeta S. Malik, Isha Maheshwari
INDIAN JOURNAL OF DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ahsas Goyal, Neetu Agrawal, Ankit Jain, Jeetendra Kumar Gupta, Debapriya Garabadu
Summary: Caveolin interacts with eNOS to suppress its activity, leading to reduced NO production. Ischemic preconditioning disrupts this interaction, activating eNOS and providing cardioprotection. Estrogen deficiency upregulates Caveolin-1 expression, increasing the risk of coronary artery diseases in postmenopausal women.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Meeting Abstract
Critical Care Medicine
Benjamin Kozyak, Maria Fraga, Courteny Juliano, Shazia Bhombal, David Munson, Erik Brandsma, Jason Stoller, Ankit Jain, Russell Kesman, Malorie Meshkati, Caroline Noh, Aaron DeWitt, Andrew Costarino, David Hehir, Alan Groves
CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Yogita Dwivedi, Ankit Jain, Vijay Pratap Yadav, Atiharsh Mohan Agarwal
Summary: This study aimed to evaluate the clinical efficacy of Airtraq laryngoscope compared to Macintosh laryngoscope for intubation in pediatric patients. The results showed that the intubation time was significantly shorter with Airtraq compared to Macintosh, and Airtraq also provided better ease of intubation and glottic opening scoring. Hemodynamically, Airtraq was found to be superior with lower post-intubation heart rate. Therefore, Airtraq can be considered a reliable and promising alternative to Macintosh for endotracheal intubation in pediatric patients.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2022)
Meeting Abstract
Pediatrics
Benjamin W. Kozyak, Alan M. Groves, Maria V. Fraga, Courtney E. Juliano, Shazia Bhombal, David A. Munson, Erik Brandsma, Jason Z. Stoller, Ankit Jain, Andrew T. Costarino, David A. Hehir