Journal
TECHNOLOGY AND HEALTH CARE
Volume 26, Issue 2, Pages 271-278Publisher
IOS PRESS
DOI: 10.3233/THC-170978
Keywords
Aging; cognitive deficits; synaptic plasticity; hippocampal neurons
Funding
- National Natural Science Foundation of China [81260489, 81460547, 81560609]
- National Natural Science Foundation of Hunan Province of China [2017JJ3260]
- Jishou University Research Award Fund [88/8819010]
- Innovative Research Training Foundation for medical students of Jisou University [JDYXCX201502]
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BACKGROUND: The aging-related disease and associated neurodegenerative complications, such as cognitive impairment, has received increasing attention. OBJECTIVE: The aim of this study was to show changes in cognitive behavior and molecular related the synaptic plasticity in aged-induced cognitive deficits rats. METHODS: We used novel object recognition testing and morphological staining as well as western blot to detect changes in cognitive behavior and molecular related the synaptic plasticity. RESULTS: The morphological changes of synaptic structure and number on hippocampal neurons and learning and memory deficits were shown during natural aging. Moreover, learning and memory improvement was associated with alterations of hippocampal synaptic plasticity-related proteins, such as SNAP-25, synaptophysin, snapsoin-1 and so on, which distributes to cognitive decline in natural aging. CONCLUSIONS: Our study provides more behavior and molecular evidence on relationship of cognitive deficits and aging.
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