Journal
POLYMERS
Volume 10, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/polym10010089
Keywords
in-situ hydrogel; thermo-responsive polymers; drug release; cancer therapy
Categories
Funding
- National Natural Science Foundation of China [81773661]
- Fundamental Research Funds for the Central Universities [20720170066]
- A*STAR Research Grant
- A*STAR Graduate Scholarship
Ask authors/readers for more resources
In this study, we report the synthesis and characterisation of a thermogelling poly(carbonate urethane) system comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG) and poly(polytetrahydrofuran carbonate) (PTHF carbonate). The incorporation of PTHF carbonate allowed for the control of the lower critical solution temperature (LCST) and decreased critical gelation concentration (CGC) of the thermogels significantly. In addition, the as-prepared thermogels displayed low toxicity against HepG2, L02 and HEK293T cells. Drug release studies were carried out using doxorubicin (Dox). Studies conducted using nude mice models with hepatocellular carcinoma revealed that the Dox-loaded poly(PEG/PPG/PTHF carbonate urethane) thermogels showed excellent in vivo anti-tumour performance and effectively inhibited tumour growth in the tested model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available