Article
Infectious Diseases
Luc Coffeng, Johnny Vlaminck, Piet Cools, Matthew J. Denwood, Marco Albonico, Shaali Ame, Mio Ayana, Daniel Dana, Giuseppe Cringoli, Sake de Vlas, Alan F. Fenwick, Michael P. French, Adama Kazienga, Jennifer Keiser, Stefanie Knopp, Gemechu Leta, Leonardo A. Matoso, Maria Maurelli, Antonio Montresor, Greg Mirams, Zeleke Mekonnen, Rodrigo Correa-Oliveira, Simone Pinto, Laura Rinaldi, Somphou Sayasone, Peter Steinmann, Eurion Thomas, Jozef Vercruysse, Bruno Levecke
Summary: This study presents a cost-efficient survey design for monitoring the therapeutic drug efficacy of soil-transmitted helminth control programs, using fecal egg counting methods. The Kato-Katz method is the most cost-effective and has the highest sample throughput. The combination of no selection survey design (NS) and Kato-Katz method is the most cost-efficient for assessing therapeutic drug efficacy in different scenarios.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Nur Alia Johari, Dhekra Amin Annuzaili, Hani Farouk El-Talabawy, Maryam Ba-Break, Abdulsalam M. Al-Mekhlafi, Samira Al-Eryani, Abdulhakim Ali Alkohlani, Albis Francesco Gabrielli, Riadh Ben-Ismail, Sami Alhaidari, Adel Muaydh, Rasheed Alshami, Magid AL Gunaid, Alaa Hamed, Nehad Kamel, Karen Palacio, Fiona Fleming, Michael Duncan French
Summary: This study provides a comprehensive mapping of schistosomiasis, soil-transmitted helminthiasis, and anemia in Yemen, revealing the significant public health burden caused by these diseases. The findings and recommendations of this study will inform national control and elimination programs for these neglected tropical diseases in Yemen.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Health Care Sciences & Services
Hui-Hui Zhu, Ji-Lei Huang, Chang-Hai Zhou, Ting-Jun Zhu, Jin-Xin Zheng, Mi-Zhen Zhang, Men-Bao Qian, Ying-Dan Chen, Shi-Zhu Li
Summary: A national monitoring was conducted in China from 2016 to 2020 to analyze the prevalence, changing trends, and factors influencing soil-transmitted helminthiasis. The infection rates of soil-transmitted helminths showed a decreasing trend, but there were still areas with high infection rates and exhibited spatiotemporal aggregation.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Infectious Diseases
Eun Seok Kim, Moses Adriko, Wamboko Aidah, Kabarangira Christine Oseku, David Lokure, Kalpana Sabapathy, Emily Webb
Summary: This study aimed to evaluate the efficacy of dual-dose albendazole compared to single-dose albendazole for treating hookworm infection in Mayuge district, Uganda. The results showed that dual-dose albendazole improved the cure rate of hookworm, but co-administration with fatty food did not significantly improve the treatment efficacy.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Cara Tupps, Ibrahim Kargbo-Labour, Jusufu Paye, Sanjaya Dhakal, Mary H. Hodges, Alexander H. Jones, Stacy Davlin, Mustapha Sonnie, Sallay Manah, Rubina Imtiaz, Yaobi Zhang
Summary: This study assessed the prevalence of parasitic infections in different age groups in Sierra Leone. The results showed that treatment for STH infection is needed annually in children and should also be considered for women of reproductive age. The study also found that having access to toilet facilities significantly reduced the infection rates of various parasites. Therefore, improving sanitation at the community and household levels is crucial for controlling these diseases.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Caitlin Sheehy, Heather Lawson, Emmanuel H. Andriamasy, Hannah J. Russell, Alice Reid, Gina U. Raderalazasoa, Graham Dodge, Robbie Kornitschky, James M. StJ. Penney, Tahiry N. Ranaivoson, Antsa Andrianiaina, Jenny S. Emmanoela, Amaya L. Bustinduy, J. Russell Stothard, Louis Andrianjaka, Stephen A. Spencer
Summary: The study revealed a high prevalence of intestinal schistosomiasis and soil-transmitted helminthiasis in pre-school aged children in Madagascar, with a significant rate of co-infection. These findings provide evidence for the overlooked burden of intestinal schistosomiasis in pre-school aged children and offer technical guidance for the national control programme in Madagascar.
INFECTIOUS DISEASES OF POVERTY
(2021)
Article
Public, Environmental & Occupational Health
Collins Okoyo, Suzy J. Campbell, Mark Minnery, Chrispin Owaga, Nelson Onyango, Graham Medley, Charles Mwandawiro
Summary: The study found a significant decline in STH prevalence among PSAC and SAC after six rounds of MDA, but not below the threshold of 1% which signifies a public health problem. There is a weak negative correlation between treatment coverage and prevalence, suggesting that current coverage may not be sufficient to drive overall STH prevalence below 1%.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Collins Okoyo, Mark Minnery, Idah Orowe, Chrispin Owaga, Suzy J. Campbell, Christin Wambugu, Nereah Olick, Jane Hagemann, Wyckliff P. Omondi, Kate Mccracken, Antonio Montresor, Graham F. Medley, Claudio Fronterre, Peter Diggle, Charles Mwandawiro
Summary: This study used a model-based geostatistical approach to analyze the impact of a national school-based deworming program in Kenya and provide information for treatment strategy changes. The results provide prevalence estimates of soil-transmitted helminths in different counties in Kenya and guide treatment strategies for each county.
Article
Infectious Diseases
Benjamin Tinkitina, Prudence Beinamaryo, Moses Adriko, Betty Nabatte, Moses Arinaitwe, Alfred Mubangizi, Paul Emerson, Sanjaya Dhakal, Kristin M. Sullivan
Summary: The prevalence of soil-transmitted helminth (STH) infections has decreased significantly in Uganda, but some districts still have high infection rates. The national deworming program should consider adjusting the frequency of drug distribution based on the situation.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Stephen A. Spencer, Cortland Linder, James M. StJ Penney, Hannah J. Russell, Kate Hyde, Caitlin Sheehy, Alice Reid, Emmanuel H. Andriamasy, Gina U. Raderalazasoa, Daniel A. L. Rakotomampianina, Anjara M. Nandimbiniaina, Tahiry N. Ranaivoson, Antsa Andrianiaina, Sheena M. Cruickshank, Amaya L. Bustinduy, J. Russell Stothard, Glenn T. Edosoa, Alain M. Rahetilahy
Summary: Schistosomiasis control programs in the hard-to-reach Marolambo district of eastern Madagascar have shown a reduction in infection prevalence and intensity after four rounds of annual mass drug administration and health education. However, challenges still remain in combating the disease in this endemic area.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Infectious Diseases
Ebrima Joof, Abdoulie M. Sanyang, Yaya Camara, Alhagie Papa Sey, Ignatius Baldeh, Sharmila Lareef Jah, Serign Jawo Ceesay, Sana M. Sambou, Saikou Sanyang, Christopher M. Wade, Bakary Sanneh
Summary: This study evaluated the prevalence and associated risk factors of schistosomiasis among primary school children in The Gambia, using data from a previous study conducted in four regions. Urinary schistosomiasis was found to be the most prevalent form of the disease, with CRR having the highest prevalence. Being male was a risk factor for urinary schistosomiasis, while water contact activities like playing and swimming unexpectedly posed less risk for infection. The study provides valuable information for schistosomiasis control efforts in The Gambia.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Kristin Vahle, Julia W. Gargano, Rayleen M. Lewis, Troy D. Querec, Elizabeth R. Unger, Robert A. Bednarczyk, Lauri E. Markowitz
Summary: The prevalence of any HPV, high-risk HPV, and non-high-risk HPV decreases with age in a cohort of women born between 1950 and 1979, indicating that the decline in HPV prevalence cannot be solely attributed to birth cohort differences.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Samanta Grubyte, Jurgita Urboniene, Laura Nedzinskiene, Auguste Jelinskaite, Kestutis Zagminas, Arvydas Ambrozaitis, Ligita Jancoriene
Summary: The study analyzed data from the National Blood Center of Lithuania from 2004 to 2018 and found a decreasing trend in residual risk of HBV, HCV and HIV transmission among blood donors. Despite the decrease, the current risk remains quite high, indicating the need for a population screening program for transfusion transmitted viruses.
Article
Infectious Diseases
Suye Zhao, Yidan Li, Shihong Fu, Ming Liu, Fan Li, Chunting Liu, Jing Yu, Liping Rui, Dingming Wang, Huanyu Wang
Summary: Despite vaccination efforts since 2004, Japanese encephalitis remains a public health issue in Guizhou Province. A study was conducted to understand the spatiotemporal distribution of JE and its relationship with environmental factors from 2004 to 2016. The study found that JE incidence decreased post-vaccination and was associated with cultivated land, GDP per capita, vegetation coverage, and urban area coverage, with the highest risk in mid-level developed areas.
BMC INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Joseph Kawuki, Quraish Sserwanja, David Mukunya, Abigail Sitsope Sepenu, Milton Wamboko Musaba
Summary: The study revealed a high prevalence of sexual violence among rural Ugandan women, which is significantly associated with factors such as educational level, region, wealth index, justified beating, health care decision-making, and husband's/partner's frequency of getting drunk.
Editorial Material
Public, Environmental & Occupational Health
Christina L. Faust, Kirstyn Brunker, Diana Ajambo, Mary Ryan, Arinaitwe Moses, Candia Rowel, Robert Mandela Wangoola, Eddie M. Wampande, Andrew Guma, Moses Adriko, Poppy H. L. Lamberton, Edridah M. Tukahebwa, Albert Mugenyi, Charles Waiswa
Summary: The editorial emphasizes the importance of building genetic and genomic technology capacity in low and middle income countries to improve disease diagnostics and provide feedback to affected communities. The authors call on the wider tropical medicine community to embrace these methods, help build capacity, and ultimately benefit communities affected by endemic infectious diseases.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Immunology
Jessica Clark, Moses Arinaitwe, Andrina Nankasi, Christina L. Faust, Adriko Moses, Diana Ajambo, Fred Besigye, Alon Atuhaire, Aidah Wamboko, Lauren Carruthers, Rachel Francoeur, Edridah M. Tukahebwe, Joaquin M. Prada, Poppy H. L. Lamberton
Summary: The impact of treatment for schistosomiasis in high-endemicity settings is short-lived due to less efficacy than expected and rapid reinfection. Current surveillance methods may underestimate infection prevalence, and improved diagnostics such as POC-CCA+ test may provide more accurate estimates of reinfection rate but face interpretation challenges. Frequent sampling is necessary to understand the clearance and reinfection dynamics post-treatment.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Medicine, Research & Experimental
Emily L. Webb, Andrew Edielu, Hannah W. Wu, Narcis B. Kabatereine, Edridah M. Tukahebwa, Alfred Mubangizi, Moses Adriko, Alison M. Elliott, William W. Hope, Patrice A. Mawa, Jennifer F. Friedman, Amaya L. Bustinduy
Summary: This trial aims to investigate the safety and efficacy of the 80 mg/kg PZQ dose in preschool-aged children with intestinal schistosomiasis, as well as the impact of six-monthly versus annual treatment. The study will involve 600 children in Uganda and the Philippines, with co-primary outcomes including cure rate and egg reduction rate at 4 weeks.
Article
Multidisciplinary Sciences
Duncan J. Berger, Thomas Crellen, Poppy H. L. Lamberton, Fiona Allan, Alan Tracey, Jennifer D. Noonan, Narcis B. Kabatereine, Edridah M. Tukahebwa, Moses Adriko, Nancy Holroyd, Joanne P. Webster, Matthew Berriman, James A. Cotton
Summary: The study analyzed whole-genome sequencing data of Schistosoma mansoni larvae from infected children in Uganda with varying histories of praziquantel administration, revealing extensive gene flow and limited positive selection, suggesting minimal changes post mass drug administration.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Electrical & Electronic
Xin Guo, Muhammad Arslan Khalid, Ivo Domingos, Anna Lito Michala, Moses Adriko, Candia Rowel, Diana Ajambo, Alice Garrett, Shantimoy Kar, Xiaoxiang Yan, Julien Reboud, Edridah M. Tukahebwa, Jonathan M. Cooper
Summary: A smartphone-based end-to-end platform for multiplexed DNA diagnosis of malaria using paper-based microfluidic diagnostic tests, deep learning algorithms, and blockchain technology was validated through field tests in rural Uganda, achieving over 98% accuracy in identifying tested cases. The platform also offers secure geotagged diagnostic information for potential integration into infectious disease surveillance frameworks.
NATURE ELECTRONICS
(2021)
Article
Public, Environmental & Occupational Health
Moses Arinaitwe, Moses Adriko, Brian Kibwika, Edridah M. Tukahebwa, Christina L. Faust, Poppy H. L. Lamberton
Summary: Schistosomiasis, the second most important parasitic infection globally, affects more than 240 million people worldwide, with Uganda having a high burden of cases despite long-term mass drug administration. A recent study in Bugoto community identified age group, longer residence times, and daily contact with lake water as key drivers of Schistosoma mansoni infection, highlighting the need for interventions to control persistent transmission hotspots.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Microbiology
Rachel Francoeur, Alon Atuhaire, Moses Arinaitwe, Moses Adriko, Diana Ajambo, Andrina Nankasi, Simon A. Babayan, Poppy H. L. Lamberton
Summary: Schistosoma mansoni, a parasite causing significant public health challenges globally, remains a concern in high-endemicity communities in Uganda despite efforts of mass drug administration. Conflicting results were found on the impact of blood type on infection dynamics, with this study revealing no significant associations between blood type and S. mansoni burden in these communities. Variations in infection profiles were observed between villages, and egg burden decreased with age.
Article
Infectious Diseases
Julius Mulindwa, Joyce Namulondo, Anna Kitibwa, Jacent Nassuuna, Asanya Nyangiri, Magambo Phillip Kimuda, Alex Boobo, Barbara Nerima, Fred Busingye, Rowel Candia, Annet Namukuta, Ronald Ssenyonga, Noah Ukumu, Paul Ajal, Moses Adriko, Harry Noyes, Claudia J. de Dood, Paul L. A. M. Corstjens, Govert J. van Dam, Alison M. Elliott, Enock Matovu
Summary: Understanding the prevalence of schistosomiasis and its impact on child growth and development is crucial for effective control and elimination of the disease. A survey conducted in villages along the Albert-Nile shoreline in North Western Uganda revealed a high prevalence of schistosomiasis among school aged children. The study also found a high incidence of stunting in these children, which was not directly associated with schistosomiasis infection.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Nicholas Ngwili, Derrick N. Sentamu, Max Korir, Moses Adriko, Prudence Beinamaryo, Michel M. Dione, Joyce Moriku Kaducu, Alfred Mubangizi, Pauline Ngina Mwinzi, Lian F. Thomas, Matthew A. Dixon
Summary: A mapping study conducted in Uganda revealed high-risk areas for the zoonotic cestode Taenia solium, indicating the need for urgent control efforts to achieve the World Health Organization's milestones.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biology
Elias Kabbas-Pinango, Moses Arinaitwe, Govert J. J. van Dam, Adriko Moses, Annet Namukuta, Andrina Barungi Nankasi, Nicholas Khayinja Mwima, Fred Besigye, Joaquin M. Prada, Poppy H. L. Lamberton
Summary: Schistosomiasis affects over 240 million people worldwide. Detecting the parasite eggs using Kato-Katz method is specific but not sensitive, while the urine-based POC-CCA test is more sensitive but has specificity issues and interpretation challenges. This study explores the variation in test results and suggests different thresholds for accurate diagnosis and prevalence monitoring.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Infectious Diseases
Eun Seok Kim, Moses Adriko, Wamboko Aidah, Kabarangira Christine Oseku, David Lokure, Kalpana Sabapathy, Emily Webb
Summary: This study aimed to evaluate the efficacy of dual-dose albendazole compared to single-dose albendazole for treating hookworm infection in Mayuge district, Uganda. The results showed that dual-dose albendazole improved the cure rate of hookworm, but co-administration with fatty food did not significantly improve the treatment efficacy.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Emily Webb, Andrew Edielu, Wu Hannah, Narcis Kabatereine, Tukahebwa Edridah, Alfred Mubangizi, Moses Adriko, Alison Elliott, William Hope, Patrice Mawa, Jennifer Friedman, Amaya L. Bustinduy
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)