Article
Pharmacology & Pharmacy
Bin Wu, Wenchao Zhu, Qinghe Wang, Chunguang Ren, Lizhen Wang, Guannan Xie
Summary: This study compared the efficacy and safety of ciprofol-remifentanil with propofol-remifentanil for patients undergoing fiberoptic bronchoscopy. The results showed that ciprofol-remifentanil had a higher success rate of fiberoptic bronchoscopy and improved patient satisfaction and willingness to repeat the procedure compared to propofol-remifentanil.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Surgery
Paulina Salminen, Suvi Sippola, Jussi Haijanen, Pia Nordstrom, Tuomo Rantanen, Tero Rautio, Ville Sallinen, Eliisa Loyttyniemi, Saija Hurme, Ville Tammilehto, Johanna Laukkarinen, Heini Savolainen, Sanna Merilainen, Ari Leppaniemi, Juha Gronroos
Summary: This study conducted a double-blind placebo-controlled trial on uncomplicated acute appendicitis and found that omission of antibiotics did not significantly affect treatment success rate. Therefore, a non-inferiority trial against placebo is warranted for adults with CT-confirmed mild appendicitis.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Plant Sciences
Jia Xu, Lu Zhang, Yanping Xu, Jiahui Yu, Lianyu Zhao, Hui Deng, Meiling Li, Mingying Zhang, Xujie Lei, Congqi Hu, Wei Jiao, Zhao Dai, Lijuan Liu, Guangxing Chen
Summary: This study aimed to compare the efficacy and safety of traditional Chinese medicine (TCM) and methotrexate (MTX) in the treatment of active rheumatoid arthritis (RA). The results showed that the TCM compound formula was as effective as MTX and had superior efficacy following short-term treatment. This study provided evidence-based medicine in the treatment of RA with TCM compound prescriptions.
Article
Infectious Diseases
Ildiko Gagyor, Eva Hummers, Guido Schmiemann, Tim Friede, Sebastian Pfeiffer, Kambiz Afshar, Jutta Bleidorn
Summary: In this study, initial treatment with the herbal drug uva ursi (UU) reduced antibiotic use for uncomplicated urinary tract infection (UTI) in women, but led to a higher symptom burden and more safety concerns compared with antibiotic treatment.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Michael W. Dunne, Steven Aronin, Anita F. Das, Karthik Akinapelli, Michael T. Zelasky, Sailaja Puttagunta, Helen W. Boucher
Summary: This study demonstrates that sulopenem is an effective alternative for the treatment of urinary tract infections, with superiority in infections caused by resistant pathogens.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Matthieu Lafaurie, Sylvie Chevret, Jean-Paul Fontaine, Pierre Mongiat-Artus, Victoire de Lastours, Lelia Escaut, Stephane Jaureguiberry, Louis Bernard, Franck Bruyere, Caroline Gatey, Sophie Abgrall, Milagros Ferreyra, Hugues Aumaitre, Caroline Aparicio, Valerie Garrait, Vanina Meyssonnier, Anne Bourgarit-Durand, Amelie Chabrol, Emilie Piet, Jean-Philippe Talarmin, Marine Morrier, Etienne Canoui, Caroline Charlier, Manuel Etienne, Jerome Pacanowski, Nathalie Grall, Kristell Desseaux, Florence Empana-Barat, Isabelle Madeleine, Beatrice Bercot, Jean-Michel Molina, Agnes Lefort
Summary: This multicenter randomized, double-blind placebo-controlled noninferiority trial compared 7 days to 14 days of antibiotic treatment for febrile urinary tract infections (UTIs) in men. The study found that a 7-day treatment was inferior to a 14-day treatment. It is therefore not recommended for men with febrile UTIs to receive a 7-day antibiotic therapy.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Emergency Medicine
Ozge Can, Guclu Selahattin Kiyan, Sercan Yalcinli
Summary: This study compared the effects of IV ibuprofen and IV paracetamol in treating febrile patients in the emergency department, showing no significant differences between the two drugs in controlling fever, improving accompanying symptoms, and the need for rescue medication.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Immunology
Thijs ten Doesschate, Sander Kuiper, Cees van Nieuwkoop, Robert-Jan Hassing, Tom Ketels, Suzan P. van Mens, Wouter van den Bijllaardt, Akke K. van der Bij, Suzanne E. Geerlings, Ad Koster, Evert L. Koldewijn, Judith Branger, Andy I. M. Hoepelman, Cornelis H. van Werkhoven, Marc J. M. Bonten
Summary: Fosfomycin is noninferior to ciprofloxacin as oral step-down treatment for febrile urinary tract infections (fUTIs) caused by E. coli in women, but its use is associated with more gastrointestinal events.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Urology & Nephrology
S. Nestler, C. Peschel, A. H. Horstmann, W. Vahlensieck, W. Fabry, A. Neisius
Summary: This study evaluated the efficacy and safety of StroVac vaccination compared to placebo in patients with recurrent urinary tract infections (rUTI). The results showed that StroVac had a similar effect in reducing UTIs compared to the placebo. However, in patients with multiple UTIs prior to the study, StroVac showed a significant advantage. Further studies with a different ineffective placebo preparation are needed to determine the importance of StroVac in the prophylaxis of rUTI.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Microbiology
Eric Farfour, Laurent Dortet, Thomas Guillard, Nicolas Chatelain, Agathe Poisson, Assaf Mizrahi, Damien Fournier, Remy A. Bonnin, Nicolas Degand, Philippe Morand, Frederic Janvier, Vincent Fihman, Stephane Corvec, Lauranne Broutin, Cecile Le Brun, Nicolas Yin, Genevieve Hery-Arnaud, Antoine Grillon, Emmanuelle Bille, Helene Jean-Pierre, Marlene Amara, Francoise Jaureguy, Christophe Isnard, Vincent Cattoir, Tristan Diedrich, Emilie Flevin, Audrey Merens, Herve Jacquier, Marc Vasse
Summary: There are some trends in antibiotic resistance among Enterobacterales isolates recovered from urinary tract samples in France. Certain carbapenem-sparing drugs remain highly active.
Article
Infectious Diseases
Luciano Garofalo, Claudia Nakama, Douglas Hanes, Heather Zwickey
Summary: Urobiome dysbiosis is a common problem in women with uncomplicated urinary tract infection. Traditional antibiotics are not effective in addressing this issue, so new treatment approaches are needed. A whole-person, multi-modal approach may be more effective in reducing recurrent UTI.
Review
Infectious Diseases
Niels Frimodt-Moller, Lars Bjerrum
Summary: Understanding the usual benign course of UTIs can help reduce antibiotic treatment in many cases, e.g. starting treatment by pain relief and awaiting the course of infection without antibiotics. Better rapid tests in primary care are urgently needed to enforce such policies.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2023)
Article
Urology & Nephrology
Antonella Giannantoni, Marilena Gubbiotti, Emanuele Rubilotta, Matteo Balzarro, Alessandro Antonelli, Vittorio Bini
Summary: In patients with refractory neurogenic incontinence due to spinal cord injury or multiple sclerosis, IncobotulinumtoxinA was found to be as effective as OnabotulinumtoxinA in improving clinical and urodynamic findings in the short-term follow-up. The adverse effects were similar, with minor costs associated with Incobot/A.
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Article
Plant Sciences
Cristina Esposito, Emanuele Ugo Garzarella, Bruno Bocchino, Maria D'Avino, Giuseppe Caruso, Antonio Riccardo Buonomo, Roberto Sacchi, Fabio Galeotti, Gian Carlo Tenore, Vincenzo Zaccaria, Maria Daglia
Summary: The study demonstrates that propolis oral spray can help alleviate symptoms of mild upper respiratory tract infections without the need for pharmacological treatment, leading to a prompt resolution of symptoms.
Review
Urology & Nephrology
Mary Zare, Maria J. G. T. Vehreschild, Florian Wagenlehner
Summary: This review discusses the optimal management of recurrent urinary tract infections (UTIs) in women. Women are particularly susceptible to rUTI due to female anatomy, as well as behavioral, genetic, and urological factors. Various non-antibiotic strategies, prophylactic approaches, and emerging experimental treatments like faecal microbiota transfer (FMT) and bacteriophages show promising effects in interrupting the cycle of rUTI. Further clinical research is needed to explore the potential of these novel treatment options for bacterial infections, especially UTIs.
Editorial Material
Infectious Diseases
Marius Troseid, Maxime Hentzien, Florence Ader, Sandra Wagner Cardoso, Jose R. Arribas, Jean-Michel Molina, Nicolas Mueller, Maya Hites, Fabrice Bonnet, Oriol Manuel, Dominique Costagliola, Beatriz Grinsztejn, Inge Christoffer Olsen, Yazdan Yazdapanah, Alexandra Calmy
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Pharmacology & Pharmacy
Vida Terzic, Lea Levoyer, Melanie Figarella, Elisabetta Bigagli, Noemie Mercier, Lucie De Gastines, Severine Gibowski, Marius Troseid, Jacques Demotes, Inge Christoffer Olsen, Maya Hites, Florence Ader, Jose Ramon Arribas Lopez, France Mentre, Helene Esperou, Dominique Costagliola, John-Arne Rottingen, Julien Poissy, Jean-Christophe Roze, Adilia Warris, Jackie O'Leary, Ricardo M. Fernandes, Lambert Assoumou, Regis Hankard, Mark A. Turner, Yazdan Yazdanpanah, Alpha Diallo
Summary: To ensure the safety of participants and regulatory compliance in academic trials, a centralized pharmacovigilance system was established, allowing sponsors to delegate work. This system consisted of key procedures, a local safety officer network, and centralized safety activities. Lessons learned from four trials demonstrated the ability to manage diverse European requirements and communicate effectively with trial teams.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Roberto Rubem da Silva-Brandao, Sandi Michele de Oliveira, Juliana Silva Correa, Luiz Felipe Zago, Lislaine Aparecida Fracolli, Maria Clara Padoveze, Gloria Cristina Cordoba Currea
Summary: Antimicrobial resistance (AMR) is a growing threat to global health, particularly among those in Low- and Middle-Income Countries (LMICs). Understanding the social drivers behind antibiotic prescribing and dispensing practices in primary care settings in LMICs is limited. This study in Brazil aims to explore the social factors influencing such practices. The findings highlight the individual, relational, contextual, and structural challenges faced by healthcare professionals in primary care, and the need for interventions considering the social context and complexities of the health system.
Article
Medicine, General & Internal
Liv Cathrine Heggebo, Ida Maria Henriksen Borgen, Hillevi Rylander, Cecilie Kiserud, Tonje Haug Nordenmark, Taran Paulsen Hellebust, Morten Egeberg Evensen, Magnus Gustavsson, Christina Ramberg, Mette Sprauten, Henriette Magelssen, Hanne Blakstad, Janani Moorthy, Karin Andersson, Ingela Raunert, Thomas Henry, Cecilie Moe, Carin Granlund, Dorota Goplen, Jorunn Brekke, Tor-Christian Aase Johannessen, Tora Skeidsvoll Solheim, Kirsten Marienhagen, Oyvind Humberset, Per Bergstrom, Mans Agrup, Ludvig Dahl, Michael Gubanski, Helene Gojon, Carl-Johan Brahme, Isabelle Ryden, Asgeir S. Jakola, Einar O. Vik-Mo, Hanne C. Lie, Lars Asphaug, Maziar Hervani, Ingrid Kristensen, Corina Silvia Rueegg, Inge C. Olsen, Rolf J. Ledal, Eskil Degsell, Katja Werlenius, Malin Blomstrand, Petter Brandal
Summary: This study is an open-label, multicenter, randomized phase III non-inferiority study comparing proton therapy and photon therapy in the treatment of IDH-mutated diffuse gliomas grade 2-3. The results of this study will provide important information on the safety, cognition, fatigue, and quality of life parameters for this patient population.
Article
Medicine, General & Internal
Oliver Van Hecke, Lars Bjerrum, Ivan Gentile, Rogier Hopstaken, Hasse Melbye, Andreas Plate, Jan Y. Verbakel, Carl Llor, Annamaria Staiano
Summary: The threat of increasing antimicrobial resistance necessitates swift action to improve the rational use of antibiotics and increase stewardship to protect this key resource in healthcare. This paper discusses the role of CRP point-of-care testing in improving antibiotic stewardship in primary care for the diagnosis and treatment of adult patients with lower respiratory tract infections. It recommends promoting CRP POCT to identify adults who may benefit from antibiotics, and suggests enhanced communication and delayed prescribing as complementary strategies to reduce inappropriate antibiotic use.
FRONTIERS IN MEDICINE
(2023)
Correction
Infectious Diseases
Maria L. V. Jensen, Volkert Siersma, Lillian M. Soes, Dagny Nicolaisdottir, Lars Bjerrum, Barbara J. Holzknecht
Article
Health Care Sciences & Services
Laura Trolle Saust, Volkert Dirk Siersma, Lars Bjerrum, Malene Plejdrup Hansen
Summary: A set of quality indicators for the diagnosis and antibiotic treatment of adult patients with suspected urinary tract infections in general practice was developed. Consensus was reached through expert discussion, resulting in 24 quality indicators that can strengthen the focus on managing patients with potential urinary tract infections in general practice.
Article
Primary Health Care
Carl Llor, Yannick Hoyos Mallecot, Ana Moragas, Amelia Troncoso-Marino, Lars Bjerrum, Heidi C. Villmones
Summary: Over the past few years, the susceptibility activity of common microorganisms causing community-acquired infections in Spain has undergone significant changes. Based on susceptibility rates collected in 2021 from outpatients aged 15 or older with respiratory or urinary tract infection symptoms in Catalonia, penicillin V should be the first choice for most respiratory tract infections, amoxicillin and clavulanate for exacerbations of chronic obstructive pulmonary disease, and a single dose of fosfomycin or a short-course nitrofurantoin should be the first-line treatments for uncomplicated urinary tract infections. Updated information on antimicrobial resistance is crucial for general practitioners to ensure appropriate empirical management of common infections and promote more rational antibiotic use.
Letter
Biochemistry & Molecular Biology
Erica Telford, Beatriz Grinsztejn, Inge Christoffer Olsen, Nicolas Pulik, France Mentre, Skerdi Haviari, Maxime Hentzien, Olivier Segeral, Miquel B. Ekkelenkamp, Dimie Ogoina, Nathalie Strub-Wourgaft, Alpha Diallo, Yazdan Yazdanpanah, Alexandra Calmy
Article
Public, Environmental & Occupational Health
Kevin L. L. Schwartz, Alice X. T. Xu, Sarah Alderson, Lars Bjerrum, Jamie Brehaut, Benjamin C. C. Brown, Heiner C. C. Bucher, An De Sutter, Nick Francis, Jeremy Grimshaw, Ronny Gunnarsson, Sigurd Hoye, Noah Ivers, Donna M. M. Lecky, Morten Lindbaek, Jeffrey A. A. Linder, Paul Little, Benedikte Olsen Michalsen, Denise O'Connor, Celine Pulcini, Par-Daniel Sundvall, Pia Touboul Lundgren, Jan Y. Y. Verbakel, Theo J. J. Verheij
Summary: We have developed 13 best practice guidelines for designing and evaluating peer comparison audit and feedback on antibiotic prescribing in primary care. These guidelines can optimize the impact of quality improvement interventions and improve antibiotic prescribing in primary care.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Pediatrics
Annamaria Staiano, Lars Bjerrum, Carl Llor, Hasse Melbye, Rogier Hopstaken, Ivan Gentile, Andreas Plate, Oliver van Hecke, Jan Y. Verbakel
Summary: This paper discusses the application of C-reactive protein point-of-care testing in primary care for children with acute respiratory tract infections, as well as the role of enhanced communication skills training and delayed prescribing in improving antibiotic stewardship. The study found that CRP POCT can aid clinical assessment and decision-making, but clinical assessment should still be the primary factor in treatment or referral decisions.
FRONTIERS IN PEDIATRICS
(2023)
Article
Critical Care Medicine
Marius Troseid, Jose R. Arribas, Lambert Assoumou, Aleksander Rygh Holten, Julien Poissy, Vida Terzic, Fulvia Mazzaferri, Jesus Rodriguez Bano, Joe Eustace, Maya Hites, Michael Joannidis, Jose-Artur Paiva, Jean Reuter, Isabel Puentmann, Thale D. J. H. Patrick-Brown, Elin Westerheim, Katerina Nezvalova-Henriksen, Lydie Beniguel, Tuva Borresdatter Dahl, Maude Bouscambert, Monika Halanova, Zoltan Peterfi, Sotirios Tsiodras, Michael Rezek, Matthias Briel, Serhat Unal, Martin Schlegel, Florence Ader, Karine Lacombe, Cecilie Delphin Amdal, Serge Rodrigues, Kristian Tonby, Alexandre Gaudet, Lars Heggelund, Joy Mootien, Asgeir Johannessen, Jannicke Horjen Moller, Beatriz Diaz Pollan, Anders Aune Tveita, Anders Benjamin Kildal, Jean-Christophe Richard, Olav Dalgard, Victoria Charlotte Simensen, Aliou Balde, Lucie de Gastines, Marta del Alamo, Burc Aydin, Fridtjof Lund-Johansen, Mary-Anne Trabaud, Alpha Diallo, Bente Halvorsen, John-Arne Rottingen, Evelina Tacconelli, Yazdan Yazdanpanah, Inge C. Olsen, Dominique Costagliola
Summary: The study conducted a placebo-controlled trial of baricitinib in severe/critical COVID cases. The results showed that baricitinib did not reduce mortality within 60 days, and there may be safety risks in vaccinated participants, which require further investigation.
Review
Critical Care Medicine
Alain Amstutz, Benjamin Speich, France Mentre, Corina Silvia Rueegg, Drifa Belhadi, Lambert Assoumou, Charles Burdet, Srinivas Murthy, Lori Elizabeth Dodd, Yeming Wang, Kari A. O. Tikkinen, Florence Ader, Maya Hites, Maude Bouscambert, Mary Anne Trabaud, Mike Fralick, Todd C. Lee, Ruxandra Pinto, Andreas Barratt-Due, Fridtjof Lund-Johansen, Fredrik Mueller, Olli P. O. Nevalainen, Bin Cao, Tyler Bonnett, Alexandra Griessbach, Ala Taji Heravi, Christof Schonenberger, Perrine Janiaud, Laura Werlen, Soheila Aghlmandi, Stefan Schandelmaier, Yazdan Yazdanpanah, Dominique Costagliola, Inge Christoffer Olsen, Matthias Briel
Summary: This systematic review and meta-analysis assessed the benefits and harms of remdesivir compared to placebo or usual care in COVID-19 patients hospitalized. The study found that remdesivir reduced mortality in patients who required no or conventional oxygen support but did not have enough evidence for patients on ventilators.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Juliana Silva Correa, Luiz Felipe Zago, Roberto Rubem Da Silva-Brandao, Sandi Michele de Oliveira, Lislaine Aparecida Fracolli, Maria Clara Padoveze, Gloria Cordoba
Summary: This article explores stakeholders' perceptions of the challenges in developing and implementing a One Health agenda to tackle antimicrobial resistance (AMR) in Brazil. Through 27 interviews conducted with stakeholders from human, environmental, and animal health sectors, including academics, managers, and policymakers, three interconnected themes were identified: governance, the health system, and technical and scientific challenges. The findings highlight the lack of political priority given to AMR in Brazil and the lack of awareness regarding its clinical, social, and economic impacts. It is emphasized that the agenda's progress requires better integration across disciplines and ministries, reinforced by policymaker engagement and sustainable governance structures less affected by political influence.
GLOBAL PUBLIC HEALTH
(2023)
Article
Primary Health Care
Anders Bjerrum, Ana Garcia-Sangenis, Daniela Modena, Gloria Cordoba, Lars Bjerrum, Athina Chalkidou, Jesper Lykkegaard, Malene Plejdrup Hansen, Jens Sondergaard, Jorgen Nexoe, Ingrid Rebnord, Isabel Sebjornsen, Jette Nygaard Jensen, Matilde Bogelund Hansen, Katja Taxis, Maarten Lambert, Ria Benko, Beatriz Gonzalez Lopez-Valcarcel, Fabiana Raynal, Nieves Barragan, Pia Touboul, Pascale Bruno, Ruta Radzeviciene, Lina Jaruseviciene, Auste Bandzaite, Maciek Godycki-Cwirko, Anna Kowalczyk, Christos Lionis, Maria-Nefeli Karkana, Marilena Anastasaki, Jamie Coleman, Helena Glasova, Michiel van Agtmael, Pierre Tattevin, Alicia Borras, Carl Llor
Summary: The HAPPY PATIENT project aims to combat antimicrobial resistance by improving the management quality of common community-acquired infections through multifaceted interventions. The project evaluates the adaptation of EU recommendations on prudent use of antimicrobials by assessing the impact of interventions targeting healthcare professionals in different settings. The results will be compared before and after the interventions to determine the effectiveness in reducing inappropriate prescribing and dispensing of antibiotics.