A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment
Published 2018 View Full Article
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Title
A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment
Authors
Keywords
Cancer stem cells, Cancer treatment, Stem cells, Cell differentiation, Cell death, Tumor stem cells, Endothelial cells, Cell binding
Journal
PLoS Computational Biology
Volume 14, Issue 1, Pages e1005920
Publisher
Public Library of Science (PLoS)
Online
2018-01-20
DOI
10.1371/journal.pcbi.1005920
References
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Note: Only part of the references are listed.- The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories
- (2016) Benjamin Werner et al. CANCER RESEARCH
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- (2016) Kelsey A. Finkel et al. NEOPLASIA
- The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
- (2015) Vicki Plaks et al. Cell Stem Cell
- The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition
- (2015) Christoph Garbers et al. CURRENT OPINION IN IMMUNOLOGY
- Characterizing inhibited tumor growth in stem-cell-driven non-spatial cancers
- (2015) Ignacio A. Rodriguez-Brenes et al. MATHEMATICAL BIOSCIENCES
- Upregulated interleukin-6 expression contributes to erlotinib resistance in head and neck squamous cell carcinoma
- (2015) Aditya Stanam et al. Molecular Oncology
- Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma
- (2015) Daiki Mochizuki et al. Oncotarget
- Cisplatin Induces Bmi-1 and Enhances the Stem Cell Fraction in Head and Neck Cancer
- (2015) Carolina Nör et al. NEOPLASIA
- Endothelial cell-derived interleukin-6 regulates tumor growth
- (2014) Kathleen G Neiva et al. BMC CANCER
- A Multicompartment Mathematical Model of Cancer Stem Cell-Driven Tumor Growth Dynamics
- (2014) Suzanne L. Weekes et al. BULLETIN OF MATHEMATICAL BIOLOGY
- Metastatic Stem Cells: Sources, Niches, and Vital Pathways
- (2014) Thordur Oskarsson et al. Cell Stem Cell
- Circulating tumour cells in metastatic head and neck cancers
- (2014) Arutha Kulasinghe et al. INTERNATIONAL JOURNAL OF CANCER
- Cutting Edge: Soluble IL-6R Is Produced by IL-6R Ectodomain Shedding in Activated CD4 T Cells
- (2014) E. M. Briso et al. JOURNAL OF IMMUNOLOGY
- Endothelial Interleukin-6 Defines the Tumorigenic Potential of Primary Human Cancer Stem Cells
- (2014) Sudha Krishnamurthy et al. STEM CELLS
- The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment
- (2014) Jun Ye et al. TUMOR BIOLOGY
- Epidemiologic Trends in Head and Neck Cancer and Aids in Diagnosis
- (2014) Nadarajah Vigneswaran et al. Oral and Maxillofacial Surgery Clinics of North America
- Microenvironmental Variables Must Influence Intrinsic Phenotypic Parameters of Cancer Stem Cells to Affect Tumourigenicity
- (2014) Jacob G. Scott et al. PLoS Computational Biology
- Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells
- (2013) Seog-Young Kim et al. CELLULAR SIGNALLING
- In vitro cytokine release profile: Predictive value for metastatic potential in head and neck squamous cell carcinomas
- (2013) Omar Shkeir et al. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- A Mathematical Model of Cancer Stem Cell Driven Tumor Initiation: Implications of Niche Size and Loss of Homeostatic Regulatory Mechanisms
- (2013) Sara N. Gentry et al. PLoS One
- The Tumor Growth Paradox and Immune System-Mediated Selection for Cancer Stem Cells
- (2012) Thomas Hillen et al. BULLETIN OF MATHEMATICAL BIOLOGY
- Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division Kinetics
- (2012) X. Gao et al. CANCER RESEARCH
- Defining the mode of tumour growth by clonal analysis
- (2012) Gregory Driessens et al. NATURE
- A Simple Mathematical Model Based on the Cancer Stem Cell Hypothesis Suggests Kinetic Commonalities in Solid Tumor Growth
- (2012) Rodolfo Molina-Peña et al. PLoS One
- Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
- (2011) Benjamin D. Simons et al. CELL
- Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
- (2011) Christina Scheel et al. CELL
- Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
- (2011) D. Iliopoulos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HOW Is Required for Stem Cell Maintenance in the Drosophila Testis and for the Onset of Transit-Amplifying Divisions
- (2010) Adrian C. Monk et al. Cell Stem Cell
- Glioblastoma stem-like cells give rise to tumour endothelium
- (2010) Rong Wang et al. NATURE
- Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization
- (2010) Tomoyuki Igawa et al. NATURE BIOTECHNOLOGY
- Cancer stem cells in solid tumors
- (2010) Patrick C. Hermann et al. SEMINARS IN CANCER BIOLOGY
- Paradoxical Dependencies of Tumor Dormancy and Progression on Basic Cell Kinetics
- (2009) H. Enderling et al. CANCER RESEARCH
- Cancer stem cells and their niche
- (2009) Hiroko Iwasaki et al. CANCER SCIENCE
- Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineage
- (2009) Megan L. Insco et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A methodology for performing global uncertainty and sensitivity analysis in systems biology
- (2008) Simeone Marino et al. JOURNAL OF THEORETICAL BIOLOGY
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