ELKS active zone proteins as multitasking scaffolds for secretion

Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites

(2018) Changliang Liu et al.   CELL

Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses

(2018) Man Yan Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones

(2017) Hiroshi Kawabe et al.   JOURNAL OF CELL BIOLOGY

Transcellular Nanoalignment of Synaptic Function

(2017) Thomas Biederer et al.   NEURON

Neurosecretion: what can we learn from chromaffin cells

(2017) Erwin Neher   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming

(2017) Marcial Camacho et al.   Nature Communications

Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

(2017) Anand Patwardhan et al.   Nature Communications

A novel region in the CaV2.1 α1 subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

(2017) Matthias Lübbert et al.   eLife

How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release

(2016) Stephan Maxeiner et al.   EMBO JOURNAL

Loss of the calcium channel β4subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice

(2016) Bruno Benedetti et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The active zone protein CAST regulates synaptic vesicle recycling and quantal size in the mouse hippocampus

(2016) Shizuka Kobayashi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The calcium sensor synaptotagmin 7 is required for synaptic facilitation

(2016) Skyler L. Jackman et al.   NATURE

How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs

(2016) Claudio Acuna et al.   NEURON

Fusion Competent Synaptic Vesicles Persist upon Active Zone Disruption and Loss of Vesicle Docking

(2016) Shan Shan H. Wang et al.   NEURON

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses

(2016) M. Katharina Grauel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels

(2016) Caixia Lv et al.   Cell Reports

ELKS controls the pool of readily releasable vesicles at excitatory synapses through its N-terminal coiled-coil domains

(2016) Richard G Held et al.   eLife

Maturation of active zone assembly byDrosophilaBruchpilot

(2016) Wernher Fouquet et al.   JOURNAL OF CELL BIOLOGY

Liprin-α1 and ERC1 control cell edge dynamics by promoting focal adhesion turnover

(2016) Veronica Astro et al.   Scientific Reports

RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse

(2015) Yunyun Han et al.   JOURNAL OF NEUROPHYSIOLOGY

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RIM-BPs Mediate Tight Coupling of Action Potentials to Ca 2+ -Triggered Neurotransmitter Release

(2015) Claudio Acuna et al.   NEURON

Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains

(2015) Karen Perez de Arce et al.   NEURON

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A 1.5Mb terminal deletion of 12p associated with autism spectrum disorder

(2014) Isabela M.W. Silva et al.   GENE

Liprin- 1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration

(2014) V. Astro et al.   JOURNAL OF CELL SCIENCE

The Active Zone Protein Family ELKS Supports Ca2+ Influx at Nerve Terminals of Inhibitory Hippocampal Neurons

(2014) C. Liu et al.   JOURNAL OF NEUROSCIENCE

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

(2014) Samantha J. Stehbens et al.   NATURE CELL BIOLOGY

Bassoon Specifically Controls Presynaptic P/Q-type Ca2+ Channels via RIM-Binding Protein

(2014) Daria Davydova et al.   NEURON

The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles

(2013) Tanja Matkovic et al.   JOURNAL OF CELL BIOLOGY

Ultrafast endocytosis at mouse hippocampal synapses

(2013) Shigeki Watanabe et al.   NATURE

Molecular Profiling of Synaptic Vesicle Docking Sites Reveals Novel Proteins but Few Differences between Glutamatergic and GABAergic Synapses

(2013) Janina Boyken et al.   NEURON

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

CAST: Functional scaffold for the integrity of the presynaptic active zone

(2013) Toshihisa Ohtsuka   NEUROSCIENCE RESEARCH

Structure and function of the β subunit of voltage-gated Ca2+ channels

(2012) Zafir Buraei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ca2+ channels and transmitter release at the active zone

(2012) Ralf Schneggenburger et al.   CELL CALCIUM

12p13.33 microdeletion including ELKS/ERC1, a new locus associated with childhood apraxia of speech

(2012) Julien Thevenon et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Physical and functional interaction of the active zone protein CAST/ERC2 and the  -subunit of the voltage-dependent Ca2+ channel

(2012) S. Kiyonaka et al.   JOURNAL OF BIOCHEMISTRY

RIM Controls Homeostatic Plasticity through Modulation of the Readily-Releasable Vesicle Pool

(2012) M. Muller et al.   JOURNAL OF NEUROSCIENCE

Deletion of the Presynaptic Scaffold CAST Reduces Active Zone Size in Rod Photoreceptors and Impairs Visual Processing

(2012) S. tom Dieck et al.   JOURNAL OF NEUROSCIENCE

Formation of Golgi-Derived Active Zone Precursor Vesicles

(2012) C. Maas et al.   JOURNAL OF NEUROSCIENCE

Molecular machines governing exocytosis of synaptic vesicles

(2012) Reinhard Jahn et al.   NATURE

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

RIM genes differentially contribute to organizing presynaptic release sites

(2012) P. S. Kaeser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

Rab6, Rab8, and MICAL3 Cooperate in Controlling Docking and Fusion of Exocytotic Carriers

(2011) Ilya Grigoriev et al.   CURRENT BIOLOGY

Calcium Channels Link the Muscle-Derived Synapse Organizer Laminin  2 to Bassoon and CAST/Erc2 to Organize Presynaptic Active Zones

(2011) J. Chen et al.   JOURNAL OF NEUROSCIENCE

Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses

(2011) Emmanuel Eggermann et al.   NATURE REVIEWS NEUROSCIENCE

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

(2011) Lunbin Deng et al.   NEURON

RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

(2011) Yunyun Han et al.   NEURON

ELKS1 and Ca2+ channel subunit β4 interact and colocalize at cerebellar synapses

(2011) Sara E. Billings et al.   NEUROREPORT

RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release

(2011) K. S. Y. Liu et al.   SCIENCE

Cell biology of Ca2+-triggered exocytosis

(2010) Zhiping P Pang et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms of short‐term plasticity at neuromuscular active zones of Drosophila

(2010) Stefan Hallermann et al.   HFSP Journal

Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography

(2010) Rubén Fernández-Busnadiego et al.   JOURNAL OF CELL BIOLOGY

Naked Dense Bodies Provoke Depression

(2010) S. Hallermann et al.   JOURNAL OF NEUROSCIENCE

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain

(2010) C. S. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

(2009) Heidi de Wit et al.   CELL

A Protein Interaction Node at the Neurotransmitter Release Site: Domains of Aczonin/Piccolo, Bassoon, CAST, and Rim Converge on the N-Terminal Domain of Munc13-1

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses

(2009) Pascal S. Kaeser et al.   NEURON

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels

(2008) Marco Morciano et al.   JOURNAL OF NEUROCHEMISTRY

RIM1  and RIM1  Are Synthesized from Distinct Promoters of the RIM1 Gene to Mediate Differential But Overlapping Synaptic Functions

(2008) P. S. Kaeser et al.   JOURNAL OF NEUROSCIENCE

Membrane fusion

(2008) William Wickner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY