Biological function of Lemur tyrosine kinase 2 (LMTK2): implications in neurodegeneration

Intracellular and Extracellular Roles for Tau in Neurodegenerative Disease

(2018) Diane P. Hanger et al.   JOURNAL OF ALZHEIMERS DISEASE

Biological functions of CDK5 and potential CDK5 targeted clinical treatments

(2017) Alison Shupp et al.   Oncotarget

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria

(2017) Michael J. Strong et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

A Lewy-testes demencia klinikai és neuropatológiai jellemzői

(2017) János Bencze et al.   ORVOSI HETILAP

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia

(2016) Erika Bereczki et al.   Alzheimers & Dementia

Loss of cargo binding in the human myosin VI deafness mutant (R1166X) leads to increased actin filament binding

(2016) S. D. Arden et al.   BIOCHEMICAL JOURNAL

Meta-Analysis of Parkinson's Disease Transcriptome Data Using TRAM Software: Whole Substantia Nigra Tissue and Single Dopamine Neuron Differential Gene Expression

(2016) Elisa Mariani et al.   PLoS One

Depression and Synaptic Zinc Regulation in Alzheimer Disease, Dementia with Lewy Bodies, and Parkinson Disease Dementia

(2015) David R. Whitfield et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Neuronal cell cycle: the neuron itself and its circumstances

(2015) José M Frade et al.   CELL CYCLE

The discovery of modular binding domains: building blocks of cell signalling

(2015) Bruce J. Mayer   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis

(2015) Burcin Ikiz et al.   Cell Reports

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

(2015) Mar Matarin et al.   Cell Reports

Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer’s disease

(2015) Sachin S Tiwari et al.   Molecular Brain

The associations between Parkinson’s disease and cancer: the plot thickens

(2015) Danielle D. Feng et al.   Translational Neurodegeneration

LMTK2-mediated Phosphorylation Regulates CFTR Endocytosis in Human Airway Epithelial Cells

(2014) Simão Luz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment

(2014) David R. Whitfield et al.   NEUROBIOLOGY OF AGING

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Autophagy and apoptosis dysfunction in neurodegenerative disorders

(2013) Saeid Ghavami et al.   PROGRESS IN NEUROBIOLOGY

Determination of the membrane topology of lemur tyrosine kinase 2 (LMTK2) by fluorescence protease protection

(2012) Alexander Nixon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates A  production

(2012) A. Vagnoni et al.   HUMAN MOLECULAR GENETICS

The axonal transport of mitochondria

(2012) W. M. Saxton et al.   JOURNAL OF CELL SCIENCE

Cdk5/p35 phosphorylates lemur tyrosine kinase-2 to regulate protein phosphatase-1C phosphorylation and activity

(2012) Catherine Manser et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome

(2012) David A. Tumbarello et al.   NATURE CELL BIOLOGY

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

Transforming Growth Factor-β Signaling in Motor Neuron Diseases

(2011) M. Katsuno et al.   CURRENT MOLECULAR MEDICINE

Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

(2011) N. M. Kanaan et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport

(2011) Nicholas M. Kanaan et al.   NEUROBIOLOGY OF AGING

Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo

(2011) C Manser et al.   ONCOGENE

Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer

(2010) Lorna W Harries et al.   BMC CANCER

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

(2010) Elizabeth A. Thomas et al.   HUMAN MOLECULAR GENETICS

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease

(2010) Nobutaka Hirokawa et al.   NEURON

No difference in kinetics of tau or histone phosphorylation by CDK5/p25 versus CDK5/p35 in vitro

(2010) D. W. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1

(2009) Annick Hendrickx et al.   CHEMISTRY & BIOLOGY

CFTR Function and Prospects for Therapy

(2008) John R. Riordan   Annual Review of Biochemistry

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

Nucleocytoplasmic shuttling of Smad proteins

(2008) Caroline S Hill   CELL RESEARCH

BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking

(2008) Takeshi Inoue et al.   GENES TO CELLS

Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs

(2008) Douglas L. Sheridan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between Cyclin-Dependent Kinase 5 and Glycogen Synthase Kinase 3  Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing

(2008) Y. Wen et al.   JOURNAL OF NEUROSCIENCE

Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo

(2008) Kwang-Woo Ahn et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

(2008) Terrence Town et al.   NATURE MEDICINE