Article
Ophthalmology
Martin Hein, Andrew Mehnert, K. Bailey Freund, Dao-Yi Yu, Chandrakumar Balaratnasingam
Summary: This study investigates the variability of macular perfusion in patients with branch retinal vein occlusion (BRVO) using a novel approach based on optical coherence tomography angiography (OCTA) coefficient of variation (CoV) analysis. It was found that there is an increased variability in microvasculature perfusion in the ischemic regions of the macula affected by BRVO. This new technique has potential applications in studying the pathophysiology of other retinal vascular diseases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Medicine, General & Internal
Bilge Batu Oto, Oguzhan Kilicarslan, Yasemin Kayadibi, Aslihan Yilmaz cebi, Ibrahim Adaletli, Senihe Rengin Yildirim
Summary: This study aimed to analyze the differences in retinal microvascular parameters between patients with internal carotid artery stenosis and healthy individuals using optical coherence tomography angiography. The results showed that even mild stenosis can lead to changes in the retinal microvascular bed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nanna Vestergaard, Lasse Jorgensen Cehofski, Alexander Norgard Alsing, Anders Kruse, Jonas Ellegaard Nielsen, Anders Schlosser, Grith Lykke Sorensen, Bent Honore, Henrik Vorum
Summary: This study found that retinal artery occlusion (RAO) results in the upregulation of multiple inflammatory proteins and the downregulation of proteins involved in visual pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Daniel A. Wenzel, Sven Poli, Maria Casagrande, Vasyl Druchkiv, Martin S. Spitzer, Karl Ulrich Bartz-Schmidt, Carsten Grohmann, Maximilian Schultheiss
Summary: This study investigated the correlation between inner retinal hyperreflectivity and acute central retinal artery occlusion (CRAO) using optical coherence tomography (OCT). The results showed a strong correlation between inner retinal hyperreflectivity and CRAO, suggesting that it could serve as a potential biomarker for prompt diagnosis of CRAO.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Deokho Lee, Yohei Tomita, Yukihiro Miwa, Heonuk Jeong, Ari Shinojima, Norimitsu Ban, Shintaro Yamaguchi, Ken Nishioka, Kazuno Negishi, Jun Yoshino, Toshihide Kurihara
Summary: This study demonstrated for the first time the protective effect of NMN in cardiovascular disease-induced retinal ischemia in a mouse model, suppressing retinal dysfunction and pathological gliosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Hao Li, Chuan Chen, Zhangyu Li, Cong Ling, Jun Sun, Hui Wang
Summary: The study demonstrates that STA-PCA bypass surgery can improve cerebral blood flow perfusion in CBAO patients, with a significant increase in STA diameter and flow rate at 12 months post-operation. Patients showed improvements in neurological function scores and quality of life scores after surgery.
WORLD NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Deokho Lee, Yohei Tomita, Heonuk Jeong, Yukihiro Miwa, Kazuo Tsubota, Kazuno Negishi, Toshihide Kurihara
Summary: Experimental findings show that pemafibrate can enhance liver function, increase serum levels of the neuroprotective molecule fibroblast growth factor 21 (FGF21), and alleviate retinal dysfunction caused by cardiovascular diseases, by modulating retinal gliosis and preserving oscillatory potentials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Weihao Lv, Xiuquan Wu, Yanan Dou, Yiwen Yan, Leiying Chen, Zhou Fei, Fei Fei
Summary: This study suggests that Homer1 can protect against pyroptosis of retinal ganglion cells (RGCs) and preserve visual function by inhibiting endoplasmic reticulum stress and the activation of TXNIP/NLRP3 inflammasome in MCAO-induced retinal ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Rony Carlos Preti, Claudio Iovino, Maria Fernanda Abalem, Rafael Garcia, Helen Nazareth Veloso dos Santos, Gustavo Sakuno, Adrian Au, Leonardo Provetti Cunha, Leandro Cabral Zacharias, Mario Luiz Ribeiro Monteiro, Srinivas Reddy Sadda, David Sarraf
Summary: The purpose of the study was to determine the prevalence of focal inner, middle, and combined inner/middle retinal thinning in different stages of diabetic retinopathy, and to assess the relationship between such findings with ocular and systemic parameters. The results showed that focal retinal thinning was common in all stages of diabetic retinopathy and increased with severity of the disease. The study suggests that OCT identification of focal retinal thinning may serve as a surrogate biomarker of retinal and systemic disease in diabetic patients.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Clinical Neurology
Brian Mac Grory, Sean R. Landman, Paul D. Ziegler, Chantal J. Boisvert, Shane P. Flood, Christoph Stretz, Tracy E. Madsen, Michael E. Reznik, Shawna Cutting, Elizabeth E. Moore, Hunter Hewitt, James B. Closser, Jose Torres, Patrick J. Lavin, Karen L. Furie, Ying Xian, Wayne Feng, Valerie Biousse, Matthew Schrag, Shadi Yaghi
Summary: The study found that the cumulative incidence of new atrial fibrillation (AF) after central retinal artery occlusion (CRAO) was approximately 49.6% at 2 years. Patients with CRAO had a higher risk of developing AF compared to controls and a similar risk to patients with stroke. CRAO was also associated with an increased incidence of new stroke.
Article
Medicine, General & Internal
Maria Casagrande, Nils Alexander Steinhorst, Susanne Kathrin Dippel, Fabian Kueck, Carsten Grohmann, Martin S. Spitzer, Sven Poli, Nicolas Feltgen, Maximilian Schultheiss
Summary: This study investigates the sensitivity and specificity of the CRAO-Detection Score in diagnosing CRAO without requiring fundoscopy. The questionnaire can be used as a screening tool to detect CRAO patients, which is crucial for prompt diagnosis and treatment of CRAO.
FRONTIERS IN MEDICINE
(2023)
Article
Ophthalmology
Ramesh Venkatesh, Shama Sharief, Chitturi Venkata Sai Prashanti, Nikitha Gurram Reddy, Rubble Mangla, Yash Parmar, Aaditi Anilkumar, Naresh Kumar Yadav, Jay Chhablani
Summary: Aberrant filling of the retinal vein in patients with branch or hemi-central retinal artery occlusions is associated with less severe retinal ischemia and better visual outcomes. This finding may be attributed to altered retinal vascular anatomy or arteriovenous shunts. The presence of aberrant filling of the retinal vein could indicate a better visual prognosis.
Article
Clinical Neurology
Dong-Wan Kang, Keun-Hwa Jung, Wookjin Yang, Hyeong Min Kim, Youngjoon Kim, Matthew Chung, Jiyeon Ha, Monique Therese Punsalan, Eung-Joon Lee, Han-Yeong Jeong, Jeong-Min Kim, Sang-Bae Ko, Seung-Hoon Lee
Summary: This study investigated the impact of embolic sources on outcomes in central retinal artery occlusion (CRAO) patients, finding that patients with embolic sources were more likely to experience visual improvement.
Article
Medicine, General & Internal
Wei-Yu Lai, Pei-Chin Lin, Chun-Hao Yin, Kuang-Tsu Yang, En-Jie Shih, Jin-Shuen Chen
Summary: This study investigated the relationship between hematocrit (Hct) levels and retinal artery occlusion (RAO). The results showed that Hct levels ≥40% were associated with the occurrence of RAO. In male patients, there was a trend of a non-linear dose-response association between Hct levels and ischemic vascular events. Hct levels ≥40% in patients older than 65 years with at least six comorbidities could be associated with RAO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Maneesh M. Bapaye, Akshay Gopinathan Nair, Charuta M. Bapaye, Meena M. Bapaye, Juilee J. Shukla
Summary: COVID-19 infection can lead to systemic coagulopathy and acquired thrombophilia, including complications such as vasculitis and retinal artery occlusion. Early detection and intervention are crucial.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2021)
Editorial Material
Ophthalmology
Andreas Berlin, Ling Chen, Jeffrey Messinger, Daniela Ferrara, K. Bailey Freund, Christine A. Curcio
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
Claudio Iovino, Adrian Au, Prithvi Ramtohul, Tommaso Bacci, Abdullah AlBahlal, Abdullah M. Khan, Abdulelah A. Al-Abdullah, Robert Wendel, Jay Chhablani, SriniVas Sadda, K. Bailey Freund, David Sarraf
Summary: This study analyzed the imaging characteristics and clinical course of patients with coincident lesions of PAMM and AMN in the same eye, and found that this phenomenon may be associated with retinal vein impairment and hypoperfusion in the deep retinal capillary plexus.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Xiaofei Wang, Stanley Chang, Jack Grinband, Lawrence A. Yannuzzi, K. Bailey Freund, Quan Hoang, Michael J. A. Girard
Summary: The axial length is longer in highly myopic eyes and the adjusted tortuosity of the optic nerve is lower, suggesting higher traction forces during eye movements. Optic nerve displacements differ significantly between adduction and abduction, with smaller displacements in highly myopic eyes. Additionally, posterior segment displacements are smaller in highly myopic eyes in both gaze directions, with larger displacements in the anterior-most segment during adduction.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Max Brinkmann, Tommaso Bacci, Deepayan Kar, Jeffrey D. Messinger, Kenneth R. Sloan, Ling Chen, Timothy Hamann, Maximilian Wiest, K. Bailey Freund, Sandrine Zweifel, Christine A. Curcio
Summary: This study evaluated the role of acquired vitelliform lesion (AVL) in age-related macular degeneration pathophysiology and analyzed the histological and clinical features of AVL. The results showed that AVL deposits have low levels of retinal pigment epithelium (RPE) organelles and outer segments. The growth rates of collapsing and non-collapsing AVLs were different, suggesting dysregulation of lipid transfer pathways specific to cone photoreceptors and supporting cells in the formation of AVL deposits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ling Chen, Dongfeng Cao, Jeffrey D. Messinger, Thomas Ach, Daniela Ferrara, K. Bailey Freund, Christine A. Curcio
Summary: Melanotic cells with large spherical melanosomes, possibly originating from retinal pigment epithelium, were found in eyes with neovascular age-related macular degeneration. These cells exhibit molecular differences from RPE, suggesting a process of transdifferentiation. Studying detailed histology of eyes affected by nvAMD may lead to the development of new therapies for fibrosis.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Ophthalmology
Meira Fogel-Levin, SriniVas R. Sadda, Philip J. Rosenfeld, Nadia Waheed, Giuseppe Querques, Bailey K. Freund, David Sarraf
Summary: Imaging is crucial in the evaluation and management of retinal disorders, and different imaging modalities have unique capabilities to show different aspects of the disease. Multimodal retinal imaging provides abundant and insightful information, but integrating the complex data can be overwhelming. This article discusses the applications, strengths, and limitations of various retinal imaging tools, including color fundus photography, widefield imaging, fundus autofluorescence, near infrared reflectance, optical coherence tomography angiography, and en face optical coherence tomography, as well as the advantages and disadvantages of a multimodal approach.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Marc J. Sirks, Elon H. C. van Dijk, Noa Rosenberg, Carla E. M. Hollak, Stamatios Aslanis, Chui Ming Gemmy Cheung, Itay Chowers, Chiara M. Eandi, K. Bailey Freund, Frank G. Holz, Peter K. Kaiser, Andrew J. Lotery, Kyoko Ohno-Matsui, Giuseppe Querques, Yousif Subhi, Ramin Tadayoni, Charles C. Wykoff, Dinah Zur, Roselie M. H. Diederen, Camiel J. F. Boon, Reinier O. Schlingemann
Summary: Since July 2021, there has been a worldwide shortage of verteporfin (Visudyne (R)), which has had a significant impact on the care of ophthalmic patients worldwide and may result in serious and irreversible vision loss.
ACTA OPHTHALMOLOGICA
(2022)
Article
Ophthalmology
K. Bailey Freund, Giovanni Staurenghi, Jesse J. Jung, Sandrine A. Zweifel, Mariano Cozzi, Lauren Hill, Steven Blotner, Min Tsuboi, Shamika Gune
Summary: The study aimed to investigate the relationship between the Consensus on Neovascular Age-Related Macular Degeneration (CONAN) Study Group classifications of macular neovascularization (MNV) and visual responses to ranibizumab therapy in patients with neovascular age-related macular degeneration (nAMD). Results showed that the different lesion types had varying effects on best-corrected visual acuity (BCVA) outcomes, supporting the use of an anatomic classification system to evaluate and predict visual responses to anti-vascular endothelial growth factor therapy for nAMD.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Editorial Material
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Letter
Ophthalmology
Prithvi Ramtohul, Maria Vittoria Cicinelli, K. Bailey Freund
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Riccardo Sacconi, David Sarraf, SriniVas R. Sadda, K. Bailey Freund, Andrea Servillo, Meira Miri Fogel Levin, Eliana Costanzo, Giulia Corradetti, Diogo Cabral, Dinah Zur, Omer Trivizki, Mariacristina Parravano, Francesco Bandello, Anat Loewenstein, Giuseppe Querques
Summary: This study investigated the association between nascent geographic atrophy (GA) and the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD). The results showed that 22.7% of the patients had nascent GA preceding exudative type 3 MNV. Therefore, the detection of nascent GA in AMD patients may require closer surveillance to identify early exudative type 3 MNV warranting treatment.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Prithvi Ramtohul, Diogo Cabral, Daniel Oh, Daniel Galhoz, K. Bailey Freund
Summary: The purpose of this study was to investigate whether noninvasive en face ultrawidefield (UWF) OCT can demonstrate distinctive features of choroidal vasculature in eyes with central serous chorioretinopathy (CSC). Patients diagnosed with CSC underwent UWF indocyanine green angiography (ICGA) and widefield OCT imaging. The results showed that en face UWF OCT imaging can show distinctive features of choroidal venous insufficiency previously identified with UWF ICGA in eyes with CSC.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Russel H. Dinh, Edmund Tsui, Matthew S. Wieder, Alexander Barash, Michael M. Park, Ehsan Rahimy, Prithvi Mruthyunjaya, Louise J. Lu, Suzanne M. Michalak, Rohan J. Shah, David Sierpina, Timothy W. Winter, Ryan A. Shields, Eduardo Uchiyama, Gregory D. Lee, Rahul Komati, Eric Lee, Sundeep K. Kasi, Brian K. Do
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Hong-Uyen Hua, Nadim Rayess, Angela S. S. Li, Diana Do, Ehsan Rahimy
Summary: This study assessed the quality, accountability, readability, accessibility, and presence of Spanish translation in online material about macular degeneration. The top 5 websites from a Google search did not have better quality or readability compared to other websites. Improving quality, accountability, and readability can help improve patients' health literacy regarding macular degeneration.
JOURNAL OF VITREORETINAL DISEASES
(2022)
Meeting Abstract
Ophthalmology
M. Ali Ali Khan, Ehsan Rahimy, Allen C. Ho, Ryan Corley, Mark Gallivan, Daniel Jones, Ramiro Ribeiro, Theodore Leng, Nancy M. Holekamp
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)