Journal
JOURNAL OF SAUDI CHEMICAL SOCIETY
Volume 23, Issue 1, Pages 52-60Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jscs.2018.04.005
Keywords
Metal complexes; Antibacterial activity; Anticancer activity; Molecular docking with EGFR
Categories
Ask authors/readers for more resources
The complexes of Co(II), Ni(II), Cu(II) and Zn(II) metal ions has been synthesized through template method by the condensation of succinic acid dihydrazide with 5-chloroisatin in alcoholic medium. Complexes were characterized by C H N analysis, molar conductance, thermal analysis, magnetic susceptibility, mass spectrometry, FTIR, EPR, H-1 NMR, UV-Visible spectroscopy. These studies suggest an octahedral geometry for all the complexes. The compounds were found active against B. subtdis and S. aureus and P. aeruginosa and E. coli bacteria. The Zn(II) complex showed significant anticancer activity against Squamous Cell Carcinoma cells tested by the MTT assay method. Molecular docking studies with EGFR tyrosine kinase were also carried out. All these results show that some of the synthesized compounds have remarkable antibacterial and anticancer property. (C) 2018 King Saud University. Production and hosting by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available