Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 14, Issue 12, Pages 2964-2970Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2018.1502529
Keywords
Live attenuated influenza vaccine (LAIV); respiratory syncytial virus (RSV); cytotoxic T cells; epitope-based vaccine; viral vector system
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Funding
- Russian Science Fund [17-75-20054]
- Russian Science Foundation [17-75-20054] Funding Source: Russian Science Foundation
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The development of viral vector vaccines against various pathogens for which conventional vaccination approaches are not applicable has been a priority for a number of years. One promising approach is the insertion of immunodominant conservative cytotoxic T-cell (CTL) epitopes into the genome of a viral vector, which then delivers these epitopes to target cells, inducing immunity. Many different viruses have been assessed as viral vectors for CTL-based vaccines, but only a few of them are clinically relevant, mainly because of safety issues and limited knowledge about their performance in humans. In this regard, the use of licensed cold-adapted live attenuated influenza vaccine (LAIV) viruses as a vector delivery system has clear advantages for CTL-based vector vaccines against other respiratory pathogens: LAIV is known to induce all arms of the adaptive immune system and is administered via nasal spray, and its production process is relatively easy and inexpensive. Here we present the first results of the use of an LAIV backbone for designing a CTL epitope-based vaccine against respiratory syncytial virus (RSV). The chimeric LAIV-RSV vaccine candidates were attenuated in mice and induced strong, fully functional CTL immunity in this animal model.
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