Journal
HUMAN VACCINES & IMMUNOTHERAPEUTICS
Volume 14, Issue 4, Pages 941-946Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2017.1417713
Keywords
Antigenic escape; influenza; LAIV; nucleoprotein; T cell epitope
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Funding
- Russian Science Foundation Grant [14-15-00034]
- Russian Science Foundation [14-15-00034] Funding Source: Russian Science Foundation
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Live attenuated influenza vaccines (LAIV) induce CD8(+) T lymphocyte responses that play an important role in killing virus-infected cells. Despite the relative conservation of internal influenza A proteins, the epitopes recognized by T cells can undergo drift under immune pressure. The internal proteins of Russian LAIVs are derived from the master donor virus A/Leningrad/134/17/57 (Len/17) isolated 60 years ago and as such, some CD8(+) T cell epitopes may vary between the vaccine and circulating wild-type strains. To partially overcome this issue, the nucleoprotein (NP) gene of wild-type virus can be incorporated into LAIV reassortant virus, along with the HA and NA genes. The present study compares the human CD8(+) T cell memory responses to H3N2 LAIVs with the Len/17 or the wild-type NP using an in vitro model.
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