Article
Biology
Kacper Nijakowski, Piotr Eder, Marek Simon, Katarzyna Korybalska, Janusz Witowski, Anna Surdacka
Summary: The study found that the levels of S100A8/calprotectin, myeloperoxidase, and IgA in the saliva of patients with inflammatory bowel disease were significantly decreased. Myeloperoxidase and TNF-R1 concentrations showed high differentiation potential for distinguishing between Crohn's disease and ulcerative colitis.
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Gastroenterology & Hepatology
Peter M. Irving, Krisztina B. Gecse
Summary: Therapeutic drug monitoring (TDM) is an optimization strategy in the treatment of inflammatory bowel diseases, aiming to achieve maximal treatment benefits by monitoring drug concentrations. There are variations in optimal drug concentrations based on treatment targets, disease phenotypes, inflammatory burden, and sampling timing. This review discusses the role of TDM in biologic and oral small molecule therapies, the differences between reactive and proactive TDM, and the areas where evidence is lacking. Future adaptations in TDM usage may contribute to personalized treatment for patients with IBD.
Review
Medicine, General & Internal
Benjamin L. Gordon, Robert Battat
Summary: Therapeutic drug monitoring (TDM) is a useful strategy in ulcerative colitis (UC), particularly in acute severe UC (ASUC). While there is limited data available for the use of TDM of infliximab in ASUC, observational data suggest that higher serum infliximab concentrations and lower clearance are associated with better clinical outcomes and decreased rates of colectomy. However, more studies are needed to evaluate optimal dosing and TDM targets in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Sanket Patel, Andres Yarur
Summary: Therapeutic drug monitoring (TDM) plays a crucial role in optimizing treatment for patients with inflammatory bowel disease (IBD), especially those receiving combination therapy of biologics and immunomodulators. Through rigorous monitoring and therapy optimization, TDM significantly improves treatment outcomes and reduces adverse events.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Andrea Nieto-Veloza, Zhihong Wang, Qixin Zhong, Doris D'Souza, Hari B. Krishnan, Vermont P. Dia
Summary: This study assessed the in vivo anti-inflammatory properties of Lunasin protease inhibitor concentrate (LPIC). In vitro tests showed that LPIC induced the production of nitric oxide and maintained cytokine levels. In vivo experiments demonstrated that LPIC significantly attenuated tissue damage in ulcerative colitis.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Mathilde Barrau, Manon Duprat, Pauline Veyrard, Quentin Tournier, Nicolas Williet, Jean Marc Phelip, Louis Waeckel, Adam S. Cheifetz, Konstantinos Papamichael, Xavier Roblin, Stephane Paul
Summary: This study systematically reviewed the feasibility of using drug-tolerant assays to monitor patients treated with anti-TNFs. Most ADAb detection methods are drug-sensitive and cannot be used close to drug administration, but several drug-tolerant techniques have been developed to overcome this limitation.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Genetics & Heredity
Dasa Jevsinek Skok, Nina Hauptman, Miha Jerala, Nina Zidar
Summary: Ulcerative colitis (UC) and Crohn's disease (CD) involve imbalance in cytokine levels, with INSL5, LEFTY1, and BMP8B identified as potential key genes that may play a role in both diseases and require further investigation for diagnostic potential.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Chemistry, Medicinal
Jose Israel Rodrigues Jr, Joice Kelly Gomes de Vasconcelos, Lylian Ellen Militao dos Santos Xavier, Amanda da Silva Gomes, Juliana Celia de Farias Santos, Samara Bomfim Gomes Campos, Amylly Sanuelly da Paz Martins, Marilia Oliveira Fonseca Goulart, Fabiana Andrea Moura
Summary: The objective of this study was to assess the effectiveness of treatment for inflammatory bowel diseases in modulating oxidative stress biomarkers and cytokine levels. A systematic review and meta-analysis were conducted, and it was found that antioxidant capacity and lipid peroxidation levels were not significantly modulated, while superoxide dismutase levels showed significant modulation. However, there is still limited research on oxidative stress biomarkers and cytokines in the context of alternative therapies for IBD treatment. The results highlight the potential of antioxidant supplementation in IBD management and emphasize the need for further investigations into its effects on oxidative stress biomarkers and cytokines.
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Vivien Dolby, Tanya Clark, Veronica Hall, Suzanne Tattersall, Francesca Fairhurst, Catherine Kenneth, Rachael Walker, Karen Kemp, Simon Borg-Bartolo, Jimmy K. Limdi, Jo Taylor, Tristan Townsend, Sree Subramanian, Daniel Storey, Arash Assadsangabi, Catherine Stansfield, Paul Smith, Debra Byrne, Annalisa De Silvestri, Christian P. Selinger
Summary: The study showed that ustekinumab was more effective than vedolizumab at 14 weeks in CD patients, but there was no significant difference between the two at 52 weeks. Ustekinumab was found to be effective and well tolerated in this real-world cohort.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pediatrics
Laura De Nardi, Samuele Naviglio, Elena Battistuz, Valentina Kiren, Elisabetta Cattaruzzi, Egidio Barbi, Marco Rabusin
ARCHIVES OF DISEASE IN CHILDHOOD-EDUCATION AND PRACTICE EDITION
(2023)
Article
Allergy
Giovanni Santacroce, Marco Vincenzo Lenti, Nicola Aronico, Emanuela Miceli, Elisabetta Lovati, Pietro Carlo Lucotti, Luigi Coppola, Antonella Gentile, Mario Andrea Latorre, Francesco Di Terlizzi, Simone Soriano, Chiara Frigerio, Ivan Pellegrino, Alessandra Pasini, Cristina Ubezio, Jacopo Mambella, Roberta Canta, Alessandra Fusco, Giovanni Rigano, Antonio Di Sabatino
Summary: Conflicting data regarding the risk of SARS-CoV-2 infection in patients with autoimmune disorders are currently available. This study assessed the susceptibility to COVID-19 in drug-naive patients with autoimmune diseases and found that autoimmunity per se does not increase the susceptibility to COVID-19. The study also suggests that COVID-19 is mild in these patients.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Emanuela Miceli, Michele Di Stefano, Marco Vincenzo Lenti, Lavinia Pitotti, Gino Roberto Corazza, Antonio Di Sabatino
DIGESTIVE AND LIVER DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Giacomo Broglio, Antonio Di Sabatino
Article
Pediatrics
Samuele Naviglio, Antonio Giacomo Grasso, Chiara Iacono, Giada Zanella, Valentina Kiren, Nagua Giurici, Federico Verzegnassi, Natalia Maximova, Marco Rabusin
Summary: Shwachman-Diamond syndrome is a rare bone marrow failure syndrome characterized by pancreatic insufficiency, bone abnormalities, and increased risk of MDS and AML. Venetoclax has shown promise in treating AML in elderly adults, but there is limited evidence on its use in pediatric patients with SDS-related MDS or AML.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Michele Di Stefano, Emanuela Miceli, Caterina Mengoli, Gino Roberto Corazza, Antonio Di Sabatino
Summary: Celiac disease is a chronic autoimmune disorder affecting the small intestine, leading to villous atrophy, crypt hyperplasia, and an increase in intraepithelial lymphocytes. This condition often causes disturbances in bone mass and mineral metabolism, including changes in serum levels of vitamin D. A gluten-free diet can reverse these abnormalities, raising questions about the necessity of vitamin supplementation for all patients. Currently available data do not support widespread use of vitamin supplementation, and a thorough evaluation of bone and mineral metabolism is needed to determine which patients require this approach.
Article
Pediatrics
Erica Valencic, Samuele Naviglio, Luca Ronfani, Giuseppe Abbracciavento, Alberto Tommasini
Letter
Gastroenterology & Hepatology
Carlo Maria Rossi, Marco Vincenzo Lenti, Antonio Di Sabatino
Review
Nutrition & Dietetics
Carlo Maria Rossi, Marco Vincenzo Lenti, Stefania Merli, Hellas Cena, Antonio Di Sabatino
Summary: Allergen-free diets are an effective therapy for eosinophilic esophagitis, but should be approached with caution to reduce side effects and improve adherence. Empirical diets with fewer eliminated food categories and a step-up approach are recommended to minimize endoscopies and improve clinical outcomes. Geographical sensitization patterns may be relevant in specific regions.
Article
Oncology
Marco Lucioni, Sara Fraticelli, Giovanni Santacroce, Arturo Bonometti, Nicola Aronico, Roberta Sciarra, Marco Vincenzo Lenti, Paola Ilaria Bianchi, Giuseppe Neri, Monica Feltri, Benedetto Neri, Giuseppina Ferrario, Roberta Riboni, Gino Roberto Corazza, Alessandro Vanoli, Luca Arcaini, Marco Paulli, Antonio Di Sabatino
Summary: This retrospective study aimed to describe the clinical-pathological characteristics of intestinal T-cell lymphomas (ITCL) and possibly identify their hallmarks. The study included 28 patients, with most cases associated with celiac disease. The presence of CD, peripheral lymphocytosis, advanced Lugano clinical stage, and the histological subtype ITCL-NOS were significantly associated with worse survival.
Article
Biochemistry & Molecular Biology
Valentina Boz, Alessandra Tesser, Martina Girardelli, Francesca Burlo, Alessia Pin, Giovanni Maria Severini, Ginevra De Marchi, Federico Verzegnassi, Samuele Naviglio, Alberto Tommasini, Erica Valencic
Summary: Inborn errors of immunity associated with immune dysregulation are not adequately addressed in shared recommendation. Precision medicine is urgently needed to diagnose and treat these defects before severe complications occur. Our study confirms that a significant number of children with IEIs may display immune dysregulation symptoms and share similarities with common immune conditions.
Letter
Gastroenterology & Hepatology
Marco Vincenzo Lenti, Daniela Girardi, Alba Muzzi, Viola Novelli, Antonio Di Sabatino, Carlo Marena, Marco Rissone, Anna Odone, Catherine Klersy, Annalisa De Silvestri, Federico De Grazia, Patrizia Cambieri
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Oncology
Chiara Barteselli, Stefano Mazza, Valentina Ravetta, Francesca Torello Viera, Letizia Veronese, Chiara Frigerio, Giulia Gori, Gaetano Bergamaschi, Carmelo Sgarlata, Antonio Facciorusso, Marcello Maestri, Antonio Di Sabatino, Andrea Anderloni
Summary: This study aimed to evaluate whether different ultrasound patterns were associated with tumor prognosis in hepatocellular carcinoma (HCC) patients. The findings demonstrated that different ultrasound patterns correlated with different survival outcomes and tumor behavior in patients with HCC.
Article
Cell Biology
Camilla Guerini, Daniela Furlan, Giuseppina Ferrario, Federica Grillo, Laura Libera, Giovanni Arpa, Catherine Klersy, Marco Lenti, Roberta Riboni, Enrico Solcia, Matteo Fassan, Luca Mastracci, Sandro Ardizzone, Annick Moens, Gert De Hertogh, Marc Ferrante, Rondell P. Graham, Fausto Sessa, Marco Paulli, Antonio Di Sabatino, Alessandro Vanoli
Summary: The study investigated the clinicopathological and immunophenotypical features, as well as methylation profiles, of IDH1-mutated Crohn's disease small bowel adenocarcinomas. IDH1-mutated CrD-SBAs were found to have distinctive immunophenotypical features and methylation profiles, with potential therapeutic implications. Non-conventional, serrated dysplasia associated with IDH1 mutations is likely a precursor lesion to CrD-SBAs.