Article
Rheumatology
Laurie Cachen, Gaetane Nocturne, Michael Collins, Antoine Meyer, Aude Gleizes, Salima Hacein-Bey-Abina, Franck Carbonnel, Xavier Mariette, Raphaele Seror
Summary: About 13% of patients treated with anti-TNF for IBD developed inflammatory articular manifestations. More than a quarter of these manifestations were linked to immunisation against anti-TNF, and about 40% were paradoxical. In most cases, these symptoms were transient and did not require discontinuation of anti-TNF treatment.
Article
Rheumatology
Yongdong Zhao, Erin Sullivan, Mary Beth Son, Timothy Beukelman
Summary: In a large prospective registry study of juvenile idiopathic arthritis patients, a nearly threefold increased risk of psoriasis was observed after TNFi exposure.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Clinical Neurology
Rosa Cortese, Luca Prosperini, Alessandro Stasolla, Shalom Haggiag, Veronica Villani, Isabella Laura Simone, Claudio Gasperini, Carla Tortorella
Summary: This study described 8 patients who experienced demyelinating CNS events while on anti-TNF alpha treatment, with most patients showing a good medium-term prognosis. The results support an association between anti-TNF alpha treatment and demyelinating events, and suggest that prompt discontinuation of the drug may lead to a favorable demyelinating disease outcome.
JOURNAL OF NEUROLOGY
(2021)
Article
Rheumatology
Maria Konsta, Michael T. Nurmohamed, Alexios Iliopoulos, Petros P. Sfikakis, J. Christiaan van Denderen, Ingrid Visman, Grigorios T. Sakelariou, Irene E. van der Horst-Bruinsma
Summary: The study aims to examine the prevalence of hip involvement in patients with ankylosing spondylitis (AS) treated with tumor necrosis factor inhibitors (TNFi) and estimate the effect of TNFi on radiographic progression of hip involvement compared to the spine. The results showed that approximately one-third of AS patients had hip involvement, which seemed to stabilize with TNFi treatment. There were no sex differences in the prevalence or progression of this manifestation.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Medicine, General & Internal
Soo Min Ahn, Minju Kim, Ye-Jee Kim, Yusun Lee, Yong-Gil Kim
Summary: This study evaluated the risk of acute anterior uveitis (AAU) in patients with ankylosing spondylitis (AS) during treatment with tumor necrosis factor-alpha inhibitors (TNFis). The data showed that compared to adalimumab, the use of etanercept increased the risk of AAU, and this risk was not influenced by the history of AAU.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Ulf Lindstrom, Karin Bengtsson, Tor Olofsson, Daniela Di Giuseppe, Bente Glintborg, Helena Forsblad-d'Elia, Lennart T. H. Jacobsson, Johan Askling
Summary: Comparing the risk of anterior uveitis (AU) in patients with spondyloarthritis (SpA) treated with secukinumab versus tumor necrosis factor inhibitors (TNFi), it was found that secukinumab appears to be associated with a higher risk of AU compared to monoclonal TNFi, while the risk is similar to etanercept.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Tomona Hiyama, Yosuke Harada, Yoshiaki Kiuchi
Summary: This retrospective study investigated the clinical features and efficacy of adalimumab and low-dose methotrexate combination therapy in patients with Vogt-Koyanagi-Harada disease. The results showed that the combination therapy may achieve better control of advanced disease, while methotrexate treatment had a high relapse rate and the use of cyclosporine A was associated with a high rate of side effects requiring discontinuation.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
Katelyn Baggett, Timothy G. Brandon, Rui Xiao, Zachary Valenzuela, Lisa H. Buckley, Pamela F. Weiss
Summary: The study found no significant difference in the risk of developing psoriasis after treatment with ADA, IFX, or ETN among children who received TNFi therapy. However, the risk of psoriasis was significantly lower in patients who were also exposed to DMARDs.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Siri Lillegraven, Nina Paulshus Sundlisaeter, Anna-Birgitte Aga, Joseph Sexton, Inge Christoffer Olsen, Ase Stavland Lexberg, Tor Magne Madland, Hallvard Fremstad, Christian A. Hoili, Gunnstein Bakland, Cristina Spada, Hilde Haukeland, Inger Myrnes Hansen, Ellen Moholt, Till Uhlig, Daniel H. Solomon, Desiree Van der Heijde, Tore K. Kvien, Espen A. Haavardsholm
Summary: This study aimed to assess the effect of tapering tumor necrosis factor inhibitor (TNFi) to withdrawal compared with stable treatment on the risk of disease activity flares in patients with rheumatoid arthritis (RA) in remission for more than 1 year. The results showed that in the tapering TNFi group, 63% experienced a flare during 12 months, compared to 5% in the stable TNFi group. Therefore, tapering TNFi to discontinuation is not non-inferior to continued stable treatment.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Daniel H. Solomon, Jon T. Giles, Katherine P. Liao, Paul M. Ridker, Pamela M. Rist, Robert J. Glynn, Rachel Broderick, Fengxin Lu, Meredith T. Murray, Kathleen Vanni, Leah M. Santacroce, Shady Abohashem, Philip M. Robson, Zahi Fayad, Venkatesh Mani, Ahmed Tawakol, Joan Bathon
Summary: This study found that adding either a TNFi or triple therapy led to clinically important improvements in vascular inflammation. However, adding a TNFi did not reduce arterial inflammation more than triple therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Jo L. W. Lambert, Sofie De Schepper, Reinhart Speeckaert
Summary: Biologics used in the treatment of Crohn's disease and ulcerative colitis can lead to various skin eruptions, especially those targeting TNF-alpha and Th17 pathway. It is important to recognize and adapt the treatment strategy accordingly to manage these adverse reactions effectively.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Ming-Han Chen, Shan-Fu Yu, Jia-Feng Chen, Wei-Sheng Chen, The-Ling Liou, Chung-Tei Chou, Chung-Yuan Hsu, Han-Ming Lai, Ying-Chou Chen, Chang-Youh Tsai, Tien-Tsai Cheng
Summary: The study compared the impact of different treatment regimens for rheumatoid arthritis on patients' bone mineral density, finding that abatacept may have a better effect in preserving bone density. Anti-osteoporosis therapy can prevent systemic bone loss in patients regardless of the type of rheumatoid arthritis treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Yu-Jih Su, Hui-Ming Chen, Tien-Ming Chan, Tien-Tsai Cheng, Shan-Fu Yu, Jia-Feng Chen, Chun-Yu Lin, Chung-Yuan Hsu
Summary: This study aimed to investigate whether patients using disease-modifying anti-rheumatic drugs (DMARDs) may have different levels of risk for diabetes and to analyze other risk factors for diabetes. The results showed that certain DMARDs can reduce the risk of diabetes.
Review
Pharmacology & Pharmacy
Xinwei Zhou, Xianghui Shi, Yanxia Ren, Tingting Yan, Qiao Ye
Summary: This study systematically reviewed the efficacy and safety of anti-TNF-alpha therapy for Behcet's disease patients. The results showed that anti-TNF-alpha therapy reduces relapse rates in uveitis patients compared to traditional immunosuppressants. However, the evidence for using anti-TNF-alpha therapy across the full spectrum of BD subtypes is limited, highlighting the need for caution.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Aliki I. Venetsanopoulou, Konstantina Mavridou, Paraskevi V. Voulgari, Alexandros A. Drosos
Summary: In recent years, the use of biological drugs in the treatment of autoimmune arthritides and systematic diseases has shown good clinical improvement. However, blocking components of the immune system can lead to autoimmune phenomena and cutaneous immune-related adverse events (irAEs). This article reviews the clinical features and mechanisms of specific cutaneous irAEs observed during treatment with biological therapies, and provides new cases to help physicians better manage patients receiving biologic therapies.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Ethics
Georgina D. Campelia, Hilkiah K. Suga, John H. Kempen, James N. Kirkpatrick, Nancy S. Jecker
Summary: During the COVID-19 pandemic, hospital policies aimed at reducing the risk of virus transmission have had adverse effects on underserved communities.
DEVELOPING WORLD BIOETHICS
(2023)
Article
Ophthalmology
Sanil Joseph, Renu P. Rajan, Balagiri Sundar, Soundarya Venkatachalam, John H. Kempen, Ramasamy Kim
Summary: The purpose of this study was to validate the fundus image grading results for detecting diabetic retinopathy (DR) and diabetic macular oedema (DMO) by a trained grader (Non-ophthalmologist) and an ophthalmologist grader against a fundus examination by a retina specialist. The results demonstrated that the fundus image grading performed by a trained non-ophthalmologist was comparable with the grading by an ophthalmologist.
Review
Rheumatology
Peter Stoustrup, Cory M. Resnick, Shelly Abramowicz, Thomas K. Pedersen, Ambra Michelotti, Annelise Kuseler, Bernd Koos, Carlalberta Verna, Ellen B. Nordal, Eric J. Granquist, Josefine Mareile Halbig, Kasper D. Kristensen, Leonard B. Kaban, Linda Z. Arvidsson, Lynn Spiegel, Matthew L. Stoll, Melissa A. Lerman, Mia Glerup, Patrizia Defabianis, Paula Frid, Per Alstergren, Randy Q. Cron, Sarah Ringold, Sven Erik Norholt, Timo Peltomaki, Tore A. Larheim, Troels Herlin, Zachary S. Peacock, Christian J. Kellenberger, Marinka Twilt
Summary: This study aimed to develop interdisciplinary recommendations for the management of orofacial manifestations of juvenile idiopathic arthritis (JIA) and to create a future research agenda for the treatment of temporomandibular joint (TMJ) arthritis in children with JIA. The recommendations were developed through online surveying, literature review, consensus meetings, and Delphi study iterations. Twelve recommendations and a future research agenda were outlined, filling an important gap in current clinical practice.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Melissa A. Lerman, Michael Francavilla, Lindsay Waqar-Cowles, Michael A. Levine
Summary: In this study, denosumab was used as monotherapy for multicentric carpotarsal osteolysis syndrome (MCTO) in an 11.5-year-old male with a specific mutation. The treatment resulted in reduced bone turnover markers, increased bone density, and maintained renal function. However, MCTO-related osteolysis and joint immobility still progressed during denosumab treatment, and rebound hypercalcemia and hypercalciuria occurred after discontinuation of the drug, indicating that denosumab may not be efficacious for MCTO.
Article
Ophthalmology
Nicholas J. Butler, Devin Cohen, Yinxi Yu, John H. Kempen, Lucia Sobrin, Brian L. VanderBeek
Summary: Currently, there is limited knowledge about bone health surveillance and baseline risks of skeletal fragility outcomes for glucocorticoid-exposed non-infectious uveitis (NIU) patients. Using claims data, the study found that NIU patients are 36% less likely to receive dual-energy x-ray absorptiometry (DXA) screening compared to rheumatoid arthritis (RA) patients. Furthermore, NIU patients did not show an elevated risk of osteoporosis compared to normal controls, while RA patients had an increased risk.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Nisha R. Acharya, Albert T. Vitale, Elizabeth A. Sugar, Janet T. Holbrook, Alyce E. Burke, Jennifer E. Thorne, Michael M. Altaweel, John H. Kempen, Douglas A. Jabs
Summary: This study evaluated the effectiveness of three different intravitreal treatments for persistent or recurrent uveitic macular edema. The results showed that dexamethasone was more effective than methotrexate or ranibizumab in treating uveitic macular edema. However, there was a risk of increased intraocular pressure with dexamethasone treatment.
Article
Rheumatology
Joyce C. C. Chang, Shreya A. A. Varghese, Edward M. M. Behrens, Sabrina Gmuca, Jane S. S. Kennedy, Emily J. J. Liebling, Melissa A. A. Lerman, Jay J. J. Mehta, Beth H. H. Rutstein, David D. D. Sherry, Cory J. J. Stingl, Lehn K. K. Weaver, Pamela F. F. Weiss, Jon M. M. Burnham
Summary: The study aimed to evaluate high-quality care delivery in pediatric lupus using an electronic health record-enabled registry. Provider goal-setting activities and multidisciplinary care models were found to be associated with better care quality and outcomes in childhood SLE. Attention to quality metrics and population management can facilitate equitable care delivery.
ARTHRITIS CARE & RESEARCH
(2023)
Editorial Material
Rheumatology
Melissa A. A. Lerman
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Ophthalmology
Douglas A. Jabs, Elizabeth A. Sugar, Alyce E. Burke, Michael M. Altaweel, James P. Dunn, Sapna Gangaputra, John H. Kempen, Kathryn L. Pepple, Richard J. Stawell, Janet T. Holbrook
Summary: This study evaluated the rate of cataract surgery, risk factors, and outcomes in patients with intermediate, posterior, and panuveitis treated with systemic corticosteroids and immunosuppression. The results showed a substantial long-term risk of cataract surgery in these patients. Visual acuity outcomes after cataract surgery were generally good.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Zheng Xian Thng, Ikhwanuliman R. Putera, Ilaria Testi, Kevin Chan, Mark Westcott, Soon-Phaik Chee, Andrew Dick, John I. Kempen, Bahram Bodaghi, Jennifer Thorne, Talin Barisani-Asenbauer, Marc W. de Smet, Justine Smith, Peter McCluskey, Rina La Distia Nora, Douglas Jabs, Joke de Boer, H. Nida Sen, Debra Goldstein, Moncef Khairallah, Janet Davis, James Rosenbaum, Nicholas Jones, Quan Dong Nguyen, Carlos Pavesio, Rupesh Agrawal, Vishali Gupta
Summary: This study presents current expert practice patterns and formulates a consensus for the management of HSV and VZV anterior uveitis (AU) worldwide. A survey was conducted among uveitis experts from multiple countries, and consensus guidelines were developed based on the responses. The study identified specific characteristics for HSV and VZV AU and recommended treatment options.
Article
Ophthalmology
Zheng Xian R. Thng, Ikhwanuliman Putera, Ilaria Testi, Kevin P. Chan, Mark Westcott, Soon-Phaik Chee, Andrew Dick, John I. Kempen, Bahram Bodaghi, Jennifer Thorne, Talin Barisani-Asenbauer, Marc W. de Smet, Justine Smith, Peter S. McCluskey, Rina La Distia Nora, Douglas Jabs, Joke de Boer, H. Nida Sen, Debra Goldstein, Moncef Khairallah, Janet Davis, James Rosenbaum, Nicholas Jones, Quan Dong Nguyen, Carlos Pavesio, Rupesh Agrawal, Vishali Gupta
Summary: This study aimed to present the current practice patterns in the diagnosis and management of CMV AU by uveitis experts worldwide. The results showed that there is considerable variation in diagnostic approaches and preferred management of CMV AU among experts. However, there was consensus on performing diagnostic aqueous tap and starting topical antiviral treatment.
Article
Ophthalmology
William Rojas-Carabali, Carlos Cifuentes-Gonzalez, Xin Wei, Ikhwanuliman Putera, Alok Sen, Zheng Xian Thng, Rajdeep Agrawal, Tobias Elze, Lucia Sobrin, John H. Kempen, Bernett Lee, Jyotirmay Biswas, Quan Dong Nguyen, Vishali Gupta, Alejandra de-la-Torre, Rupesh Agrawal
Summary: This study evaluates the performance of an AI-based chatbot in the diagnosis and management of uveitis, showing that ophthalmologists outperformed the AI in diagnostic accuracy, although the AI showed some improvement. There was a moderate agreement between ophthalmologists and AI in diagnosis and treatment plans.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Zheting Zhang, Konstadina Griva, William Rojas-Carabali, Gazal Patnaik, Renee Liu, Lucia Sobrin, John H. Kempen, Robert P. Finger, Vishali Gupta, Bryan Ang, Rupesh Agrawal
Summary: This review summarizes the existing tools for evaluating psychosocial well-being and/or QOL in patients with uveitis, explores the biological and non-biological factors affecting psychosocial well-being and/or QOL, and proposes future directions for incorporating these tools into clinical practice.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
William Rojas-Carabali, Alok Sen, Aniruddha Agarwal, Gavin Tan, Carol Y. Cheung, Andres Rousselot, Rajdeep Agrawal, Renee Liu, Carlos Cifuentes-Gonzalez, Tobias Elze, John H. Kempen, Lucia Sobrin, Quan Dong Nguyen, Alejandra de-la-Torre, Bernett Lee, Vishali Gupta, Rupesh Agrawal
Summary: ChatGPT demonstrated promising diagnostic capabilities in uveitis cases, and ophthalmologists showed enthusiasm for the integration of artificial intelligence into clinical practice.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
John H. Kempen, Craig W. Newcomb, Terri L. Washington, C. Stephen Foster, Lucia Sobrin, Jennifer E. Thorne, Douglas A. Jabs, Eric B. Suhler, James T. Rosenbaum, H. Nida Sen, Grace A. Levy-Clarke, Robert B. Nussenblatt, Nirali P. Bhatt, Careen Y. Lowder, Debra A. Goldstein, Yannek I. Leiderman, Nisha R. Acharya, Gary N. Holland, Russell W. Read, James P. Dunn, Kurt A. Dreger, Pichaporn Artornsombudh, Hosne A. Begum, Tonetta D. Fitzgerald, Srishti Kothari, Abhishek R. Payal, Ebenezer Daniel, Sapna S. Gangaputra, R. Oktay Kacmaz, Teresa L. Liesegang, Siddharth S. Pujari, Naira Khachatryan, Armin Maghsoudlou, Hilkiah K. Suga, Clara M. Pak, Kathy J. Helzlsouer, Jeanine M. Buchanich
Summary: This retrospective cohort study aimed to determine the incidence of all-cause and cancer mortality in patients receiving immunosuppression for ocular inflammatory disease. The study found that commonly used immunosuppressants were not associated with increased overall and cancer mortality.
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)