Article
Medicine, General & Internal
Reiko Arita, Shima Fukuoka
Summary: This study evaluated the efficacy and safety of intense pulsed light (IPL) combined with meibomian gland expression (MGX) for the treatment of refractory multiple and recurrent chalazia. The combination therapy significantly improved all parameters except meiboscore and the Schirmer value, while MGX alone only significantly improved meibum grade. No adverse events occurred in either group. IPL-MGX treatment was effective and safe for multiple and recurrent chalazia without surgery or curettage.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Reut Ifrah, Lluisa Quevedo, Gal Hazrati, Shiran Maman, Huluager Mangisto, Eden Shmuel, Liat Gantz
Summary: This study found that contact lens wearers are more likely to have meibomian gland dysfunction compared to non-contact lens wearers. Contact lens wearers who did not attend regular follow-up visits had more pronounced symptoms and higher likelihood of meibomian gland loss and other abnormalities.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2023)
Article
Biochemistry & Molecular Biology
Kenneth G. Ooi, Stephanie L. Watson
Summary: Posterior blepharitis and dry eye are common disorders associated with meibomian gland dysfunction (MGD). Ocular rosacea can manifest as MGD and dyslipidaemia. Treating ocular rosacea-associated dyslipidaemia and systemic inflammation may improve cardiovascular health and reduce tear film instability.
Article
Ophthalmology
Reiko Arita, Shima Fukuoka
Summary: Azithromycin eyedrops showed significant improvements in symptoms, lipid layer thickness, and tear film stability in Japanese individuals with MGD-associated posterior blepharitis, indicating it to be a safe and effective treatment option.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Kathy Ming Feng, Chi-Hsiang Chung, Yi-Hao Chen, Wu-Chien Chien, Ke-Hung Chien
Summary: Blepharitis is a common eye disorder with symptoms like irritation and itchiness; the use of statins can reduce the risk of developing blepharitis.
FRONTIERS IN MEDICINE
(2022)
Review
Ophthalmology
Shokufeh Tavassoli, Nathan Wong, Elsie Chan
Summary: Ocular rosacea is a chronic inflammatory condition that primarily affects the eyes with symptoms such as chronic blepharoconjunctivitis and meibomian gland dysfunction. Corneal complications can include vascularization, ulceration, and scarring, and treatment options vary depending on disease severity. Ocular rosacea can also be associated with systemic disorders like cardiovascular disease.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Medicine, General & Internal
Young-Sik Yoo, Sun-Kyoung Park, Ho-Sik Hwang, Hyun-Seung Kim, Reiko Arita, Kyung-Sun Na
Summary: This review discusses the relationship between serum lipid and meibomian gland dysfunction (MGD). While a causal relationship has not been established, serum lipid levels or dyslipidemia may be directly or indirectly related to MGD. Further research is needed to determine the role of serum lipid levels in meibocyte differentiation and lipid synthesis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Hong Zhang, Yuqing Wu, Xichen Wan, Yan Shen, Qihua Le, Pei Yang, Shuyun Zhou, Xujiao Zhou, Feng Zhou, Hao Gu, Jiaxu Hong
Summary: The study aimed to evaluate the efficacy and safety of eyelid hygiene using topical 0.01% hypochlorous acid (HOCL) through ultrasonic atomization after 2 weeks in patients with blepharitis. The results showed that the HOCL group demonstrated significant improvements in ocular surface disease index scores, lid margin redness, lid margin abnormalities, meibum expressibility, and meibum quality compared to the control group. The questionnaire confirmed good patient compliance with the treatment. In conclusion, topical 0.01% HOCL through ultrasonic atomization is a tolerable and effective eyelid hygiene treatment for blepharitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Xiaowei Yang, Xingwu Zhong, Andrew J. W. Huang, Lixing W. Reneker
Summary: In this study, a conditional knockout mouse model was used to investigate the spontaneous recovery of the Mei-bomian gland (MG) after atrophy. The results showed that the MG could recover after atrophy, but the recovery was less robust in mice that received a second injection of doxycycline. The findings further supported the role of FGFR2 in MG homeostasis and suggested that FGFR2 signaling could be a potential strategy for regenerating acini in age-related MG dysfunction.
Article
Medicine, General & Internal
Reiko Arita, Shima Fukuoka, Motoko Kawashima
Summary: Treatment selection for meibomian gland dysfunction (MGD) should be based on a comprehensive stage classification that includes ocular symptoms, lid margin abnormalities, meibum grade, and ocular surface staining. Different treatment modalities have varying efficacy based on the meiboscore determined by noncontact meibography, with intense pulsed light therapy showing improvement even in cases with high meiboscore. Prospective studies are needed to further validate these findings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Ophthalmology
Erin M. Rueff, Anna A. Tichenor, William Ngo, Andrew D. Pucker
Summary: This literature review aims to provide a balanced evaluation of the impact of contact lenses on meibomian gland health. The findings suggest conflicting relationships between contact lens use and MG morphology/function, with variations likely attributed to differences in study populations, designs, and evaluation durations. Future longitudinal studies with standardized clinical assessments are necessary to determine the true impact of contact lenses on MG health.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Ophthalmology
Aparna Mahajan, Lenka Hasikova, Ulrike Hampel, Anika Grueneboom, Xiaomei Shan, Irmgard Herrmann, Fabian Garreis, Felix Bock, Jasmin Knopf, Jeeshan Singh, Christine Schauer, Siddharth Mahajan, Moritz Leppkes, Friedrich Paulsen, Ursula Schloetzer-Schrehardt, Veit Krenn, Anselm Juenemann, Bettina Hohberger, Georg Schett, Martin Herrmann, Luis E. Munoz
Summary: The study found that aggregated neutrophil extracellular traps (aggNETs) were present in ocular discharge from patients with blepharitis, leading to Meibomian gland congestion. Tear fluid from patients with MGD showed elevated levels of neutrophil chemoattractants (C5a, IL6, IL8, and IL18). In a murine model of allergic eye disease (AED), aggNETs accumulation in the Meibomian glands caused duct occlusion and acinar atrophy.
Article
Biochemistry & Molecular Biology
Danson Vasanthan Muttuvelu, Lasse Jorgensen Cehofski, Jeppe Holtz, Tor Paaske Utheim, Xiangjun Chen, Henrik Vorum, Steffen Heegaard, Marie Louise Roed Rasmussen, Asif Manzoor Khan, Ahmed Basim Abduljabar, Bent Honore
Summary: Meibomian gland dysfunction (MGD) is a common condition and the main cause of evaporative dry eye disease. Proteomic analysis has revealed that cystatin-SN and immunoglobulin chains are associated with MGD, and their dysregulation may be related to inflammation and tear film evaporation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Jose Vicente Garcia-Marques, Cristian Talens-Estarelles, Santiago Garcia-Lazaro, Alejandro Cervino
Summary: This study aims to evaluate the effects of soft contact lens wear and its duration on tear film and meibomian gland. The results showed that contact lens wearers had higher meibomian gland dropout and lower gland visibility. Prolonged contact lens wear was associated with increased dry eye symptoms and entropy of the meibomian glands.
Article
Medicine, General & Internal
Xiangjun Chen, Reza A. Badian, Havard Hynne, Behzod Tashbayev, Lene Hystad Hove, Janicke Liaaen Jensen, Tor Paaske Utheim
Summary: In this study, meibography of 65-year-old residents in Oslo, Norway was analyzed, and it was found that moderate meibomian gland atrophy was common and not gender-specific. Meibography alone cannot discriminate between meibomian gland dysfunction (MGD) and non-MGD, thus both morphological and functional tests are necessary for screening MGD.
JOURNAL OF CLINICAL MEDICINE
(2022)