Correction

A Global Interactome Map of the Dengue Virus NS1 Identifies Virus Restriction and Dependency Host Factors (vol 21, pg 3900, 2017)

CELL REPORTS (2018)

Journal

CELL REPORTS

Volume 22, Issue 5, Pages 1364-1364

Publisher

CELL PRESS

DOI: 10.1016/j.celrep.2018.01.038

Keywords

-

Categories

Cell Biology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Recommended

Article Multidisciplinary Sciences

Highly sensitive detection of dengue biomarker using streptavidin-conjugated quantum dots

Linh Tran, Sangkwon Park

Summary: A highly sensitive immunosensor using quantum dots and streptavidin was developed for detecting the dengue biomarker NS1, offering a fast, convenient, and sensitive approach. However, interference in human plasma serum solution was observed, suggesting the need for further solutions.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Biochemical Research Methods

NS1 glycoprotein detection in serum and urine as an electrochemical screening immunosensor for dengue and Zika virus

Priscila D. Mendonca, Lorenna K. B. Santos, Marcos Foguel, Marco A. B. Rodrigues, Marli T. Cordeiro, Luis M. Goncalves, Ernesto T. A. Marques, Rosa F. Dutra

Summary: The incidence of dengue virus infection has grown dramatically worldwide, affecting 128 countries. The diagnosis is challenging due to similarities with other viruses such as Zika, and the underreporting of cases leads to potentially higher numbers of affected people. An immunosensor using carbon nanotube-ethylenediamine for NS1 detection shows promising results for diagnosis of dengue and Zika viruses.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

Add to Collection

Article Virology

Identification of Key Residues in Dengue Virus NS1 Protein That Are Essential for Its Secretion

Brandon E. K. Tan, Michael R. Beard, Nicholas S. Eyre

Summary: In this study, random point mutagenesis was used to identify residues within NS1 that are essential for its secretion. Ten point mutations were identified that corresponded with impaired NS1 secretion. Additional studies on two of these mutants, V220D and A248V, revealed that they prevented viral RNA replication and disrupted NS1 processing or maturation.

VIRUSES-BASEL (2023)

Add to Collection

Article Public, Environmental & Occupational Health

Surveillance and Epidemiology of Dengue in Medellin, Colombia from 2009 to 2017

Colin M. Warnes, Eduardo Santacruz-Sanmartin, Fausto Bustos Carrillo, Ivan Dario Velez

Summary: This study conducted a descriptive analysis of dengue cases in Medellin, Colombia from 2009 to 2017, examining the burden on the healthcare system during outbreak years, risk of severe illness, gender and age as risk factors, and spatio-temporal patterns of disease occurrence. The study found that human movement contributed to dengue spread, with males and individuals younger than 15 years having higher incidence rates. However, limitations in diagnostic information, strain data, and lack of phylogenetic information were identified.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2021)

Add to Collection

Article Infectious Diseases

High performance dengue virus antigen-based serotyping-NS1-ELISA (plus): A simple alternative approach to identify dengue virus serotypes in acute dengue specimens

Tanapan Prommool, Pongpawan Sethanant, Narodom Phaenthaisong, Nattaya Tangthawornchaikul, Adisak Songjaeng, Panisadee Avirutnan, Dumrong Mairiang, Prasit Luangaram, Chatchawan Srisawat, Watchara Kasinrerk, Sirijitt Vasanawathana, Kanokwan Sriruksa, Wannee Limpitikul, Prida Malasit, Chunya Puttikhunt

Summary: The study modified the stNS1-ELISA method by introducing biotinylated serotype-specific antibodies and a new DENV2-specific antibody, resulting in a significant improvement in sensitivity for dengue virus serotype detection. The modified assay is efficient for early dengue diagnosis and epidemiological studies.

PLOS NEGLECTED TROPICAL DISEASES (2021)

Add to Collection

Article Infectious Diseases

NS1-based ELISA test efficiently detects dengue infections without cross-reactivity with Zika virus

Samuel Santos Pereira, Robert Andreata-Santos, Lennon Ramos Pereira, Camila Pereira Soares, Alvina Clara Felix, Patricia de Mello Jungmann Cardoso de Andrade, Edison Luis Durigon, Camila Malta Romano, Luis Carlos de Souza Ferreira

Summary: The study aimed to achieve greater specificity in DENV serological tests by using a recombinant antigen (Delta NS1) to differentiate DENV and ZIKV. The Delta NS1-based DENV IgG ELISA detected anti-DENV NS1 IgG without cross-reactivity with ZIKV-positive samples, with a sensitivity of 82% and specificity of 93%. This method may be particularly useful for serological analyses in endemic regions for both DENV and ZIKV transmission.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Article Virology

Potential Phosphorylation of Viral Nonstructural Protein 1 in Dengue Virus Infection

Thanyaporn Dechtawewat, Sittiruk Roytrakul, Yodying Yingchutrakul, Sawanya Charoenlappanit, Bunpote Siridechadilok, Thawornchai Limjindaporn, Arunothai Mangkang, Tanapan Prommool, Chunya Puttikhunt, Pucharee Songprakhon, Kessiri Kongmanas, Nuttapong Kaewjew, Panisadee Avirutnan, Pa-thai Yenchitsomanus, Prida Malasit, Sansanee Noisakran

Summary: This study uncovered the phosphorylation modification of the dengue virus NS1 protein, with mutational analysis showing specific phosphorylation sites affecting DENV infectivity and the production of NS1 dimers post-infection.

VIRUSES-BASEL (2021)

Add to Collection

Article Virology

Dengue Virus NS1 Uses Scavenger Receptor B1 as a Cell Receptor in Cultured Cells

Ana C. Alcala, Jose L. Maravillas, David Meza, Octavio T. Ramirez, Juan E. Ludert, Laura A. Palomares

Summary: Dengue is a common viral disease transmitted by mosquitoes. This study reveals that the dengue virus NS1 enters cells through the human HDL receptor, which has significant implications for viral replication and pathogenesis.

JOURNAL OF VIROLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of neo-andrographolide compound targeting NS1 Lys14: an important residue in NS1 activity driving dengue pathogenesis

Elakkiya Elumalai, M. Suresh Kumar

Summary: In this study, the NS1 protein of Dengue virus was modeled and simulated, and the compound neo-andrographolide was found to have the potential to inhibit the activity of NS1, thereby inhibiting Dengue virus replication.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

Add to Collection

Article Immunology

Unbiased Identification of Dengue Virus Non-Structural Protein 1 Peptides for Use in Vaccine Design

Nikole L. L. Warner, Susan B. B. Core, Kathryn M. M. Frietze

Summary: Dengue virus is a global health problem and there is a need for more effective vaccines. This study identified peptide epitopes of the non-structural protein 1 of the virus that could induce antibodies capable of binding to infected cells. These peptides may be potential targets for future vaccine development.

VACCINES (2022)

Add to Collection

Article Virology

The Dengue Virus Nonstructural Protein 1 (NS1) Interacts with the Putative Epigenetic Regulator DIDO1 to Promote Flavivirus Replication in Mosquito Cells

Gerson I. Caraballo, Romel Rosales, Mercedes Viettri, Juan Manuel Castillo, Raymundo Cruz, Siyuan Ding, Harry B. Greenberg, Juan E. Ludert

Summary: Dengue is the most important mosquito-borne viral disease to humans. Dengue virus NS1 is a multifunctional protein essential for replication and modulation of innate immunity. The protein interactome of DENV NS1 in mosquito cells was investigated, revealing interactions with various mosquito protein targets. This study provides novel insights into the functions of NS1 and its role in promoting viral replication, as well as identifying new protein pathways involved in mosquito cells.

JOURNAL OF VIROLOGY (2022)

Add to Collection

Article Chemistry, Analytical

Development of a Dengue Virus Serotype-Specific Non-Structural Protein 1 Capture Immunochromatography Method

Kanaporn Poltep, Emi E. Nakayama, Tadahiro Sasaki, Takeshi Kurosu, Yoshiki Takashima, Juthamas Phadungsombat, Nathamon Kosoltanapiwat, Borimas Hanboonkunupakarn, Sarin Suwanpakdee, Hisham A. Imad, Narinee Srimark, Chiaki Kitamura, Atsushi Yamanaka, Akio Okubo, Tatsuo Shioda, Pornsawan Leaungwutiwong

Summary: The research team successfully developed serotype-specific immunochromatography systems for all four DENV serotypes, showing high specificity and sensitivity. These systems can rapidly detect DENV with good performance in laboratory and clinical validation. In DENV-endemic areas, these assay systems could accelerate both infection diagnosis and epidemiologic studies.

SENSORS (2021)

Add to Collection

Article Virology

A 5-year study of dengue seropositivity among suspected cases attending a teaching hospital of North-Western region of India

Jitu M. Kalita, Alisha Aggarwal, Kavita Yedale, Ravisekhar Gadepalli, Vijaya L. Nag

Summary: This study in western India revealed a higher seroprevalence of dengue infection and a gradual increase in seroprevalence in the region. Most laboratory-confirmed dengue cases were observed in the 21-30 age group. The most common serotype detected in the tested samples was DEN-3.

JOURNAL OF MEDICAL VIROLOGY (2021)

Add to Collection

Article Microbiology

Arbovirus-vector protein interactomics identifies Loquacious as a co-factor for dengue virus replication in Aedes mosquitoes

Benoit Besson, Oscar M. Lezcano, Gijs J. Overheul, Kirsten Janssen, Cornelia G. Spruijt, Michiel Vermeulen, Jieqiong Qu, Ronald P. van Rij

Summary: Loqs protein is essential for the replication of DENV and ZIKV in mosquitoes, and DENV hijacks a factor of the RNAi mechanism for replication of its own RNA.

PLOS PATHOGENS (2022)

Add to Collection

Article Cell Biology

High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses

Sundy N. Y. Yang, Belinda Maher, Chunxiao Wang, Kylie M. Wagstaff, Johanna E. Fraser, David A. Jans

Summary: This study identifies two drugs that can inhibit the replication of dengue virus and other flaviviruses by directly binding to a viral protein.

CELLS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes

Laure Perrin-Cocon, Cindy Kundlacz, Clemence Jacquemin, Xavier Hanoulle, Anne Aublin-Gex, Marianne Figl, Jeremy Manteca, Patrice Andre, Pierre-Olivier Vidalain, Vincent Lotteau, Olivier Diaz

Summary: The HCV protein NS5A activates the glucokinase isoenzyme to redirect central carbon metabolism towards lipogenesis, contributing to the replication needs of the virus.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Meeting Abstract Biochemistry & Molecular Biology

A Myosin Vb Splice Variant Regulates Coronavirus M Protein Trafficking in Polarized Epithelial Cells

James R. Goldenring, Lynne A. Lapierre, Joseph T. Roland, Elizabeth Manning, Cathy Caldwell, Honor L. Glenn, Pierre-Olivier Vidalain, Frederic Tangy, Brenda G. Hogue, C. A. M. de Haan

FASEB JOURNAL (2022)

Add to Collection

Article Virology

RACK1 Associates with RNA-Binding Proteins Vigilin and SERBP1 to Facilitate Dengue Virus Replication

Alexis Brugier, Mohamed Lamine Hafirrassou, Marie Pourcelot, Morgane Baldaccini, Vasiliya Kril, Laurine Couture, Beate M. Kummerer, Sarah Gallois-Montbrun, Lucie Bonnet-Madin, Pierre-Olivier Vidalain, Constance Delaugerre, Sebastien Pfeffer, Laurent Meertens, Ali Amara

Summary: In this study, the researchers identified the scaffolding RACK1 protein as an important host-dependency factor for dengue virus (DENV) infection. They found that RACK1 mediates infection by binding to the 40S ribosomal subunit. They also discovered Vigilin and SERBP1 as DENV host-dependency factors, which interact with the DENV genome to regulate viral replication. The researchers propose that RACK1 recruits Vigilin and SERBP1 to link the DENV genome to the translation machinery, facilitating efficient infection.

JOURNAL OF VIROLOGY (2022)

Add to Collection

Article Cell Biology

Characterization and functional interrogation of the SARS-CoV-2 RNA interactome

Athena Labeau, Luc Fery-Simonian, Alain Lefevre-Utile, Marie Pourcelot, Lucie Bonnet-Madin, Vassili Soumelis, Vincent Lotteau, Pierre-Olivier Vidalain, Ali Amara, Laurent Meertens

Summary: This study identifies 107 cellular factors that interact with the SARS-CoV-2 genome during infection and demonstrates that HNRNPA2B1, ILF3, QKI, and SFPQ promote viral RNA amplification. These findings provide valuable resources for future investigations into SARS-CoV-2 replication mechanisms and the development of host-centered antiviral therapies.

CELL REPORTS (2022)

Add to Collection

Editorial Material Immunology

Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis

Alexandre Bolze, Trine H. Mogensen, Shen-Ying Zhang, Laurent Abel, Evangelos Andreakos, Lisa M. Arkin, Alessandro Borghesi, Petter Brodin, David Hagin, Giuseppe Novelli, Satoshi Okada, Jonny Peter, Laurent Renia, Karine Severe, Pierre Tiberghien, Donald C. Vinh, Elizabeth T. Cirulli, Jean-Laurent Casanova, Elena W. Y. Hsieh

JOURNAL OF CLINICAL IMMUNOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Respiratory Syncytial Virus NS1 Protein Targets the Transactivator Binding Domain of MED25

Jiawei Dong, Vincent Basse, Maxime Bierre, Andressa Peres de Oliveira, Pierre-Olivier Vidalain, Pierre Sibille, Frederic Tangy, Marie Galloux, Jean-Francois Eleouet, Christina Sizun, Monika Bajorek

Summary: Human RSV is a major cause of infant bronchiolitis and childhood deaths in resource-poor areas. NS1 protein of RSV interacts with MED25 subunit of the Mediator complex, hindering the recruitment of cellular TADs and affecting transcription of specific genes.

JOURNAL OF MOLECULAR BIOLOGY (2022)

Add to Collection

Article Immunology

The mechanisms underlying the immune control of Zika virus infection at the maternal-fetal interface

Ana Espino, Jordi Gouilly, Qian Chen, Philippe Colin, Paul Guerby, Jacques Izopet, Ali Amara, Julie Tabiasco, Reem Al-Daccak, Hicham El Costa, Nabila Jabrane-Ferrat

Summary: Unlike other Flaviviruses, Zika virus (ZIKV) infection during the first trimester of pregnancy causes severe pregnancy outcomes including microcephaly and diseases associated with placental dysfunctions. However, the rate of congenital infection is low, indicating the presence of a natural barrier against viral infection. Decidual stromal cells (DSCs), through their interactions with dNK cells or production of proinflammatory cytokines, play a crucial role in regulating ZIKV infection during pregnancy. AXL has been validated as a crucial receptor for ZIKV entry in DSCs, and targeted inhibition of ligand-receptor interaction in the early stage of infection effectively reduces virus pathogenesis at the maternal-fetal interface.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Immunology

What role for cellular metabolism in the control of hepatitis viruses?

Olivier Diaz, Pierre-Olivier Vidalain, Christophe Ramiere, Vincent Lotteau, Laure Perrin-Cocon

Summary: Hepatitis viruses actively alter cellular metabolism through molecular interactions, which can have a direct impact on the antiviral immune response. The complex interactions between viral components, innate immunity, and hepatocyte metabolism may explain the progression of chronic hepatitis infections to liver inflammation, fibrosis, and hepatocellular carcinoma.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Immunology

Immunostimulating Effect of Inactivated Parapoxvirus Ovis on the Serological Response to Equine Influenza Booster Vaccination

Flora Carnet, Romain Paillot, Christine Fortier, Erika S. S. Hue, Laurie Briot, Frederic de Geoffroy, Pierre-Olivier Vidalain, Stephane Pronost

Summary: By stimulating the immune system with iPPVO after vaccination, the effectiveness of equine influenza virus (EIV) vaccines can be improved, leading to higher levels of antibodies produced. The study found that iPPVO could enhance the immune response and increase protective antibodies in horses receiving the EIV vaccine boost.

VACCINES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli

Antoine Gedeon, Gouzel Karimova, Nour Ayoub, Julien Dairou, Quentin Giai Gianetto, Sophie Vichier-Guerre, Pierre-Olivier Vidalain, Daniel Ladant, Helene Munier-Lehmann

Summary: In this study, the protein-protein interactions network among the enzymes involved in de novo purine nucleotide biosynthesis in Escherichia coli was characterized using a bacterial two-hybrid approach. The results showed a dense network of interactions connecting most enzymes, with PurK as one of the central hubs. Mutations in PurK disrupted multiple interactions in the network, leading to changes in purine nucleotide pools and bacterial fitness. These findings indicate that bacterial de novo purine nucleotide biosynthesis enzymes can form a supramolecular complex, and proper interactions within this complex are crucial for bacterial fitness.

FEBS JOURNAL (2023)

Add to Collection

Review Veterinary Sciences

An inventory of adjuvants used for vaccination in horses: the past, the present and the future

Flora Carnet, Laure Perrin-Cocon, Romain Paillot, Vincent Lotteau, Stephane Pronost, Pierre-Olivier Vidalain

Summary: Vaccination is a widely used strategy to protect horses against pathogens, but current equine vaccines have limitations in providing long-term and effective protection. This review provides an inventory of approved adjuvants for equine vaccines worldwide, including aluminium salts, emulsions, polymers, saponins, and ISCOMs. Additionally, it discusses veterinary adjuvants used in other species and evaluated in horses, as well as new adjuvants in development. The objective is to help professionals understand the composition of equine vaccines and provide researchers with potential adjuvants for developing new vaccines.

VETERINARY RESEARCH (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.