Reference values for peak oxygen uptake: cross-sectional analysis of cycle ergometry-based cardiopulmonary exercise tests of 10 090 adult German volunteers from the Prevention First Registry

Objective This study aims to construct quantile reference values for peak oxygen uptake ((V) over dotO(peak)) measured by cycle ergornetry-based incremental cardiopulmonary exercise tests. Design Cross-sectional study using quantile regressions to fit sex-specific and age-specific quantile curves. Exercise tests were conducted using cycle ergornetry. Maximal effort in the exercise tests was assumed when respiratory exchange ratio >= 1.1 or lactate >= 8 mmol/L or maximal heart rate >= 90% of the age-predicted maximal heart rate. This was assessed retrospectively for a random subsample with an a priori calculated sample size of n=252 participants. Setting A network of private outpatient clinics in three German cities recorded the results of cycle ergornetry-based cardiopulmonary exercise tests to a central database (Prevention First Registry) from 2001 to 2015. Participants 10 090 participants (6462 men, 3628 women) from more than 100 local companies volunteered in workplace health promotion programmes. Participants were aged 21 to 83 years, were free of acute complaints and had primarily sedentary working environments. Main outcome measure Peak oxygen uptake was measured as absolute (V) over dotO(2peak) in litres of oxygen per minute and relative (V) over dotO(2peak) in millilitres of oxygen per kilogram of body mass per minute. Results The mean age for both men and women was 46 years. Median relative (V) over dotO(2peak) was 36 and 30 rnL/kg/min at 40 to 49 years, as well as 32 and 26rnL/kg/min at 50 to 59 years for men and women, respectively. An estimated proportion of 97% of the participants performed the exercise test until exertion. Conclusions Reference values and nomograms for (V) over dotO(2peak) were derived from a large sample of preventive healthcare examinations of healthy white-collar workers. The presented results can be applied to participants of exercise tests using cycle ergornetry who are part of a population that is comparable to this study.