Journal
ACS MACRO LETTERS
Volume 7, Issue 2, Pages 178-183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.7b00891
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Funding
- University of Warwick
- ERC [CRYOMAT 638661]
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Carbohydrate-carbohydrate interactions are proposed to be biologically significant but have lower affinities than the well-studied carbohydrate-protein interactions. Here we introduce multivalent glyconanostructures where the surface expression of lactose can be triggered by an external stimulus, and a gold nanoparticle core enables colorimetric signal outputs to probe binding. Macromolecular engineering of a responsive polymer gate enables the lactose moieties to be presented only when an external stimulus is present, mimicking how nature uses enzymes to dynamically regulate glycan expression. Two different carbohydrate-carbohydrate interactions are investigated using this tool.
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