Article
Genetics & Heredity
Mary Kathryn Abel, Kaitlyn Wald, Marcelle I. Cedars, Martha Noel
Summary: This case series is the first to suggest a possible effect of endometrial dysfunction on fertility resumption following levonorgestrel IUD removal in nulliparous patients. It is possible that a small subset of patients may be at risk for Asherman syndrome after IUD use. Larger prospective trials are needed to explore this possible association.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
Yuval Fouks, Adi Kidron, Inbar Lavie, Ziv Shapira, Yoni Cohen, Ishai Levin, Foad Azem, Aviad Cohen
Summary: This study evaluated the impact of Asherman syndrome (AS) on reproductive outcomes and time to achieve pregnancy in infertile women undergoing in vitro fertilization (IVF) treatment. The study found that moderate and severe AS had a detrimental effect on reproductive performance, and endometrial thickness was an important predictor for achieving live births.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Angelo B. Hooker, Robert A. de Leeuw, Mark Hans Emanuel, Velja Mijatovic, Hans A. M. Brolmann, Judith A. F. Huirne
Summary: Intrauterine adhesions (IUAs) are a common reproductive system disease in women worldwide, leading to impaired reproductive function and outcomes. A precise understanding of the underlying causes, related mechanisms, and processes explaining the association with IUAs and impaired fertility is still lacking.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Minghong Shen, Hua Duan, Yanan Chang, Qi Lin
Summary: This study investigated the prevalence and risk factors of intrauterine adhesions (IUA) in patients with a septate uterus. The results showed that the prevalence of IUA in patients with a septate uterus was 31.6%. Patients who had experienced one or more miscarriages or undergone one or more dilatation and curettage (D&C) procedures were more likely to have IUA.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Surgery
Elena Puente Gonzalo, Luis Alonso Pacheco, Auxiliadora Vega Jimenez, Salvatore Giovanni Vitale, Antonio Raffone, Antonio Simone Lagana
Summary: Asherman syndrome is characterized by intrauterine adhesions due to trauma, radiation, or infection in the endometrium. Diagnosis and treatment usually involve hysteroscopy, with postoperative therapies often providing temporary effects. In a reported case, intrauterine autologous platelet-rich plasma (PRP) infusion successfully promoted endometrial regeneration, leading to a successful pregnancy.
UPDATES IN SURGERY
(2021)
Article
Obstetrics & Gynecology
M. Mara, M. Borcinova, Z. Lisa, B. Boudova, A. Richtarova, D. Kuzel
Summary: Perinatal complications in patients with Asherman syndrome after hysteroscopic treatment should be considered moderate to high risk, especially in those who have undergone multiple hysteroscopies or repeated postpartum instrumental revisions. Prospective studies evaluating perinatal outcomes in women with Asherman syndrome history are limited, and the characteristics accounting for the respective morbidity of these patients remain to be elucidated.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Minghong Shen, Hua Duan, Yanan Chang, Qi Lin, Chao Chen, Sirui Wang
Summary: Concomitant intrauterine adhesions significantly reduce pregnancy rates and live birth rates, and increase the risk of abnormal placentation in women with a septate uterus.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Jeremy Sroussi, Antoine Bourret, Anne-Gaelle Pourcelot, Thibault Thubert, Magali Lesavre, Guillaume Legendre, Sophie Tuffet, Alexandra Rousseau, Jean-Louis Benifla
Summary: Hyaluronic acid gel reduces the rate of intrauterine adhesions in women treated with dilation and curettage for miscarriage. The study found that the rate of intrauterine adhesions was lower in the group that received hyaluronic acid gel compared to the control group. The overall pregnancy rate at one year after surgery was similar in both groups.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Angelo B. Hooker, Robert A. de Leeuw, Jos W. R. Twisk, Hans A. M. Brolmann, Judith A. F. Huirne
Summary: Long-term reproductive outcomes following recurrent D&C for miscarriage in women with identified and treated intrauterine adhesions (IUAs) are impaired compared to women without IUAs; fewer ongoing pregnancies and live births are achieved with a prolonged time to a live birth.
HUMAN REPRODUCTION
(2021)
Editorial Material
Obstetrics & Gynecology
Attilio Di Spiezio-Sardo, Maria Chiara De Angelis, Kafetzis Dimitrios, Alfonso Manzi, Brunella Zizolfi, Jose Carugno, Keith Isaacson
Summary: This study describes an effective in-office hysteroscopic strategy to restore fertility in patients with severe Asherman's syndrome. The technique involves miniaturized instruments and the use of 2D and 3D ultrasound for preoperative assessment and guidance during the procedure.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Jude E. Okohue, Nkeiruka Ameh, Adebayo Adewole
Summary: This retrospective comparative study examined the occurrence of intrauterine adhesions (IUA) following open myomectomy and uterine trauma caused by uterine instrumentation after termination of pregnancy or spontaneous miscarriage. The study found that open myomectomy was a significant factor leading to a higher proportion of IUA. It was recommended to perform postoperative hysteroscopy to exclude IUA in cases where pregnancy is desired after open myomectomy.
AFRICAN JOURNAL OF REPRODUCTIVE HEALTH
(2022)
Article
Obstetrics & Gynecology
Yuxue Zhang, Xiaohong Zhu, Tengfei Zhang, Yanling Zhang, Mengsi Zhang, Xiaona Lin
Summary: Menstrual pattern and gestational history may be main predictive factors for pregnancy loss in pregnant women who previously underwent hysteroscopic adhesiolysis. The extent of cavity involved and times of adhesive separation surgeries were associated with placenta accreta.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Review
Obstetrics & Gynecology
Zaraq Khan
Summary: Asherman syndrome is a condition characterized by pain, menstrual abnormalities, and infertility, resulting from intrauterine scar tissue after surgery. Hysteroscopy is the preferred method for diagnosis and treatment usually involves hysteroscopic-guided lysis of adhesions. Various methods are being explored to reduce the reformation of scar tissue after surgery, including the use of stem cells and platelet-rich plasma for regenerative therapy.
OBSTETRICS AND GYNECOLOGY
(2023)
Review
Surgery
Rahul Manchanda, Aayushi Rathore, Jose Carugno, Luigi Della Corte, Jan Tesarik, Peter Torok, George Angelos Vilos, Salvatore Giovanni Vitale
Summary: Intrauterine adhesion formation leading to Asherman's syndrome is a clinical condition that can cause menstrual issues and fertility problems, requiring timely diagnosis and surgical intervention.
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2021)
Article
Pathology
Gulistan Sanem Saribas, Ozen Akarca Dizakar, Candan Ozogul, Ekin Celik, Mahmut Cerkez Ergoren
Summary: The study aimed to investigate the effect of ellagic acid (EA) on fibrosis in intrauterine adhesion (IUA) model rats and to increase endometrial receptivity. The results showed a decrease in fibrotic structure, down-regulation of TGFβ1 activity, up-regulation of BMP7 activity, and an increase in LIF expression and implantation rates in the EA-treated group compared to the control group. Therefore, it can be concluded that EA treatment reduces fibrosis and increases implantation rates in IUA by promoting uterine tissue healing and enhancing endometrial receptivity.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Physical
Guijun Yan, Guomin Sui, Wentao Chen, Kuo Su, Yaqing Feng, Bao Zhang
Summary: Introducing fluorosubstituted aromatic alkylammonium spacer cations can effectively enhance the performance and stability of quasi-two-dimensional perovskite solar cells.
CHEMISTRY OF MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Hui Liu, Daniel Mullan, Shancen Zhao, Yong Zhang, Jun Ye, Yong Wang, Aimin Zhang, Xiaoqing Zhao, Guannan Liu, Chi Zhang, Kenneth Chan, Zhanyuan Lu, Guijun Yan
Summary: This study conducted a genome-wide association study (GWAS) in six different environments in Australia and North China to identify alleles responsible for wheat yield traits. They found significant marker-trait associations (MTAs) and candidate genes, and observed that MTAs tended to cluster together at certain chromosome segments. This finding suggests that marker-assisted selection (MAS) targeting a larger genomic region may be more effective than targeting a single gene.
Article
Biochemistry & Molecular Biology
Chao-Fan Yang, Wen-Wen Liu, Hai-Quan Wang, Jia-Le Zhang, Kang Li, Zhen-Yu Diao, Qiu-Ling Yue, Gui-Jun Yan, Chao-Jun Li, Hai-Xiang Sun
Summary: Gonadal white adipose tissue (gWAT) plays a crucial role in gonad function by influencing whole-body homeostasis and maintaining local metabolic and immune niches.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Materials Science, Ceramics
Meng Miao, Zhipeng Wang, Zhiming Guo, Guijun Yan, Jinfeng Xing
Summary: Researchers have developed a precursor ink for a lattice-matched methylammonium lead iodide solid sol of lead sulfide quantum dots (PbS-QDs/MAPbI3 solid sol) through ligand exchange. They then fabricated a high-performance uncooled photoconductive near-infrared sensor based on this solid sol using a simple dip coating method. This sensor exhibits outstanding overall performance in sensing near-infrared light with high external quantum efficiency, responsivity, detectivity, speed, linearity, and response retention rate.
CERAMICS INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Manlin Xu, Yuan Yan, Xiaoyue Shen, Haixiang Sun, Guijun Yan, Na Kong, Yue Jiang
Summary: This study aims to compare the effects of prolonging progesterone exposure on pregnancy outcomes. The primary outcome measure is the clinical pregnancy rate, while secondary outcome measures include the miscarriage rate and live birth rate.
Article
Medicine, General & Internal
Xinyu Cai, Yue Jiang, Zhiwen Cao, Mei Zhang, Na Kong, Lina Yu, Yedong Tang, Shuangbo Kong, Wenbo Deng, Haibin Wang, Jianxin Sun, Lijun Ding, Ruiwei Jiang, Haixiang Sun, Guijun Yan
Summary: The expression of Mammalian sterile 20 (STE20)-like kinase 1 (Mst1) in the endometrium was decreased in women with recurrent implantation failure (RIF), but its activation promoted trophoblast-uterine epithelium adhesion. Nur77 facilitated trophoblast-uterine epithelium adhesion through the Mst1 signaling pathway and regulated embryo implantation by modulating integrin signaling. This study provides a new approach for assessing endometrial receptivity and treating implantation failure.
Article
Cell Biology
Zhiwen Cao, Qiang Yan, Mei Zhang, Yingchun Zhu, Jingyu Liu, Yue Jiang, Xin Zhen, Manlin Xu, Qiuling Yue, Jidong Zhou, Quan Zhou, Xiaoying Wang, Lijun Ding, Haixiang Sun, Guijun Yan
Summary: This study reveals that aberrant expression of FHL1 in the endometrium can lead to embryo implantation failure. FHL1 regulates downstream gene expression and the beta3 integrin/FAK pathway by increasing HOXA10 protein stability and activating HOXA10. FHL1 promotes blastocyst-epithelial adhesion.
CELL DEATH DISCOVERY
(2022)
Article
Plant Sciences
Rudra Bhattarai, Hui Liu, Kadambot H. M. Siddique, Guijun Yan
Summary: This study compared two NIL pairs with the most contrasting performance in metribuzin treatment and different genetic backgrounds using RNA sequence analysis, identifying nine candidate genes underlying Qsns.uwa.4 A.2 responsible for metribuzin resistance. Quantitative RT-qPCR further validated the candidate genes, with TraesCS4A03G1099000 (nitrate excretion transporter), TraesCS4A03G1181300 (aspartyl protease), and TraesCS4A03G0741300 (glycine-rich proteins) identified as key factors for metribuzin resistance.
Article
Genetics & Heredity
Hui Zhang, Zhilong Wang, Quan Zhou, Zhiwen Cao, Yue Jiang, Manlin Xu, Jingyu Liu, Jidong Zhou, Guijun Yan, Haixiang Sun
Summary: This study found that the expression of INHBB is significantly reduced in women with recurrent implantation failure. The INHBB-ADCY1-mediated cAMP signaling pathway regulates decidualization in these patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Environmental Sciences
Yajie Guan, Manlin Xu, Zhe Zhang, Chuanming Liu, Jidong Zhou, Fei Lin, Junshun Fang, Yang Zhang, Qiuling Yue, Xin Zhen, Guijun Yan, Haixiang Sun, Wenwen Liu
Summary: Circadian disturbance, caused by factors like shift employment and nighttime light pollution, is common in modern culture. This study investigated the effects of maternal circadian disruption before pregnancy on the reproductive health of offspring in mice. It was found that the female offspring exposed to constant light showed obesity, abnormal lipid metabolism, earlier puberty onset, impaired ovarian function, and downregulated expression of various genes involved in circadian rhythm and ovarian function. This study also identified altered immune responses as a potential mechanism for the damage to ovarian function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Tanushree Halder, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Identifying quantitative trait loci (QTL) for different root traits in bread wheat can help breeders develop climate-resilient and high-yielding wheat varieties. This study detected 14 QTL for eight root traits on nine wheat chromosomes and validated two QTL for shallow root depth and high root dry mass in independent populations. The identified QTL and candidate genes are valuable resources for future root trait improvement in wheat.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Endocrinology & Metabolism
Qingqing Shi, Chenyang Huang, Jingyu Liu, Yifan Li, Na Kong, Jie Mei, Xiaoyue Shen, Yanxin Sun, Feifei Lu, Haixiang Sun, Guijun Yan
Summary: Investigated the effects of hormone replacement therapy (HRT) alone or in combination with tamoxifen on patients with thin endometrium in frozen-thawed embryo transfer (FET) cycles. Found that while tamoxifen can significantly increase endometrial thickness, it may not improve the pregnancy outcomes of patients with thin endometrium.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Agronomy
Guannan Liu, Dongcheng Liu, Aimin Zhang, Hui Liu, Md Sultan Mia, Daniel Mullan, Guijun Yan
Summary: This study identified a novel SNP and developed a highly efficient KASP marker for drought tolerance in wheat. The findings have significant implications for research on drought tolerance in wheat.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Agronomy
Guannan Liu, Daniel Mullan, Aimin Zhang, Hui Liu, Dongcheng Liu, Guijun Yan
Summary: Common wheat is an important crop, but markers and genes related to pre-harvest sprouting (PHS) resistance in white-grained wheat are limited. In this study, KASP markers and functional genes related to PHS resistance on wheat chromosome 3AL were identified using near isogenic lines and the 90K SNP chip. These markers and genes are valuable for high-throughput evaluation, marker-assisted selection, and understanding the genetic pathways controlling PHS.