Article
Chemistry, Multidisciplinary
Tamas Olah, Xiaoyu Cai, Liang Gao, Frederic Walter, Dietrich Pape, Magali Cucchiarini, Henning Madry
Summary: Osteoarthritis is characterized by changes in both cartilage and subchondral bone microstructure. Clinical computed tomography (CT) can be used to monitor these changes and is comparable to micro-CT. It provides a valuable tool for investigating osteoarthritis and other bone-related diseases.
Article
Medicine, General & Internal
Hiroaki Hasegawa, Nobuhito Nango, Masafumi Machida
Summary: This study aimed to validate the use of QDCT scanner for evaluating trabecular structure in the diagnosis of osteoporosis. Statistical analysis and linear regression were performed on micro-CT and QDCT images, and evidence was found that QDCT can contribute to the evaluation of bone fragility.
Article
Engineering, Chemical
Giuseppe Falvo D'Urso Labate, Thomas De Schryver, Francesco Baino, Charlotte Debbaut, Gionata Fragomeni, Chiara Vitale-Brovarone, Luc Van Hoorebeke, Patrick Segers, Matthieu Boone, Gerardo Catapano
Summary: This study used micro-computed tomography and image analysis techniques to characterize the space distribution in the shell of HFMBs and investigate how to manufacture HFMBs with uniform and biomimetic distribution of intermembrane spaces in the ECS.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Endocrinology & Metabolism
Michael Dieckmeyer, Nico Sollmann, Malek El Husseini, Anjany Sekuboyina, Maximilian T. Loeffler, Claus Zimmer, Jan S. Kirschke, Karupppasamy Subburaj, Thomas Baum
Summary: This study aimed to identify long-term reproducible texture features (TFs) of spinal CT and analyze variations with regard to gender, age, and vertebral level. The results showed significant differences in TFs between genders and spinal levels, indicating a potential role in osteoporosis diagnostics and investigations of vertebral microstructure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yiwei Chen, Yu Miao, Kexin Liu, Bin Zhu, Feng Xue, Junhui Yin, Jian Zou, Guangyi Li, Changqing Zhang, Yong Feng
Summary: This study investigated the differences in bone microarchitecture, bone remodeling activity, and histomorphological characteristics between glucocorticoid-associated osteonecrosis of femoral head (GONFH) and alcohol-associated osteonecrosis of femoral head (AONFH). The results showed that GONFH exhibited a less sclerotic bone microarchitecture and a more active bone metabolic status in both the reactive interface and normal region. These differences might contribute to the development of disease-modifying strategies and treatments for osteonecrosis of femoral head.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefanie J. Bette, Franziska M. Braun, Mark Haerting, Josua A. Decker, Jan H. Luitjens, Christian Scheurig-Muenkler, Thomas J. Kroencke, Florian Schwarz
Summary: In this study comparing PCD-CT and EID-CT in mouse specimens, PCD-CT demonstrated lower image noise, higher SNR, and better edge sharpness compared to EID-CT. Radiologists consistently preferred PCD-CT for visualizing bone details, even in SNR-matched pairs.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Kun Li, Yucheng Ji, Jun Shi, Shaojie Zhang, Haoyu Song, Peng Wang, Chunying Ma, Yansong Zhang, Yexing Dang, Yuan Ma, Xing Wang, Zhijun Li
Summary: This study measured and analyzed the microstructures and morphometric parameters of the cervical facet using high-resolution 3D micro-computed tomography. It revealed that the cervical facet has complicated 3D microstructures and inhomogeneities, and correct identification and evaluation of its microstructure can help in the diagnosis of orthopedic disease and predict early phases of fracture risk.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jannis Bodden, Michael Dieckmeyer, Nico Sollmann, Sebastian Ruehling, Philipp Prucker, Maximilian T. Loeffler, Egon Burian, Karupppasamy Subburaj, Claus Zimmer, Jan S. Kirschke, Thomas Baum
Summary: This study investigates the reproducibility of texture features and volumetric bone mineral density (vBMD) extracted from trabecular bone in routine clinical multi-detector computed tomography (MDCT) data in a single scanner environment. The results show that texture features have better reproducibility compared to vBMD. Higher-order texture features exhibit the lowest scan-rescan variability.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Agriculture, Dairy & Animal Science
Francesco Maria Achille Consoli, Yara Bernaldo de Quiros, Manuel Arbelo, Stefania Fulle, Marco Marchisio, Mario Encinoso, Antonio Fernandez, Miguel A. Rivero
Summary: Cetaceans are marine mammals that have evolved to adapt to life in the water. However, the characteristics of their bone tissue are still not well-studied. This study used computed tomography to measure the bone radiodensity of cetacean humerus and compared it between different species and within the same species. The results showed significant differences in bone density between different types of bone and different portions of the humerus. These differences were also observed between species with different diving and swimming habits. This technique can be used to compare and understand the unique adaptations of cetaceans in the aquatic ecosystem.
Article
Medicine, General & Internal
Kosuke Suzuki, Akihiko Kitami, Momoka Okada, Shinnosuke Takamiya, Shinichi Ohashi, Yoko Tanaka, Syugo Uematsu, Mitsutaka Kadokura, Takashi Suzuki, Norihiro Hashizume, Hidefumi Fujisawa
Summary: This study aimed to investigate if CT attenuation values can improve the identification of age-related changes in the thymus. Through evaluation of CT images of 405 patients, the study found that the thymus area and attenuation value exhibited different patterns of change with age. The decrease in attenuation values indicated adipose degeneration of the thymus, which was found to begin after puberty and progress with age.
Article
Chemistry, Multidisciplinary
Tae-Hyun Kim, Dong-Yul Lee, Seok-Ki Jung
Summary: This study measured the bone mineral density of specific regions of the maxilla, mandible, and first cervical vertebra using the Hounsfield unit and trabecular microstructure pattern analysis. Results showed the distribution characteristics of trabecular bone in different sites.
APPLIED SCIENCES-BASEL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhenghua Liu, Dageng Huang, Yuting Zhang, Rong Chang, Xiaoyue Zhang, Yonghong Jiang, Xiaowen Ma
Summary: This study evaluated the accuracy of dual-energy computed tomography (DECT) in quantifying bone marrow adipose tissue (BMAT) and its applicability in the study of osteoporosis (OP), comparing it with magnetic resonance imaging (MRI). The results showed that DECT can accurately quantify BMAT and has the same applicability as MRI.
INSIGHTS INTO IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Runlei Ma, Marly van Assen, Daan Ties, Gert Jan Pelgrim, Randy van Dijk, Grigory Sidorenkov, Peter M. A. van Ooijen, Pim van der Harst, Rozemarijn Vliegenthart
Summary: This study found that lesion-specific PCAT(MA) in arteries with plaque was higher than proximal PCAT(MA) in arteries without plaque, and lesion-specific PCAT(MA) was higher in non-calcified and mixed plaques compared to calcified plaques, and in minimal stenosis compared to severe.
EUROPEAN RADIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yihan Li, Wei-Ju Tseng, Chantal M. J. de Bakker, Hongbo Zhao, Rebecca Chung, X. Sherry Liu
Summary: Postmenopausal osteoporosis is influenced by reduced estrogen levels during menopause, impacting bone remodeling, bone mass, and fracture risk. Peak bone mass and microstructure are important predictors of osteoporosis risk, with thicker trabeculae being associated with lower rates of bone loss in response to estrogen deficiency. Thicker trabeculae are less likely to disconnect or perforate, leading to a lower degree of bone loss.
Article
Radiology, Nuclear Medicine & Medical Imaging
Liping Zuo, Ziyu Tian, Binbin Zhou, Mingyuan Hou, Yinghui Chen, Pei Han, Chune Ma, Xuan Wu, Dexin Yu
Summary: The study investigated whether FAI values could be used to identify changes in inflammation status in patients undergoing stent implantation, especially in non-target lesions (NTLs).
EUROPEAN RADIOLOGY
(2023)
Article
Pathology
Qingqiu Yang, Mandi J. Lopez
Summary: The equine hoof capsule plays a vital role in protecting the third phalanx, but can be affected by conditions such as laminitis. More research is needed to understand the mechanisms of healthy tissue formation in the equine hoof, especially in relation to progenitor cells.
TOXICOLOGIC PATHOLOGY
(2021)
Article
Veterinary Sciences
Chiara E. Hampton, Jeannette Cremer, Sarah G. Shippy, Patricia Queiroz-Williams, Mandi J. Lopez, Natalie Rademacher
JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
(2020)
Article
Chemistry, Physical
Jonathan S. Casey, Julien H. Arrizabalaga, Mohammad Abu-Laban, Jeffrey C. Becca, Benjamin J. Rose, Kevin T. Strickland, Jacob B. Bursavich, Jacob S. McCann, Carlos N. Pacheco, Lasse Jensen, Anilchandra Attaluri, Daniel J. Hayes
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2020)
Review
Orthopedics
Takashi Taguchi, Mandi J. Lopez
Summary: The idea of "one health" promotes shared discoveries among medical disciplines, and carefully selected animal models are crucial for the development of therapies. While inherent differences among species limit the direct translation of scientific knowledge, advancements in de novo tissue generation are driving revolutionary innovation.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Cell & Tissue Engineering
Lisa Berntsen, Anoosha Forghani, Daniel J. Hayes
Summary: This study demonstrates the potential of composite cell sheets, fabricated with adipose-derived stem cells, for engineering the tendon-bone interface. By stacking tenogenic and osteogenic cell sheets, the researchers were able to create a composite structure expressing markers of tendon, mineralized fibrocartilage, and bone. This research is an important step towards regenerating the biological gradient of the enthesis and has clinical translation implications.
TISSUE ENGINEERING PART A
(2022)
Article
Medicine, General & Internal
Takashi Taguchi, Francisco Morales J. Yniguez, Catherine Takawira, Frank M. Andrews, Mandi J. Lopez
Summary: Agmatine sulfate may be a viable option for improving thoracic limb movement in horses with osteoarthritis, while reducing the risk of gastric ulcers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rita Aoun, Iyana Charles, Abigail DeRouen, Catherine Takawira, Mandi J. Lopez
Summary: Equine shoes protect hooves and support weakened tissues. The study found that laminitic hooves have greater motion and deformation compared to unaffected hooves, regardless of shoe type. Different shoe configurations have distinct effects on hoof deformation and P3 motion in both unaffected and laminitic hooves, with heart-bar shoes providing the greatest stability in laminitic hooves.
Article
Nanoscience & Nanotechnology
Tyus J. Yeingst, Julien H. Arrizabalaga, Ferdousi S. Rawnaque, Lindsay P. Stone, Amar Yeware, Angelica M. Helton, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes
Summary: This study developed an ultrasound-responsive polymer system that can degrade on demand when exposed to high-intensity focused ultrasound (HIFU). Diels-Alder cycloadducts were used to crosslink polycaprolactone (PCL) polymers and underwent a retro Diels-Alder reaction under HIFU stimulation. The relationship between reverse reaction energy barriers and polymer degradation rates was evaluated for two Diels-Alder polymer compositions. HIFU exposure time and amplitude were found to correlate with an increase in PCL degradation for Diels-Alder-based polymers. The study demonstrated that HIFU is an effective image-guided stimulus to control the degradation of Diels-Alder-based PCL polymers on-demand.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Mandi J. Lopez, Catherine Takawira, Mary P. Fox, Pengju Wang, Evan Boatwright, Thomas Lucak, Chin-Chi Liu, Bryce Fugarino
Summary: Restricted wrist motion during touch screen device use may contribute to injuries. Design and use of devices should consider sex and handedness for optimal performance and injury prevention.
Review
Oncology
Debarati Bhanja, Hannah Wilding, Angel Baroz, Mara Trifoi, Ganesh Shenoy, Becky Slagle-Webb, Daniel Hayes, Yasaman Soudagar, James Connor, Alireza Mansouri
Summary: This review focuses on summarizing the potential and shortcomings of photodynamic therapy (PDT) in the treatment of glioblastoma (GBM), analyzing the current challenges that hinder its effectiveness, and highlighting novel investigations in this field. By addressing these barriers and proposing solutions, this review provides a path for optimizing PDT as a paradigm-shifting treatment for GBM.
Article
Nanoscience & Nanotechnology
Julien H. Arrizabalaga, Molly Smallcomb, Mohammad Abu -Laban, Yiming Liu, Tyus J. Yeingst, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes
Summary: This study presents the development of tunable, ultrasound-responsive hydrogels that can release protein payload on-demand when exposed to focused ultrasound. The reversible Diels-Alder linkers were used to achieve this ultrasound response. The results showed that the retro Diels-Alder reaction induced by focused ultrasound can control the release of the payload and enable real-time visualization of the process, suggesting potential therapeutic applications.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Julien H. Arrizabalaga, Molly Smallcomb, Mohammad Abu-Laban, Yiming Liu, Tyus J. Yeingst, Aman Dhawan, Julianna C. Simon, Daniel J. Hayes
Summary: This study describes the development of tunable, ultrasound-responsive hydrogels that can deliver protein payload on-demand when exposed to focused ultrasound. The results demonstrate the correlation between ultrasound response and the rate of protein release.
ACS APPLIED BIO MATERIALS
(2022)
Review
Polymer Science
Tyus J. Yeingst, Julien H. Arrizabalaga, Daniel J. Hayes
Summary: Stimuli-responsive hydrogel drug delivery systems that release drugs under external stimuli, such as ultrasound, have gained importance in the field of drug delivery. This review summarizes the current understanding of ultrasound-responsive hydrogels, including mechanisms of drug release, innovative formulations, and applications in cancer treatment and tissue engineering.
Article
Engineering, Biomedical
Anoosha Forghani, Leah Garber, Cong Chen, Fariborz Tavangarian, Timothy B. Tighe, Ram Devireddy, John A. Pojman, Daniel Hayes
BIOMEDICAL MATERIALS
(2019)
Article
Engineering, Biomedical
Anoosha Forghani, Srinivas Koduru, Cong Chen, Ashley N. Leberfinger, Dino J. Ravnic, Daniel J. Hayes
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2020)