Journal
SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-018-28367-0
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT, and Future Planning (MSIP) of Korea [NRF-2017R1A2A1A17069427]
- Nano Material Technology Development Program [2017M3A7B8065278]
- Basic Science Research Program [2017R1E1A1A03070458]
- Global Ph.D. Fellowship Program of the NRF - MSIP, Korea [2015H1A2A1034046]
- Russian Foundation for Basic Research (RFBR) [16-52-51028]
- Russian Ministry of Education and Science
- Saint Petersburg State University [6.37.204.2016]
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The commercially pure Ti (CP Ti) and equal-channel angular pressing (ECAP) processed Ti can contribute to the downsizing of medical devices with their superior mechanical properties and negligible toxicity. However, the ECAP-processed pure Ti has the risk of bacterial infection. Here, the coarse-and ultrafinegrained Ti substrates were surface-modified with molybdenum disulfide (MoS2) to improve the cell proliferation and growth with antibacterial effect for further dental applications. According to in vitro tests using the pre-osteoblast of MC3T3-E1 cell and a bacterial model of Escherichia coli (E. coli), MoS2 nanoflakes coated and ECAP-processed Ti substrates showed a significant increase in surface energy and singlet oxygen generation resulting in improved cell attachment and antibacterial effect. In addition, we confirmed the stability of the surface modified Ti substrates in a physiological solution and an artificial bone. Taken together, MoS2 modified and ECAP-processed Ti substrates might be successfully harnessed for various dental applications.
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