Article
Physiology
Ciaran J. McMullan, Andrew W. McHill, Joseph T. Hull, Wei Wang, John P. Forman, Elizabeth B. Klerman
Summary: Prolonged exposure to chronic sleep restriction and shiftwork can lead to hypertension and cardiovascular diseases. This study found that rotating sleep schedules caused circadian disruption, resulting in increased blood pressure, renal sodium retention, and aldosterone excretion. These findings provide mechanistic insights into the adverse effects of shiftwork on cardiovascular and renal health.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jeanne F. Duffy, Wei Wang, Joseph M. Ronda, Charles A. Czeisler
Summary: Aging is associated with changes in sleep, and improving sleep can have important consequences for the health and quality of life of older adults. Melatonin, especially at higher doses, may be a viable option for sleep aid in older adults, as it can increase sleep efficiency during both the day and night.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Lee Di Milia, Simon Folkard
Summary: The study focused on the impact of rhythm amplitude and stability on self-report tools, found a correlation of -0.12 between amplitude and stability, with amplitude negatively associated with phase and stability showing a weak link with phase. The structural equation modeling showed a high model-fit for the factor structure in the sample, with LV and FR scales contributing to explaining variance.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Jonathon Pye, Andrew J. K. Phillips, Sean W. Cain, Maryam Montazerolghaem, Loren Mowszowski, Shantel Duffy, Ian B. Hickie, Sharon L. Naismith
Summary: In older adults with current or remitted major depression, lower Sleep Regularity Index and relative amplitude were found in the current depression group, along with higher activity during sleeping and post-midnight hours. The remitted depression group displayed lower daytime activity, reduced average activity, and lower amplitude compared to controls, with all groups showing significant differences in self-reported sleep quality and depression severity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Khyla Muzni, John A. Groeger, Derk-Jan Dijk, Alpar S. Lazar
Summary: This study examined the impact of sleep quality, sleep duration, and chronotype on mental and physical health in 410 men and 261 women. The results showed that sleep quality was the strongest predictor of health outcomes, particularly mental health, with a greater effect in women than in men.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Critical Care Medicine
Melissa P. Knauert, Najib T. Ayas, Karen J. Bosma, Xavier Drouot, Mojdeh S. Heavner, Robert L. Owens, Paula L. Watson, M. Elizabeth Wilcox, Brian J. Anderson, Makayla L. Cordoza, John W. Devlin, Rosalind Elliott, Brian K. Gehlbach, Timothy D. Girard, Biren B. Kamdar, Kenneth Kiedrowski Amy S. Korwin, Elizabeth R. Lusczek, Sairam Parthasarathy, Claudia Spies, Jag Sunderram, Irene Telias, Gerald L. Weinhouse, Phyllis C. Zee
Summary: Sleep and circadian disruption (SCD) is common and severe in the ICU, and it has a profound negative impact on patient outcomes. Establishing research priorities to advance understanding of ICU SCD is urgent.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Geriatrics & Gerontology
Sarah T. Stahl, Stephen F. Smagula, Juleen Rodakowski, Mary Amanda Dew, Jordan F. Karp, Steven M. Albert, Meryl Butters, Ariel Gildengers, Charles F. Reynolds
Summary: The study identified two trajectories of inflammation in older adults, with one group showing consistently lower levels and the other group showing consistently higher levels. Poor sleep quality may lead to consistently elevated levels of inflammation.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Genetics & Heredity
Yuntao Lu, Bing Liu, Junjie Ma, Shuo Yang, Ju Huang
Summary: Short-term sleep deprivation causes changes in the circadian gene expression of approximately 3,000 genes in the mouse lung, particularly in genes associated with metabolism and signaling pathways regulating protein phosphorylation. The positive correlation between mean expression and amplitude of cycling genes is maintained under sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression.
FRONTIERS IN GENETICS
(2021)
Review
Geriatrics & Gerontology
Elyse J. Carlson, Kristine A. Wilckens, Mark E. Wheeler
Summary: Adequate sleep is crucial for healthy physical, emotional, and cognitive functioning, including memory. However, sleep ability declines with age. Older adults generally have shorter and more disrupted sleep compared to younger adults. Age-related sleep changes are believed to contribute to episodic memory deficits in older adults, but the relationship between sleep and memory deficits is still uncertain. Additionally, age-related alterations in circadian rhythms may also influence memory abilities. This review focuses on age-related sleep and circadian rhythm changes and explores their interaction in affecting episodic memory, specifically encoding and retrieval. Open questions, methodological considerations, and clinical implications for diagnosing and monitoring age-related memory impairments are discussed.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Chuen-Ru Liu, Yiing Mei Liou, Jwo-Huei Jou
Summary: The use of bright ambient light intervention significantly improves sleep quality and circadian rhythms in elderly patients with dementia, especially in terms of sleep efficiency and sleep duration.
Review
Neurosciences
Yun Shen, Qian-kun Lv, Wei-ye Xie, Si-yi Gong, Sheng Zhuang, Jun-yi Liu, Cheng-jie Mao, Chun-feng Liu
Summary: Disruptions of circadian rhythms and sleep cycles are bidirectionally related to neurodegenerative diseases, aggravating neurodegeneration and increasing the risk of such diseases. Harnessing circadian biology findings can reduce the risk of neurodegeneration and improve symptoms and quality of life via precision medicine approaches. This review summarizes evidence from human and animal studies, highlighting the bidirectional links between sleep, circadian rhythms, and prevalent forms of neurodegeneration, providing valuable insights into the pathogenesis of these diseases and suggesting the potential of circadian-based interventions.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Clinical Neurology
Michele Deantoni, Mathilde Reyt, Christian Berthomier, Vincenzo Muto, Gregory Hammad, Stella De Haan, Marine Dourte, Jacques Taillard, Eric Lambot, Christian Cajochen, Carolin F. Reichert, Micheline Maire, Marion Baillet, Christina Schmidt
Summary: This study explores the importance of sleep in brain plasticity and finds a reduction in REM sleep regulation in older adults with increasing age. Additionally, it is observed that a more distinctive allocation of REM sleep over the 24-hour cycle is associated with increased cortical gyrification in specific brain regions in aging. These findings suggest a protective role of circadian REM sleep regulation for age-related changes in brain organization.
Article
Psychology, Multidisciplinary
Alison M. O'Connor, Deston Chung Eng Kea, Qinggong Li, Xiao Pan Ding, Angela D. Evans
Summary: This study explores the influence of age and culture on moral evaluations of dishonesty. It finds that older adults are more tolerant of blunt truths compared to younger adults. Across different cultures, older adults provide harsher evaluations of polite lies and modesty lies. Chinese adults tend to rate lies more positively, which is mediated by their higher levels of collectivism.
CURRENT PSYCHOLOGY
(2022)
Article
Health Care Sciences & Services
Jing Wei, Jennifer Boger
Summary: This study examined the impact of age and dementia on sleep detection through movement and wrist temperature. The results showed that Mi Band 2 was unable to accurately detect sleep in older adults who had greater levels of nighttime movement, while all participants had a distinct sleep and wake wrist temperature contrast. Further research with a larger sample size and greater diversity of wearable devices is needed to explore these trends more conclusively.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Clinical Neurology
Eunjin Lee Tracy, Jun Zhang, Kristine Wilckens, Robert T. Krafty, Brant P. Hasler, Martica H. Hall, Daniel J. Buysse
Summary: This study investigated the differences in homeostatic sleep drive and circadian rhythmicity between older adults with insomnia (OAI) and older good sleepers (GS). The results showed that OAI and GS did not differ in their response to sleep deprivation in delta EEG or repeated sleep latency tests. There were also no differences in circadian phase or amplitude of melatonin or core body temperature rhythms, but OAI had significantly elevated core body temperature mesor. These findings suggest that effective treatments for insomnia in older adults may focus on maintaining stable sleep and circadian regulatory mechanisms, rather than repairing defective sleep and circadian regulation.
Review
Clinical Neurology
Sarah L. Chellappa, Daniel Aeschbach
Summary: Anxiety, the most common mental health problem globally, is closely related to insomnia. Studies have identified specific brain mechanisms that impact anxiety and sleep. While various treatment methods for anxiety exist, a percentage of patients may not respond to frontline treatments.
SLEEP MEDICINE REVIEWS
(2022)
Article
Clinical Neurology
Eva-Maria Elmenhorst, Daniel Rooney, Sibylle Benderoth, Martin Wittkowski, Juergen Wenzel, Daniel Aeschbach
Summary: The study investigates the importance of sleep recuperation during commercial long-haul flights for flight crews. It found that sleep under flight conditions induces hypobaric hypoxia, which may impair sleep quality and blood oxygen saturation. The results suggest that crew recovery in-flight may not be equivalent to recovery on the ground, and oxygen enrichment may be a promising countermeasure.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Environmental Sciences
Sandra Sanok, Moritz Berger, Uwe Muller, Matthias Schmid, Sarah Weidenfeld, Eva-Maria Elmenhorst, Daniel Aeschbach
Summary: Nocturnal traffic noise has a negative impact on residents' sleep continuity. This study establishes an exposure-response relationship for the probability of awakening due to intermittent road traffic noise. The maximum sound pressure level, the maximum slope of the increasing sound pressure level during a vehicle pass-by, and the age of the exposed individual contribute to the awakening probability.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Danni Tu, Mathias Basner, Michael G. Smith, E. Spencer Williams, Valerie E. Ryder, Amelia A. Romoser, Adrian Ecker, Daniel Aeschbach, Alexander C. Stahn, Christopher W. Jones, Kia Howard, Marc Kaizi-Lutu, David F. Dinges, Haochang Shou
Summary: This paper explores the impact of stressors faced by astronauts during spaceflight on their sleep, alertness, and neurobehavioral performance, and proposes a predictive model to accurately predict astronauts' neurobehavioral performance.
SCIENTIFIC REPORTS
(2022)
Letter
Medicine, General & Internal
Mark E. Czeisler, Charles A. Czeisler
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Construction & Building Technology
Anas Mohamed, Vineetha Kalavally, Yin Jou Khong, Chee Pin Tan, Sean W. Cain, Andrew J. K. Phillips
Summary: Circadian misalignment affects travelers, shift workers, and individuals with irregular sleep patterns, leading to cognitive impairment and increased health risks. Lighting interventions in the built environment can realign circadian rhythms, but the inter-individual differences pose challenges, especially in shared living spaces. A new method is presented here to synchronize the circadian rhythms of a group of individuals with different intrinsic circadian periods, using an experimentally validated oscillator model and an iterative process to adjust light exposure schedules.
BUILDING AND ENVIRONMENT
(2023)
Article
Clinical Neurology
Anthony J. Hand, Julia E. Stone, Lin Shen, Celine Vetter, Sean W. Cain, Bei Bei, Andrew J. K. Phillips
Summary: This study explores the relationship between sleep and light regularity in adolescents. New metrics for light regularity were developed and tested. The findings suggest that irregular sleep patterns are associated with irregular light inputs, potentially contributing to circadian disruption.
Article
Clinical Neurology
Angus C. Burns, Andrew J. K. Phillips, Martin K. Rutter, Richa Saxena, Sean W. Cain, Jacqueline M. Lane
Summary: This study conducted a genome-wide gene-by-environment interaction study in a large cohort to identify genetic variants associated with light sensitivity and their impact on chronotype, sleep, and mental health. The researchers found a significant genetic variant that enhances the effect of daytime light exposure on individual time preference and is associated with gene expression in brain and retinal tissues. This study provides insights into the genetic architecture of human circadian light sensitivity and its implications for sleep and mental health.
Review
Biology
Carolyn B. Swope, Shengliang Rong, Carolina Campanella, Regina Vaicekonyte, Andrew J. K. Phillips, Sean W. Cain, Elise M. McGlashan
Summary: Light is the main environmental signal for synchronizing circadian rhythms. Recent research shows inter-individual differences in light sensitivity, measured by melatonin suppression. These differences could affect vulnerability to circadian disruption and health impacts.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Neurosciences
Congying Chu, Sebastian C. Holst, Eva-Maria Elmenhorst, Anna L. Foerges, Changhong Li, Denise Lange, Eva Hennecke, Diego M. Baur, Simone Beer, Felix Hoffstaedter, Gitte M. Knudsen, Daniel Aeschbach, Andreas Bauer, Hans-Peter Landolt, David Elmenhorst
Summary: Sleep loss has a pervasive impact on the human brain at various levels. Aging is associated with reduced sleep quality, and sleep disruption may accelerate the aging process. Total sleep deprivation can increase brain age, but recovery sleep can reverse these changes. Acute or chronic partial sleep restriction, however, does not significantly alter brain age. The findings suggest that sleep loss affects brain morphology in an aging-like manner, with potential reversibility through adequate sleep.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Changhong Li, Tina Kroll, Andreas Matusch, Daniel Aeschbach, Andreas Bauer, Eva-Maria Elmenhorst, David Elmenhorst
Summary: This study found that sleep deprivation affects spontaneous brain activity and A(1) adenosine receptor availability. Furthermore, the study revealed a negative correlation between A(1) adenosine receptor availability and BOLD activity in certain brain regions, providing insights into the molecular basis of neuronal responses induced by high homeostatic sleep pressure.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Naemi L. Tichelman, Anna L. Foerges, Eva-Maria Elmenhorst, Denise Lange, Eva Hennecke, Diego M. Baur, Simone Beer, Tina Kroll, Bernd Neumaier, Andreas Bauer, Hans-Peter Landolt, Daniel Aeschbach, David Elmenhorst
Summary: The genetic variant of ADORA2A affects individual alpha power, while a direct modulatory effect via A1 adenosine receptors is suggested in females.
Article
Clinical Neurology
Daniel P. Windred, Angus C. Burns, Jacqueline M. Lane, Richa Saxena, Martin K. Rutter, Sean W. Cain, Andrew J. K. Phillips
Summary: Sleep regularity is a stronger predictor of mortality risk than sleep duration, with higher sleep regularity associated with a lower risk of all-cause, cancer, and cardiometabolic mortality.
Letter
Clinical Neurology
Sabra M. Abbott, Andrew J. Phillips, Kathryn J. Reid, Sean W. Cain, Phyllis C. Zee
Article
Nutrition & Dietetics
Titiaan E. Post, Jan Schmitz, Cayla Denney, Riccardo De Gioannis, Henning Weis, Dominik Pesta, Andreas Peter, Andreas L. Birkenfeld, Sven Haufe, Uwe Tegtbur, Petra Frings-Meuthen, Ann C. Ewald, Daniel Aeschbach, Jens Jordan
Summary: This study aimed to investigate whether ingesting fructose could improve endurance and cognitive performance in humans under hypoxic conditions. The results showed that fructose intake did not acutely enhance exercise and cognitive performance during moderate hypoxia. Therefore, it is difficult for humans to replicate the hypoxia tolerance seen in naked mole rats through fructose metabolism.
FRONTIERS IN NUTRITION
(2023)