Article
Multidisciplinary Sciences
Jiabao Chen, Qingsong Yu, Haidong Wang, Huangda An, Chenhao Dou, Zhe Lu, Aoran Ding, Lei Ma
Summary: In this retrospective study, 91 patients with thoracic ossification of the ligamentum flavum (OLF) were included. It was found that the non-DO group had significantly higher residual area ratio (RAR) and short shaft ratio (SSR) compared to the DO group. SSR had a higher accuracy in predicting DO and could be a better predictor.
Article
Genetics & Heredity
Baoliang Zhang, Guanghui Chen, Xiaoxi Yang, Tianqi Fan, Xi Chen, Zhongqiang Chen
Summary: Pathological changes in the ligamentum flavum, including hypertrophy and ossification, have unclear pathogenesis. MicroRNAs play a crucial role in regulating gene expression and revealing the pathological mechanisms of these changes. Studies have shown the importance of miRNAs in regulating ligamentum flavum pathology.
FRONTIERS IN GENETICS
(2021)
Review
Orthopedics
Alan H. Daniels, Christopher L. McDonald, Bryce A. Basques, Eren O. Kuris
Summary: Ossification of the ligamentum flavum (OLF) is a spinal condition that can potentially cause compression of the spinal canal and neurological damage. The exact cause is debated but is likely related to gene overexpression and signaling pathways. Progressive myelopathy is the most common symptom, and radiographic analysis can show ossification in different areas. Surgical treatment options exist but may result in complications and postoperative neurological deficits.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Orthopedics
Yueh-Hsiu Lu, Hsi-Hsien Lin, Hsuan-Ying Chen, Po-Hsin Chou, Shih-Tien Wang, Chien-Lin Liu, Ming-Chau Chang
Summary: Calcium pyrophosphate dihydrate deposition disease involving the cervical ligamentum flavum is rare, with specific clinical and imaging characteristics differentiating it from other conditions such as ossification of ligamentum flavum. Different image signs, including acute on chronic phenomenon, can help distinguish this condition from others.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Multidisciplinary Sciences
Kuankuan Liu, Li Shu, Ann Yehong Huang, Yanan Chang, Zhongqiang Chen, Chi Zhang
Summary: This study identified the increased expression of PTGR1 in thoracic ossification of the ligamentum flavum (TOLF) and demonstrated its involvement in cell proliferation, possibly through activating the expression of c-Myc and CyclinD1 via the JNK pathway.
Article
Clinical Neurology
Guanghui Chen, Zhongqiang Chen, Weishi Li, Yu Jiang, Xinhu Guo, Baoliang Zhang, Liyuan Tao, Chunli Song, Chuiguo Sun
Summary: Dural ossification (DO) is a common condition in patients with ossification of the ligamentum flavum (OLF), leading to dural tears. However, current methods for diagnosing DO are limited. This study proposed a novel CT-based imaging sign, called the Banner cloud sign (BCs), and investigated its clinical characteristics and correlations with DO.
EUROPEAN SPINE JOURNAL
(2022)
Article
Surgery
Qiangqiang Pan, Zhenhui Zhang, Yanyu Zhu, Wentao Jiang, Kai Su, Peilin Liu, Yongsheng Kang, Zhe Shao, Wei Mei, Qingde Wang
Summary: This study proposed a zoning laminectomy to reduce the incidence of nerve injury during spinal surgery for thoracic ossification of the ligamentum flavum (TOLF). Retrospective analysis of 45 TOLF patients who underwent zoning laminectomy showed that it was a safe and effective surgical option.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Jialiang Lin, Fei Xu, Shuai Jiang, Longjie Wang, Zhuoran Sun, Zhongqiang Chen, Zhaoqing Guo, Qiang Qi, Yan Zeng, Chuiguo Sun, Weishi Li
Summary: The study investigates the relationship between BMI and thoracic ossification of the ligamentum flavum (TOLF), finding that BMI is a crucial risk factor for TOLF. Prompt detection and treatment of TOLF progression are necessary for asymptomatic TOLF patients with high BMI.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Yin Zhao, Bo Yuan, Li Cheng, Shengyuan Zhou, Yifan Tang, Zhichao Zhang, Yanqing Sun, Zheng Xu, Fengning Li, Xinyuan Liao, Xiongsheng Chen
Summary: This study induced ossification of ligamentum flavum (OLF) in rats using cyclic tensile stress, showing that longer duration of stress led to more visible osteogenesis. Western blot and RT-PCR analyses revealed increased expression of seven osteogenesis-related molecules in the experimental groups.
Article
Cell Biology
Xiaoxi Yang, Chuiguo Sun, Xiangyu Meng, Guanghui Chen, Tianqi Fan, Chi Zhang, Zhongqiang Chen
Summary: This study revealed the differential gene expression profile associated with LGR and Wnt signaling pathway in thoracic ligamentum flavum cells (TLFCs) during different stages of ossification through RNA sequencing and gene ontology enrichment analysis. The findings suggest that LGR5 enhances osteogenesis by activating the Wnt signaling pathway in thoracic ossification of the ligamentum flavum (TOLF).
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Anatomy & Morphology
Qian Chen, Jue-han Wang, Yong Wang, Qing-yan Zhang, Jun-fei Feng, Ke Jiang, Xing-kuan Wang, Chao Xiang, Yu-ling Li
Summary: This study investigated the role of CX43 in TOLF and found that it promotes TOLF through the p38MAPK-RUNX2 pathway. Furthermore, it was discovered that RUNX2 can bind to the CX43 promoter, forming a positive feedback regulatory loop.
Article
Endocrinology & Metabolism
Baoliang Zhang, Lei Yuan, Guanghui Chen, Xi Chen, Xiaoxi Yang, Tianqi Fan, Chuiguo Sun, Dongwei Fan, Zhongqiang Chen
Summary: This study identifies obesity-related genes and explores their functional signatures in ligamentum flavum ossification (OLF). The results show that these genes are mainly involved in metabolism, inflammation, and immune-related processes. A crucial gene cluster associated with inflammatory/immune responses is identified. The core gene SOCS3 is found to be associated with immune infiltrates and methylation modifiers. This study provides insights into the molecular mechanisms and therapeutic targets of obesity-related OLF.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Jia-lin He, Qian Du, Wan-dong Hu, Zhi-jun Xin, Xin-xin Shao, Wen-bo Liao
Summary: This study evaluated the efficacy of posterior percutaneous full-endoscopic technique for patients with thoracic myelopathy caused by ossification of ligamentum flavum (TOLF). The results showed that endoscopic surgery has a good clinical effect on TOLF, with minimal impact on the spinal structure.
Review
Clinical Neurology
Pang Hung Wu, Brian Zhao Jie Chin, Hyeun Sung Kim, Seth Ian Sim, Il-Tae Jang
Summary: Endoscopic posterior decompression is a safe and effective technique for treating TOLF, with low rates of complications and improvement in pain and function.
WORLD NEUROSURGERY
(2023)
Article
Neurosciences
Venkata Vemula Ramesh Chandra, Bodapati C. M. Prasad, Paradesi Rajesh, Sudharsan Agarwal, Mohana Murali Krishna
Summary: This study identified age, associated trauma, OLF level, tuberous type OLF, intramedullary signal change on T2WI, preoperative severity of myelopathy, preoperative mJOA score, and Nurick grade as important predictors of surgical outcome in patients with T-OLF.
Article
Anthropology
Jonny Geber, Eileen Murphy
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
(2012)
Review
Anthropology
Jonny Geber
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
(2014)
Article
Anthropology
Jonny Geber, Eileen Murphy
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
(2018)
Article
Multidisciplinary Sciences
Jonny Geber, Monica Tromp, Ashley Scott, Abigail Bouwman, Paolo Nanni, Jonas Grossmann, Jessica Hendy, Christina Warinner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Anthropology
Jonny Geber, Catriona Pickard, Sarah Macaud, Sabine Sten, Dan Carlsson
Summary: The discovery of burials at S:t Olofsholm in Sweden sheds light on the cultural context of medieval legends and sagas through a combination of bioarchaeology and archaeological records. The study investigates the individuals buried at S:t Olofsholm and their potential connection to folklore and sagas associated with the site. The analysis of the burials and stable isotope data suggests violent deaths and both local and non-local origins, potentially linked to various regions in Scandinavia and beyond.
INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY
(2023)
Article
Archaeology
Jonny Geber, Barra O'Donnabhain
HISTORICAL ARCHAEOLOGY
(2020)
Article
Archaeology
Cormac McSparron, Colm Donnelly, Eileen Murphy, Jonny Geber
INTERNATIONAL JOURNAL OF HISTORICAL ARCHAEOLOGY
(2020)
Article
Anthropology
J. Geber, R. Hensey, P. Meehan, S. Moore, T. Kador
INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY
(2017)
Article
Social Sciences, Interdisciplinary
Jonny Geber
CONTINUITY AND CHANGE
(2016)
Article
Anthropology
J. Geber
INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY
(2015)
Article
Archaeology
Andrew Mudd, Mark Brett, Hugo Anderson-Whymark, Stuart Black, Sarah Cobain, Jonny Geber, Frances Healy, Nathalie Marini, E. R. McSloy, Elaine L. Morris, Kathryn M. Price, Sylvia Warman, Geoff Warren, Nick Watson, Keith Wilkinson, Tim P. Young
ARCHAEOLOGICAL JOURNAL
(2012)