Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

(2017) Felicity E. Lumb et al.   Scientific Reports

From Christian de Duve to Yoshinori Ohsumi: More to autophagy than just dining at home

(2017) Margaret M. Harnett et al.   Biomedical Journal

Basal autophagy prevents autoactivation or enhancement of inflammatory signals by targeting monomeric MyD88

(2017) Takeshi Into et al.   Scientific Reports

Testing small molecule analogues of theAcanthocheilonema viteaeimmunomodulator ES-62 against clinically relevant allergens

(2016) L. Janicova et al.   PARASITE IMMUNOLOGY

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

(2016) J. C. Coltherd et al.   Scientific Reports

The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosomal degradation of TLR-transducers, as exemplified by PKCδ

(2016) Russell J. Eason et al.   Scientific Reports

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation

(2015) Lamyaa Al-Riyami et al.   EXPERIMENTAL PARASITOLOGY

The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model

(2015) Tamar R. Aprahamian et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

(2015) Justyna Rzepecka et al.   JOURNAL OF AUTOIMMUNITY

From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis

(2015) M A Pineda et al.   LUPUS

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus

(2015) D T Rodgers et al.   LUPUS

Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen

(2015) Mark A. Olson et al.   Scientific Reports

The Parasitic Worm Product ES-62 Targets Myeloid Differentiation Factor 88-Dependent Effector Mechanisms to Suppress Antinuclear Antibody Production and Proteinuria in MRL/lprMice

(2015) David T. Rodgers et al.   Arthritis & Rheumatology

Structure-Based Design and Synthesis of a Small Molecule that Exhibits Anti-inflammatory Activity by Inhibition of MyD88-mediated Signaling to Bacterial Toxin Exposure

(2014) Shahabuddin Alam et al.   Chemical Biology & Drug Design

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

(2014) Justyna Rzepecka et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae

(2014) Miguel A. Pineda et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

ES-62 Protects Against Collagen-Induced Arthritis by Resetting Interleukin-22 Toward Resolution of Inflammation in the Joints

(2014) Miguel A. Pineda et al.   Arthritis & Rheumatology

Targeting the Toll-like Receptor/Interleukin 1 Receptor Pathway in Human Diseases: Rational Design of MyD88 Inhibitors

(2013) Maria Loiarro et al.   Clinical Lymphoma Myeloma & Leukemia

Protection against collagen-induced arthritis in mice afforded by the parasitic worm product, ES-62, is associated with restoration of the levels of interleukin-10-producing B cells and reduced plasma cell infiltration of the joints

(2013) David T. Rodgers et al.   IMMUNOLOGY

The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype

(2013) Justyna Rzepecka et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Mutational Analysis Identifies Residues Crucial for Homodimerization of Myeloid Differentiation Factor 88 (MyD88) and for Its Function in Immune Cells

(2013) Maria Loiarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced Arthritis

(2013) Lamyaa Al-Riyami et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases

(2013) Jing Li et al.   PHARMACOLOGY & THERAPEUTICS

Lipopolysaccharide induces IFN-γ production in human NK cells

(2013) Leonid M. Kanevskiy et al.   Frontiers in Immunology

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites

(2012) Miguel A. Pineda et al.   ARTHRITIS AND RHEUMATISM

Therapeutic Inhibition of Pro-Inflammatory Signaling and Toxicity to Staphylococcal Enterotoxin B by a Synthetic Dimeric BB-Loop Mimetic of MyD88

(2012) Teri L. Kissner et al.   PLoS One

A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1 (IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice

(2011) Teri L. Kissner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DSX: A Knowledge-Based Scoring Function for the Assessment of Protein–Ligand Complexes

(2011) Gerd Neudert et al.   Journal of Chemical Information and Modeling

An unexpected role for MHC class II

(2011) Ghada S Hassan et al.   NATURE IMMUNOLOGY

Activation of MyD88 Signaling upon Staphylococcal Enterotoxin Binding to MHC Class II Molecules

(2011) Teri L. Kissner et al.   PLoS One

Staphylococcal enterotoxin A induction of pro-inflammatory cytokines and lethality in mice is primarily dependent on MyD88

(2010) Teri L. Kissner et al.   IMMUNOLOGY

MyD88-dependent pro-inflammatory cytokine response contributes to lethal toxicity of staphylococcal enterotoxin B in mice

(2010) Teri L Kissner et al.   Innate Immunity

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA