Article
Psychiatry
Congchong Wu, Lili Jia, Qingli Mu, Zhe Fang, Hammza Jabbar Abdl Sattar Hamoudi, Manli Huang, Shaohua Hu, Peng Zhang, Yi Xu, Shaojia Lu
Summary: This study investigates the structural changes in the hippocampus and its subfields in major depressive disorder (MDD) patients with and without anhedonia. The results suggest that MDD patients with anhedonia exhibit unique atrophy in the hippocampus, particularly in the left CA1 and DG regions.
Article
Geriatrics & Gerontology
Niels Hansen, Aditya Singh, Claudia Bartels, Frederic Brosseron, Katharina Buerger, Arda C. Cetindag, Laura Dobisch, Peter Dechent, Birgit B. Ertl-Wagner, Klaus Fliessbach, John D. Haynes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Coraline D. Metzger, Matthias H. Munk, Oliver Peters, Josef Priller, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Eike J. Spruth, Stefan Teipel, Maike Tscheuschler, Ruth Vukovich, Jens Wiltfang, Emrah Duezel, Frank Jessen, Roberto Goya-Maldonado
Summary: The study found significant differences in hippocampal volumes among patients with different diseases, particularly between AD patients and those with mood disorders. A linear relationship was observed between left hippocampal volume and duration since the first depressive episode.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychiatry
Judy Alper, Rui Feng, Gaurav Verma, Sarah Rutter, Kuang-han Huang, Long Xie, Paul Yushkevich, Yael Jacob, Stephanie Brown, Marin Kautz, Molly Schneider, Hung-Mo Lin, Lazar Fleysher, Bradley N. Delman, Patrick R. Hof, James W. Murrough, Priti Balchandani
Summary: This study aimed to assess volumetric differences in hippocampal subfields between patients with major depressive disorder (MDD), treatment-resistant depression (TRD) and healthy controls (HC) using high-resolution MRI data. The results showed that MDD and TRD patients had reduced volume in the right-hemisphere CA2/3 subfield compared to HC. Negative correlations between subfield volumes and life-stressor checklist scores were also found. This study provides valuable insights into the pathophysiology of depression.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Artemis Zavaliangos-Petropulu, Shawn M. Mcclintock, Shantanu H. Joshi, Brandon Taraku, Noor B. Al-Sharif, Randall T. Espinoza, Katherine L. Narr
Summary: This study examined the effects of ketamine treatment on hippocampal subfield volumes and the relationship between pre-treatment volumes and changes in depressive symptoms and neurocognitive performance. The results showed that hippocampal subfield volumes remained stable following ketamine treatment and that pre-treatment volumes were associated with neurocognitive improvement after treatment, but not with improvements in depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Sport Sciences
Ya-wen Ao, Yu-shuang LI, Yi-lin Zhao, L. I. A. N. G. Zhang, Ren-jie Yang, Yun-fei Zha
Summary: This study found that amateur marathon runners have larger volumes of specific hippocampal subfields and better sleep quality. Sleep duration was not significantly different between runners and healthy controls, and there was no significant correlation between hippocampal subfield volumes and sleep quality.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biochemistry & Molecular Biology
Kevin Kirchner, Linda Garvert, Katharina Wittfeld, Sabine Ameling, Robin Buelow, Henriette Meyer zu Schwabedissen, Matthias Nauck, Henry Voelzke, Hans J. Grabe, Sandra Van der Auwera
Summary: The effects of different genetic factors on hippocampal subfield volumes were investigated using three approaches: a candidate gene approach, a GWAS approach, and a polygenic approach. Results showed associations between genetic variants, such as APOE epsilon 4, BDNF Val, and 5-HTTLPR L, and hippocampal volume alterations. Replication of GWAS findings was also observed. However, interaction analyses did not reveal significant results. This study highlights the importance of specific genetic analyses in understanding the biology of hippocampal volume loss and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Lianqing Zhang, Lu Lu, Xuan Bu, Hailong Li, Shi Tang, Yingxue Gao, Kaili Liang, Suming Zhang, Xinyue Hu, Yanlin Wang, Lei Li, Xinyu Hu, Kelvin O. Lim, Qiyong Gong, Xiaoqi Huang
Summary: The study found that in PTSD patients, the left amygdala, right hippocampal body, and presubiculum were larger, potentially specific to PTSD, while generally smaller volumes in the hippocampus and amygdala were more likely to be trauma-related than specific to PTSD.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Mu-N Liu, Jakobus Gerick Pantouw, Kai-Chun Yang, Li-Yu Hu, Ying-Jay Liou, Jiing-Feng Lirng, Yuan-Hwa Chou
Summary: This study examined the alterations of hippocampal sub-regional volumes in first episode drug-naive major depressive disorder patients, finding significant reductions in the volumes of the hippocampal head in patients compared to healthy controls, as well as higher asymmetry index values in a specific subfield for patients. These findings suggest that changes in hippocampal sub-regional volumes could serve as imaging biomarkers in the early stages of major depressive disorder.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Kasumi Yasuda, Shinichi Yamada, Shinya Uenishi, Natsuko Ikeda, Atsushi Tamaki, Yuji Ohoshi, Tomikimi Tsuji, Shun Takahashi
Summary: This study investigated the relationship between hippocampal subfield volume and cognitive function in patients with schizophrenia, bipolar disorder, and major depressive disorder. The results showed that patients with schizophrenia had poorer cognitive function, which was related to their hippocampal pathology.
NEUROPSYCHOBIOLOGY
(2022)
Article
Psychiatry
Claudia Barth, Stener Nerland, Kjetil N. Jorgensen, Beathe Haatveit, Laura A. Wortinger, Ingrid Melle, Unn K. Haukvik, Torill Ueland, Ole A. Andreassen, Ingrid Agartz
Summary: This study examined sex and diagnostic group differences in hippocampal subfield volumes in individuals with schizophrenia spectrum disorder, bipolar disorders, and healthy controls. The results showed a larger volumetric deficit in male patients compared to female patients when compared with same-sex controls. There were no significant sex differences in the associations between hippocampal volumes and clinical or cognitive measures in schizophrenia and bipolar disorder.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Genetics & Heredity
Nana Liu, Longjiang Zhang, Tian Tian, Jingliang Cheng, Bing Zhang, Shijun Qiu, Zuojun Geng, Guangbin Cui, Quan Zhang, Weihua Liao, Yongqiang Yu, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Wen Qin, Feng Liu, Meng Liang, Qiang Xu, Jilian Fu, Jiayuan Xu, Wenzhen Zhu, Peng Zhang, Wei Li, Dapeng Shi, Caihong Wang, Su Lui, Zhihan Yan, Feng Chen, Jiance Li, Jing Zhang, Dawei Wang, Wen Shen, Yanwei Miao, Junfang Xian, Jia-Hong Gao, Xiaochu Zhang, Mulin Jun Li, Kai Xu, Xi-Nian Zuo, Meiyun Wang, Zhaoxiang Ye, Chunshui Yu, CHIMGEN Consortium
Summary: Genome-wide association meta-analyses in populations of East Asian and European ancestries identify variant-trait associations for 44 hippocampal traits and provide insight into the genetic architectures of hippocampal and subfield volumes.
Article
Psychiatry
Isabel Maurus, Lukas Roell, Daniel Keeser, Boris Papazov, Irina Papazova, Moritz Lembeck, Astrid Roeh, Elias Wagner, Dusan Hirjak, Berend Malchow, Birgit Ertl-Wagner, Sophia Stoecklein, Alkomiet Hasan, Andrea Schmitt, Andreas Meyer-Lindenberg, Peter Falkai
Summary: There is a positive association between aerobic fitness levels and hippocampal subfield volumes in individuals with schizophrenia, especially in the cornu ammonis, dentate gyrus, and subiculum. However, the effects of aerobic fitness on hippocampal subfield functional connectivity and verbal memory are not yet established.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Kathryn L. Kern, Thomas W. Storer, Karin Schon
Summary: The study found that aging and exercise have opposing effects on mnemonic discrimination task performance; in older adults, cardiorespiratory fitness may have differential effects on hippocampal subfield integrity.
HUMAN BRAIN MAPPING
(2021)
Article
Medicine, General & Internal
Min Seok Baek, Narae Lee, Jin Woo Kim, Jin Yong Hong
Summary: This study investigated the relationship between hippocampal subfield volumes and cortical amyloid-beta (A β) deposition in Alzheimer's disease (AD). It found that patients with mild cognitive impairment (MCI) and AD had decreased volumes in specific parts of the hippocampal subfield, which were correlated with increased A β deposition in the global cortex. The hippocampal subfield volumes showed potential as imaging biomarkers for the diagnosis and detection of AD and A β deposition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Simon Doran, Daniel Carey, Silvin Knight, James F. Meaney, Rose Anne Kenny, Celine De Looze
Summary: This study examined the relationship between hippocampal subfield volumes and cognitive decline and identified several hippocampal subfields associated with global cognitive decline. The results strengthen the predictive value of hippocampal subfield atrophy in risk of cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Neurosciences
Philipp G. Samann, Juan Eugenio Iglesias, Boris Gutman, Dominik Grotegerd, Ramona Leenings, Claas Flint, Udo Dannlowski, Emily K. Clarke-Rubright, Rajendra A. Morey, Theo G. M. van Erp, Christopher D. Whelan, Laura K. M. Han, Laura S. van Velzen, Bo Cao, Jean C. Augustinack, Paul M. Thompson, Neda Jahanshad, Lianne Schmaal
Summary: This article provides an overview of structural abnormalities in the hippocampus in neurological and psychiatric disorders. It discusses the use of automated algorithms and quality control procedures in analyzing hippocampal subregions. The authors also summarize previous studies and offer suggestions to optimize hippocampal subfield research.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Clinical
Cristiane dos Santos Machado, Pedro L. Ballester, Bo Cao, Benson Mwangi, Marco Antonio Caldieraro, Flavio Kapczinski, Ives Cavalcante Passos
Summary: This study successfully developed models using machine-learning approaches to predict suicide attempt risk with high accuracy among a nationally representative sample and participants with lifetime major depressive episodes.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Vincent I. O. Agyapong, Marianne Hrabok, Reham Shalaby, Wesley Vuong, Jasmine M. Noble, April Gusnowski, Kelly Mrklas, Daniel Li, Liana Urichuck, Mark Snaterse, Shireen Surood, Bo Cao, Xin-Min Li, Russell Greiner, Andrew J. Greenshaw
Summary: This study examined the changes in stress, anxiety, and depressive symptoms of subscribers after 3 months of using Text4Hope, and found that the supportive text messaging program led to significant reductions in psychological distress. The results suggest that Text4Hope is an effective population-level psychological intervention during COVID-19.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Article
Psychiatry
James R. A. Benoit, Serdar M. Dursun, Russell Greiner, Bo Cao, Matthew R. G. Brown, Raymond W. Lam, Andrew J. Greenshaw
Summary: Utilizing machine learning algorithms on baseline clinical data, a model with 26 features was developed to predict symptom remission for MDD patients after desvenlafaxine treatment. The resulting classifier had an accuracy of 69.0% on held-out data, significantly better than chance, demonstrating stability with an average accuracy of 67.0% +/- 1.8% through repeated sampling. This model may lead to more accurate DVS treatment outcomes without the need to wait 8 weeks, marking a potential shift in psychiatric care towards incorporating machine-learned models for clinical assistance.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2022)
Review
Pharmacology & Pharmacy
Fernanda Talarico, Sucheta Chakravarty, Yang S. Liu, Andrew J. Greenshaw, Ives Cavalcante Passos, Bo Cao
Summary: This article provides a systematic review of the psychiatric adverse effects of chloroquine and hydroxychloroquine, comparing clinical trials, populational studies, and case report studies. The current literature suggests that both drugs carry a risk of short-term psychiatric adverse effects.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Psychiatry
Yang S. Liu, Lawrence Kiyang, Jake Hayward, Yanbo Zhang, Dan Metes, Mengzhe Wang, Lawrence W. Svenson, Fernanda Talarico, Pierre Chue, Xin-Min Li, Russell Greiner, Andrew J. Greenshaw, Bo Cao
Summary: A machine learning model based on representative large-scale health data was developed and prospectively validated for predicting individual OUD cases.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Clinical Neurology
Feng Fang, Beata Godlewska, Raymond Y. Cho, Sean I. Savitz, Sudhakar Selvaraj, Yingchun Zhang
Summary: This study investigated the effects of the antidepressant drug escitalopram on functional brain controllability in patients with major depressive disorder (MDD). The results showed that escitalopram treatment improved the brain controllability of MDD patients and predicted improvements in clinical scores.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Huixia Zhou, Dongmei Wang, Bo Cao, Xiangyang Zhang
Summary: A study found that cortical thickness is generally thinner in drug-naive Chinese Han patients with schizophrenia compared to healthy controls, and it is associated with clinical symptoms.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
(2023)
Article
Psychology, Developmental
Yang S. Liu, Bo Cao, Pratap R. Chokka
Summary: Screening for adult ADHD and differentiating it from comorbid mental health disorders are still clinically challenging. This pilot study showed that a novel screening method using composite scoring can improve detection accuracy of ADHD and inform the risk of ADHD with comorbidity.
JOURNAL OF ATTENTION DISORDERS
(2023)
Letter
Biochemistry & Molecular Biology
Albert J. Fenoy, Joao Quevedo, Jair C. Soares
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Sugai Liang, Bo Cao, Wei Deng, Xiangzhen Kong, Liansheng Zhao, Yan Jin, Xiaohong Ma, Yingcheng Wang, Xiaojing Li, Qiang Wang, Wanjun Guo, Xiangdong Du, Pak C. Sham, Andrew J. Greenshaw, Tao Li
Summary: This study investigated the aberrant resting-state functional connectivity of anterior cingulate cortex (ACC) in schizophrenia and bipolar disorder (BP), and its relationship with clinical manifestations. The results showed that different subregions of ACC exhibited varying connectivity patterns in patients with schizophrenia, psychotic BP, and nonpsychotic BP. Transdiagnostic dysconnectivity was found in ACC subregions associated with cortical, limbic, striatal, and cerebellar regions. The study also identified disorder-specific dysconnectivity in patients with schizophrenia and psychotic BP, which were correlated with specific clinical symptoms.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Clinical Neurology
Yipeng Song, Lei Qian, Jie Sui, Russell Greiner, Xin-min Li, Andrew J. Greenshaw, Yang S. Liu, Bo Cao
Summary: Based on the Canadian Longitudinal Study on Aging, machine learning models can accurately predict the risk of future depression among middle-aged and elderly individuals. The identified risk factors include subthreshold depression symptoms, emotional instability, low life satisfaction, perceived health, social support, and nutrition risk.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
John-Jose Nunez, Yang S. Liu, Bo Cao, Benicio N. Frey, Keith Ho, Roumen Milev, Daniel J. Mueller, Susan Rotzinger, Claudio N. Soares, Valerie H. Taylor, Rudolf Uher, Sidney H. Kennedy, Raymond W. Lam
Summary: Depression is a complex disorder with a heterogeneous response to treatment. This study used machine learning to cluster patients with depression and found three distinct response patterns. The subjective mood state/anhedonia was identified as the core feature of response to escitalopram, but there were also other patterns related to neurovegetative symptoms, activation, and cognition.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Clinical
Haoran Shen, Likun Ge, Bo Cao, Gao-Xia Wei, Xiangyang Zhang
Summary: The purpose of this study was to further clarify the important role of the cingulate cortex in the treatment of depressive symptoms in first-episode drug naive schizophrenia patients. The findings showed that risperidone alleviated psychotic symptoms in all patients, but only reduced depressive symptoms in patients with comorbid depression. The increase in volume of the cingulate cortex was negatively associated with improvement in depressive symptoms.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)