Mapping of Adenovirus of serotype 3 fibre interaction to desmoglein 2 revealed a novel ‘non-classical’ mechanism of viral receptor engagement

Desmoglein-2 is overexpressed in non-small cell lung cancer tissues and its knockdown suppresses NSCLC growth by regulation of p27 and CDK2

(2016) Feng Cai et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Structural basis of adhesive binding by desmocollins and desmogleins

(2016) Oliver J. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connections matter - how viruses use cell-cell adhesion components

(2015) M. Mateo et al.   JOURNAL OF CELL SCIENCE

Intracellular Signaling and Desmoglein 2 Shedding Triggered by Human Adenoviruses Ad3, Ad14, and Ad14P1

(2015) Hongjie Wang et al.   JOURNAL OF VIROLOGY

Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier

(2015) Ryuta Kamekura et al.   MOLECULAR BIOLOGY OF THE CELL

Preclinical safety and efficacy studies with an affinity-enhanced epithelial junction opener and PEGylated liposomal doxorubicin

(2015) Maximilian Richter et al.   Molecular Therapy-Methods & Clinical Development

Structural and Functional Studies on the Interaction of Adenovirus Fiber Knobs and Desmoglein 2

(2013) H. Wang et al.   JOURNAL OF VIROLOGY

Penton-Dodecahedral Particles Trigger Opening of Intercellular Junctions and Facilitate Viral Spread during Adenovirus Serotype 3 Infection of Epithelial Cells

(2013) Zhuo-Zhuang Lu et al.   PLoS Pathogens

Impact of Human Adenovirus Type 3 Dodecahedron on Host Cells and Its Potential Role in Viral Infection

(2012) P. Fender et al.   JOURNAL OF VIROLOGY

A New Human DSG2-Transgenic Mouse Model for Studying the Tropism and Pathology of Human Adenoviruses

(2012) H. Wang et al.   JOURNAL OF VIROLOGY

Ad3-hTERT-E1A, a Fully Serotype 3 Oncolytic Adenovirus, in Patients With Chemotherapy Refractory Cancer

(2012) Otto Hemminki et al.   MOLECULAR THERAPY

Epithelial Junction Opener JO-1 Improves Monoclonal Antibody Therapy of Cancer

(2011) I. Beyer et al.   CANCER RESEARCH

Avidity Binding of Human Adenovirus Serotypes 3 and 7 to the Membrane Cofactor CD46 Triggers Infection

(2011) H. V. Trinh et al.   JOURNAL OF VIROLOGY

Multimerization of Adenovirus Serotype 3 Fiber Knob Domains Is Required for Efficient Binding of Virus to Desmoglein 2 and Subsequent Opening of Epithelial Junctions

(2011) H. Wang et al.   JOURNAL OF VIROLOGY

Oncolytic adenovirus based on serotype 3

(2010) O Hemminki et al.   CANCER GENE THERAPY

Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF

(2010) Anniina Koski et al.   MOLECULAR THERAPY

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14

(2010) Hongjie Wang et al.   NATURE MEDICINE

The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis

(2010) Emma C Nilsson et al.   NATURE MEDICINE

Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic Adenoviruses

(2009) R. Strauss et al.   CANCER RESEARCH