Journal
SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41598-018-26148-3
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Funding
- China Scholarship Council [201506280092]
- National Natural Science Foundation of China [81570381, 81600327, 81600574, 81700368]
- China Postdoctoral Science Foundation [2018M631177]
- Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University of China [XJTU1AF-CRF-2015-006, XJTU1AF-CRF-2017-021]
- Major Chronic Non-communicable Disease Prevention [2017YFC1307604, 2016YFC1300104]
- Ministry of Science and Technology of the People's Republic of China
- Key Research Project of Shaanxi Province [2017ZDXM-SF-107]
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High uric acid (UA) level and high salt intake are reportedly associated with cardiovascular disease. This study investigated the association between UA and urinary sodium excretion, as well as its interaction on the risk of prehypertension. A total of 1869 participants without hypertension were recruited from a previously established cohort in Shaanxi Province, China. The participants were classified as normotensive or prehypertensive on the basis of their blood pressure. Increasing quartiles of sodium excretion were associated with high urinary UA/creatinine levels in prehypertensive participants. Estimated sodium excretion positively correlated with urinary UA/creatinine excretions in the prehypertensive group. In addition, the multivariate-adjusted odds ratios for prehypertension compared with normotension were 1.68 (1.27-2.22) for sodium excretion and 1.71 (1.21-2.42) for serum UA. Increasing sodium excretion and serum UA were associated with higher risk of prehypertension. Compared with the lowest quartiles, the highest sodium excretion and serum UA quartiles entailed 3.48 times greater risk of prehypertension. Sodium excretion is associated with urinary UA excretion in prehypertensive participants. The present study shows that high levels of salt intake and serum UA simultaneously are associated with a higher risk of prehypertension.
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