Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling

Early antiretroviral therapy and potent second-line drugs could decrease HIV incidence of drug resistance

(2017) Mingwang Shen et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation

(2017) Alexander Zhyvoloup et al.   PLoS Pathogens

Suppression of Adenovirus Replication by Cardiotonic Steroids

(2016) Filomena Grosso et al.   JOURNAL OF VIROLOGY

A high throughput Cre–lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry

(2016) Anthony M. Esposito et al.   VIROLOGY

Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection

(2016) Alison W. Ashbrook et al.   mBio

Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis

(2015) Noëlie Campos et al.   Retrovirology

Combined Na + /Ca 2+ Exchanger and L-Type Calcium Channel Block as a Potential Strategy to Suppress Arrhythmias and Maintain Ventricular Function

(2013) Vincent J.A. Bourgonje et al.   Circulation-Arrhythmia and Electrophysiology

A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides

(2013) G. M. Laird et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Characterization of novel inhibitors of HIV-1 replication that function via alteration of viral RNA processing and rev function

(2013) Raymond W. Wong et al.   NUCLEIC ACIDS RESEARCH

Sodium/calcium exchanger is upregulated by sulfide signaling, forms complex with the β1 and β3 but not β2 adrenergic receptors, and induces apoptosis

(2013) Jana Markova et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Transcriptional and Posttranscriptional Regulation of HIV-1 Gene Expression

(2013) J. Karn et al.   Cold Spring Harbor Perspectives in Medicine

Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing

(2013) Raymond W. Wong et al.   PLoS Pathogens

Human Cytomegalovirus Inhibition by Cardiac Glycosides: Evidence for Involvement of the hERG Gene

(2012) Arun Kapoor et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bufalin, a Traditional Oriental Medicine, Induces Apoptosis in Human Cancer Cells

(2012) Noriyuki Takai et al.   Asian Pacific Journal of Cancer Prevention

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

(2012) Joost CM Uitdehaag et al.   BRITISH JOURNAL OF PHARMACOLOGY

Na+,K+-ATPase as a docking station: protein–protein complexes of the Na+,K+-ATPase

(2012) Linda Reinhard et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B

(2012) E. S. Anderson et al.   RNA

High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor

(2011) Sofiya Micheva-Viteva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Digitoxin-Induced Cytotoxicity in Cancer Cells Is Mediated through Distinct Kinase and Interferon Signaling Networks

(2011) I. Prassas et al.   MOLECULAR CANCER THERAPEUTICS

Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression

(2011) Nicole Lund et al.   NUCLEIC ACIDS RESEARCH

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

(2011) Raymond Wong et al.   Retrovirology

The sodium pump and cardiotonic steroids-induced signal transduction protein kinases and calcium-signaling microdomain in regulation of transporter trafficking

(2010) Jiang Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Involvement of Na+, K+-ATPase and its inhibitors in HuR-mediated cytokine mRNA stabilization in lung epithelial cells

(2010) Su Feng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selectivity of Digitalis Glycosides for Isoforms of Human Na,K-ATPase

(2010) Adriana Katz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cardiac glucoside within vitroanti-HIV activity isolated fromElaeodendron croceum

(2010) Gerhard Prinsloo et al.   NATURAL PRODUCT RESEARCH

Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?

(2009) Youcef Mehellou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

(2009) Andrea Perne et al.   PLoS One

Control of alternative pre-mRNA splicing by Ca++ signals

(2008) Jiuyong Xie   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY