Article
Biochemical Research Methods
Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, Charles Lee
Summary: A new method for establishing orthotopic xenograft of gastric cancer was developed, allowing for the insertion of soft tissue fragments or minced tissues into the stomach submucosa layer of immunodeficient mice. This surgical procedure demonstrated high reproducibility with a success rate of 96% and tumor formation rate of 93% in generating mouse models.
BIOLOGICAL PROCEDURES ONLINE
(2021)
Article
Multidisciplinary Sciences
Takeshi Takasago, Ryohei Hayashi, Yoshitaka Ueno, Misa Ariyoshi, Kana Onishi, Ken Yamashita, Yuichi Hiyama, Hidehiko Takigawa, Ryo Yuge, Yuji Urabe, Shiro Oka, Yasuhiko Kitadai, Shinji Tanaka
Summary: Anti-TNF alpha mAb acts as an inhibitor of tumor progression in the tumor microenvironment of a colorectal cancer orthotopic transplant mouse model by regulating immune response, apoptosis, angiogenesis, and tumor immunity.
Article
Anatomy & Morphology
Kentaro Miyake, Qinghong Han, Takashi Murakami, Tasuku Kiyuna, Kei Kawaguchi, Kentaro Igarashi, Thinzar M. Lwin, Masuyo Miyake, Jun Yamamoto, Michael Bouvet, Itaru Endo, Robert M. Hoffman
Summary: The efficacy of recombinant methioninase (rMETase) on a mouse model of colorectal cancer liver metastasis was investigated in this study. The results showed that rMETase significantly inhibited the increase of liver metastasis. Therefore, rMETase may have future potential as a therapy for colorectal cancer liver metastasis.
Correction
Biochemical Research Methods
Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, Charles Lee
Summary: An amendment to the paper has been published and can be accessed through the original article.
BIOLOGICAL PROCEDURES ONLINE
(2021)
Article
Oncology
Lei Jiang, Yan Chen, Guangtao Min, Jun Wang, Wei Chen, Hongpeng Wang, Xiangwen Wang, Nan Yao
Summary: BAG4 has been found to be overexpressed in gastric cancer tissues compared to normal tissues, and its elevated expression is associated with advanced tumor characteristics and poor patient outcomes. Mechanistically, BAG4 promotes invasion and metastasis of gastric cancer cells by activating the PI3K/AKT/NF-kappa B/ZEB1 axis to induce epithelial-mesenchymal transition.
Article
Biochemistry & Molecular Biology
Yiyang Hu, Chunli Gong, Zhibin Li, Jiao Liu, Yang Chen, Yu Huang, Qiang Luo, Sumin Wang, Yu Hou, Shiming Yang, Yufeng Xiao
Summary: This study established an ALKBH5-PKMYT1-IGF2BP3 regulation system in metastasis, providing a new therapeutic target for gastric cancer metastasis.
Article
Anatomy & Morphology
Xiangwen Zhang, Jiaming Xue, Huiliang Yang, Tingting Zhou, Guo Zu
Summary: TNFAIP6 plays an important role in the prognosis of gastric cancer patients, with higher expression levels associated with tumor invasion depth, lymph node metastasis, TNM stage, and poorer overall survival. Knockdown of TNFAIP6 inhibited proliferation, invasion, and metastasis of gastric cancer cells in vitro.
Article
Oncology
Wu Yanzhang, Li Guanghua, Zhou Zhihao, Wang Zhixiong, Wang Zhao
Summary: This study evaluated the pattern and clinical significance of LNM in EGC, finding that tumor size, differentiation status, and lymphovascular invasion were independent risk factors for LNM. Patients with LNM had a significantly higher 5-year disease-free survival rate than those without LNM, with tumor size and LNM being independent predictive factors for poor survival outcome in all patients.
Review
Oncology
Itaru Hashimoto, Takashi Oshima
Summary: This review highlights the biological and clinical significance of claudin (CLDN) expression in gastric cancer (GC), with a focus on CLDN18.2 and clinical trials centered around it. Abnormal expression of CLDNs, particularly CLDN18, is observed in GC. CLDNs are potential targets for antibody drugs in GC treatment.
Article
Multidisciplinary Sciences
Zirui Jia, Jiacheng Gao, Yuhang Wang, Tingting Zhou, Xiangwen Zhang, Guo Zu
Summary: Through meta-analysis and bioinformatics analysis, the study investigated the relationship between LOX expression and methylation level with clinicopathological parameters and prognosis in GC patients. Results showed that LOX expression was related to lymph node metastasis, tumor distant metastasis, and poor prognosis, while low methylation levels were associated with advanced tumor stage and poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Wenjie Zhou, Junqing Li, Xiaofang Lu, Fangjie Liu, Tailai An, Xing Xiao, Zi Chong Kuo, Wenhui Wu, Yulong He
Summary: This study utilized CRISPR-Cas9 tool to investigate the expression and prognostic significance of Cancer Dependency Map genes in gastric adenocarcinoma, identifying 147 upregulated and 99 downregulated differentially expressed CDMs. A prognostic model based on ten CDMs was constructed, showing good predictive performance. Additionally, PWP2 gene was found to promote cell invasion and migration in gastric adenocarcinoma through the EMT signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Geriatrics & Gerontology
Wouter R. P. H. van de Worp, Jan Theys, Alba Sanz Gonzalez, Brent van der Heyden, Frank Verhaegen, Duncan Hauser, Florian Caiment, Hubertus J. M. Smeets, Annemie M. W. J. Schols, Ardy van Helvoort, Ramon C. J. Langen
Summary: A syngeneic, orthotopic lung cancer mouse model was evaluated to see if it replicates the systemic and muscle-specific alterations associated with human lung cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Nutrition & Dietetics
Cho-Won Kim, Kyung-Chul Choi
Summary: Iridoid glycosides play an important role in anti-cancer by inhibiting cancer cell growth and metastasis through multiple mechanisms. They can influence cancer cell growth by regulating the cell cycle and apoptosis-related signaling pathways, while also suppressing the activity of matrix metalloproteinases and reducing cancer cell invasiveness.
Review
Oncology
Yue Deng, Sicheng Cai, Jian Shen, Huiming Peng
Summary: Tetraspanins play diverse roles in the progression of gastric cancer, including promoting or inhibiting cell proliferation and invasion, regulating cell motility, and impacting lymph node metastasis. They also have significant clinical implications in therapeutic targeting, drug resistance development, and prognosis prediction for gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Wladyslaw Januszewicz, Wei Keith Tan, Katie Lehovsky, Irene Debiram-Beecham, Tara Nuckcheddy, Susan Moist, Sudarshan Kadri, Massimiliano di Pietro, Alex Boussioutas, Nicholas J. Shaheen, David A. Katzka, Evan S. Dellon, Rebecca C. Fitzgerald
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Multidisciplinary Sciences
Marek Cmero, Ke Yuan, Cheng Soon Ong, Jan Schroeder, Niall M. Corcoran, Tony Papenfuss, Christopher M. Hovens, Florian Markowetz, Geoff Macintyre
NATURE COMMUNICATIONS
(2020)
Article
Cell & Tissue Engineering
Alexandra Grubman, Teresa H. Vandekolk, Jan Schroder, Guizhi Sun, Jessica Hatwell-Humble, Jonathan Chan, Minna Oksanen, Sarka Lehtonen, Cameron Hunt, Jan E. Koistinaho, Susan K. Nilsson, John M. Haynes, Colin W. Pouton, Jose M. Polo
Article
Multidisciplinary Sciences
Xiaodong Liu, John F. Ouyang, Fernando J. Rossello, Jia Ping Tan, Kathryn C. Davidson, Daniela S. Valdes, Jan Schroeder, Yu B. Y. Sun, Joseph Chen, Anja S. Knaupp, Guizhi Sun, Hun S. Chy, Ziyi Huang, Jahnvi Pflueger, Jaber Firas, Vincent Tano, Sam Buckberry, Jacob M. Paynter, Michael R. Larcombe, Daniel Poppe, Xin Yi Choo, Carmel M. O'Brien, William A. Pastor, Di Chen, Anna L. Leichter, Haroon Naeem, Pratibha Tripathi, Partha P. Das, Alexandra Grubman, David R. Powell, Andrew L. Laslett, Laurent David, Susan K. Nilsson, Amander T. Clark, Ryan Lister, Christian M. Nefzger, Luciano G. Martelotto, Owen J. L. Rackham, Jose M. Polo
Article
Multidisciplinary Sciences
Naiara G. Bediaga, Hannah D. Coughlan, Timothy M. Johanson, Alexandra L. Garnham, Gaetano Naselli, Jan Schroeder, Liam G. Fearnley, Esther Bandala-Sanchez, Rhys S. Allan, Gordon K. Smyth, Leonard C. Harrison
Summary: Activation of T cells leads to widespread changes in chromatin architecture, including alterations in chromatin accessibility, chromosome conformation, and gene expression. These changes are shared between CD4(+) and CD8(+) T cells and are associated with transcription factors relevant to T cell biology, indicating a close relationship between chromatin structure regulation and gene expression.
SCIENTIFIC REPORTS
(2021)
Article
Cell & Tissue Engineering
Anja S. Knaupp, Monika Mohenska, Michael R. Larcombe, Ethan Ford, Sue Mei Lim, Kayla Wong, Joseph Chen, Jaber Firas, Cheng Huang, Xiaodong Liu, Trung Nguyen, Yu B. Y. Sun, Melissa L. Holmes, Pratibha Tripathi, Jahnvi Pflueger, Fernando J. Rossello, Jan Schroder, Kathryn C. Davidson, Christian M. Nefzger, Partha P. Das, Jody J. Haigh, Ryan Lister, Ralf B. Schittenhelm, Jose M. Polo
Article
Multidisciplinary Sciences
Xiaodong Liu, Jia Ping Tan, Jan Schroder, Asma Aberkane, John F. Ouyang, Monika Mohenska, Sue Mei Lim, Yu B. Y. Sun, Joseph Chen, Guizhi Sun, Yichen Zhou, Daniel Poppe, Ryan Lister, Amander T. Clark, Owen J. L. Rackham, Jennifer Zenker, Jose M. Polo
Summary: The study describes a method to reprogram fibroblasts into human blastocyst models, known as iBlastoids. This model can mimic the overall structure of blastocysts, including inner cell mass, epiblast, primitive endoderm-like cells, blastocoel-like cavity, and trophectoderm-like cells. The iBlastoids system is believed to facilitate the study of early human development, the effects of gene mutations and toxins during early embryogenesis, and the development of new therapies associated with in vitro fertilization.
Article
Multidisciplinary Sciences
Xuan Sun, Benjamin Cao, Marina Naval-Sanchez, Tony Pham, Yu Bo Yang Sun, Brenda Williams, Shen Y. Heazlewood, Nikita Deshpande, Jinhua Li, Felix Kraus, James Rae, Quan Nguyen, Hamed Yari, Jan Schroder, Chad K. Heazlewood, Madeline Fulton, Jessica Hatwell-Humble, Kaustav Das Gupta, Ronan Kapetanovic, Xiaoli Chen, Matthew J. Sweet, Robert G. Parton, Michael T. Ryan, Jose M. Polo, Christian M. Nefzger, Susan K. Nilsson
Summary: Nicotinamide riboside treatment can restore metabolic capacity of hematopoietic stem cells through various ways and shift aged HSC function, metabolism, and molecular characteristics towards a youthful state.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Sabrina E. Wang, S. Ghazaleh Dashti, Allison M. Hodge, Suzanne C. Dixon-Suen, Natalia Castano-Rodriguez, Robert J. S. Thomas, Graham G. Giles, Roger L. Milne, Alex Boussioutas, Bradley J. Kendall, Dallas R. English
Summary: The study found that men, but not women, who were H. pylori sero-negative had increased risks of GERD and Barrett's esophagus, possibly due to differences in patterns of H. pylori-induced atrophic antral gastritis between sexes.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Cell Biology
Jason C. Lao, Christine B. Bui, Merrin A. Pang, Steven X. Cho, Ina Rudloff, Kirstin Elgass, Jan Schroder, Anton Maksimenko, Niamh E. Mangan, Malcolm R. Starkey, Elisabeth M. Skuza, Yu B. Y. Sun, Friederike Beker, Clare L. Collins, Omar F. Kamlin, Kai Konig, Atul Malhotra, Kenneth Tan, Christiane Theda, Morag J. Young, Catriona A. McLean, Nicholas J. Wilson, Arvind Sehgal, Philip M. Hansbro, James T. Pearson, Jose M. Polo, Alex Veldman, Philip J. Berger, Claudia A. Nold-Petry, Marcel F. Nold
Summary: This study reveals the impact of postnatal immune system maturation on early life diseases, particularly bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension. By studying blood samples and mouse lungs, the strong association between type 2 immune polarization and cardiopulmonary diseases is identified. Blocking type 2 mediators can alleviate inflammation and protect pulmonary integrity. This research provides important insights into developmental immunology and therapeutic approaches for early life diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Gerhard Leinenga, Liviu-Gabriel Bodea, Jan Schroder, Giuzhi Sun, Yichen Zhou, Jae Song, Alexandra Grubman, Jose M. Polo, Jurgen Gotz
Summary: Transcranial scanning ultrasound combined with intravenously injected microbubbles can transiently open the blood-brain barrier and reduce amyloid-beta pathology in an Alzheimer's disease mouse model. The response of microglial cells to this treatment is complex and has potential applications for AD therapy.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Psychology, Social
Erin Tutty, Rowan Forbes Shepherd, Cass Hoskins, Rebecca Purvis, Mary Shanahan, Alex Boussioutas, Laura E. Forrest
Summary: This study explored the experiences of young people with hereditary diffuse gastric cancer (HDGC) as they navigate becoming and being a parent. The findings suggest that young people with HDGC face unique challenges in reproductive decision-making and parenting after undergoing gastrectomy.
JOURNAL OF PSYCHOSOCIAL ONCOLOGY
(2023)
Article
Cell Biology
A. Huyghe, G. Furlan, J. Schroeder, E. Cascales, A. Trajkova, M. Ruel, F. Studer, M. Larcombe, Y. Bo Yang Sun, F. Mugnier, L. De Matteo, A. Baygin, J. Wang, Y. Yu, N. Rama, B. Gibert, J. Kielbassa, L. Tonon, P. Wajda, N. Gadot, M. Brevet, M. Siouda, P. Mulligan, R. Dante, P. Liu, H. Gronemeyer, M. Mendoza-Parra, J. M. Polo, F. Lavial
Summary: Coordinated changes of cellular plasticity and identity are critical for pluripotent reprogramming and oncogenic transformation. This study provides insights into the partitioned control of cellular plasticity and identity for both regenerative and cancer biology.
NATURE CELL BIOLOGY
(2022)
Article
Immunology
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S. Gabriel, Wolfgang Kastenmueller, Christian Kurts, Sarah L. Londrigan, Axel Kallies, Katherine Kedzierska, Paul J. Hertzog, Eicke Latz, Yu-Chen E. Chen, Kristen J. Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E. Sander, Birgit Sawitzki, Joachim L. Schultze, Susanne V. Schmidt, Sammy Bedoui
Summary: Bedoui and colleagues discovered a sequential integration process in APCs that enhances their ability to activate antiviral CD8(+) T cell responses. This process involves the gradual induction of specific transcriptional regulators and co-stimulatory molecules, led by CD4(+) T cell-mediated CD40 stimulation and interferon-alpha/interferon-beta activation. These findings highlight the importance of APC-T cell interactions in antiviral immunity.
Article
Oncology
Kunning Wang, Enxiao Li, Rita A. Busuttil, Joseph C. Kong, Sharon Pattison, Joseph J. Y. Sung, Jun Yu, Emad M. El-Omar, Julie A. Simpson, Alex Boussioutas
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2020)