Journal
SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-017-18841-6
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Funding
- China Postdoctoral Science Foundation [2016M602056]
- Xiamen Ocean Economic Innovation and Development Demonstration Project [16PZP001SF16]
- National Natural Science Foundation of China [41676130, 21372233]
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Nine new guaianes (graphostromanes A-I, 1-9) were isolated from the deep-sea-derived fungus Graphostroma sp. MCCC 3A00421, along with four known ones (10-13). The relative configurations were established mainly by detailed analysis of the NMR and HRESIMS data, while the absolute configurations were assigned using the X-ray crystallography and modified Mosher's method. All isolates were evaluated for their inhibitory effects against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages. Graphostromanes F (6) showed remarkable inhibitory effect with an IC50 value of 14.2 mu M, which was even stronger than that of aminoguanidine, a positive control with an IC50 value of 23.4 mu M.
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