Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

(2016) Noga Ron-Harel et al.   Cell Metabolism

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging

(2016) Jun-Ichi Hayashi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Heterozygous mutation ofUsh1g/Sansin mice causes early-onset progressive hearing loss, which is recovered by reconstituting the strain-specific mutation inCdh23

(2016) Yuki Miyasaka et al.   HUMAN MOLECULAR GENETICS

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

(2015) Dohoon Kim et al.   NATURE

Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

(2015) Osamu Hashizume et al.   Scientific Reports

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development

(2013) Takayuki Mito et al.   PLoS One

Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

(2012) O. Hashizume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation

(2011) Elena J. Tucker et al.   Cell Metabolism

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Dependence of Mouse Embryonic Stem Cells on Threonine Catabolism

(2009) Jian Wang et al.   SCIENCE

Mitochondrial DNA mutations and aging: devils in the details?

(2008) Konstantin Khrapko et al.   TRENDS IN GENETICS