Review
Medicine, Research & Experimental
Yajie Wang, Zejuan Gu
Summary: The study evaluated the role of bioimpedance-defined overhydration (BI-OH) parameters in predicting mortality and cardiovascular events in dialysis patients. The analysis found that certain BI-OH indicators were associated with increased risk of mortality and cardiovascular events, while an increase in phase angle was found to be a protective factor against both outcomes in dialysis patients. These findings suggest that BI-OH parameters may serve as independent predictors for mortality and cardiovascular events in this patient population.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Review
Psychology, Clinical
Simone Jayakumar, Stacey Jennings, Kristoffer Halvorsrud, Christophe Clesse, Muhammad Magdi Yaqoob, Livia A. Carvalho, Kamaldeep Bhui
Summary: This study reviewed and analyzed multiple studies to find that depression in CKD/ESKF patients is associated with increased inflammation levels and decreased levels of anti-inflammatory cytokines.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Fabiana Lourenco Costa, Nayrana Soares do Carmo Reis, Fabricio Moreira Reis, Rogerio Carvalho de Oliveira, Silmeia Garcia Zanati Bazan, Maryanne Zilli Canedo da Silva, Luis Cuadrado Martin, Pasqual Barretti
Summary: This study evaluated the superiority of multifrequency bioimpedance spectroscopy (BIS) over control based on clinical assessment plus single-frequency bioimpedance (SF-BIA) in fluid control and intermediate cardiovascular outcomes in peritoneal dialysis (PD) patients. The results showed that BIS was more effective in fluid control and had positive effects on cardiovascular parameters compared to the control group.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Ahmet Yontem, Cagla Cagli, Dincer Yildizdas, Ozden Ozgur Horoz, Faruk Ekinci, Bahriye Atmis, Aysun Karabay Bayazit
Summary: This study evaluated the predictive capability of lung ultrasounds and cIVC in assessing predialysis fluid overload in children with end-stage kidney disease. The results showed that both lung ultrasounds and cIVC could successfully predict fluid overload, especially in the predialysis stage. When combined, these methods had a high predictive accuracy for identifying severe predialysis fluid overload.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Transplantation
Lucas Lindeboom, Seulki Lee, Fokko Wieringa, Willemijn Groenendaal, Carlo Basile, Frank van der Sande, Jeroen Kooman
Summary: Bioimpedance spectroscopy (BIS) is a promising non-invasive technique for fluid monitoring in haemodialysis patients, with the development of wearable devices opening up opportunities for unobtrusive longitudinal fluid status monitoring. This advancement may ultimately lead to improved fluid management, lower mortality rates, and enhanced quality of life for HD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Branden D. Tarlow, W. Ray Kim, Ajitha Mannalithara, Paul Y. Kwo, C. Andrew Bonham, Allison Kwong
Summary: This study found that MELD 3.0 scores beyond 40 are associated with increasing waitlist mortality without adversely affecting posttransplant outcomes. Uncapping the MELD score for waitlist candidates may lead to greater survival benefits from liver transplantation.
Article
Urology & Nephrology
Sihui Ma, Nan Pu, Juan Ma
Summary: This study compared the effects of high-flux hemodialysis (HFHD) and hemodiafiltration (HDF) on the survival of patients with end-stage kidney disease (ESKD) through a systematic review and meta-analysis. The results showed that HFHD has no significant impact on the overall mortality and cardiovascular mortality of ESKD patients compared to HDF, but it can reduce the risk of infection-related death.
Review
Urology & Nephrology
Nikolaos Pyrgidis, Ioannis Mykoniatis, Ioannis Sokolakis, Ioanna Minopoulou, Meletios P. Nigdelis, Petros Sountoulides, Paolo Verze, Georgios Hatzichristodoulou, Dimitrios Hatzichristou
Summary: Renal transplantation improves erectile function and reduces the risk of erectile dysfunction postoperatively compared to preoperatively, although the evidence is mostly based on low quality data due to methodological concerns and high heterogeneity among included studies. More studies with standardized outcomes are needed to validate and strengthen these findings.
JOURNAL OF UROLOGY
(2021)
Review
Urology & Nephrology
Anna Pisano, Carmine Zoccali, Davide Bolignano, Graziella D'Arrigo, Francesca Mallamaci
Summary: The study aimed to define the clinical penetrance of sleep apnoea in patients with chronic kidney disease and end-stage kidney disease, revealing a high prevalence of sleep apnoea in both non-dialysis CKD and ESKD patients. This highlights the importance of using objective diagnostic tools to identify sleep apnoea in kidney disease patients.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Kullaya Takkavatakarn, Kavita Jintanapramote, Jeerath Phannajit, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong
Summary: This systematic review and meta-analysis compared the benefits and risks of incremental hemodialysis (HD) with conventional thrice-weekly HD. The results showed that incremental HD was associated with lower hospitalization rates and loss of residual kidney function (RKF) compared to conventional HD. However, there was no significant difference in mortality and cardiovascular events between the two groups. These findings suggest that incremental HD could be a safe and potentially superior option in clinical outcomes for appropriately selected patients.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Ben F. J. Goudsmit, Hein Putter, Maarten E. Tushuizen, Serge Vogelaar, Jacques Pirenne, Ian P. J. Alwayn, Bart van Hoek, Andries E. Braat
Summary: This study refitted the MELD score for the Eurotransplant region and found that reMELD-Na had significantly higher predictive power than UNOS-MELD, prioritizing patients with higher 90-day mortality rates.
Article
Multidisciplinary Sciences
Lijun Zhao, Fang Liu, Lin Li, Junlin Zhang, Tingli Wang, Rui Zhang, Wei Zhang, Xiaoyan Yang, Xiaoxi Zeng, Yiting Wang, Yucheng Wu, Hao Yang, Shisheng Wang, Yi Zhong, Huan Xu, Shanshan Wang, Ruikun Guo, Honghong Ren, Lichuan Yang, Baihai Su, Jie Zhang, Nanwei Tong, Xin J. Zhou, Mark E. Cooper
Summary: This study analyzed the histological features of 322 Chinese type 2 diabetic patients with confirmed diabetic nephropathy to identify risk factors for end-stage renal disease (ESRD). The findings showed that solidified glomerulosclerosis and extracapillary hypercellularity were independent predictors of ESRD in Chinese patients with diabetes, with complement C9 and apolipoprotein E being highly expressed in solidified glomerulosclerosis. Single glomerular proteomics identified solidified glomerulosclerosis as a unique pathological change associated with complement overactivation and abnormal lipid metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Emilie Gaiffe, Mathilde Colladant, Maxime Desmaret, Jamal Bamoulid, Franck Leroux, Caroline Laheurte, Sophie Brouard, Magali Giral, Philippe Saas, Cecile Courivaud, Nicolas Degauque, Didier Ducloux
Summary: Unsupervised hierarchical clustering analysis was performed on pre-transplant immunological phenotype in 1113 renal transplant recipients, identifying three immune profiles correlated with clinical phenotypes. The memory immune cluster was associated with older age and diabetes, while the activated immune cluster was associated with younger age and previous exposure to CMV. Both were associated with an increased risk of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Urology & Nephrology
Tatsuhiko Azegami, Noriyuki Kounoue, Tadashi Sofue, Masahiko Yazawa, Makoto Tsujita, Kosuke Masutani, Yuki Kataoka, Hideyo Oguchi
Summary: This study found that pre-emptive kidney transplantation has potential benefits in terms of lower mortality and graft failure rates, and it is recommended for adults with end-stage kidney disease.
Article
Public, Environmental & Occupational Health
Deepika Shrestha, Sally Picciotto, Michael P. LaValley, Sa Liu, S. Katharine Hammond, Daniel E. Weiner, Ellen A. Eisen, Katie M. Applebaum
Summary: Despite increasing prevalence of end-stage renal disease, this study found no overall association between metalworking fluids (MWF) and ESRD. However, there were modest associations between MWF and ESRD classification of glomerulonephritis and diabetic nephropathy. Differences by race suggest that black males may have higher disease rates following MWF exposure, indicating a need for further examination of this relationship.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Urology & Nephrology
Kerry Allen, Sarah L. Damery, Kim Sein, David W. Johnson, Simon J. Davies, Mark Lambie, Els Holvoet, Gill M. Combes
Summary: This study aimed to understand the transition experience and perceptions of patients and caregivers from peritoneal dialysis (PD) to haemodialysis (HD). The findings suggest that while each transition is unique, there are common themes such as resistance to change, importance of family support, and bodily adjustment that affect the transition. Expert support during the transition and providing information about potential treatment options could optimize the process.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Review
Urology & Nephrology
Emma Elphick, Matthew Holmes, Matthew Tabinor, Yeoungjee Cho, Thu Nguyen, Tess Harris, Angela Yee Moon Wang, Arsh K. Jain, Daniela Ponce, Josephine S. F. Chow, Annie-Claire Nadeau-Fredette, Adrian Liew, Neil Boudville, Allison Tong, David W. Johnson, Simon J. Davies, Jeffrey Perl, Karine E. Manera, Mark Lambie
Summary: The study found substantial heterogeneity in how PD technique survival is defined and measured in different studies of patients receiving peritoneal dialysis, leading to considerable variability in reported rates. Standardised measures are needed to improve comparability in PD studies.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Sofian Youssef, Syed Zaidi, Mark Lambie, Shahzada Ahmed
Summary: This article provides frameworks to simplify the challenges of the specialised foundation programme application process and interviews for doctors interested in research, medical education, and leadership.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2022)
Article
Urology & Nephrology
Mark Lambie, Junhui Zhao, Keith McCullough, Simon J. Davies, Hideki Kawanishi, David W. Johnson, James A. Sloand, Mauricio Sanabria, Talerngsak Kanjanabuch, Yong-Lim Kim, Jenny I. Shen, Ronald L. Pisoni, Bruce M. Robinson, Jeffrey Perl, PDOPPS Steering Comm
Summary: This study analyzes data from a multinational observational study to demonstrate the relationship between time on peritoneal dialysis and outcomes such as transfer to hemodialysis, death, and kidney transplantation. The study finds that countries with higher rates of kidney transplantation tend to have shorter median times on peritoneal dialysis, and infection is the leading cause of hemodialysis transfer.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Endocrinology & Metabolism
Andrew H. Frankel, Mona Wahba, Vicky Ashworth, Rachna Bedi, Rachel Berrington, Maria Buckley, Lakshmi Chandrasekharan, Fiona Doyle, Deborah Duval, Frances Game, Susie Hamilton, Sufyan Hussain, June James, Hannah Jebb, Janaka Karalliedde, Marie-France Kong, Apexa Kuverji, Mark Lambie, Claire Main, Sara Price, Piyumi Wijewickrama, Jennifer Williams, Ketan Dhatariya, Tahseen A. Chowdhury
Summary: Diabetes is the leading cause of end-stage kidney disease worldwide, and its complications pose challenges for people on dialysis. The updated guidance from the Joint British Diabetes Societies focuses on glycaemic monitoring and covers clinical issues related to diabetes management in people on peritoneal dialysis, as well as acute and chronic complications.
Article
Urology & Nephrology
Ivan Damgov, Maria Bartosova, Iva Marinovic, Obaida Istanbuly, Meinhard Kieser, Mark Lambie, Simon J. Davies, Claus Peter Schmitt
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Simon J. Davies, David Coyle, Elizabeth J. Lindley, David Keane, John Belcher, Fergus J. Caskey, Indranil Dasgupta, Andrew Davenport, Ken Farrington, Sandip Mitra, Paula Ormandy, Martin Wilkie, Jamie MacDonald, Mandana Zanganeh, Lazaros Andronis, Ivonne Solis-Trapala, Julius Sim
Summary: Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function. A randomized controlled trial was conducted to examine whether knowledge of estimated normally hydrated weight could reduce the rate of loss of residual kidney function. The results showed that using a standardized clinical protocol for fluid assessment can effectively preserve residual kidney function without the need for bioimpedance measurements.
KIDNEY INTERNATIONAL
(2023)
Review
Urology & Nephrology
Piyumi Wijewickrama, Jennifer Williams, Steve Bain, Indranil Dasgupta, Tahseen A. Chowdhury, Mona Wahba, Andrew H. Frankel, Mark Lambie, Janaka Karalliedde
Summary: There is a lack of guidelines for managing glucose control in people with diabetes on peritoneal dialysis (PD). Therefore, a summarized review of relevant literature was conducted, focusing on individualized care, burden of hypo-glycemia, glycemic variability, and treatment choices for optimizing glucose control in this population. The lack of sufficient and suitable clinical studies limited the ability to conduct a formal systematic review, but available evidence was reviewed to provide guidance.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Johann Morelle, Mark Lambie, Carl M. Oberg, Simon Davies
Summary: A healthy peritoneal membrane is crucial for effective peritoneal dialysis treatment. Variability and dysfunction of the membrane can lead to fluid overload and complications. This review provides an overview of the structure, function, and pathophysiology of the peritoneal membrane and discusses their clinical implications for patient-centered care.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Microbiology
Kirellos Abbas Said, Maximillian Will, Adnan I. Qureshi, Chun Shing Kwok
Summary: A retrospective cohort study using data from the National Inpatient Sample in the United States was conducted to evaluate the proportion of patients undergoing cardiac surgery who had antimicrobial resistance. The study found that patients with antimicrobial resistance were more likely to be female and had a higher in-hospital mortality rate. Antimicrobial resistance significantly increased the length of stay and cost for patients.
MICROBIOLOGY RESEARCH
(2023)
Article
Urology & Nephrology
Simon J. Davies
Article
Urology & Nephrology
Simon J. Davies, Junhui Zhao, Keith P. McCullough, Yong-Lim Kim, Angela Yee-Moon Wang, Sunil Badve, Rajnish Mehrotra, Talerngsak Kanjanabuch, Hideki Kawanishi, Bruce M. Robinson, Ronald Pisoni, Jeffrey Perl
Summary: There are significant differences in the prescription of icodextrin internationally, with the United States using it less frequently. Icodextrin prescription is associated with hypertonic glucose avoidance and equivalent ultrafiltration, but not with mortality or permanent transfer to hemodialysis.
