Article
Biochemistry & Molecular Biology
Fatima Merech, Vanesa Hauk, Daniel Paparini, Laura Fernandez, Zaira Naguila, Rosanna Ramhorst, James Waschek, Claudia Perez Leiros, Daiana Vota
Summary: The study reveals that deficiency of VIP in the placenta leads to reduced fetal weight in a normal maternal background, accompanied by increased glucose uptake and gene expression. However, in a maternal VIP-deficient environment, placental uptake and transplacental transport of glucose increase while fetal weights remain unaffected.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Endocrinology & Metabolism
Xiaojing Lin, Yunqi Zhang, Xiaoling He, Yan Chen, Nan Chen, Juncheng Liu, Miaoran Wang, Yue Li, Hong Yang, Lei Fan, Yi Hou, Jibin Li, Chaodong Wu, Hongbo Qi, Hua Zhang, Xiaoqiu Xiao
Summary: In this study, it was found that higher levels of TMAO and the formation of abnormal NETs were associated with GDM. TMAO not only promoted the development of the placenta and fetuses but also inhibited the formation of NETs.
Article
Cell Biology
Aditi Karmakar, Md. Maqsood Ahamad Khan, Nidhi Kumari, Nalini Devarajan, Senthil Kumar Ganesan
Summary: This study integrates multiple datasets of retinoblastoma to investigate the effects of RB gene mutation on epigenetic modifications and identifies potential biomarkers and therapeutic targets. The results suggest that E2F3, ESR1, and UNC5D may play crucial roles in retinoblastoma tumorigenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Xiang, Stephanie Langlois, Marie-Eve St-Pierre, Anna Blinder, Philippe Charron, Tyson E. Graber, Stephanie L. Fowler, Stephen D. Baird, Steffany A. L. Bennett, Tommy Alain, Kyle N. Cowan
Summary: In this study, the molecular changes induced by PANX1 re-expression in RMS were investigated, revealing a PANX1 interactome involving proteins such as AHNAK. Knockdown of AHNAK abrogated the PANX1-mediated reduction in RMS cell viability and migration, highlighting AHNAK as a key modifier of PANX1-mediated changes in RMS malignant properties.
Article
Biochemistry & Molecular Biology
Shuxian Wang, Jie Ning, Jing Huai, Huixia Yang
Summary: This study identifies a new regulatory pathway for GLUT1 in hyperglycemia during pregnancy and highlights the potential therapeutic target of AMPK alpha in alleviating diabetes insults in HIP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jiawen Liao, Jesse Goodrich, Douglas I. Walker, Yan Lin, Fred Lurmann, Chenyu Qiu, Dean P. Jones, Frank Gilliland, Lida Chazi, Zhanghua Chen
Summary: Mounting evidence suggests that air pollution influences lipid metabolism and dyslipidemia. In this study conducted on young adults in southern California, a cross-sectional analysis revealed significant associations between exposure to NO2, O3, PM2.5, PM10 and altered lipid profile and metabolomic features. Metabolic pathways such as fatty acid and steroid hormone biosynthesis were found to be affected by air pollutants. The study emphasizes the importance of understanding the metabolic mechanisms linking air pollution exposure and dyslipidemia.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Nicola Antonio di Meo, Davide Loizzo, Savio Domenico Pandolfo, Riccardo Autorino, Matteo Ferro, Camillo Porta, Alessandro Stella, Cinzia Bizzoca, Leonardo Vincenti, Felice Crocetto, Octavian Sabin Tataru, Monica Rutigliano, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli
Summary: Metabolomic analysis has played an important role in bladder cancer research, aiding in biomarker discovery, understanding pathological behavior, and providing starting points for new diagnostic and therapeutic strategies. However, further research is needed to provide stronger evidence and make these tools feasible in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Maya A. Deyssenroth, Shouneng Peng, Ke Hao, Carmen J. Marsit, Jia Chen
Summary: This study presents the first genome-wide characterization of placental transcript usage and its association with intrauterine metal exposure and fetal growth restriction. The results highlight the importance of interrogating the transcriptome at a finer-scale transcript-level resolution to identify novel placental biomarkers of exposure-induced outcomes.
FRONTIERS IN GENETICS
(2022)
Article
Environmental Sciences
Kirtan Kaur, Corina Lesseur, Maya A. Deyssenroth, Itai Kloog, Joel D. Schwartz, Carmen J. Marsit, Jia Chen
Summary: Exposure to PM2.5 during pregnancy may alter placental gene expression related to lipid and glucose metabolism. The effects may vary depending on the sex of the fetus. Further research is needed to understand the long-term programming effects of gestational PM2.5 exposure on postnatal metabolic health.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Victoria Palin, Matthew Russell, Robert Graham, John D. Aplin, Melissa Westwood
Summary: Women with pre-existing diabetes have altered placental O-GlcNAcome, potentially affecting fetal growth, indicating that the maternal metabolic environment in diabetes can impact the placental response to clathrin-mediated endocytosis.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Zain Nurazah, Abu Seman Idris, Amiruddin Mohd Din, Mohamad Arif Abd Manaf, Abrizah Othman, Umi Salamah Ramli
Summary: This study compared the metabolic profiles of natural Ganoderma-infected and healthy control oil palm root samples, revealing differential metabolites associated with BSR in oil palm roots. Systematic metabolic pathway analysis identified the significant involvement of amino acid metabolism, carbohydrate metabolism, and biosynthesis of other secondary metabolites in response to BSR disease.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Dirk L. Christensen, Theonest K. Mutabingwa, Ib C. Bygbjerg, Allan A. Vaag, Louise G. Grunnet, Fanny Lajeunesse-Trempe, Jannie Nielsen, Christentze Schmiegelow, Kaushik L. Ramaiya, Kathryn H. Myburgh
Summary: This study assessed muscle fibre distribution 20 years after placental and/or peripheral in-utero malaria exposure. The results showed that there were no differences in muscle fibre types or enzymatic activity between the malaria-exposed and non-exposed groups. The findings supported the idea that the mild elevations of plasma glucose levels in people exposed to placental malaria in pregnancy were due to compromised pancreatic insulin secretion rather than insulin resistance.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Kathleen M. Hudson, Emily Shiver, Jianshi Yu, Sanya Mehta, Dereje D. Jima, Maureen A. Kane, Heather B. Patisaul, Michael Cowley
Summary: Cadmium is a toxic heavy metal that can impair fetal growth and development, as well as negatively impact neurodevelopment when maternal exposure occurs. Exposure to cadmium during pregnancy disrupts multiple pathways in the developing brain, including retinoic acid signaling and cellular energy pathways.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Mary Alexandra Schleiff, Deepika Dhaware, Jasleen K. Sodhi
Summary: The drug metabolism field addresses the issue of variable or unexpected metabolism that can lead to drug efficacy variability or adverse reactions, through studying drug-drug interactions, pharmacogenomics, computational modeling, and more. This study focuses on summarizing seven exceptional manuscripts in recent years, with main topics including novel computational modeling approaches and experimental approaches to understanding the impacts of variability and species differences on drug metabolism.
DRUG METABOLISM REVIEWS
(2021)
Article
Obstetrics & Gynecology
Victoria H. J. Roberts, Aaron D. Streblow, Jessica E. Gaffney, Samantha P. Rettke, Antonio E. Frias, Ov D. Slayden
Summary: The study showed that long-term consumption of a Western-style high-fat diet affects glucose uptake in the placenta of female rhesus macaques, with reduced expression of glucose transporter proteins. However, the significant increase in maternal blood glucose levels may be a factor contributing to this disparity.
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
John D. Aplin, Adam Stevens
Summary: The text discusses the importance of precise and personalized timing of the endometrial cycle for optimal embryo replacement, highlighting the challenges and uncertainties in defining the relationship between the endometrial cycle and implantation. Despite advancements in 'omics technologies, there remains a lack of consensus regarding the molecular characterization of the receptive state, suggesting a need for further research and exploration in this area.
HUMAN REPRODUCTION
(2022)
Article
Clinical Neurology
Charlotte H. Hulme, Heidi R. Fuller, John Riddell, Sally L. Shirran, Catherine H. Botting, Aheed Osman, Karina T. Wright
Summary: The study aimed to characterize the blood proteome following spinal cord injury using rat models and identified differentially regulated pathways in response to SCI, providing insights for future research in developing therapeutic interventions and prognostic indicators.
Review
Genetics & Heredity
Salvo Danilo Lombardo, Ivan Fernando Wangsaputra, Jorg Menche, Adam Stevens
Summary: This article highlights the importance of the early developmental phase for human health and disease, focusing on the integration and analysis methods for studying transcriptomic and epigenetic processes relevant to the periconceptional period.
Article
Oncology
Ayse Ufuk, Terence Garner, Adam Stevens, Ayse Latif
Summary: This study reveals the association between monocarboxylate transporters (MCTs) and desmoplasia in pancreatic ductal adenocarcinoma (PDAC), highlighting the importance of MCTs as therapeutic targets and opening up new pathways to improve patient survival.
Article
Obstetrics & Gynecology
Laura Ormesher, Suzanne Higson, Matthew Luckie, Stephen A. Roberts, Heather Glossop, Andrew Trafford, Elizabeth Cottrell, Edward D. Johnstone, Jenny E. Myers
Summary: This study found that postnatal cardiovascular morbidity persists in women with preterm pre-eclampsia six months after childbirth, particularly in the form of diastolic dysfunction and increased total vascular resistance. Earlier gestation at delivery and lower birthweight are associated with worse cardiovascular function at six months postpartum.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Medicine, Research & Experimental
Alice Hurrell, Jenie Sparkes, Kate Duhig, Paul T. Seed, Jenny Myers, Cheryl Battersby, Katherine Clark, Marcus Green, Rachael M. Hunter, Andrew H. Shennan, Lucy C. Chappell, Louise Webster
Summary: The PARROT-2 trial is a multi-centre randomised controlled trial investigating the impact of repeat PIGF-based testing on women with suspected pre-eclampsia between 22-35 weeks of gestation. The primary objective of the trial is to determine whether repeat PIGF-based testing reduces severe adverse outcomes for both mother and baby. The clinical and cost-effectiveness of repeat PIGF-based testing has not yet been evaluated.
Article
Multidisciplinary Sciences
Laura Ormesher, Sarah Vause, Suzanne Higson, Anna Roberts, Bernard Clarke, Stephanie Curtis, Victoria Ordonez, Faiza Ansari, Thomas R. Everett, Claire Hordern, Lucy Mackillop, Victoria Stern, Tessa Bonnett, Alice Reid, Suzanne Wallace, Ebruba Oyekan, Hannah Douglas, Matthew Cauldwell, Maya Reddy, Kirsten Palmer, Maggie Simpson, Janet Brennand, Laura Minns, Leisa Freeman, Sarah Murray, Nirmala Mary, James Castleman, Katie R. Morris, Elizabeth Haslett, Christopher Cassidy, Edward D. Johnstone, Jenny E. Myers
Summary: This multicentre retrospective cohort study aimed to determine the prevalence of pre-eclampsia in women with pre-existing cardiac dysfunction and explore the relationship between pregnancy outcome and pre-pregnancy cardiac phenotype. The study found that there was a modest increase in preterm pre-eclampsia and significant increase in fetal growth restriction in women with pre-existing cardiac dysfunction. The study also found that there was no correlation between cardiac function and pregnancy outcome, but the use of antenatal ss blockers was associated with lower birthweight.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
James M. Roberts, Tekoa L. King, John R. Barton, Stacy Beck, Ira M. Bernstein, Tiffani E. Buck, Michele A. Forgues-Lackie, Francesca L. Facco, Alison D. Gernand, Cornelia R. Graves, Arundhati Jeyabalan, Alisse Hauspurg, Tracy A. Manuck, Jenny E. Myers, Trashaun M. Powell, Elizabeth F. Sutton, Elizabeth Tinker, Eleni Tsigas, Leslie Myatt
Summary: Preeclampsia is a pregnancy disorder that affects a large number of pregnant individuals worldwide. Low-dose aspirin has been found to modestly reduce the occurrence of preeclampsia, but its long-term effects on infants are not well-studied. Expert groups have identified clinical factors and tests that can help assess the risk of preeclampsia and recommend preventive therapy. Additional care and interventions can improve outcomes for individuals at risk. A collaborative care plan has been developed to reduce the risk of preeclampsia and its associated morbidities.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Orthopedics
Charlotte H. Hulme, Mandy J. Peffers, Sally Roberts, Pete Gallacher, Paul Jermin, Karina T. Wright
Summary: This study used proteomic analyses to identify differences in the plasma proteome between responders and nonresponders to autologous chondrocyte implantation (ACI). However, the findings from pooled plasma analysis were not replicated using an alternative nonpooled technique. The study highlights cartilage acidic protein 1 as a potential biomarker for predicting ACI outcome.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Review
Cell & Tissue Engineering
Charlotte H. Hulme, Claire Mennan, Helen S. Mccarthy, Rebecca Davies, Tian Lan, Larissa Rix, Jade Perry, Karina Wright
Summary: This article reviews the applications of the Quantum cell expansion system manufactured by Terumo-BCT, which is compliant with Good Manufacturing Practice and used for expanding adherent cell populations. Recent publications have also discussed the use of this system for suspension cultures and extracellular vesicle manufacturing. The article highlights the potential widespread use of this system in the rapidly expanding field of cell therapy research and regenerative medicine.
Article
Obstetrics & Gynecology
Lucy Hammer, Alexander E. P. Heazell, Andrew Povey, Jenny E. Myers, John M. D. Thompson, Edward D. Johnstone
Summary: This study found that levels of ambient air pollution during pregnancy in the UK, which were all below recommended thresholds, are not associated with an increased risk of stillbirth. However, periconceptual exposure to NO2 may be associated with an increased risk, but further research is needed to investigate this association.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Peripheral Vascular Disease
Thomas Willmott, Laura Ormesher, Andrew J. Mcbain, Gavin J. Humphreys, Jenny E. Myers, Gurdeep Singh, Jon O. Lundberg, Eddie Weitzberg, Carina Nihlen, Elizabeth C. Cottrell
Summary: This study aimed to investigate the role of oral microbiota profiles and oral nitrate-reducing capacity in explaining individual differences in blood pressure (BP) lowering following dietary nitrate supplementation. The results showed that women with hypertension had lower salivary nitrite concentrations and reduced abundance of nitrate-reducing bacteria compared to normotensive women. Oral nitrate reductase (NaR) activity did not differ significantly between pregnant and nonpregnant women, but it tended to be lower in hypertensive women. Oral NaR activity was associated with both baseline diastolic BP and changes in diastolic BP after acute nitrate intake.
Article
Cell Biology
Peter W. West, Chiara Tontini, Haris Atmoko, Orsolya Kiss, Terence Garner, Rajia Bahri, Richard B. Warren, Christopher E. M. Griffiths, Adam Stevens, Silvia Bulfone-Paus
Summary: In this study, the role of mast cells in skin inflammation and itch in psoriasis was investigated. The density, distribution, and molecular signature of mast cells in psoriasis skin were examined and compared to healthy skin. The results showed that mast cells were spatially associated with nerve fibres and their increase in density correlated with disease severity. Moreover, the upregulation of cathepsin B in mast cells was found to be a reliable indicator of psoriasis.
Article
Medicine, General & Internal
Jameela Sheikh, John Allotey, Tania Kew, Borja M. Fernandez-Felix, Javier Zamora, Asma Khalil, Shakila Thangaratinam
Summary: Globally, babies born to Black women in underserved groups consistently have poorer perinatal outcomes than those born to White women, despite variations in risks for other ethnic groups. The effects of race and ethnicity on adverse perinatal outcomes do not vary across regions.
Article
Endocrinology & Metabolism
Samuel Parsons, Adam Stevens, Andrew Whatmore, Peter E. Clayton, Philip G. Murray
Summary: This study found that single-nucleotide polymorphisms (SNPs) within the ZBTB38 gene associated with idiopathic short stature (ISS) are linked to birth size and response to growth hormone therapy in ISS patients. Additionally, ZBTB38 expression is positively correlated with age.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
