Article
Plant Sciences
Honglin Chen, Gengyang Shen, Qi Shang, Peng Zhang, Die Yu, Xiang Yu, Zhida Zhang, Wenhua Zhao, Zixian Wu, Fuyu Tang, De Liang, Xiaobing Jiang, Hui Ren
Summary: The study demonstrates that Plastrum testudinis extract (PTE) can inhibit osteoclast differentiation and bone resorption in vitro, effectively alleviating bone loss caused by senile osteoporosis. Additionally, PTE can suppress osteoclast formation by blocking the NF-kappa B signaling pathway, presenting a potential therapeutic treatment for bone loss disorders.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mina Ding, Eunjin Cho, Zhihao Chen, Sang-Wook Park, Tae-Hoon Lee
Summary: In this study, the effects of EPZ compounds, PRMT5 inhibitors, on RANKL-induced osteoclast differentiation were investigated. EPZ015866 attenuated osteoclast differentiation more effectively than EPZ015666. The compounds inhibited the nuclear translocation of NF-kappa B, preventing osteoclast differentiation and bone resorption. EPZ015866 may be a potential drug candidate for the treatment of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Chunchun Xue, Huan Luo, Libo Wang, Qing Deng, Wenyun Kui, Weiwei Da, Lin Chen, Shuang Liu, Yongpeng Xue, Jiafan Yang, Lingxing Li, Wenlan Du, Qi Shi, Xiaofeng Li
Summary: Aconine (AC) is a potential natural compound for treating osteoporosis by reversing osteoclast ferroptosis and formation mediated by NF-kappa B signaling.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Rong Hu, Libo Chen, Xiaolong Chen, Zhong Xie, Chao Xia, Yong Chen
Summary: Aloperine has been shown to inhibit osteoclast activity and formation mediated by RANKL, indicating its potential as a new drug for the prevention and treatment of postmenopausal osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xue Yang, Jiamin Liang, Ziyi Wang, Yuangang Su, Yunfei Zhan, Zuoxing Wu, Jing Li, Xuedong Li, Runfeng Chen, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
Summary: This study found that sesamolin has the potential to treat osteoporosis by effectively inhibiting the formation of osteoclasts in vitro, attenuating bone loss through modulating multiple signaling pathways and gene expression, and demonstrating a preventive effect against bone loss induced by estrogen deficiency in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Zhihui Kuang, Xiaowei Yang, Zhiyou Cao, Yanhua Li, Jiawei Hu, Xin Hong, Bo Li, Changjian Wu, Qihua Qi, Xuqiang Liu, Min Dai
Summary: Surfactin, a highly effective biosurfactant, inhibits osteoclastogenesis and promotes osteogenic differentiation, suggesting its potential as a treatment for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yongjie Chen, Linlin Zhang, Zongguang Li, Zuoxing Wu, Xixi Lin, Na Li, Rong Shen, Guojun Wei, Naichun Yu, Fengqing Gong, Gang Rui, Ren Xu, Guangrong Ji
Summary: Mogrol, an active component of Siraitia grosvenorii, exhibits anti-inflammatory, anticancer and neuroprotective effects. This study demonstrated that mogrol dose-dependently inhibited osteoclast formation and function by regulating gene expression and signaling pathway. Furthermore, mogrol reduced bone mass loss in postmenopausal mice, suggesting its promising potential for osteoporosis prevention or therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Huanlian Tian, Feng Chen, Yingfang Wang, Yixuan Liu, Guojing Ma, Yuhong Zhao, Yanan Ma, Tingting Tian, Ruze Ma, Yang Yu, Difei Wang
Summary: The role of nuclear receptor 77 (Nur77) in osteoporosis was investigated in this study. The findings showed that knockout of Nur77 accelerated femoral bone loss in mice and increased the levels of inflammatory markers hsCRP and IL-6. In vitro experiments demonstrated that Nur77 suppressed osteoclast differentiation by inhibiting the NF-kappa B signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Tao Li, Guangyao Jiang, Xuantao Hu, Daishui Yang, Tingting Tan, Zhi Gao, Zhuoyuan Chen, Cheng Xiang, Shizhen Li, Zhengxiao Ouyang, Xiaoning Guo
Summary: Punicalin inhibits osteoclast formation and bone resorption by suppressing the NF-κB signaling pathway, showing potential in suppressing breast cancer-induced bone metastasis and promoting apoptosis of breast cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Fan Yang, Yuangang Su, Jiamin Liang, Keyi Wang, Haoyu Lian, Junchun Chen, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: Postmenopausal osteoporosis is a chronic metabolic disease characterized by low bone mineral density and bone fragility. In this study, it was found that Casticin inhibits osteoclast activation and differentiation induced by the receptor activator of nuclear factor-κB ligand. Casticin also prevents bone loss and reduces osteoclast activity in vivo, suggesting its potential as a preventive treatment for osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Huijiang Liu, Ronghe Gu, Qian Huang, Yun Liu, Chong Liu, Shijie Liao, Wenyu Feng, Tianyu Xie, Jinmin Zhao, Jiake Xu, Qian Liu, Xinli Zhan
Summary: This study found that isoliensinine can inhibit the differentiation of osteoclasts and reduce bone loss, showing great potential for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yan Zheng, Xing Wang, Ya-Jing Pan, Xiao-Feng Shi, Lei Yang, Yong-Liang Lou
Summary: In this study, it was found that Ori inhibits the production and activation of osteoclasts induced by RANKL, and reduces intracellular ROS levels by activating ROS-scavenging enzymes. It also downregulates the expression of c-Fos, NFATc1, CTSK, and NFATc2, which are genes and proteins unique to osteoclasts, by inhibiting RANKL-induced NF-κB. In the animal model, Ori therapy restores bone mass and improves microarchitecture.
FOOD SCIENCE & NUTRITION
(2023)
Article
Chemistry, Medicinal
Xuedong Li, Xixi Lin, Zuoxing Wu, Yuangang Su, Jiamin Liang, Runfeng Chen, Xue Yang, Lei Hou, Jinmin Zhao, Qian Liu, Feng Xu
Summary: The study demonstrates that PRI has therapeutic potential in treating osteolytic diseases like osteoporosis by inhibiting osteoclast formation and bone resorption activity both in vitro and in vivo. PRI exerts its effects through the suppression of NF-κB and ERK MAPK signaling pathways, preventing the production of mature osteoclasts.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Meipeng Zhu, Qian Guo, Honglei Kang, Renpeng Peng, Yimin Dong, Yayun Zhang, Sibo Wang, Haiyang Liu, Hongjian Zhao, Zijian Dong, Kehan Song, Shimeng Xu, Pengju Wang, Liangxi Chen, Jian Liu, Feng Li
Summary: Fatty amide hydrolase (FAAH) is involved in various biological processes and may play an important role in osteoclastogenesis. Inhibition of FAAH in bone marrow-derived macrophages (BMMs) suppressed osteoclastogenesis and bone resorption. The FAAH inhibitor PF-04457845 improved bone loss in mice, and its effects were mediated through the NF-kappa B and MAPK pathways. Targeting FAAH may be a promising strategy for treating osteoclast-related diseases, particularly osteoporosis.
Article
Chemistry, Applied
Ratchanaporn Chokchaisiri, Waraluck Chaichompoo, Oratai Sukcharoen, Apichart Suksamrarn, Lucksagoon Ganranoo
NATURAL PRODUCT RESEARCH
(2019)
Article
Chemistry, Analytical
Lucksagoon Ganranoo, Ratchanaporn Chokchaisiri, Kate Grudpan
Article
Biochemistry & Molecular Biology
Takakazu Mitani, Shun Watanabe, Kenjiro Wada, Hiroshi Fujii, Soichiro Nakamura, Shigeru Katayama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Plant Sciences
Ratchanaporn Chokchaisiri, Waraluck Chaichompoo, Warangkana Chunglok, Sarot Cheenpracha, Lucksagoon Ganranoo, Nathaporn Phutthawong, Sareeya Bureekaew, Apichart Suksamrarn
JOURNAL OF NATURAL PRODUCTS
(2020)
Article
Chemistry, Medicinal
Ratchanaporn Chokchaisiri, Jaranwit Srijun, Waraluck Chaichompoo, Sarot Cheenpracha, Lucksagoon Ganranoo, Apichart Suksamrarn
MEDICINAL CHEMISTRY RESEARCH
(2020)
Article
Agriculture, Dairy & Animal Science
W. Wongngam, T. Mitani, S. Katayama, S. Nakamura, J. Yongsawatdigul
Article
Biochemistry & Molecular Biology
Emi Tanaka, Takakazu Mitani, Momona Nakashima, Eito Yonemoto, Hiroshi Fujii, Hitoshi Ashida
Summary: Theobromine (TB) induces browning in subcutaneous white adipose tissue in mice, increasing UCP1 expression and potentially offering a treatment for obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wasana Wongngam, Sittiruk Roytrakul, Takakazu Mitani, Shigeru Katayama, Soichiro Nakamura, Jirawat Yongsawatdigul
Summary: VSKRLNGDA, a potent ACE-inhibitory peptide, reduces SBP in SHRs and modulates the expression of various genes involved in blood pressure control after oral intake.
PROCESS BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Machi Yamamoto, Mana Miyoshi, Kamino Morioka, Takakazu Mitani, Tomohide Takaya
Summary: A study found that the myogenetic oligodeoxynucleotide iSN04 can inhibit inflammatory responses in muscle cells by suppressing the activity of the nuclear transcription factor NF-kB, thereby promoting myocyte differentiation. The study also observed anti-inflammatory effects of iSN04 in rat smooth muscle cells and murine adipocyte-like fibroblast cells, suggesting its potential use in preventing inflammation caused by metabolic disorders.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Shun Watanabe, Riki Haruyama, Koji Umezawa, Ikuo Tomioka, Soichiro Nakamura, Shigeru Katayama, Takakazu Mitani
Summary: In this study, the effects of genistein on the NAD+ level in adipocytes and the underlying molecular mechanisms were investigated. Genistein was found to enhance NAD+ biosynthesis by increasing the expression of NAMPT. PHB1 was identified as a target protein of genistein and its binding contributed to the stabilization of transcription factor CCAAT/enhancer-binding protein beta. Genistein also dephosphorylated peroxisome proliferator-activated receptor and increased the level of adiponectin. These findings suggest the potential efficacy of genistein in increasing the NAD+ level and restoring metabolic function in adipocytes.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Momona Nakashima, Takakazu Mitani
Summary: Vitamin D and its receptor play a role in regulating calcium homeostasis in mammals. Recent studies have shown that vitamin D is negatively associated with insulin resistance and the incidence of type 2 diabetes. In adipocytes, vitamin D stimulates glucose uptake and adipocyte differentiation through the expression of GLUT4 and HSD11B1.
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2022)
Article
Genetics & Heredity
Abdallah Ahmed Elbakkoush, Anas Khaleel, Albakush Nura Ahmed Mohamed, Ahmad Alathamneh
Summary: This research analyzed gene expression data from whole blood samples to investigate the effect of sepsis on molecular pathways. The study identified significant alterations in gene pathways in sepsis patients, particularly in the inhibition of ARE-mediated mRNA degradation pathway and the Pl3K/AKT signaling spliceosomal cycle. These findings provide potential targets for sepsis treatment.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Takahiro Ikeda, Shun Watanabe, Takakazu Mitani
Summary: Genistein interacts with adenine nucleotide translocase-2 to suppress its function, leading to reduced transcriptional activity of CCAAT/enhancer-binding protein beta, activation of AMP-activated protein kinase, and inhibition of adipogenesis.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Yasukiyo Yoshioka, Tomoya Kitakaze, Takakazu Mitani, Takashi Furuyashiki, Hitoshi Ashida
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2020)
Article
Biology
Kanet Pakdeepak, Ratchanaporn Chokchaisiri, Jiraporn Tocharus, Pranglada Jearjaroen, Chainarong Tocharus, Apichart Suksamrarn