Article
Geriatrics & Gerontology
Shou-En Wu, Yi-Lin Chiu, Tung-Wei Kao, Wei-Liang Chen
Summary: The soluble receptor for advanced glycation end products (sRAGE) level is positively associated with sarcopenia, especially in female groups, possibly attributed to the loss of protection from estrogen in postmenopausal women. Using sRAGE level as a prospective marker for sarcopenia warrants further investigation in future studies.
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yu Wing Tong, Jennifer Ka Yee Ko, Karen Siu Ling Lam, Sidney Tam, Vivian Chi Yan Lee, Pak Chung Ho, Ernest Hung Yu Ng, Raymond Hang Wun Li
Summary: This study evaluated the association between serum advanced glycation end-products (AGEs) and soluble receptor of AGEs (sRAGE) levels with dysglycaemia and metabolic syndrome in women with polycystic ovary syndrome (PCOS). The results showed that women with dysglycaemia or metabolic syndrome had significantly lower sRAGE levels. However, after adjusting for body mass index, free androgen index and homeostatic model assessment for insulin resistance (HOMA-IR), sRAGE did not have a significant independent association with these outcome measures.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Review
Nutrition & Dietetics
Elham Sharifi-Zahabi, Fatemeh Hajizadeh Sharafabad, Hadi Abdollahzad, Mahsa Malekahmadi, Nadya Bahari Rad
Summary: Our meta-analysis showed that higher serum AGE concentration was associated with increased risk of all-cause and CVD mortality. Additionally, higher circulating sRAGE levels were also linked to an increased risk of CVD mortality.
ADVANCES IN NUTRITION
(2021)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Biochemistry & Molecular Biology
Olivia May, Laure Yatime, Nicolas S. Merle, Florian Delguste, Mike Howsam, Marie Daugan, Charles Paul-Constant, Muriel Billamboz, Alina Ghinet, Steve Lancel, Jordan D. Dimitrov, Eric Boulanger, Lubka T. Roumenina, Marie Frimat
Summary: The interaction between RAGE and heme with micromolar affinity could potentially promote proinflammatory and prothrombotic signaling in vivo. This suggests that this interaction may play a role in heme-overload conditions.
Review
Dentistry, Oral Surgery & Medicine
Julie Toby Thomas, Betsy Joseph, Timo Sorsa, Matti Mauramo, Sukumaran Anil, Tuomas Waltimo
Summary: The systematic review aims to compare the levels of advanced glycation end products (AGEs) and RAGE expression in diabetic periodontitis patients with non-diabetic periodontitis patients and to identify the relationship of AGE and RAGE levels with periodontal disease severity.
Article
Nutrition & Dietetics
Elom K. Aglago, Ana-Lucia Mayen, Viktoria Knaze, Heinz Freisling, Veronika Fedirko, David J. Hughes, Li Jiao, Anne Kirstine Eriksen, Anne Tjonneland, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Anna Birukov, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Fulvio Ricceri, Bas Bueno-de-Mesquita, Jeroen W. G. Derksen, Guri Skeie, Inger Torhild Gram, Torkjel Sandanger, J. Ramon Quiros, Leila Lujan-Barroso, Maria-Jose Sanchez, Pilar Amiano, Maria-Dolores Chirlaque, Aurelio Barricarte Gurrea, Ingegerd Johansson, Jonas Manjer, Aurora Perez-Cornago, Elisabete Weiderpass, Marc J. Gunter, Alicia K. Heath, Casper G. Schalkwijk, Mazda Jenab
Summary: The study found a negative association between dietary advanced glycation end-products (dAGEs) and colorectal cancer risk, contrary to initial hypotheses. More research is needed to confirm these results and better understand the exact role of these substances in the development of colorectal cancer.
Article
Medicine, Research & Experimental
Takashi Nishinaka, Omer Faruk Hatipoglu, Hidenori Wake, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Masahiro Nishibori, Hideo Takahashi
Summary: Glycol-AGEs impair the innate immune response by suppressing the upstream process in TLR4 signaling, and also have a suppressive effect on STING signaling in macrophages.
Review
Biochemistry & Molecular Biology
Mieke Steenbeke, Reinhart Speeckaert, Stephanie Desmedt, Griet Glorieux, Joris R. Delanghe, Marijn M. Speeckaert
Summary: Patients with chronic kidney disease (CKD) are more prone to oxidative stress and chronic inflammation, resulting in increased production and decreased clearance of advanced glycation end products (AGEs). AGEs may contribute to decreased kidney function and increased all-cause mortality in CKD patients. Interaction between AGEs and their cell-bound receptor RAGE activates nuclear factor kappa-B (NF-kappa B), leading to cell dysfunction and increased production of inflammatory cytokines. Alterations in the AGE-RAGE system are associated with the development of various chronic kidney diseases. Soluble RAGE (sRAGE) acts as a decoy receptor to inhibit membrane-bound RAGE activation and AGE-RAGE-related toxicity. The ratio of AGEs to sRAGE may be a useful tool for predicting the prognosis of kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Anesthesiology
Raiko Blondonnet, Marc Begard, Pierre Bouzat, Matthieu Jabaudon
ANESTHESIA AND ANALGESIA
(2022)
Article
Medicine, Research & Experimental
Brijesh Patel, Sharon Mumby, Nicholas Johnson, Emanuela Falaschetti, Jorgen Hansen, Ian Adcock, Danny McAuley, Masao Takata, Dan S. Karbing, Matthieu Jabaudon, Peter Schellengowski, Stephen E. Rees
Summary: This study aims to compare mechanical ventilation in ARDS patients following the application of the Beacon Caresystem to standard routine care. Personalized management and decision support systems can improve the effectiveness of mechanical ventilation and patient outcomes.
Article
Anesthesiology
Pierre Bouzat, Adrien Bougle, Matthieu Jabaudon, Bertrand Dureuil, Etienne Gayat, Fanny Bounes, Thomas Clavier, Guillaume Besch, Gerald Chanques, Marc-Olivier Fischer, Denis Frasca, Gilles Orliaguet, Mathieu Raux, Emmanuel Samain, Alexy Tran-Dinh, Benoit Plaud, Lionel Velly, Benoit Veber, Julien Pottecher
Summary: The French College of Anaesthesia and Critical Care Teachers (CNEAR) is an organization that brings together 181 university-affiliated physicians involved in teaching and research in the field of anaesthesia, critical care, and perioperative medicine. They primarily focus on educational goals for medical students and work closely with the Digital University in Health and Sport (UNESS) to provide online educational content and monitor the curriculum for students.
ANESTHESIE & REANIMATION
(2022)
Article
Anesthesiology
Samir Jaber, Marc Garnier, Karim Asehnoune, Fanny Bounes, Louis Buscail, Jean-Baptiste Chevaux, Claire Dahyot-Fizelier, Lucie Darrivere, Matthieu Jabaudon, Olivier Joannes-Boyau, Yoann Launey, Eric Levesque, Philippe Levy, Philippe Montravers, Laurent Muller, Thomas Rimmele, Claire Roger, Celine Savoye-Collet, Philippe Seguin, Jean-Pierre Tasu, Ronan Thibault, Geoffroy Vanbiervliet, Emmanuel Weiss, Audrey De Jong
Summary: This study aims to provide guidelines for the management of intensive care patients with severe acute pancreatitis. A consensus was reached among experts on 24 recommendations, demonstrating strong agreement.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Editorial Material
Anesthesiology
Matthieu Jabaudon, Ary Serpa Neto
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Medicine, General & Internal
Raiko Blondonnet, Laure-Anne Simand, Perine Vidal, Lucile Borao, Nathalie Bourguignon, Dominique Morand, Lise Bernard, Laurence Roszyk, Jules Audard, Thomas Godet, Antoine Monsel, Marc Garnier, Christophe Quesnel, Jean-Etienne Bazin, Vincent Sapin, Julie A. Bastarache, Lorraine B. Ware, Christopher G. Hughes, Pratik P. Pandharipande, E. Wesley Ely, Emmanuel Futier, Bruno Pereira, Jean-Michel Constantin, Matthieu Jabaudon
Summary: This study aims to investigate whether sevoflurane can improve clinical outcomes in patients with severe ARDS. The primary outcome measures the number of days without ventilator support within 28 days, considering death as a competing event, and the key secondary outcome is 90-day survival. The trial will evaluate the efficacy and safety of sevoflurane inhalation sedation in ARDS patients, as well as explore its mechanisms of action.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Giovanni Landoni, Olivia Belloni, Giada Russo, Alessandra Bonaccorso, Gianmarco Cara, Matthieu Jabaudon
Summary: This study summarized the research on the use of volatile anesthetics in COVID-19 patients by searching online databases and clinical trial registries. The findings showed that isoflurane was the most frequently used volatile agent in COVID-19 patients and allowed a reduction in the use of other sedative and analgesic drugs. Additionally, ongoing studies on the use of inhaled sedation in ARDS patients were also identified.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Anesthesiology
Matthieu Jabaudon, Ruoyang Zhai, Raiko Blondonnet, Woodys Lenga Ma Bonda
Summary: Inhaled sedation with halogenated agents is a feasible strategy in ICU patients, offering efficient and titratable sedation with potential clinical benefits.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Raiko Blondonnet, Aissatou Balde, Ruoyang Zhai, Bruno Pereira, Emmanuel Futier, Jean-Etienne Bazin, Thomas Godet, Jean-Michel Constantin, Celine Lambert, Matthieu Jabaudon
Summary: The use of inhaled sedation in French ICUs has increased due to the COVID-19 pandemic and is becoming an alternative to intravenous sedation for more physicians.
Article
Nutrition & Dietetics
Jean-Baptiste Bouillon-Minois, Louisa Khaled, Florence Vitte, Ludovic Miraillet, Romain Eschalier, Matthieu Jabaudon, Vincent Sapin, Lucas Derault, Samy Kahouadji, Marina Brailova, Julie Durif, Jeannot Schmidt, Fares Moustafa, Bruno Pereira, Emmanuel Futier, Damien Bouvier
Summary: The study establishes the reference values for ionized magnesium (iMg) and finds a strong correlation between plasmatic magnesium (pMg) and iMg. The interpretation of iMg is not influenced by pH and albumin variations. The incidencce of ionized hypomagnesemia among de novo atrial fibrillation patients is 8.5%.
Review
Medicine, General & Internal
Khaled Ahmed Yassen, Matthieu Jabaudon, Hussah Abdullah Alsultan, Haya Almousa, Dur Shahwar, Fatimah Yousef Alhejji, Zainab Yaseen Aljaziri
Summary: Based on a review of literature published between 2005 and 2023, inhaled sedation has been found to reduce extubation and weaning time for mechanically ventilated patients in the ICU, as well as decrease opioid and muscle relaxant consumption. It also has potential cardio-protective, anti-inflammatory, and bronchodilator properties, but careful monitoring and management are required to prevent potential risks.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Karen Coste, Shaam Bruet, Caroline Chollat-Namy, Odile Filhol, Claude Cochet, Denis Gallot, Geoffroy Marceau, Loic Blanchon, Vincent Sapin, Corinne Belville
Summary: Fetal membranes (FM) play a crucial role at the feto-maternal interface. Rupture of FM at term involves sterile inflammation mechanisms, including the activation of the RAGE pathway. The protein kinase CK2 is also implicated in inflammation, and this study aims to characterize the expressions of RAGE and CK2 and their potential regulatory relationship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Florian Blanchard, Thomas Godet, Stephanie Pons, Natacha Kapandji, Matthieu Jabaudon, Vincent Degos, Lucile Borao, Adrien Bougle, Antoine Monsel, Emmanuel Futier, Jean-Michel Constantin, Arthur James
Summary: The study found that patients with non-focal ARDS had a higher 1-year mortality rate compared to those with focal ARDS, mainly driven by differences in the first 90 days. Lung morphology had no impact on patient-reported outcomes.
Meeting Abstract
Critical Care Medicine
M. Jabaudon, R. Coupet, M. Schlaepfer, T. A. Neff, P. Boucher, P. Bailly, M. Bellgardt, R. Badenes, T. Becher, C. Varillon, U. Gunther, D. Morand, B. Pereira, B. O'Gara
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Emergency Medicine
Ruoyang Zhai, Woodys Lenga Ma Bonda, Gustavo Matute-Bello, Matthieu Jabaudon
Summary: This study summarizes the strengths and limitations of current available models for ARDS, including animal, in vitro, and clinical models, and discusses the current challenges and future prospects for research in this area.