Journal
SCIENTIFIC REPORTS
Volume 8, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-20985-y
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Funding
- DFG Cluster of Excellence Munich-Centre for Advanced Photonics (MAP)
- DFG Gottfried Wilhelm Leibniz program
- Helmholtz Association
- German Center of Lung Research (DZL DPLD)
- European Research Council (ERC, FP7) [StG 240142]
- Hans-und-Klementia-Langmatz Foundation
- Karlsruhe Nano Micro Facility (KNMF), Helmholtz Research Infrastructure at Karlsruhe Institute of Technology (KIT)
- Helmholtz Association, Germany [NWG VH-NG-829]
- Helmholtz Zentrum Muenchen, Germany [NWG VH-NG-829]
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The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-based large-animal dark-field scanner before and after induction of a unilateral pneumothorax. Image contrast-tonoise ratios between lung tissue and the air-filled pleural cavity were quantified for transmission and dark-field radiograms. The projected area in the object plane of the inflated lung was measured in dark-field images to quantify the collapse of lung parenchyma due to a pneumothorax. Means and standard deviations for lung sizes and signal intensities from dark-field and transmission images were tested for statistical significance using Student's two-tailed t-test for paired samples. The contrast-to-noise ratio between the air-filled pleural space of lateral pneumothoraces and lung tissue was significantly higher in the dark-field (3.65 +/- 0.9) than in the transmission images (1.13 +/- 1.1; p = 0.002). In case of dorsally located pneumothoraces, a significant decrease (-20.5%; p > 0.0001) in the projected area of inflated lung parenchyma was found after a pneumothorax was induced. Therefore, the detection of pneumothoraces in x-ray dark-field radiography was facilitated compared to transmission imaging in a large animal model.
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