Article
Medicine, Research & Experimental
Pavitra Solanki, Mohd Danish Ansari, Anjali, Iram Khan, Rao Nargis Jahan, Nikita, Jayamanti Pandit, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: The study proposes the use of transdermal delivery of hyaluronic acid linked Pentosan polysulfate sodium through polyion complex nanoparticle therapy for the treatment of osteoarthritis, which is a novel therapeutic approach that targets inflammatory sites with minimal side effects.
MEDICAL HYPOTHESES
(2021)
Article
Materials Science, Biomaterials
Yuta Yoshizaki, Manami Yamasaki, Takuya Nagata, Kengo Suzuki, Rio Yamada, Takuma Kato, Nobuo Murase, Akinori Kuzuya, Akira Asai, Kazuhide Higuchi, Kosuke Kaji, Hitoshi Yoshiji, Yuichi Ohya
Summary: Developing drug delivery vehicles that can accumulate drugs in the liver and transfer to hepatic stellate cells is crucial for treating hepatic fibrosis. In this study, HA-coated polymeric micelles were developed as potential drug delivery vehicles for liver fibrosis. These micelles exhibited specific cellular uptake in human hepatic stellate cells and high accumulation in the liver in vivo. Moreover, intravenous injection of HA-coated micelles entrapping an anti-fibrotic drug showed remarkable anti-fibrotic effects in a liver cirrhosis mouse model. Therefore, HA-coated micelles show promise for the clinical management of liver fibrosis.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Polymer Science
Asmariah Ahmad, Teruki Nii, Takeshi Mori, Yoshiki Katayama, Masanori Toyofuku, Akihiro Kishimura
Summary: This study develops novel nanovehicles for polymyxin-type antibiotics using a polyion complex (PICs) system. The importance of guanidine moieties in enhancing the interaction between catiomer and colistimethate sodium (CMS) is demonstrated. The ratio of guanidine residues determines the formation of micellar or vesicular PIC nanostructures. The encapsulation efficiency of CMS depends on the guanidinium modification ratio.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Mitsuru Naito, Hiroyuki Chaya, Kazuko Toh, Beob Soo Kim, Kotaro Hayashi, Shigeto Fukushima, Tetsuya Nagata, Takanori Yokota, Kazunori Kataoka, Kanjiro Miyata
Summary: The researchers found that chemical modification of oligonucleotides to have higher negative charges facilitated the formation of polyion pairs between the oligonucleotide and bPEG-PLys under harsh biological conditions, leading to enhanced blood circulation of uPICs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biophysics
Sakhiran Sakulwech, Nattaya Lourith, Mayuree Kanlayavattanakul, Sarunya Phunpee, Kunat Suktham, Suvimol Surassmo, Uracha Rungsardthong Ruktanonchai
Summary: Quaternized cyclodextrin grafted chitosan was combined with anionic hyaluronic acid to form nanocomplexes, which improved hydration and skin penetration. The combination of the two polymers shows promising potential as a skin delivery system.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Hironori Izawa, Shota Ishisaka, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: The effects of the physical properties of skin layers and substrates on drying-induced surface wrinkling were investigated. It was found that the size of surface wrinkles formed by different polymers on skin layers varied. The hardness of the skin layers was the primary factor determining wrinkle size.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Biochemistry & Molecular Biology
Radostina Kalinova, Ivaylo Dimitrov
Summary: This study aimed to construct novel functional PIC micelles with cell targeting ligands on the surface and evaluate the possibility of encapsulating hydrophobic drugs. The results showed that PIC micelles can successfully be used as carriers for hydrophobic drugs, expanding their potential applications in nanomedicine.
Article
Biochemistry & Molecular Biology
Namit Dey, Franklin Pulikkottil Mohny, G. Betsy Reshma, Divya Rao, Munia Ganguli, Deenan Santhiya
Summary: This study presents the synthesis and characterization of nanocomposites of bioactive glass and hyaluronic acid for effective delivery of HA to skin and bone. The environmentally friendly synthesis method resulted in mesoporous nanocomposites with good cellular viability and uptake. The nanocomposites were able to penetrate skin cells and artificial skin membrane, demonstrating their potential for HA delivery to the skin. The study aims to develop nanocomposites with potential applications in noninvasive treatments and cosmeceuticals.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Masaki Odahara, Kenta Watanabe, Riku Kawasaki, Kousuke Tsuchiya, Ayaka Tateishi, Yoko Motoda, Takanori Kigawa, Yutaka Kodama, Keiji Numata
Summary: The direct protein delivery system, utilizing a cell-penetrating peptide-displayed polyion complex vesicle as a biological nanocarrier, successfully demonstrated nuclear genome editing in plants through delivery of a Cas9 ribonucleoprotein complex.
ACS APPLIED NANO MATERIALS
(2021)
Article
Polymer Science
Gabriel Siquier-Dameto, Sylvie Boisnic, Pere Boadas-Vaello, Enrique Verdu
Summary: The study evaluates the rejuvenating effects of a complex consisting of hyaluronic acid, vitamins, amino acids, and oligopeptides on human skin explants. The results show that the complex significantly reduces the percentage of skin cells with high melanin content and reverses the decrease in collagen, elastin, and sulfated GAGs caused by UVA/UVB irradiation.
Article
Pharmacology & Pharmacy
Xiaoyu Ning, Christian Wiraja, Wan Ting Sharon Chew, Chen Fan, Chenjie Xu
Summary: This study utilized dissolvable hyaluronic acid microneedles as a carrier to enhance transdermal delivery of the anti-scarring traditional Chinese medicine shikonin, showing potential for treating hypertrophic scars. The shikonin HA MNs significantly reduced the viability and proliferation of skin fibroblasts and downregulated fibrotic-related gene expression levels, indicating a localized therapeutic effect that is beneficial for site-specific treatment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Dermatology
Jin Hyeok Hyeong, Joon Woo Jung, Suk Bae Seo, Hong Seok Kim, Kwang Ho Kim
Summary: This study aimed to investigate the efficacy and histologic differences of intradermal injection of a filler using an MFRF device for the treatment of acne scars. The results showed that this treatment method had good effects in improving acne scar grading and satisfaction, as well as increasing collagen and elastic fibers.
DERMATOLOGIC SURGERY
(2022)
Article
Polymer Science
Leon Capeloa, Mina Yazdi, Heyang Zhang, Xiaobing Chen, Yu Nie, Ernst Wagner, Ulrich Lachelt, Matthias Barz
Summary: ABC-type triblock copolymers are synthesized and used as vehicles to deliver siRNA. The self-assembly behavior and cross-linking ability of the polymers are utilized to construct polyion complex (PIC) micelles with a diameter of 50-60 nm, allowing efficient delivery of functional siRNA and specific gene knockdown in cells.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Engineering, Chemical
Sandra Cordeiro, Beatriz Silva, Ana Margarida Martins, Helena Margarida Ribeiro, Lidia Goncalves, Joana Marto
Summary: The development of novel chitosan/hyaluronic acid nanoparticles with mucoadhesive properties, encapsulating antioxidant molecules to reduce eye oxidative stress, is a promising approach for the delivery of antioxidants to the eye.
Article
Nanoscience & Nanotechnology
Jiangxiu Niu, Ming Yuan, Zhaowei Zhang, Liye Wang, Yanli Fan, Xianghui Liu, Xianming Liu, Huiyuan Ya, Yansong Zhang, Yang Xu
Summary: In this study, octadecylamine modified hyaluronic acid (OHA) copolymer was synthesized to prepare curcumin (CUR)-loaded micelles (CUR-M) for topical transdermal administration. The results showed that CUR-M had good physicochemical properties and stability, significantly enhanced the permeation and retention of CUR, and exhibited better analgesic and anti-inflammatory activities in vivo without causing skin irritation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Dermatology
Koji Nomoto, Yurina Itaya, Ken Watanabe, Tadashi Yamashita, Toshiro Okazaki, Yoshihiro Tokudome
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Chemistry, Applied
Mariko Yokota, Shoichi Yahagi, Yoshihiro Tokudome, Hitoshi Masaki
JOURNAL OF OLEO SCIENCE
(2018)
Article
Nutrition & Dietetics
Yoshihiro Tokudome
Article
Dermatology
Shota Sakai, Asami Makino, Akihito Nishi, Takeshi Ichikawa, Tadashi Yamashita, Makoto Taniguchi, Yoshihiro Tokudome, Yoshio Hirabayashi, Masashi Akiyama, Debra Crumrine, Yoshikazu Uchida, Peter M. Elias, Tetsuya Tsuchida, Sumiko Hamanaka
Summary: The absence of epidermal SM synthase 2 leads to ichthyotic phenotype in mice, which gradually normalizes over time. Additionally, the study highlights that nonlethal gene abnormalities can result in skin phenotype abnormalities.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kei Tsukui, Takuya Kakiuchi, Hidetomo Sakurai, Yoshihiro Tokudome
Summary: The switch between keratinocyte proliferation and differentiation is regulated by extracellular calcium levels. The Shotokuseki extract affects keratinocyte differentiation, but not through calcium-dependent mechanisms. Simultaneous application of multiple ions and/or trace ions can alter calcium sensitivity and response of epidermal cells.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Medicinal
Kei Tsukui, Takuya Kakiuchi, Masamitsu Suzuki, Hidetomo Sakurai, Yoshihiro Tokudome
Summary: This study found that the application of Shotokuseki extract (SE) can increase the levels of ions, amino acids, and pyrrolidone carboxylic acid in three-dimensional cultured epidermis. It also increases the expression of key genes involved in amino acid synthesis and natural moisturizing factor (NMF) production, as well as the activity of bleomycin hydrolase. This suggests that the ionic composition of SE may contribute to its moisturizing effect on the stratum corneum.
NATURAL PRODUCTS AND BIOPROSPECTING
(2022)
Article
Biotechnology & Applied Microbiology
Yoshihiro Tokudome, Moeko Fukutomi
Summary: This study evaluated the effect of sphingomyelin, a component of cell membranes, on melanin production. It was found that sphingomyelin can decrease melanin content, inhibit intracellular tyrosinase activity, and reduce the expression of melanin synthesis-related genes. Moreover, sphingomyelin is more easily absorbed by cells and converted to ceramide. These findings contribute to the development of skin whitening methods.
Article
Biotechnology & Applied Microbiology
Kurumi Tanabe, Chihiro Moriguchi, Nao Fujiyama, Yuka Shigematsu, Nanami Haraguchi, Yuto Hirano, Huanghuang Dai, Shigeki Inaba, Yoshihiro Tokudome, Hiroshi Kitagaki
Summary: In this study, we established a system to analyze the effects of cosmetics on skin microbiota using Staphylococcus epidermidis. We found that cosmetics containing rice and soy ferments were clustered together, while cosmetics from South Asia and those containing natural plant extracts were also clustered together. This trial provides a pattern map of cosmetics in terms of their effects on skin microbiota.
FERMENTATION-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Akira Otsuka, Chihiro Moriguchi, Yuka Shigematsu, Kurumi Tanabe, Nanami Haraguchi, Sonoko Iwashita, Yoshihiro Tokudome, Hiroshi Kitagaki
Summary: The skin, as the largest organ of the human body, plays a vital role in protecting the body and maintaining body temperature. However, the rise of the chemical industry has led to an increase in skin diseases. The presence of various microorganisms and their metabolites on the skin has functional properties for skin health. Fermented cosmetics, derived from Japanese traditional fermented foods, are expected to contribute to skin health in the natural skincare product market.
FERMENTATION-BASEL
(2022)
Article
Dermatology
Moe Otsuka, Tsuyoshi Tamane, Yoshihiro Tokudome
Summary: This study aimed to determine the effects of LFPs on human epidermal cell differentiation by assessing amino acid and Cer production. The results showed that treatment with LFPs promotes human epidermal cell differentiation and increases the intercellular content of free fatty acids, Cer, contributing to improved skin barrier function. Treatment with LFPs also increased the production of the amino acid arginine in keratinocytes, which may help improve water retention.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yoshihiro Tokudome, Tsuyoshi Hoshi, Sayaka Mori, Ichiro Hijikuro
Article
Materials Science, Multidisciplinary
Miki Shigefuji, Yoshihiro Tokudome
Article
Chemistry, Physical
Yoshihiro Tokudome, Haruna Tsukiji
COLLOIDS AND INTERFACES
(2020)
Review
Pharmacology & Pharmacy
Yoshihiro Tokudome
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2019)
