Erythromycin leads to differential protein expression through differences in electrostatic and dispersion interactions with nascent proteins

Blast from the Past: Reassessing Forgotten Translation Inhibitors, Antibiotic Selectivity, and Resistance Mechanisms to Aid Drug Development

(2016) Stefan Arenz et al.   MOLECULAR CELL

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

(2016) Stefan Arenz et al.   Nature Communications

A New Method for Navigating Optimal Direction for Pulling Ligand from Binding Pocket: Application to Ranking Binding Affinity by Steered Molecular Dynamics

(2015) Quan Van Vuong et al.   Journal of Chemical Information and Modeling

Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation

(2014) Stefan Arenz et al.   MOLECULAR CELL

The general mode of translation inhibition by macrolide antibiotics

(2014) Krishna Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrolide antibiotics allosterically predispose the ribosome for translation arrest

(2014) Shanmugapriya Sothiselvam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence selectivity of macrolide-induced translational attenuation

(2014) A. R. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence-Dependent Elongation Dynamics on Macrolide-Bound Ribosomes

(2014) Magnus Johansson et al.   Cell Reports

The Dynamics of SecM-Induced Translational Stalling

(2014) Albert Tsai et al.   Cell Reports

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P

(2013) L. Peil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Protein Synthesis by Ribosomes with a Drug-Obstructed Exit Tunnel

(2012) Krishna Kannan et al.   CELL

The Amber ff99 Force Field Predicts Relative Free Energy Changes for RNA Helix Formation

(2012) Aleksandar Spasic et al.   Journal of Chemical Theory and Computation

Template-based protein structure modeling using the RaptorX web server

(2012) Morten Källberg et al.   Nature Protocols

How Robust Are Protein Folding Simulations with Respect to Force Field Parameterization?

(2011) Stefano Piana et al.   BIOPHYSICAL JOURNAL

Nascent Peptide in the Ribosome Exit Tunnel Affects Functional Properties of the A-Site of the Peptidyl Transferase Center

(2011) Haripriya Ramu et al.   MOLECULAR CELL

Role of antibiotic ligand in nascent peptide-dependent ribosome stalling

(2011) N. Vazquez-Laslop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Free Energy Profile of RNA Hairpins: A Molecular Dynamics Simulation Study

(2010) Nan-Jie Deng et al.   BIOPHYSICAL JOURNAL

The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

(2010) Nora Vázquez-Laslop et al.   EMBO JOURNAL

Programmed drug-dependent ribosome stalling

(2009) Haripriya Ramu et al.   MOLECULAR MICROBIOLOGY

Molecular Mechanism of Drug-Dependent Ribosome Stalling

(2008) Nora Vazquez-Laslop et al.   MOLECULAR CELL

Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22

(2008) S. D. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA