8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90α downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells

Understanding prostate cancer biology using metabolomics and proteomics approaches: potentials in the improvement of the diagnosis, prognosis and identification of new therapeutic targets

(2017) J. Felgueiras et al.   EUROPEAN JOURNAL OF CANCER

Novel multi-substituted benzyl acridone derivatives as survivin inhibitors for hepatocellular carcinoma treatment

(2017) Bin Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CDK4/6 inhibition and sorafenib: a ménage à deux in HCC therapy?

(2017) Diego Calvisi et al.   GUT

Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC

(2017) Riccardo Lencioni et al.   JOURNAL OF HEPATOLOGY

A luminescent europium complex for the selective detection of trace amounts of aldicarb sulfoxide and prometryne

(2017) Zeinab M. Anwar et al.   JOURNAL OF MOLECULAR STRUCTURE

High-throughput metabolomics approach reveals new mechanistic insights for drug response of phenotypes of geniposide towards alcohol-induced liver injury by using liquid chromatography coupled to high resolution mass spectrometry

(2017) Tianlei Zhang et al.   Molecular BioSystems

Emerging roles of lipid metabolism in cancer metastasis

(2017) Xiangjian Luo et al.   Molecular Cancer

Effects of inhibiting PI3K-Akt-mTOR pathway on lipid metabolism homeostasis in goose primary hepatocytes

(2016) D. D. Liu et al.   Animal

The Warsaw Proposal for the Use of Extended Selection Criteria in Liver Transplantation for Hepatocellular Cancer

(2016) Michał Grąt et al.   ANNALS OF SURGICAL ONCOLOGY

Les infirmières cliniciennes améliorent la gestion des toxicités des patients traités par sorafénib pour carcinome hépatocellulaire

(2016) Angélique Brunot et al.   BULLETIN DU CANCER

Identification of key metabolic changes in renal interstitial fibrosis rats using metabonomics and pharmacology

(2016) Liangcai Zhao et al.   Scientific Reports

Functional outcomes of partial prostate ablation and focal therapy

(2015) Jonathan A. Coleman   CURRENT OPINION IN UROLOGY

Integrative Proteomics and Metabolomics Analysis of Insect Larva Brain: Novel Insights into the Molecular Mechanism of Insect Wandering Behavior

(2015) Yi Li et al.   JOURNAL OF PROTEOME RESEARCH

Understanding different facets of cardiovascular diseases based on model systems to human studies: A proteomic and metabolomic perspective

(2015) Trayambak Basak et al.   Journal of Proteomics

Proteomic tools for the characterization of cell death mechanisms in drug discovery

(2015) Veronica G. Anania et al.   Proteomics Clinical Applications

SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma

(2015) Wenwen Zhang et al.   TUMOR BIOLOGY

High expression of small GTPase Rab3D promotes cancer progression and metastasis

(2015) Jian Yang et al.   Oncotarget

Transcriptomic and Proteomic Investigation of HSP90A as a Potential Biomarker for HCC

(2015) Yi Zhou et al.   MEDICAL SCIENCE MONITOR

Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress

(2015) Megumi Uetaki et al.   Scientific Reports

Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment

(2014) Y. Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fatty Acid Synthase Mediates the Epithelial-Mesenchymal Transition of Breast Cancer Cells

(2014) Junqin Li et al.   International Journal of Biological Sciences

Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery

(2013) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: Multicentre, open-label, phase II safety study

(2013) Jordi Bruix et al.   EUROPEAN JOURNAL OF CANCER

Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it

(2013) Douglas B. Kell   FEBS Journal

Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3β/Snail signaling

(2013) Lulu Liu et al.   HEPATOLOGY

Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series

(2013) Tony Taldone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabonomic study on the antitumor effect of flavonoid derivative 3d in HepG2 cells and its action mechanism

(2013) Dan Gao et al.   TALANTA

Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer

(2012) Michael W. Hance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Claudin-1 induces epithelial–mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells

(2012) Y Suh et al.   ONCOGENE

Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors

(2011) Cunlong Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

EGFR and VEGFR as potential target for biological therapies in HCC cells

(2008) Gianluigi Giannelli et al.   CANCER LETTERS

Epithelial-to-Mesenchymal Transition and Integrin-Linked Kinase Mediate Sensitivity to Epidermal Growth Factor Receptor Inhibition in Human Hepatoma Cells

(2008) B. C. Fuchs et al.   CANCER RESEARCH