Article
Engineering, Biomedical
Solaiman Tarafder, Jaskirti Ghataure, David Langford, Rachel Brooke, Ryunhyung Kim, Samantha Lewis Eyen, Julian Bensadoun, Jeffrey T. Felix, James L. Cook, Chang H. Lee
Summary: Meniscus injuries are common and lack regenerative therapies. Connective tissue growth factor (CTGF) and transforming growth factor beta 3 (TGF83) have been shown to promote meniscus healing. The harmful effects of lubricin on meniscus healing and the mechanism of lubricin deposition were investigated. Heparin conjugation and CD44 modification improved the healing of lubricin-coated meniscus injuries.
BIOACTIVE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Salomi Desai, Mark Dooner, Jake Newberry, John Twomey-Kozak, Janine Molino, Jay Trivedi, Jay M. Patel, Brett D. Owens, Chathuraka T. Jayasuriya
Summary: In a rodent model, treatment with stable cartilage-derived progenitor cell lines has been shown to stimulate meniscus tear healing and provide chondroprotection.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ming Hao, MengNa Duan, Zhijing Yang, Hengzong Zhou, Shuangji Li, Jingcheng Xiang, Han Wu, Huimin Liu, Lu Chang, Dongxu Wang, Weiwei Liu
Summary: Wound healing in the oral and maxillofacial area has a significant impact on the patient's quality of life and mental health. Traditional treatment methods are limited in their efficacy, but exosomes secreted by stem cells have shown promising results. However, natural stem cell exosomes have limitations, and engineered stem cell exosomes have been developed to overcome these limitations and provide targeted promotion of efficient soft tissue repair. These engineered exosomes have anti-inflammatory and cell proliferation regulatory abilities, which make them effective treatments for oral and maxillofacial wound healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Edward R. Floyd, Ariel N. Rodriguez, Kari L. Falaas, Gregory B. Carlson, Jorge Chahla, Andrew G. Geeslin, Robert F. LaPrade
Summary: This study discusses the impact of posterior medial meniscus root tears (PMMRTs) on the progression of osteoarthritis (OA) and the consequences of nonanatomic root repairs, finding that the injuries lead to an increase in contact pressure in the medial compartment and a decrease in contact area. Through a case series, it is discovered that nonanatomic repairs can result in meniscal extrusion and symptomatic meniscal extrusion.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Orthopedics
K. Magnusson, A. Turkiewicz, B. Snoeker, V. Hughes, M. Englund
Summary: The study estimates the genetic contribution to traumatic and degenerative meniscus tears and finds that environmental risk factors play a more important role than genetic factors in both men and women.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Multidisciplinary Sciences
Marc A. Fernandez-Yague, Lauren A. Hymel, Claire E. Olingy, Claire McClain, Molly E. Ogle, Jose R. Garcia, Dustin Minshew, Sofiya Vyshnya, Hong Seo Lim, Peng Qiu, Andres J. Garcia, Edward A. Botchwey
Summary: Understanding the immune response to hydrogel implantation is crucial for designing immunomodulatory biomaterials. Through the use of advanced techniques such as high-dimensional flow cytometry and intravital imaging, the study found that RGD-presenting hydrogels can promote cellular infiltration and revascularization, and can direct the immune response through controlling macrophage cytokine secretion.
Article
Orthopedics
Marjan Bahraminasab, Athar Talebi, Nesa Doostmohammadi, Samaneh Arab, Ali Ghanbari, Sam Zarbakhsh
Summary: This study investigated the in-vivo healing of critical-sized bony defects using cell-free and stem cell-seeded 3D-printed PLA scaffolds in rat calvaria bone. The results demonstrated that both types of scaffolds exhibited excellent healing capabilities compared to the empty defect controls, with the formation of new bone and connective tissues after 8 and 12 weeks postoperatively. Furthermore, the PLA + Cell scaffolds showed higher filled area, bone formation, and bone maturation after 12 weeks.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Jingsong Wang, Sally Roberts, Weiping Li, Karina Wright
Summary: This study identifies and characterizes progenitor cell populations in different regions of the human meniscus. Progenitor cells from the vascular region show enhanced proliferative and fibrochondrogenic characteristics compared to those from the avascular region. These findings indicate that meniscal progenitors may be a promising cell therapy strategy for meniscal regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rui Zheng, Daiying Song, Yangfan Ding, Binbin Sun, Changrui Lu, Xiumei Mo, Hui Xu, Yu Liu, Jinglei Wu
Summary: Injury to the meniscus is a common challenge in the clinic. The study compares three commonly used cell sources (BMSC, ADSC, and chondrocytes) for engineering meniscus tissue. Chondrocytes show superior characteristics for constructing chondrogenic tissues, while stem cells are feasible for forming fibroblastic tissues. Combining chondrocytes and stem cells may be a potential solution for meniscus repair and regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Orthopedics
Caitlin C. Chambers, John A. Lynch, Brian T. Feeley, Michael C. Nevitt
Summary: This study aimed to compare the impact of root tears (RTs) and nonroot tears (NRTs) on knee osteoarthritis (OA) and identify factors associated with radiographic worsening of OA in knees with RTs. The study found that RTs were associated with the development and progression of OA, especially in knees without pre-existing OA.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xiaokun Wang, Liam Chung, Joshua Hooks, David R. Jr Jr Maestas, Andriana Lebid, James Andorko, Luai Huleihel, Alexander F. Chin, Matthew Wolf, Nathaniel T. Remlinger, Mary Ann Stepp, Franck Housseau, Jennifer H. Elisseeff
Summary: The use of porcine urinary bladder matrix (UBM) particulate can inhibit the differentiation of corneal stromal cells and reduce corneal haze formation. Additionally, stimulating type 2 immune responses can create a pro-regenerative environment in wounded corneas, leading to improved wound healing.
Article
Orthopedics
Ryota Takase, Takashi Ohsawa, Shogo Hashimoto, Shingo Kurihara, Shinya Yanagisawa, Keiichi Hagiwara, Masashi Kimura, Hirotaka Chikuda
Summary: This study investigated the long-term changes in the dynamics of the medial meniscus after transtibial pullout repair for MMPRTs. The results showed that surgery did not reduce the extrusion in the knee extension position, and these values increased in the postoperative period. While the surgery reduced the extrusion in the knee flexion position, the restoration achieved was not sustained in the long term.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Orthopedics
Wenli Dai, Xi Leng, Jian Wang, Xiaoqing Hu, Yingfang Ao
Summary: In this systematic review, the complete healing rate was 74%, the partial healing rate was 10%, and the failure rate was 12% for arthroscopic repair of meniscal tears via second-look arthroscopic evaluation. Subgroup analysis found higher meniscal healing rates in patients with specific characteristics, such as age <40 years, male gender, body mass index <26, tear location, tear type, repair technique, and rehabilitation protocol. Overall, the results suggest that certain patient and repair characteristics may influence the healing rates of meniscal tears after arthroscopic repair.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Lucija Kadunc Polajnar, Dusko Lainscek, Rok Gaspersic, Petra Susjan-Leite, Uros Kovacic, Miha Butinar, Boris Turk, Roman Jerala, Iva Hafner-Bratkovic
Summary: Growth factors play a crucial role in tissue regeneration and healing. We developed a combinatorial platform using engineered cell lines producing multiple growth factors to enhance regeneration therapy. This approach showed better results in promoting wound closure compared to using individual growth factors or stem cell-conditioned medium.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Min Zhang, Yanjing He, Xu Zhang, Shuaiqi Gan, Xi Xie, Zheng Zheng, Jinfeng Liao, Wenchuan Chen
Summary: This study found that overexpression of circ-CTTN can enhance the osteogenic differentiation of human umbilical cord mesenchymal stem cells, promoting bone reconstruction. This provides a new strategy and theoretical basis for the clinical application of bone tissue engineering.
BIOMATERIALS SCIENCE
(2023)
Article
Orthopedics
James L. Cook, Kylee Rucinski, Cory R. Crecelius, Suzin Cunningham, Trent M. Guess
Summary: This prospective randomized clinical trial assessed a novel device for initial management of knee range of motion (ROM), pain, and function after total knee arthroplasty (TKA). The results showed that using the novel device can effectively restore knee range of motion, reduce pain, and improve knee function, with higher patient satisfaction compared to standard physical therapy.
JOURNAL OF KNEE SURGERY
(2023)
Article
Orthopedics
Lasun O. Oladeji, James P. Stannard, Matthew J. Smith, Richard Ma, Nathan W. Skelley, Seth L. Sherman, James L. Cook
Summary: This study aimed to evaluate the initial clinical outcomes associated with the use of a hyperosmolar irrigation solution in patients undergoing arthroscopic knee surgery. The results showed that the hyperosmolar saline irrigation fluid did not have any detrimental effects on the surgical procedure, postoperative pain, or periarticular fluid extravasation, and it contributed to a reduction in initial postoperative narcotic pain medication consumption.
JOURNAL OF KNEE SURGERY
(2023)
Article
Orthopedics
Abdul Fettah Buyuk, James P. Stannard, Kylee Rucinski, Cory R. Crecelius, James L. Cook
Summary: This study aimed to compare the outcomes of whole-surface osteochondral allograft (OCA) transplantation using Missouri Osteochondral Preservation System (MOPS) and standard preservation (SP) methods for the treatment of patellofemoral joint lesions. The results showed that the success rate and patient-reported outcome scores of OCA transplantation using MOPS preservation method were significantly better than those using SP preservation method. Unipolar patella OCA transplantation was superior to unipolar trochlea and bipolar patellofemoral OCA transplantation in reducing pain and improving patient-reported outcomes.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2023)
Article
Orthopedics
Alexander Rodriguez, John Baumann, Will Bezold, Conor Smith, Dimitri Thomas, James L. Cook, Matthew J. Smith
Summary: This study compared the glenohumeral biomechanics of Latarjet coracoid autograft and distal tibial osteochondral allograft (DTA) reconstructions. The results showed that both reconstruction techniques provided adequate functional stability, but DTA reconstruction appeared to be more advantageous for large anterior glenoid bone defects.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Critical Care Medicine
Kylee Rucinski, Emily Leary, Brett D. Crist, James L. Cook
Summary: This retrospective study examined key demographic and psychosocial factors associated with non-adherence to follow-up appointments for patients with orthopaedic trauma in an urban and rural population. The study found that male sex, age between 26 and 35 years, non-white race, disabled employment, low household income, low education level, lack of insurance or Medicaid coverage, and being single were associated with higher rates of no-show appointments.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Orthopedics
Joseph Temperato, Kylee Rucinski, James L. Cook, Aaron Meers, Joao Bourbon de Albuquerque, James P. Stannard
Summary: Surgical reconstruction is recommended for symptomatic posterior cruciate ligament (PCL) deficiency. This study compared clinical outcomes following PCL reconstruction using two tibial fixation techniques, transtibial (TT) and tibial inlay (TI), based on body mass index, comorbidities, and primary versus revision surgery. Results showed similarly favorable functional, social, and psychological outcomes for both techniques, with slightly lower pain scores in the TT cohort.
JOURNAL OF KNEE SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
James L. Cook, Cristi R. Cook, Kylee Rucinski, James P. Stannard
Summary: This study aimed to assess the use of serial ultrasonographic imaging in predicting short-term failure after meniscus allograft transplantation (MAT). The results showed that ultrasonographic assessment at 6 months after surgery can effectively determine the risk for short-term failure. Abnormal echogenicity, persistent effusion, and extrusion with weightbearing were associated with a higher likelihood of failure.
Article
Orthopedics
Preston N. Wolfe, Aaron M. Stoker, Emily Leary, Brett D. Crist, Chantelle C. Bozynski, James L. Cook
Summary: This study evaluated serum and urine biomarker panels for their ability to differentiate between individuals with healthy hips and those with developmental dysplasia of the hip (DDH) before the development of secondary hip osteoarthritis (OA). The results showed that multiple urine and serum biomarker panels could effectively differentiate individuals with DDH from healthy-hip controls in a population at risk for developing secondary hip OA. These findings suggest the potential clinical application of these biomarker panels for cost-effective and timely screening for DDH in at-risk populations.
Review
Orthopedics
Josephine Luk, Luke Troyer, Trent M. Guess, Emma Teixeiro, James P. Stannard, James L. Cook
Summary: Osteochondral allograft (OCA) transplantation is successful in treating articular cartilage lesions, but treatment failures still occur. The biomechanics of OCA transplantation have direct and indirect effects on graft survival and patient outcomes. Modifiable biomechanical variables should be optimized to improve outcomes for OCA transplant patients.
JOURNAL OF KNEE SURGERY
(2023)
Article
Orthopedics
Samuel D. Gieg, James P. Stannard, James L. Cook
Summary: Health literacy refers to the ability to obtain, process, and understand basic medical information and services, and to use this knowledge to improve health. While research has mainly focused on the readability of educational materials, the impact of health literacy on patient-reported outcomes in orthopaedic surgery remains unclear. This review aimed to evaluate the existing literature on health literacy and knee surgery outcomes. A comprehensive literature search was conducted, resulting in the inclusion of six articles that highlighted the influence of general and musculoskeletal health literacy on patient expectations, outcomes, and satisfaction before and after knee surgery. However, further research is needed to determine effective strategies for addressing health literacy as a barrier to optimal patient care in orthopaedics.
JOURNAL OF KNEE SURGERY
(2023)
Article
Orthopedics
Steven F. DeFroda, Brett Crist, James L. Cook
Summary: The acetabular labrum plays a crucial role in maintaining the functional health of the hip joint. When labral insufficiency occurs due to injury, overuse, developmental disorders, or failed primary labral repair, labral reconstruction becomes necessary. Although there are various graft options available for hip labral reconstruction, there is currently no established gold standard. The development of an arthroscopic technique using fresh meniscal allograft tissue aims to create a graft that closely resembles the native labrum in terms of geometry, structure, mechanical properties, and durability.
ARTHROSCOPY TECHNIQUES
(2023)
Article
Orthopedics
Preston N. Wolfe, Aaron M. Stoker, Brett D. Crist, Emily Leary, Chantelle C. Bozynski, James L. Cook
Summary: This study aimed to determine measurable differences in mechanistic urine and serum biomarkers in patients with developmental dysplasia of the hip (DDH) before and after the diagnosis of secondary hip osteoarthritis (OA), compared to controls. Urine and serum samples were collected and analyzed for protein biomarkers. The results showed differential expression of interleukin and degradation-related proteins in DDH-related hip status before and after the diagnosis of hip OA, as well as significant differences in MCP-1 and TIMP-1 between younger and older patients in the control cohorts.
JOURNAL OF ORTHOPAEDICS
(2023)
Article
Orthopedics
P. J. Reddy, B. T. Manning, W. Bezold, A. Garlapaty, J. L. Cook, K. Schweser
Summary: This study compared the biomechanical properties of nitinol compression staples and fully threaded lag screws for talonavicular arthrodesis. The results show that there were no significant differences in translation between the two fixation methods, but the staples exhibited greater rotation during static compression testing.
JOURNAL OF ORTHOPAEDICS
(2023)
Article
Engineering, Biomedical
Solaiman Tarafder, Jaskirti Ghataure, David Langford, Rachel Brooke, Ryunhyung Kim, Samantha Lewis Eyen, Julian Bensadoun, Jeffrey T. Felix, James L. Cook, Chang H. Lee
Summary: Meniscus injuries are common and lack regenerative therapies. Connective tissue growth factor (CTGF) and transforming growth factor beta 3 (TGF83) have been shown to promote meniscus healing. The harmful effects of lubricin on meniscus healing and the mechanism of lubricin deposition were investigated. Heparin conjugation and CD44 modification improved the healing of lubricin-coated meniscus injuries.
BIOACTIVE MATERIALS
(2023)
Article
Orthopedics
Shayne R. Kelly, James T. Stannard, Jahnu Reddy, James L. Cook, James P. Stannard, Clayton W. Nuelle
Summary: This article describes a technique for meniscus allograft transplantation using double bone plug and knotless all-suture anchors with cortical-button suspensory fixation. It aims to reduce complications and improve the success rate of the surgery.
ARTHROSCOPY TECHNIQUES
(2023)