Article
Immunology
Man-jun Yang, Ming Jiang, Xuan-xian Peng, Hui Li
Summary: This study investigated how water temperature affects the survival of tilapia to bacterial infection from the perspective of metabolic state. It was found that tilapia were more susceptible to infection at 33 degrees C, but the infection could be attenuated by exogenous myo-inositol. The exogenous myo-inositol inactivated the elevated TCA cycle, increasing the survival ability of tilapia at higher water temperature.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Hannah Darroch, Jonathan W. Astin, Christopher J. Hall
Summary: Immune memory operates in both adaptive and innate immune systems, known as trained immunity. Larval zebrafish, which rely solely on innate immunity, can exhibit a trained immunity-like phenotype and provide protection against subsequent infections for at least 12 days. This form of immunological memory can be enhanced through the administration of beta-glucan, resulting in increased survival and immune response in the zebrafish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Bailee N. Kain, Brandon T. Tran, Pamela N. Luna, Ruoqiong Cao, Duy T. Le, Marcus A. Florez, Laure Maneix, Jack D. Toups, Daniel E. Morales-Mantilla, Scott Koh, Hyojeong Han, Roman Jaksik, Yun Huang, Andre Catic, Chad A. Shaw, Katherine Y. King
Summary: Recent studies have found that infection can reprogram hematopoietic stem and progenitor cells (HSPCs) to enhance innate immune responses, a phenomenon known as trained immunity. In this study using mice, it was discovered that HSPCs activate interferon gamma-response genes heterogeneously upon primary infection, and rare cell populations expand. Macrophages derived from trained HSPCs demonstrated enhanced bacterial killing and metabolism, and a single dose of recombinant interferon gamma exposure was enough to induce similar training. Furthermore, transplantation of influenza-trained HSPCs in mice resulted in enhanced immunity against M. avium, demonstrating cross-protection against different pathogens. These findings suggest that HSPCs can produce long-term bone marrow derived macrophages with enhanced function and provide cross-protection against alternative pathogens.
Article
Environmental Sciences
Ning Ding, Lin Jiang, Xiao Wang, Chun Wang, Yue Geng, Jianxin Zhang, Yingxue Sun, Yanping Zhang, Quan Yuan, Hong Liu
Summary: This study assessed the toxicity of microplastic exposure using zebrafish. Results showed that microplastics can negatively affect the growth rate and intestinal enzyme activities of zebrafish. However, under the tested conditions, concurrent exposure to microplastics and bacteria did not significantly increase zebrafish mortality.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Fisheries
Zhuo-hao Ruan, Yi-fu Li, Liang-sen Jiang, Zhi-qiang Lu, Yuan-yuan Luo, Xi-quan Zhang, Yu-gu Li, Wen-sheng Liu
Summary: This study finds a strong association between NLRC3, IL4R, and C4 gene polymorphisms and resistance to A. hydrophila infection in striped catfish. The expression of these genes is induced by A. hydrophila infection in various tissues. Specific SNPs are found to be associated with resistant and susceptible phenotypes in striped catfish.
Article
Cell Biology
Natalia Nowik, Tomasz K. Prajsnar, Anna Przyborowska, Krzysztof Rakus, Waldemar Sienkiewicz, Herman P. Spaink, Piotr Podlasz
Summary: Galanin, a conserved peptide found across different species, was traditionally thought to be related to neurotransmission but recent studies have shown its involvement in immune responses. Knockout of galanin in zebrafish increased susceptibility to Mycobacterium marinum and Staphylococcus aureus infections, while administration of a galanin analogue improved the fish's ability to control the infections. Transcriptional data revealed fewer gene regulations in response to mycobacterial infections in gal-/- mutants compared to gal+/+ counterparts, indicating a significant impact of galanin deficiency on immune-related pathways. The results suggest that galanin not only serves as a neurotransmitter, but also has implications in immune responses to bacterial infections, highlighting the complexity of the neuroendocrine system and its connection to immunity.
Article
Agriculture, Dairy & Animal Science
Ghasem Rashidian, Javad Tahmasebi Boldaji, Simona Rainis, Marko D. Prokic, Caterina Faggio
Summary: The study found that oregano extract has significant effects on the growth and immune system of zebrafish, improving their antioxidant response and survival rate against bacterial invasion. Zebrafish showed the greatest benefits with 1% dietary inclusion of the extract, suggesting the potential use of Origanum vulgare in the aquaculture industry and zebrafish as an appropriate model for nutrition studies.
Review
Biochemistry & Molecular Biology
Abdul Hawil Abas, Siti Marfuah, Rinaldi Idroes, Diah Kusumawaty, Fatimawali, Moon Nyeo Park, Abolghasem Siyadatpanah, Fahad A. Alhumaydhi, Shafi Mahmud, Trina Ekawati Tallei, Talha Bin Emran, Bonglee Kim
Summary: The COVID-19 pandemic caused by the SARS-CoV-2 virus is still ongoing, with the Omicron variant being the latest mutation. While Omicron shows increased transmissibility, it also appears to have milder symptoms and lower hospitalization rates, especially among vaccinated individuals. This has led to speculation that Omicron could provide a natural form of vaccination, potentially leading to the end of the pandemic. However, it is important to note that subsequent mutations may not necessarily result in less severe disease, highlighting the need for ongoing vaccinations to adapt to the evolving virus.
Article
Fisheries
Afaf N. Abdel Rahman, Shimaa R. Masoud, Moustafa M. S. Fouda, Abdelwahab A. Abdelwarith, Elsayed M. Younis, Samah S. Khalil, Haidy T. Zaki, Ebaa Mohammed, Simon J. Davies, Rowida E. Ibrahim
Summary: Recently, researchers have become interested in green synthesized nanomaterials as a superior alternative to conventional methodologies in aquaculture. This study suggests that Moringa oleifera synthesized magnetite nanoparticles (MS-Fe3O4NPs) could be a substitute for antibiotics in treating Aeromonas sobria infection in African catfish. MS-Fe3O4NPs exhibited significant in vitro antibacterial potential and showed positive effects in recovering the health parameters of fish infected with A. sobria. These findings indicate that MS-Fe3O4NPs have potential as an antibacterial treatment in fish.
AQUACULTURE REPORTS
(2023)
Article
Gastroenterology & Hepatology
Julia A. Brown, Katherine Z. Sanidad, Serena Lucotti, Carolin M. Lieber, Robert M. Cox, Aparna Ananthanarayanan, Srijani Basu, Justin Chen, Mengrou Shan, Mohammed Amir, Fabian Schmidt, Yiska Weisblum, Michele Cioffi, Tingting Li, Florencia Madorsky Rowdo, M. Laura Martin, Chun-Jun Guo, Costas Lyssiotis, Brian T. Layden, Andrew J. Dannenberg, Paul D. Bieniasz, Benhur Lee, Naohiro Inohara, Irina Matei, Richard K. Plemper, Melody Y. Zeng
Summary: This study reveals the mechanisms by which the gut microbiome protects mammalian hosts from SARS-CoV-2 infection. Short-chain fatty acids reduce viral burden by regulating the viral entry receptor and enhancing adaptive immunity, while also regulating systemic coagulation by limiting megakaryocyte proliferation. These findings have significant implications for understanding the immune and coagulation mechanisms of COVID-19 infection.
Article
Cell Biology
G. Forn-Cuni, L. Welvaarts, F. M. Stel, C. J. van den Hondel, M. Arentshorst, A. F. J. Ram, A. H. Meijer
Summary: The activation of antifungal autophagy response improves host survival against drug-resistant Aspergillus infections, but only in the presence of phagocytes. This finding suggests that stimulating the autophagy process may be a promising approach for developing therapies against invasive Aspergillosis.
Article
Cell Biology
Yongbo Qiao, Shenghui Jin, Jiaojiao Nie, Yaotian Chang, Bo Wang, Shanshan Guan, Qinghan Li, Yuhua Shi, Wei Kong, Yaming Shan
Summary: The use of recombinant trimeric hemagglutinin (HA) as an antigen in a DNA vaccine shows promise as a competitive candidate vaccine against influenza viruses. It elicits significant immune responses and provides protection against lethal infection.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Fisheries
Ahmed F. Abdelhamid, Hala F. Ayoub, Eman A. Abd El-Gawad, Mohamed F. Abdelghany, Mohsen Abdel-Tawwab
Summary: Supplementation of seaweed extract significantly improved growth performance and immune indices of striped catfish fry, especially at 2% and 3% inclusion levels.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Qiang Fu, Jie Hu, Pei Zhang, Yuqing Li, Shoucong Zhao, Min Cao, Ning Yang, Chao Li
Summary: Seventeen CC and CXC chemokine genes were identified in the turbot genome, making it a valuable resource for comparative immunological studies and functional characterization of chemokines in teleost.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Veterinary Sciences
Yuan-Yuan Zhang, Peng Xu, Xiao-Li Wang, Li-Ping Song, Jun Wu, Bing-Li Wang, Bin Hu, Shu-Quan Mao, Bo Liu, Xian-Ping Ge
Summary: This study investigates the effects of emodin on the total bacterial count and immune response in various tissues ofWuchang bream infected with A. hydrophila. The results show that emodin supplementation significantly affects the total bacterial count in infected tissues and the immune response. Adding 100 mg/kg of emodin enhances the Wuchang bream's resistance to A. hydrophila infection.
VETERINARY SCIENCES
(2023)
Article
Biochemical Research Methods
Siva Bala Subramaniyan, Rajendran Senthilnathan, Jothi Arunachalam, Veerappan Anbazhagan
BIOCONJUGATE CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Siva Bala Subramaniyan, Sesuraj Babiola Annes, Manokaran Yuvasri, Kolanchinathan Nivedha, Subburethinam Ramesh, Veerappan Anbazhagan
Article
Biochemistry & Molecular Biology
Sharath Vaidyanath, B. S. Harish, G. Gayathri, C. Trilokesh, Kiran Babu Uppuluri, Veerappan Anbazhagan
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Materials Science, Multidisciplinary
Sengan Megarajan, Anbazhagan Veerappan
Article
Fisheries
Preetham Elumalai, Abdul Salam Rubeena, Sreeja Lakshmi, Veerappan Anbazhagan, Jesu Arockiaraj, Mani Divya, Sekar Vijayakumar, Baskaralingam Vaseeharan
Summary: In this study, CuS nanoparticles were conjugated with shrimp lectin (Md-Lec) to enhance their antimicrobial activity against aquatic pathogens. The conjugation led to a four-fold reduction in minimum inhibitory concentration (MIC) and decreased hydrophobicity index and EPS production of the pathogens. Furthermore, treated fishes showed elevated non-specific immune parameters and upregulated immune gene expression, suggesting the potential of Md-Lec-pCuS NPs as an immunostimulant for disease-free fish production in aquaculture industry.
AQUACULTURE INTERNATIONAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Jayasankari Senthilganesh, Sivaranjani Ravichandran, Rubini Durairajan, Siva BalaSubramaniyan, Lakshmi Krishnasamy, Anbazhagan Veerappan, Nithyanand Paramasivam
Summary: Vulvovaginal candidiasis is a common infection caused by Candida species, especially Candida albicans. Plant protein-based nano scaffolds were found to effectively mitigate fluconazole-resistant Candida albicans infections. Lectin-functionalized copper sulfide nanoparticles showed lower inhibitory concentrations and synergistic effects with antifungal drugs like micafungin.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Biochemical Research Methods
Siva Bala Subramaniyan, Subburethinam Ramesh, Senthilnathan Rajendran, Anbazhagan Veerappan
Summary: A novel method involving the combination of butea monosperma seed lectin and antimicrobial lipid was proposed to overcome serum protein interference and demonstrated significant antimicrobial activity against uropathogenic Escherichia coli. The conjugates showed good biocompatibility and biosafety in a zebrafish model, exhibiting high antimicrobial intensity and low likelihood of resistance development.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Physical
Siva Bala Subramaniyan, Sengan Megarajan, Karnan Singaravelu Dharshini, Anbazhagan Veerappan
Summary: Functionalizing nanoparticles to target bacteria surfaces is an effective approach to combat drug-resistant pathogens. This study synthesized N-myristoyltaurine capped silver nanoparticles (AgNPs) and functionalized them with jacalin from Artocarpus integrifolia seeds. The functionalized AgNPs (JAgNPs) had a lower minimum inhibitory concentration and showed superior biofilm inhibition activity against S. aureus compared to AgNPs, suggesting a unique way to use nanosilver for treating infections associated with S. aureus biofilm.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Parthasarathy Gayathri, Siva Bala Subramaniyan, Anbazhagan Veerappan, Mehboobali Pannipara, Abdullah G. Al-Sehemi, Dohyun Moon, Savarimuthu Philip Anthony
Summary: Aggregation-induced emissive fluorophores have attracted attention due to their controllable solid-state fluorescence. This study explored the impact of interlinking, positional isomerism, and acceptor structure on the fluorescence tuning and switchability. Results revealed that changing the acceptor group led to fluorescence tuning between 534 and 614 nm, with closer spacing and tighter packing enhancing fluorescence efficiency.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Materials Science, Multidisciplinary
Dharshini Karnan Singaravelu, Siva Bala Subramaniyan, M. P. Tharunya, Anbazhagan Veerappan
Summary: In this study, cationic antimicrobial lipid was used as a stabilizing agent in the preparation of copper sulfide nano particles for the first time. The cN16E-CuS exhibited excellent antimicrobial activity against Carbapenem-Resistant Acinetobacter baumannii, with a two-fold lower MIC compared to pure cN16E. Mechanistic study revealed that cN16E-CuS produced excess reactive oxygen species, leading to superior antimicrobial activity at lower concentrations.
Article
Biotechnology & Applied Microbiology
Siva Bala Subramaniyan, Fuad Ameen, Dharshini Karnan Singaravelu, Preetham Elumalai, Sartaj Ahmed Bhat, Anbazhagan Veerappan
Summary: The study demonstrates that BcN16E is more effective than cN16E in impairing biofilm-associated virulence factors and exerting antimicrobial activity. This finding emphasizes the potential of phytolectin in enhancing anti-virulence strategies against cross-kingdom biofilm-related infections.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Aleena Pious, Shreya Muthukumar, Dharshini Karnan Singaravelu, Periyappan Nantheeswaran, Mariappan Mariappan, Arvind Sivasubramanian, Fuad Ameen, Marek Gancarz, Anbazhagan Veerappan
Summary: This study demonstrates the use of designer micelles derived from glycine as a capping agent to prepare Bi2O3 nanoparticles, which can effectively degrade toxic dyes in industrial wastewater without harming the environment.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Siva Bala Subramaniyan, Megarajan Sengan, Ramesh Subburethinam, Anbazhagan Veerappan
Summary: The introduction of new cationic N-acylethanolamines showed promising antimicrobial activity against Mycobacterium smegmatis, with the minimum inhibitory concentration decreasing as the N-acyl chain length increased. Additionally, cNAEs in combination with isoniazid exhibited synergistic activity by disrupting bacterial membrane, generating reactive oxygen species, and depolarizing the membrane. Hemolytic study confirmed that cN16E is non-toxic to human red blood cells.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Abdul Salam Rubeena, Sreeja Lakshmi, Digi George, Siva Bala Subramaniyan, Anbazhagan Veerappan, Elumalai Preetham
Article
Chemistry, Multidisciplinary
Panneerselvam Arun Prasanth, Periyappan Nantheeswaran, Veerappan Anbazhagan, Rajendran Senthilnathan, Arunachalam Jothi, Nattamai S. P. Bhuvanesh, Lokesh Koodlur Sannegowda, Mariappan Mariappan
NEW JOURNAL OF CHEMISTRY
(2020)
