Article
Multidisciplinary Sciences
Ibrahim Musa Yola, Carlee Moser, Meredith S. Duncan, Edzard Schwedhelm, Dorothee Atzler, Renke Maas, Juliane Hannemann, Rainer H. Boeger, Ramachandran S. Vasan, Vanessa Xanthakis
Summary: The study found a significant association between the endogenous nitric oxide synthase inhibitor ADMA and the prevalence of MetS, but no significant associations were found between other methylarginines and the incidence of MetS. Further studies with larger sample sizes are needed to replicate these findings.
Article
Nutrition & Dietetics
Beegum Noorjahan Shijina, Achuthan Radhika, Sainulabdeen Sherin, Prabath Gopalakrishnan Biju
Summary: The indole alkaloid vindoline from Catharanthus roseus was found to have significant improvements in insulin resistance, oxidative stress, and inflammatory responses. It enhanced glucose metabolism and increased the expression of insulin receptors, alleviating symptoms of insulin resistance.
Article
Ophthalmology
A. Brantley Milam, Katherine S. Peters, Emilio Rivera, Cassandra Warden, Paula A. Harlow, Sabrina L. Mitchell, M. Wade Calcutt, David C. Samuels
Summary: This study aimed to investigate the differences in six arginine-related and citrulline-related metabolites between patients with type 2 diabetes and diabetic retinopathy. The results showed that plasma levels of arginine and citrulline were significantly elevated in patients with diabetic retinopathy.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aiwen Jiang, Hongyun Guo, Xiaoyu Jiang, Jingli Tao, Wangjun Wu, Honglin Liu
Summary: This study reveals the down-regulation of G6PD during skeletal muscle development and explores its importance in myogenic differentiation. G6PD deficiency may provide a new perspective for the treatment of insulin resistance and type-2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Servet Birgin Iritas, Aybike Dip, Meside Gunduzoz, Lutfiye Tutkun, Vugar Ali Turksoy, Serdar Deniz, Gulsum Tekin, Ozgur Oztan, Ali Unlu
Summary: The study revealed that long-term exposure to TCE might be an important risk factor for cardiovascular diseases by increasing methylated arginine levels.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2021)
Article
Endocrinology & Metabolism
Myung Jin Kim, Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
Summary: This study evaluated the association between insulin resistance and myosteatosis in a large Asian population. The results showed that higher insulin resistance levels were significantly associated with increased absolute values of total abdominal muscle area, normal-attenuation muscle area, low-attenuation muscle area, and intermuscular adipose tissue. However, the ratios of normal-attenuation muscle area to body mass index and normal-attenuation muscle area to total abdominal muscle area showed a decreasing trend.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jacob D. Covert, Brian A. Grice, Matthew G. Thornburg, Manpreet Kaur, Andrew P. Ryan, Lixuan Tackett, Theja Bhamidipati, Natalie D. Stull, Teayoun Kim, Kirk M. Habegger, Donald A. McClain, Joseph T. Brozinick, Jeffrey S. Elmendorf
Summary: A Western-style high-fat diet leads to an accumulation of cholesterol in skeletal muscle plasma membrane, causing insulin resistance. The hexosamine biosynthesis pathway (HBP) and increased Sp1 activity contribute to this cholesterolgenic response. Inhibition of Sp1 activity can prevent cholesterol accumulation and insulin resistance. These findings suggest that targeting HBP/Sp1 activity may be a potential therapy for preventing diet-induced insulin resistance.
MOLECULAR METABOLISM
(2023)
Article
Dentistry, Oral Surgery & Medicine
Volkan Sengul, Zeliha Guney, Sivge Kurgan, Canan Onder, Muhittin A. Serdar, Meral Gunhan
Summary: This study investigated the levels of NOS, methylated arginine metabolites, and IL-6 in serum and saliva of patients with advanced periodontal diseases. The results showed a significant relationship between clinical parameters, especially ADMA levels in saliva, and periodontal inflammation.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Chiara Volani, Johannes Rainer, Vinicius Veri Hernandes, Viviana Meraviglia, Peter Paul Pramstaller, Sigurdur Vidir Smarason, Giulio Pompilio, Michela Casella, Elena Sommariva, Giuseppe Paglia, Alessandra Rossini
Summary: ACM is a genetic-based cardiac disease characterized by severe ventricular arrhythmias and substitution of myocardium with fibro-fatty tissue. Studies have shown dysregulated metabolic status in ACM patients, with altered metabolomes compared to healthy controls, including pathways such as tryptophan metabolism, arginine and proline metabolism, and beta oxidation of fatty acids. This indicates signs of endothelium damage, impaired nitric oxide, fat, and energy metabolism in ACM patients.
Review
Biochemistry & Molecular Biology
Sinenhlanhla X. H. Mthembu, Phiwayinkosi Dludla, Khanyisani Ziqubu, Tawanda M. Nyambuya, Abidemi P. Kappo, Evelyn Madoroba, Thembeka A. Nyawo, Bongani B. Nkambule, Sonia Silvestri, Christo J. F. Muller, Sithandiwe E. Mazibuko-Mbeje
Summary: Polyphenols are natural compounds that have been increasingly studied for their potential health benefits, particularly in mitigating metabolic disorders. Research has shown the ability of polyphenols to improve mitochondrial function in skeletal muscle, which plays a crucial role in energy homeostasis.
Review
Biochemistry & Molecular Biology
Zhaolu Wang, Jinjin Yang, Xiaohui Sun, Xi Sun, Gongshe Yang, Xin'e Shi
Summary: Skeletal muscle plays a crucial role in physical activities, metabolism, and energy balance, but its homeostasis is challenged by various factors such as injury, aging, and obesity. Exosomes, a type of extracellular vesicles, have emerged as important mediators in intercellular communication and hold great potential for treating skeletal muscle diseases. This review outlines recent research progress in exosomal isolation, characterization, mechanism of action, and highlights advancements in exosomes derived from different organs and tissues, as well as engineered exosomes, which have the ability to regulate the physiological and pathological development of skeletal muscle. These advancements enhance our understanding of muscle formation and diseases, and the utilization of engineered exosomes as nanocarriers with advanced biomolecule design methodologies offers innovative therapeutic perspectives for muscle diseases.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Biochemistry & Molecular Biology
Dominika Szlezak, Marcin Ufnal, Adrian Drapala, Emilia Samborowska, Maria Wrobel
Summary: A study found that nitric oxide (NO) plays an important role in regulating the circulatory system. Decreased NO availability is associated with hypertension, cardiovascular, and kidney diseases. The study also revealed that hypertension and aging decrease tissue NO levels and are associated with reduced urinary excretion of NOS inhibitors, namely ADMA and SDMA.
Article
Biochemistry & Molecular Biology
Jongsoo Mok, Tae Sub Park, Sunhong Kim, Daehoon Kim, Cheol Soo Choi, Joonghoon Park
Summary: The study found that Prokr1 plays an important role in skeletal muscle, improving insulin sensitivity and being a potential therapeutic target for ameliorating insulin resistance in skeletal muscle.
Article
Medicine, Research & Experimental
Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacos, Fatima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon
Summary: Gestational diabetes mellitus (GDM) poses a significant public health concern, affecting 9-15% of pregnancies worldwide. This study found that EV-associated miRNAs in GDM patients undergo significant changes during gestation and can be effectively used for classification. A set of proteins associated with JAK-STAT signaling in skeletal muscle biopsies from GDM patients was identified, which may be targeted by the miRNA-92a-3p carried by circulating EVs. Overexpression of miRNA-92a-3p was shown to increase insulin sensitivity in primary skeletal muscle cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Karla E. Merz, Ragadeepthi Tunduguru, Miwon Ahn, Vishal A. Salunkhe, Rajakrishnan Veluthakal, Jinhee Hwang, Supriyo Bhattacharya, Erika M. McCown, Pablo A. Garcia, Chunxue Zhou, Eunjin Oh, Stephanie M. Yoder, Jeffrey S. Elmendorf, Debbie C. Thurmond
Summary: The levels of PAK1 protein and its downstream effector ARPC1B are significantly reduced in the skeletal muscle of type 2 diabetes patients, which may be related to glucose homeostasis. Our study shows that skeletal muscle PAK1 is required for maintaining whole body glucose homeostasis and can also affect the function of pancreatic beta cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Jin-Young Cho, Hyoung-Joo Lee, Seul-Ki Jeong, Kwang-Youl Kim, Kyung-Hoon Kwon, Jong Shin Yoo, Gilbert S. Omenn, Mark S. Baker, William S. Hancock, Young-Ki Paik
JOURNAL OF PROTEOME RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Hyoe-Jin Joo, Saeram Park, Kwang-Youl Kim, Mun-Young Kim, Heekyeong Kim, Donha Park, Young-Ki Paik
BIOCHEMICAL JOURNAL
(2016)
Article
Biochemical Research Methods
Kwang-Youl Kim, Sang-Heon Cho, Yong-Hyun Song, Moon-Suk Nam, Cheol-Woo Kim
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2016)
Article
Endocrinology & Metabolism
Heun-Sik Lee, Tao Xu, Young Lee, Nam-Hee Kim, Yeon-Jung Kim, Jeong-Min Kim, Sang Yun Cho, Kwang-Youl Kim, Moonsuk Nam, Jerzy Adamski, Karsten Suhre, Wolfgang Rathmann, Annette Peters, Rui Wang-Sattler, Bok-Ghee Han, Bong-Jo Kim
Article
Chemistry, Analytical
Kwang-Youl Kim, Hyoe-Jin Joo, Hye-Won Kwon, Heekyeong Kim, William S. Hancock, Young-Ki Paik
ANALYTICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Jeeyong Lee, Kwang-Youl Kim, Young-Ki Paik
Article
Biochemical Research Methods
Seul-Ki Jeong, Keun Na, Kwang-Youl Kim, Hoguen Kim, Young-Ki Paik
JOURNAL OF PROTEOME RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Kwang-Youl Kim, Ju-Hee Kang, Cheol-Woo Kim, Moonsuk Nam
MOLECULAR & CELLULAR TOXICOLOGY
(2011)
Letter
Biotechnology & Applied Microbiology
Young-Ki Paik, Seul-Ki Jeong, Gilbert S. Omenn, Mathias Uhlen, Samir Hanash, Sang Yun Cho, Hyoung-Joo Lee, Keun Na, Eun-Young Choi, Fangfei Yan, Fan Zhang, Yue Zhang, Michael Snyder, Yong Cheng, Rui Chen, Gyorgy Marko-Varga, Eric W. Deutsch, Hoguen Kim, Ja-Young Kwon, Ruedi Aebersold, Amos Bairoch, Allen D. Taylor, Kwang Youl Kim, Eun-Young Lee, Denis Hochstrasser, Pierre Legrain, William S. Hancock
NATURE BIOTECHNOLOGY
(2012)
Article
Chemistry, Analytical
Kwang-Youl Kim, Hyun-Jung Kwon, Sang-Heon Cho, Moonsuk Nam, Cheol-Woo Kim
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2019)
Article
Multidisciplinary Sciences
Hyo Jung Lee, Han Byul Jang, Won-Ho Kim, Keon Jae Park, Kwang Youl Kim, Sang Ick Park, Hye-Ja Lee
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Wooyoung Eric Jang, Ji Hwan Park, Gaeun Park, Geul Bang, Chan Hyun Na, Jin Young Kim, Kwang-Youl Kim, Kwang Pyo Kim, Chan Young Shin, Joon-Yong An, Yong-Seok Lee, Min-Sik Kim
Summary: This study revealed the Cntnap2-dependent molecular networks in ASD through multi-omics analysis. The findings showed that ASD cellular processes were mainly linked to excitatory neurons and exhibited mitochondrial dysfunction, axonal impairment, and synaptic activity.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Kyung Soo Kim, Seok Whan Moon, Mi Hyung Moon, Kwan Yong Hyun, Seung Joon Kim, Young Koon Kim, Kwang Youl Kim, Dong Wook Jekarl, Eun-Jee Oh, Yonggoo Kim
Summary: This study investigates the metabolic profiles of lung adenocarcinoma (LUAD) patients and identifies specific metabolites, such as arginine and lysophosphatidylcholine-acyl (Lyso.PC.a) C16:0, that are associated with LUAD diagnosis. Network analysis reveals distinct changes in network properties between early-stage and advanced-stage LUAD. These findings suggest the potential of metabolites and network analysis as biomarkers for LUAD diagnosis and prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Analytical
Kwang-Youl Kim, Bo-Hyung Kim, Won Gun Kwack, Hyun-Jung Kwon, Sang-Heon Cho, Cheol-Woo Kim
Summary: A rapid, simple, and robust LC-MS/MS method was developed and validated for quantifying colistin and colistin methanesulfonate (CMS) in human plasma, with a successful solution to the CMS instability issue.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)