Article
Biochemistry & Molecular Biology
Szymon Grochans, Jan Korbecki, Donata Siminska, Wojciech Zwierello, Sylwia Rzeszotek, Agnieszka Kolasa, Klaudyna Kojder, Maciej Tarnowski, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This study investigates the role of chemokine CCL18 and its receptors in GBM tumors. The results show higher expression of CCL18 in GBM tumors compared to the peritumoral area. Furthermore, gender differences were observed, with lower expression of PITPNM3 receptor in female GBM patients and lower expression of CCR8 in male GBM patients. The study also suggests that GBM cells migrate from hypoxic areas, which could be crucial in understanding tumorigenesis mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Tadas K. Rimkus, Austin B. Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara Manore, Calvin Wagner, Hui-Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael Chan, Waldemar Debinski, Hui-Wen Lo
Summary: The study found that TUSC2 protein expression is reduced in glioblastoma compared to normal brain due to protein destabilization. NEDD4-mediated polyubiquitination is a novel mechanism for TUSC2 degradation in glioblastoma. TUSC2 loss promotes glioblastoma progression through upregulation of Bcl-xL and its knockout gene signature predicts poor patient survival.
Article
Multidisciplinary Sciences
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juanhan Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu
Summary: Glioblastoma (GBM) shares common signaling pathways involving TIM-3, an immune checkpoint, between tumor and non-tumor cells. The study reveals that TIM-3 in glioma cells not only regulates the malignant behaviors of glioma cells but also induces macrophage migration and transition to an anti-inflammatory/protumorigenic phenotype through the TIM-3/IL6 signal. Blocking this feedback loop may provide a novel therapeutic strategy for GBM.
Review
Biochemistry & Molecular Biology
Melania Lo Iacono, Chiara Modica, Gaetana Porcelli, Ornella Roberta Brancato, Giampaolo Muratore, Paola Bianca, Miriam Gaggianesi, Alice Turdo, Veronica Veschi, Matilde Todaro, Simone Di Franco, Giorgio Stassi
Summary: The tumor microenvironment (TME) plays a crucial role in cancer growth, with adipose tissue (AT) being a prevalent component of TME and contributing to cancer development. Cancer-associated adipocytes (CAAs), reprogrammed by cancer stem cells (CSCs), promote cancer progression through the release of metabolites and inflammatory adipokines. This review highlights the mechanisms of bidirectional crosstalk between CAAs, CSCs, and stromal cells, and discusses the recent advances in targeting adipocyte-released factors as a promising strategy to counteract cancer progression.
Review
Oncology
Gianluca Trevisi, Annunziato Mangiola
Summary: In this manuscript, the authors review the biological characteristics of glioblastoma peritumoral tissue and emphasize its importance in glioblastoma progression and recurrence. The peritumoral brain zone (PBZ) is the primary target for post-operative adjuvant treatment, and understanding its unique microenvironment and cellular landscape is crucial for developing more effective treatments.
Review
Biochemistry & Molecular Biology
Alice Chaplin, Ramon Maria Rodriguez, Juan Jose Segura-Sampedro, Aina Ochogavia-Segui, Dora Romaguera, Gwendolyn Barcelo-Coblijn
Summary: Obesity is a major risk factor for colorectal cancer, and visceral adipose tissue may play a key role in tumor development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Amin Izadpanah, Fatemeh Daneshimehr, Kurtis Willingham, Zahra Barabadi, Stephen E. Braun, Aaron Dumont, Ricardo Mostany, Bysani Chandrasekar, Eckhard U. Alt, Reza Izadpanah
Summary: TRAF3IP2 has been identified as a critical regulator of angiogenesis in glioblastoma multiforme (GBM), and targeting TRAF3IP2 could significantly reduce vascularization and inhibit the expression of growth factors, providing a potential therapeutic option for GBM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Nauman Malik, Benjamin Geraghty, Archya Dasgupta, Pejman Jabehdar Maralani, Michael Sandhu, Jay Detsky, Chia-Lin Tseng, Hany Soliman, Sten Myrehaug, Zain Husain, James Perry, Angus Lau, Arjun Sahgal, Gregory J. Czarnota
Summary: This study investigated the use of radiomics-based approach to distinguish between GBM PTR and LGG, showing that quantitative analysis of conventional MRI sequences can effectively differentiate between the two types of tumors.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fabiana Moresi, Diana Valeria Rossetti, Federica Vincenzoni, Giorgia Antonia Simboli, Giuseppe La Rocca, Alessandro Olivi, Andrea Urbani, Giovanni Sabatino, Claudia Desiderio
Summary: This study applied a bioinformatic approach to investigate specific sub-proteomes in Cavitating Ultrasound Aspirator (CUSA) fluid pools of glioblastomas, aiming to understand the aggressive behavior of this brain cancer. The results showed the over-representation of certain pathways in different protein classifications and revealed variations in protein distribution between newly diagnosed and recurrent tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anastasia Geladaris, Darius Haeusler, Martin S. Weber
Summary: Therapeutically controlling chronic progression in multiple sclerosis (MS) remains a major challenge, as the exact mechanisms causing progression are still unknown. Microglia may play a key role in driving disease progression of MS, providing a unique opportunity for the development of more effective therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Rui Sun, Albert H. Kim
Summary: With the application of high throughput sequencing technologies at single-cell resolution, researchers have discovered immense cellular and tissue heterogeneity in the tumor microenvironment of glioblastoma. The interactions between malignant and immune cells generate an immunosuppressive microenvironment, while glioma stem cells play a critical role in tumor growth and therapeutic resistance.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Engineering, Biomedical
Shuhan Liu, Ji Liu, Haisong Li, Kuirong Mao, Haorui Wang, Xiandi Meng, Jialiang Wang, Chenxi Wu, Hongmei Chen, Xin Wang, Xiuxiu Cong, Yue Hou, Ye Wang, Ming Wang, Yong-Guang Yang, Tianmeng Sun
Summary: This study develops a novel cationic lipid nanoparticle (LNP) that efficiently delivers siRNA across the blood-brain barrier (BBB) and targets the tumor microenvironment in the brain of mice for immunotherapy of glioblastoma multiforme (GBM). The LNP is effective in delivering siRNA against CD47 and PD-L1 into the cranial GBM in mice, resulting in downregulation of target gene expression and activation of antitumor immunity.
Article
Immunology
Shiyuan Han, Zimu Zhang, Wenbin Ma, Jun Gao, Yongning Li
Summary: This study demonstrated that the expression of NOD family members was increased in glioblastoma tissues, which was associated with poor survival. NOD1 was identified as an independent prognostic marker for glioblastoma, and its high expression was correlated with tumor recurrence and poor prognosis. The mechanism may involve the regulation of extracellular structure, cell adhesion, and immune response by NOD1.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
Dominique S. Rubenich, Priscila O. de Souza, Natalia Omizzollo, Mariana R. Aubin, Paulo J. Basso, Luisa M. Silva, Eloisa M. da Silva, Fernanda C. Teixeira, Gabriela F. S. Gentil, Jordana L. Domagalski, Maico T. Cunha, Kerolainy A. Gadelha, Leonardo F. Diel, Nicolly E. Gelsleichter, Aline S. Rubenich, Gabriela S. Lenz, Aline M. de Abreu, Giselle M. Kroeff, Ana H. Paz, Fernanda Visioli, Marcelo L. Lamers, Marcia R. Wink, Paulo V. Worm, Anelise B. Araujo, Jean Sevigny, Niels O. S. Camara, Nils Ludwig, Elizandra Braganhol
Summary: This study demonstrates that neutrophils are reprogrammed by the tumor to ultimately promote the progression of glioblastoma (GB). The communication between GB and neutrophils directly promotes an immunosuppressive tumor microenvironment (TME). These findings are crucial for understanding tumor progression and the role of immune cells in this process.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Chao Yuan, Yanli Liao, Shengjie Liao, Mi Huang, Duanzhuo Li, Weibin Wu, Yi Quan, Liqiang Li, Xin Yu, Wenxia Si
Summary: This study confirmed that triptolide inhibited the progression of glioblastoma cells by transcriptionally depressing the expression of PROX1.
FRONTIERS IN ONCOLOGY
(2023)
