Article
Cell Biology
Dorota Gil, Marta Zarzycka, Joanna Pabijan, Ma lgorzata Lekka, Joanna Duli Dulinska-Litewka
Summary: Melanoma is resistant to chemotherapy and lacks fully effective targeted therapies. The mutations in melanoma lead to the hyperactivation of the MAPK and PI3K/AKT/mTOR pathways, which are responsible for abnormal protein synthesis. In this study, we investigated the effects of a specific PI3K/mTOR inhibitor, dactolisib, and Mnk inhibitor -CGP57380, alone and in combination on human melanoma cell lines. Both drugs showed inhibition of cell proliferation and migration when used individually, but their combination had additional antitumor effects. Simultaneous inhibition of both pathways may help overcome drug resistance.
CELLULAR SIGNALLING
(2023)
Article
Chemistry, Medicinal
Huankai Yao, Xiuli Zhang, Nan Zhang, Jindong Li, Yan Li, Qunli Wei
Summary: In the study, it was found that wikstromol inhibited cell growth and induced apoptosis in TNBC cells, suppressed cell migration, and the inhibitory effects were involved in the inactivation of the PI3K/Akt pathway.
JOURNAL OF NATURAL MEDICINES
(2021)
Article
Biochemistry & Molecular Biology
Zhonghua An, Xuelin Feng, Mengjia Sun, Yifan Wang, Hongbo Wang, Yanling Gong
Summary: The chemical constituents of chamomile essential oil (CEO) were analyzed using gas chromatography-mass spectrometry (GC/MS). CEO is rich in terpenoids, with Caryophyllene, d-Cadinene, and Caryophyllene oxide as the main components. CEO showed significant antitumor activity by inhibiting the proliferation, migration, and invasion of MDA-MB-231 cells through the inhibition of the PI3K/Akt/mTOR signaling pathway.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Chemistry, Medicinal
Shuo Li, Jia-shu Chen, Xiangqian Li, Xiaoyi Bai, Dayong Shi
Summary: Overexpression of eIF4E is common in various solid tumors and hematologic cancers, making it a potential anti-cancer target. This review provides a detailed classification and description of the anti-cancer activities of promising compounds, concluding that MNK1/2 and eIF4E/eIF4G interaction inhibitors are superior to mTOR inhibitors for targeted therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Shailima Rampogu, Seong Min Kim, Baji Shaik, Gihwan Lee, Ju Hyun Kim, Gon Sup Kim, Keun Woo Lee, Myeong Ok Kim
Summary: The study successfully designed and synthesized three compounds, showing anticancer properties in breast cancer cell lines.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Xiaomin Liu, Jinsheng Liu, Bing Yan, Zhuo Quan, Xiaolong Wang, Yujing Ma, Abdullah A. Alarfaj, Lei Yan
Summary: Breast cancer is a significant health issue for women, and its treatment has been a research focus. This study discovered that periplocin has anticancer properties against breast cancer by inhibiting the PI3K/Akt/mTOR pathway, leading to apoptosis and cell cycle arrest in breast cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Lei Wang, Zhiyu Fang, Peixiang Gao, Junfang Zheng
Summary: This study reveals a novel tumor-suppressing role of GLUD1 in ccRCC, providing new insights into inhibiting PI3K/Akt/mTOR activation and immune microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuwei Fang, Kangpei Shi, Haining Lu, Lin Lu, Bo Qiu
Summary: Mingmu Xiaomeng tablets can protect the diabetic retina by inhibiting the PI3K/Akt/mTOR signaling pathway, promoting autophagy, and improving retinal function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Ling Xie, Jun Yi, Yongjia Song, Mengyao Zhao, Liqiang Fan, Liming Zhao
Summary: GOLM1 has been identified as a prime target for cancer therapy, and EGCG is the first natural product found to downregulate GOLM1 expression, inhibiting MDA-MB-231 cell migration through the HGF/HGFR/AKT/GSK-3/ beta-catenin/c-Myc signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Dongmei Lan, Chao Yao, Xue Li, Haijiang Liu, Dan Wang, Yan Wang, Shengcai Qi
Summary: Tocopherol protects bone marrow-derived mesenchymal stem cells (BMSCs) from oxidative stress damage by inhibiting ferroptosis. This study found that tocopherol maintained cell viability, reduced intracellular oxidative stress levels, and promoted osteogenic differentiation, possibly through modulation of the PI3K/AKT/mTOR pathway.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yingnan Dai, Yeping Chen, Guoqian Wei, Li Zha, Xueqi Li
Summary: This study demonstrated that Ivabradine attenuated myocardial infarction in rats by enhancing autophagy, and the PI3K/AKT/mTOR/p70S6K pathway might be involved in this process. Activation of autophagy by Ivabradine could be a potential therapeutic strategy for the treatment of myocardial infarction.
Article
Pharmacology & Pharmacy
Jin-Long Pang, Lian-Song Xu, Qian Zhao, Wen-Wen Niu, Xiang-Yu Rong, Shan-Shan Li, Xian Li
Summary: This study found that sodium cantharidate (SCA) promotes apoptosis of breast cancer cells by inhibiting the PI3K-Akt-mTOR pathway and inducing autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Badr Alzahrani, Abozer Y. Elderdery, Abdullah Alsrhani, Nasser A. N. Alzerwi, Maryam Musleh Althobiti, Musaed Rayzah, Bandar Idrees, Ahmed M. E. Elkhalifa, Suresh K. Subbiah, Pooi Ling Mok
Summary: In this study, albumin-chlorogenic acid nanoparticles (NPs) with confirmed physio-chemical properties were synthesized and characterized. The NPs showed significant anti-microbial and anti-fungal activities against various bacterial and fungal strains. Furthermore, they exhibited anti-cancer effects by inducing apoptosis through p53-dependent and PI3/AKT/mTOR inhibition in MDA-MB-435s cells. These findings suggest that albumin-chlorogenic acid NPs have potential applications as effective anti-microbial and anti-cancer agents, but further in vivo studies are needed for confirmation.
Article
Chemistry, Medicinal
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong
Summary: In this study, it was found that thymoquinone inhibited the proliferation of gastric cancer cells and induced concentration-dependent apoptosis and autophagy. These effects were mediated through the inhibition of the PI3K/Akt/mTOR pathway. The findings provide new insights into the specific mechanism of thymoquinone as an anti-gastric cancer drug.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qinhang Wu, Xuejiao Leng, Xuelin Ma, Qixuan Xu, Ruijun Ni, Yang Pan, Zhuolin Jin, Muhammad Kalim
Summary: Triptolide has a metastatic inhibitory effect on MDA-MB-231 cells by targeting ROCK1 and inhibiting the epithelial-mesenchymal transition. It suppresses cell proliferation, induces cell apoptosis, and reduces migration and invasion capabilities of the cells. Triptolide also affects the expressions of various proteins associated with metastasis.
CHEMISTRY & BIODIVERSITY
(2023)
